Sappanone a attenuates allergic airway inflammation in ovalbumin-induced asthma

International Archives of Allergy and Immunology

Volumn 170, Issue 3, 2016, Pages 180-186

  Liu, Xueshibojie ^a   Yu, Duo ^a   Wang, Tiejun ^a  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

Asthma; Nrf2 signaling pathway; Sappanone A; Th2 cytokines

Indexed keywords

ANTIASTHMATIC AGENT; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN; SAPPANONE A; UNCLASSIFIED DRUG; CYTOKINE; ISOFLAVONE DERIVATIVE; NFE2L2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; EOSINOPHIL COUNT; FEMALE; LEUKOCYTE DIFFERENTIAL COUNT; LUNG LAVAGE; LYMPHOCYTE; LYMPHOCYTE COUNT; MACROPHAGE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; OVALBUMIN-INDUCED AIRWAY INFLAMMATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION; TH1 TH2 BALANCE; UPREGULATION; ANIMAL; BLOOD; BRONCHOALVEOLAR LAVAGE FLUID; CYTOLOGY; DISEASE MODEL; IMMUNOLOGY; LEUKOCYTE; METABOLISM; PATHOLOGY;

ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOGLOBULIN E; ISOFLAVONES; LEUKOCYTES; LYMPHOCYTES; MICE; NF-E2-RELATED FACTOR 2; OVALBUMIN; SIGNAL TRANSDUCTION;

EID: 84989849910     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000448331     Document Type: Article

References (26)

1. Wills-Karp M. Immunologic basis of antigeninduced airway hyperresponsiveness. Annu Rev Immunol 1999; 17: 255-281.
2. Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol 2004; 22: 789-815.
3. Suissa S, Ernst P. Inhaled corticosteroids: impact on asthma morbidity and mortality. J Allergy Clin Immunol 2001; 107: 937-944.
4. Williams TJ, Tuxen DV, Scheinkestel CD, Czarny D, Bowes G. Risk factors for morbidity in mechanically ventilated patients with acute severe asthma. Am Rev Respir Dis 1992; 146: 607-615.
5. Kay A. Th2- Type cytokines in asthma. Ann NY Acad Sci 1996; 796: 1-8.
6. Mazzarella G, Bianco A, Catena E, De Palma R, Abbate G. Th1/Th2 lymphocyte polarization in asthma. Allergy 2000; 55: 6-9.
7. Park H-J, Lee C-M, Jung ID, Lee JS, Jeong Y-I, Chang JH, Chun S-H, Kim M-J, Choi I-W, Ahn S-C: Quercetin regulates Th1/Th2 balance in a murine model of asthma Int Immunopharmacol 2009 9 261-267.
8. Lee JS, Lee C-M, Jeong Y-I, Jung ID, Kim B-H, Seong E-Y, Kim J-I, Choi I-W, Chung HY, Park Y-M: D-Pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma FEBS Lett 2007 581 57-64.
9. Ma C, Ma Z, Liao X-L, Liu J, Fu Q, Ma S. Immunoregulatory effects of glycyrrhizic acid exerts anti-Asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4+ CD25+ Foxp3+ regulatory T cells in ovalbumin-sensitized mice. J Ethnopharmacol 2013; 148: 755-762.
10. Chu M-J, Wang Y-Z, Itagaki K, Ma H-X, Xin P, Zhou X-G, Chen G-Y, Li S, Sun S-Q: Identification of active compounds from Caesalpinia sappan L. extracts suppressing IL-6 production in RAW 264.7 cells by PLS. J Ethnopharmacol 2013; 148: 37-44.
11. Lee S, Choi S-Y, Choo Y-Y, Kim O, Tran PT, Dao CT, Min B-S, Lee J-H: Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-?B Int Immunopharmacol 2015 28 328-336.
12. Kang L, Zhao H, Chen C, Zhang X, Xu M, Duan H. Sappanone A protects mice against cisplatin-induced kidney injury. Int Immunopharmacol 2016; 38: 246-251.
13. Liu M-H, Lin A-H, Lee H-F, Ko H-K, Lee T-S, Kou YR. Paeonol attenuates cigarette smokeinduced lung inflammation by inhibiting ROS-sensitive inflammatory signaling. Mediators Inflamm 2014; 2014: 651890.
14. HuangFu T, Lim LH, Chua KY. Efficacy evaluation of Der p 1 DNA vaccine for allergic asthma in an experimental mouse model. Vaccine 2006; 24: 4576-4581.
15. Lee KS, Lee HK, Hayflick JS, Lee YC, Puri KD. Inhibition of phosphoinositide 3-kinase d attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J 2006; 20: 455-465.
16. Zuberi RI, Hsu DK, Kalayci O, Chen H-Y, Sheldon HK, Yu L, Apgar JR, Kawakami T, Lilly CM, Liu F- T: Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma Am J Pathol 2004 165 2045-2053.
17. Steinman L: A brief history of Th17, the first major revision in the Th1/Th2 hypothesis of T cell-mediated tissue damage Nat Med 2007 13 139-145.
18. Hakonarson H, Maskeri N, Carter C, Grunstein MM. Regulation of Th1- and Th2- Type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle. J Clin Invest 1999; 103: 1077-1087.
19. Schmitz N, Kurrer M, Kopf M. The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model. Eur J Immunol 2003; 33: 991-1000.
20. Yuan Y, Yang B, Ye Z, Zhang M, Yang X, Xin C, Lin M, Huang P. Sceptridium ternatum extract exerts antiasthmatic effects by regulating Th1/Th2 balance and the expression levels of leukotriene receptors in a mouse asthma model. J Ethnopharmacol 2013; 149: 701-706.
21. Lee JM, Johnson JA. An important role of Nrf2-ARE pathway in the cellular defense mechanism. J Biochem Mol Biol 2004; 37: 139-143.
22. Shih P-H, Yeh C- T, Yen G-C: Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis J Agric Food Chem 2007 55 9427-9435.
23. Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, Di Stefano E, Slaughter N, Killeen E, Wang X, Huang A. Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals. J Immunol 2004; 173: 3467-3481.
24. Sussan TE, Gajghate S, Chatterjee S, Mandke P, McCormick S, Sudini K, Kumar S, Breysse PN, Diette GB, Sidhaye VK. Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function. Am J Physiol Lung Cell Mol Physiol 2015; 309: L27-L36.
25. Kikuchi N, Ishii Y, Morishima Y, Yageta Y, Haraguchi N, Itoh K, Yamamoto M, Hizawa N. Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/ Th2 balance. Respir Res 2010; 11: 31.
26. Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J Exp Med 2005; 202: 47-59.