The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity

Protein Science

Volumn 25, Issue 12, 2016, Pages 2152-2163

  June, Cynthia M ^a   Muckenthaler, Taylor J ^a   Schroder, Emma C ^a   Klamer, Zachary L ^a   Wawrzak, Zdzislaw ^b   Powers, Rachel A ^a   Szarecka, Agnieszka ^a   Leonard, David A ^a  

^a GRAND VALLEY STATE UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

antibiotic resistance; carbapenem; crystal structure; lactamase

Indexed keywords

BACTERIAL ENZYME; CARBAPENEMASE; DORIPENEM; INDOLE; ISOLEUCINE; LIGAND; OXA 51 CLASS D BETA LACTAMASE; PENICILLINASE; UNCLASSIFIED DRUG; BETA LACTAMASE; BETA-LACTAMASE OXA-51, ACINETOBACTER BAUMANNII; CARBAPENEM DERIVATIVE;

ACINETOBACTER BAUMANNII; ACYLATION; ARTICLE; BACTERIAL GENE; BINDING AFFINITY; BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TAUTOMER; WILD TYPE; AMINO ACID SUBSTITUTION; CHEMISTRY; ENZYMOLOGY; GENETICS; MISSENSE MUTATION; X RAY CRYSTALLOGRAPHY;

ACINETOBACTER BAUMANNII; AMINO ACID SUBSTITUTION; BETA-LACTAMASES; BINDING SITES; CARBAPENEMS; CRYSTALLOGRAPHY, X-RAY; MOLECULAR DYNAMICS SIMULATION; MUTATION, MISSENSE;

EID: 84989311551     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.3040     Document Type: Article

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