-
2
-
-
73949091032
-
Liver regeneration after partial hepatectomy: Critical analysis of mechanistic dilemmas
-
Michalopoulos, G. K. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 176, 2-13 (2010).
-
(2010)
Am J Pathol
, vol.176
, pp. 2-13
-
-
Michalopoulos, G.K.1
-
5
-
-
36048973747
-
The EGF receptor is required for efficient liver regeneration
-
Natarajan, A., Wagner, B. & Sibilia, M. The EGF receptor is required for efficient liver regeneration. Proceedings of the National Academy of Sciences of the United States of America 104, 17081-17086 (2007).
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, pp. 17081-17086
-
-
Natarajan, A.1
Wagner, B.2
Sibilia, M.3
-
6
-
-
48249122445
-
PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy
-
Jackson, L. N. et al. PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy. American journal of physiology. Gastrointestinal and liver physiology 294, G1401-G1410 (2008).
-
(2008)
American Journal of Physiology. Gastrointestinal and Liver Physiology
, vol.294
, pp. G1401-G1410
-
-
Jackson, L.N.1
-
7
-
-
0032795940
-
The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes
-
Talarmin, H. et al. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes. Molecular and cellular biology 19, 6003-6011 (1999).
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 6003-6011
-
-
Talarmin, H.1
-
8
-
-
0037047360
-
STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
-
Li, W., Liang, X., Kellendonk, C., Poli, V. & Taub, R. STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. The Journal of biological chemistry 277, 28411-28417 (2002).
-
(2002)
The Journal of Biological Chemistry
, vol.277
, pp. 28411-28417
-
-
Li, W.1
Liang, X.2
Kellendonk, C.3
Poli, V.4
Taub, R.5
-
9
-
-
84901299752
-
Knockdown and knockout of beta1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling
-
Speicher, T. et al. Knockdown and knockout of beta1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling. Nature communications 5, 3862 (2014).
-
(2014)
Nature Communications
, vol.5
, pp. 3862
-
-
Speicher, T.1
-
10
-
-
70349232394
-
Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase
-
Apte, U. et al. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology 50, 844-851 (2009).
-
(2009)
Hepatology
, vol.50
, pp. 844-851
-
-
Apte, U.1
-
11
-
-
11244258882
-
Focal adhesion kinase: In command and control of cell motility
-
Mitra, S. K., Hanson, D. A. & Schlaepfer, D. D. Focal adhesion kinase: in command and control of cell motility. Nature reviews. Molecular cell biology 6, 56-68 (2005).
-
(2005)
Nature Reviews. Molecular Cell Biology
, vol.6
, pp. 56-68
-
-
Mitra, S.K.1
Hanson, D.A.2
Schlaepfer, D.D.3
-
12
-
-
79959971564
-
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis
-
Zhao, X. & Guan, J. L. Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Advanced drug delivery reviews 63, 610-615 (2011).
-
(2011)
Advanced Drug Delivery Reviews
, vol.63
, pp. 610-615
-
-
Zhao, X.1
Guan, J.L.2
-
13
-
-
0032894567
-
Signaling through focal adhesion kinase
-
Schlaepfer, D. D., Hauck, C. R. & Sieg, D. J. Signaling through focal adhesion kinase. Progress in biophysics and molecular biology 71, 435-478 (1999).
-
(1999)
Progress in Biophysics and Molecular Biology
, vol.71
, pp. 435-478
-
-
Schlaepfer, D.D.1
Hauck, C.R.2
Sieg, D.J.3
-
14
-
-
84989280468
-
FAK is required for c-Met/beta-catenin-driven hepatocarcinogenesis
-
Shang, N. et al. FAK is required for c-Met/beta-catenin-driven hepatocarcinogenesis. Hepatology (2014).
-
(2014)
Hepatology
-
-
Shang, N.1
-
15
-
-
0029741102
-
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation
-
Gilmore, A. P. & Romer, L. H. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Molecular biology of the cell 7, 1209-1224 (1996).
-
(1996)
Molecular Biology of the Cell
, vol.7
, pp. 1209-1224
-
-
Gilmore, A.P.1
Romer, L.H.2
-
16
-
-
0029739950
-
Control of adhesion-dependent cell survival by focal adhesion kinase
-
Frisch, S. M., Vuori, K., Ruoslahti, E. & Chan-Hui, P. Y. Control of adhesion-dependent cell survival by focal adhesion kinase. The Journal of cell biology 134, 793-799 (1996).
-
(1996)
The Journal of Cell Biology
, vol.134
, pp. 793-799
-
-
Frisch, S.M.1
Vuori, K.2
Ruoslahti, E.3
Chan-Hui, P.Y.4
-
17
-
-
34250026140
-
Structural basis for the autoinhibition of focal adhesion kinase
-
Lietha, D. et al. Structural basis for the autoinhibition of focal adhesion kinase. Cell 129, 1177-1187 (2007).
-
(2007)
Cell
, vol.129
, pp. 1177-1187
-
-
Lietha, D.1
-
18
-
-
0028350859
-
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
-
Schaller, M. D. et al. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Molecular and cellular biology 14, 1680-1688 (1994).
-
(1994)
Molecular and Cellular Biology
, vol.14
, pp. 1680-1688
-
-
Schaller, M.D.1
-
19
-
-
57349112286
-
Generation and regeneration of cells of the liver and pancreas
-
Zaret, K. S. & Grompe, M. Generation and regeneration of cells of the liver and pancreas. Science 322, 1490-1494 (2008).
-
(2008)
Science
, vol.322
, pp. 1490-1494
-
-
Zaret, K.S.1
Grompe, M.2
-
20
-
-
0029861248
-
Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cellpermeable peptide mimicking phosphorylated EGF receptor
-
Rojas, M., Yao, S. & Lin, Y. Z. Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cellpermeable peptide mimicking phosphorylated EGF receptor. The Journal of biological chemistry 271, 27456-27461 (1996).
-
(1996)
The Journal of Biological Chemistry
, vol.271
, pp. 27456-27461
-
-
Rojas, M.1
Yao, S.2
Lin, Y.Z.3
-
21
-
-
84890862301
-
EGF receptor trafficking: Consequences for signaling and cancer
-
Tomas, A., Futter, C. E. & Eden, E. R. EGF receptor trafficking: consequences for signaling and cancer. Trends in cell biology 24, 26-34 (2014).
-
(2014)
Trends in Cell Biology
, vol.24
, pp. 26-34
-
-
Tomas, A.1
Futter, C.E.2
Eden, E.R.3
-
22
-
-
0037373212
-
Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy
-
Kiso, S. et al. Liver regeneration in heparin-binding EGF-like growth factor transgenic mice after partial hepatectomy. Gastroenterology 124, 701-707 (2003).
-
(2003)
Gastroenterology
, vol.124
, pp. 701-707
-
-
Kiso, S.1
-
23
-
-
84864717380
-
Effects of CRM197, a specific inhibitor of HB-EGF, in oral cancer
-
Dateoka, S., Ohnishi, Y. & Kakudo, K. Effects of CRM197, a specific inhibitor of HB-EGF, in oral cancer. Medical molecular morphology 45, 91-97 (2012).
-
(2012)
Medical Molecular Morphology
, vol.45
, pp. 91-97
-
-
Dateoka, S.1
Ohnishi, Y.2
Kakudo, K.3
-
24
-
-
79961195639
-
Antitumor effects of CRM197, a specific inhibitor of HB-EGF, in T-cell acute lymphoblastic leukemia
-
Kunami, N. et al. Antitumor effects of CRM197, a specific inhibitor of HB-EGF, in T-cell acute lymphoblastic leukemia. Anticancer research 31, 2483-2488 (2011).
-
(2011)
Anticancer Research
, vol.31
, pp. 2483-2488
-
-
Kunami, N.1
-
25
-
-
0030017083
-
Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells
-
Patterson, C. et al. Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells. The Journal of clinical investigation 98, 490-496 (1996).
-
(1996)
The Journal of Clinical Investigation
, vol.98
, pp. 490-496
-
-
Patterson, C.1
-
26
-
-
0026801421
-
Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy
-
Akerman, P. et al. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. The American journal of physiology 263, G579-G585 (1992).
-
(1992)
The American Journal of Physiology
, vol.263
, pp. G579-G585
-
-
Akerman, P.1
-
27
-
-
0031028140
-
Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type i tumor necrosis factor receptor
-
Yamada, Y., Kirillova, I., Peschon, J. J. & Fausto, N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proceedings of the National Academy of Sciences of the United States of America 94, 1441-1446 (1997).
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, pp. 1441-1446
-
-
Yamada, Y.1
Kirillova, I.2
Peschon, J.J.3
Fausto, N.4
-
28
-
-
21244472975
-
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
-
Maeda, S., Kamata, H., Luo, J. L., Leffert, H. & Karin, M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121, 977-990 (2005).
-
(2005)
Cell
, vol.121
, pp. 977-990
-
-
Maeda, S.1
Kamata, H.2
Luo, J.L.3
Leffert, H.4
Karin, M.5
-
29
-
-
34447327216
-
Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
-
Naugler, W. E. et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317, 121-124 (2007).
-
(2007)
Science
, vol.317
, pp. 121-124
-
-
Naugler, W.E.1
-
30
-
-
33645799492
-
Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: Role of IKK, JNK, and ROS pathways
-
Schwabe, R. F. & Brenner, D. A. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 290, G583-G589 (2006).
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
, pp. G583-G589
-
-
Schwabe, R.F.1
Brenner, D.A.2
-
31
-
-
84868115643
-
Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer
-
Johnson, C. et al. Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer. Translational gastrointestinal cancer 1, 58-70 (2012).
-
(2012)
Translational Gastrointestinal Cancer
, vol.1
, pp. 58-70
-
-
Johnson, C.1
-
32
-
-
0034002462
-
RAFTK/Pyk2-mediated cellular signaling
-
Avraham, H., Park, S. Y., Schinkmann, K. & Avraham, S. RAFTK/Pyk2-mediated cellular signalling. Cellular signalling 12, 123-133 (2000).
-
(2000)
Cellular Signalling
, vol.12
, pp. 123-133
-
-
Avraham, H.1
Park, S.Y.2
Schinkmann, K.3
Avraham, S.4
-
33
-
-
0032531732
-
Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK-cell migration
-
Sieg, D. J. et al. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK-cell migration. The EMBO journal 17, 5933-5947 (1998).
-
(1998)
The EMBO Journal
, vol.17
, pp. 5933-5947
-
-
Sieg, D.J.1
-
34
-
-
42049113411
-
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK
-
Weis, S. M. et al. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. The Journal of cell biology 181, 43-50 (2008).
-
(2008)
The Journal of Cell Biology
, vol.181
, pp. 43-50
-
-
Weis, S.M.1
-
35
-
-
79956306365
-
Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity
-
Fan, H. & Guan, J. L. Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. The Journal of biological chemistry 286, 18573-18582 (2011).
-
(2011)
The Journal of Biological Chemistry
, vol.286
, pp. 18573-18582
-
-
Fan, H.1
Guan, J.L.2
-
36
-
-
0034717285
-
Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60
-
Sonoda, Y. et al. Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. The Journal of biological chemistry 275, 16309-16315 (2000).
-
(2000)
The Journal of Biological Chemistry
, vol.275
, pp. 16309-16315
-
-
Sonoda, Y.1
-
37
-
-
2942531163
-
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein
-
Kurenova, E. et al. Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Molecular and cellular biology 24, 4361-4371 (2004).
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 4361-4371
-
-
Kurenova, E.1
-
38
-
-
33646422498
-
Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells
-
Zhang, H. M. et al. Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells. American journal of physiology. Cell physiology 290, C1310-1320 (2006).
-
(2006)
American Journal of Physiology. Cell Physiology
, vol.290
, pp. C1310-1320
-
-
Zhang, H.M.1
-
39
-
-
33745468872
-
Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion
-
Chen, S. Y. & Chen, H. C. Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion. Molecular and cellular biology 26, 5155-5167 (2006).
-
(2006)
Molecular and Cellular Biology
, vol.26
, pp. 5155-5167
-
-
Chen, S.Y.1
Chen, H.C.2
-
40
-
-
77952469195
-
Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer
-
Schultze, A. & Fiedler, W. Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer. Expert opinion on investigational drugs 19, 777-788 (2010).
-
(2010)
Expert Opinion on Investigational Drugs
, vol.19
, pp. 777-788
-
-
Schultze, A.1
Fiedler, W.2
-
41
-
-
84862990976
-
Safety pharmacokinetic and pharmacodynamic phase i dose-escalation trial of PF-00562271 an inhibitor of focal adhesion kinase in advanced solid tumors
-
1577-1533
-
Infante, J. R. & Chen, H. C. et al. Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 30, 1577-1533 (2012).
-
(2012)
Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
, vol.30
-
-
Infante, J.R.1
Chen, H.C.2
-
42
-
-
50249150340
-
A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
-
Mitchell, C. & Willenbring, H. A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice. Nature protocols 3, 1167-1170 (2008).
-
(2008)
Nature Protocols
, vol.3
, pp. 1167-1170
-
-
Mitchell, C.1
Willenbring, H.2
-
43
-
-
84922395037
-
Addendum: A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
-
Mitchell, C. & Willenbring, H. Addendum: A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice. Nature protocols 9 (2014).
-
(2014)
Nature Protocols
, vol.9
-
-
Mitchell, C.1
Willenbring, H.2
-
44
-
-
80053331459
-
PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice
-
Qiu, W. et al. PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice. Hepatology 54, 1249-1258 (2011).
-
(2011)
Hepatology
, vol.54
, pp. 1249-1258
-
-
Qiu, W.1
-
46
-
-
84989287413
-
FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC
-
Shang, N. et al. FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC. Gene expression 310 (2016).
-
(2016)
Gene Expression
, vol.310
-
-
Shang, N.1
|