Cadherin 17 is a novel diagnostic marker for adenocarcinomas of the digestive system

Advances in Anatomic Pathology

Volumn 21, Issue 2, 2014, Pages 131-137

  Ordóñez, Nelson G ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cadherin 17; Colorectal adenocarcinoma; Immunohistochemistry; Pancreatic adenocarcinoma

Indexed keywords

CADHERIN 17; MEMBRANE PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; ANTIBODY; CADHERIN;

ARTICLE; BILE DUCT CARCINOMA; COLORECTAL CARCINOMA; DIGESTIVE SYSTEM CANCER; GASTROINTESTINAL TRACT ADENOCARCINOMA; GERM CELL TUMOR; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LUNG ADENOCARCINOMA; MELANOMA; NEUROENDOCRINE TUMOR; OVARY CANCER; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM CARCINOMA; SOFT TISSUE SARCOMA; STOMACH ADENOCARCINOMA; THYROID CANCER; ADULT; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; EMBRYO; GASTROINTESTINAL TRACT; GENE EXPRESSION; HISTOPATHOLOGY; NONHUMAN; PANCREAS;

ADENOCARCINOMA; CADHERINS; DIAGNOSIS, DIFFERENTIAL; DIGESTIVE SYSTEM NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84989299921     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/PAP.0000000000000008     Document Type: Article

References (65)

1. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science. 1991;251:1451-1455
2. Gumbiner BM. Cell adhesion: The molecular basis of tissue architecture and morphogenesis. Cell. 1996;84:345-357
3. Tepass U, Truong K, Godt D, et al. Cadherins in embryonic and neural morphogenesis. Nat RevMol Cell Biol. 2000;1:91-100
4. Wheelock MJ, Johnson KR. Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol. 2003;19:207-235
5. Hajra KM, Fearon ER. Cadherin and catenin alterations in human cancer. Genes Chromosomes Cancer. 2002;34:255-268
6. Koch AW, Manzur KL, Shan W. Structure-based models of cadherin-mediated cell adhesion: The evolution continues. Cell Mol Life Sci. 2004;61:1884-1895
7. Boggon TJ, Murray J, Chappuis-Flament S, et al. C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science. 2002;296:1308-1313
8. Ciatto C, Bahna F, Zampieri N, et al. T-cadherin structures reveal a novel adhesive binding mechanism. Nat Struct Mol Biol. 2010;17:339-347
9. Hulpiau P, van Roy F. Molecular evolution of the cadherin superfamily. Int J Biochem Cell Biol. 2009;41:349-369
10. Gessner R, Tauber R. Intestinal cell adhesion molecules. Liverintestine cadherin. Ann N Y Acad Sci. 2000;915:136-143
11. Nollet F, Kools P, van Roy F. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. J Mol Biol. 2000;299:551-572
12. Angst BD, Marcozzi C, Magee AI. The cadherin superfamily: diversity in form and function. J Cell Sci. 2001;114:629-641
13. Wendeler MW, Jung R, Himmelbauer H, et al. Unique gene structure and paralogy define the 7D-cadherin family. Cell Mol Life Sci. 2006;63:1564-1573
14. Berndorff D, Gessner R, Kreft B, et al. Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine. J Cell Biol. 1994;125:1353-1369
15. Lee NP, Poon RT, Shek FH, et al. Role of cadherin-17 in oncogenesis and potential therapeutic implications in hepatocellular carcinoma. Biochim Biophys Acta. 2010;1806:138-145
16. Wendeler MW, Drenckhahn D, Gessner R, et al. Intestinal LIcadherin acts as a Ca2+-dependent adhesion switch. J Mol Biol. 2007;370:220-230
17. Baumgartner W, Wendeler MW, Weth A, et al. Heterotypic trans-interaction of LI- and E-cadherin and their localization in plasmalemmal microdomains. J Mol Biol. 2008;378:44-54
18. Lee NP, Cheng CY. Adaptors, junction dynamics, and spermatogenesis. Biol Reprod. 2004;71:392-404
19. Hartsock A, Nelson WJ. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta. 2008;1778:660-669
20. Kreft B, Berndorff D, Böttinger A, et al. LI-cadherin-mediated cell-cell adhesion does not require cytoplasmic interactions. J Cell Biol. 1997;136:1109-1121
21. Dantzig AH, Hoskins JA, Tabas LB, et al. Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science. 1994;264:430-433
22. Silberg DG, Swain GP, Suh ER, et al. Cdx1 and cdx2 expression during intestinal development. Gastroenterology. 2000;119:961-971
23. Angres B, Kim L, Jung R, et al. LI-cadherin gene expression during mouse intestinal development. Dev Dyn. 2001;221: 182-193
24. Takamura M, Sakamoto M, Ino Y, et al. Expression of liverintestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas. Cancer Sci. 2003;94:425-430
25. Su MC, Yuan RH, Lin CY, et al. Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. Mod Pathol. 2008;21:1379-1386
26. Lin F, Shi J, Zhu S, et al. Cadherin-17 and SATB-2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine. Arch Pathol Lab Med. [In press]
27. Panarelli NC, Yantiss RK, Yeh MM, et al. Tissue-specific cadherin CDH17 is a useful marker of gastrointestinal adenocarcinomas with higher sensitivity than CDX2. Am J Clin Pathol. 2012;138:211-222
28. Ito R, Oue N, Yoshida K, et al. Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer. Virchows Arch. 2005;447:717-722
29. Park SS, Kang SH, Park JM, et al. Expression of liver-intestine cadherin and its correlation with lymph node metastasis in gastric cancer: Can it predict N stage preoperatively? Ann Surg Oncol. 2007;14:94-99
30. Qiu HB, Zhang LY, Ren C, et al. Targeting CDH17 suppresses tumor progression in gastric cancer by downregulating Wnt/bcatenin signaling. PLoS One. 2013;8:e56959
31. Werling RW, Yaziji H, Bacchi CE, et al. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: An immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol. 2003;27:303-310
32. Kaimaktchiev V, Terracciano L, Tornillo L, et al. The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas. Mod Pathol. 2004;17:1392-1399
33. Mazziotta RM, Borczuk AC, Powell CA, et al. CDX2 immunostaining as a gastrointestinal marker: Expression in lung carcinomas is a potential pitfall. Appl Immunohistochem Mol Morphol. 2005;13:55-60
34. Long KB, Hornick JL. SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract. Hum Pathol. 2009;40:1768-1773
35. DiMaio MA, Kwok S, Montgomery KD, et al. Immunohistochemical panel for distinguishing esophageal adenocarcinoma from squamous cell carcinoma: A combination of p63, cytokeratin 5/6, MUC5AC, and anterior gradient homolog 2 allows optimal subtyping. Hum Pathol. 2012;43:1799-1807
36. Aulakh KS, Chisholm CD, Smith DA, et al. TTF-1 and Napsin A do not differentiate metastatic lung adenocarcinomas from primary esophageal adenocarcinomas: Proposal of a novel staining panel. Arch Pathol Lab Med. 2013;137:1094-1098
37. Magnusson K, de Wit M, Brennan DJ, et al. SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas. Am J Surg Pathol. 2011;35:937-948
38. Barbareschi M, Murer B, Colby TV, et al. CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs. Am J Surg Pathol. 2003;27: 141-149
39. Mizoshita T, Tsukamoto T, Tanaka H, et al. Colonic and small-intestinal phenotypes in gastric cancers: Relationships with clinicopathological findings. Pathol Int. 2005;55:611-618
40. Bai Z, Ye Y, Chen D, et al. Homeoprotein Cdx2 and nuclear PTEN expression profiles are related to gastric cancer prognosis. APMIS. 2007;115:1383-1390
41. Moll R, Robine S, Dudouet B, et al. Villin: A cytoskeletal protein and a differentiation marker expressed in some human adenocarcinomas. Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;54:155-169
42. Zhang MQ, Lin F, Hui P, et al. Expression of mucins, SIMA, villin, and CDX2 in small-intestinal adenocarcinoma. Am J Clin Pathol. 2007;128:808-816
43. Moskaluk CA, Zhang H, Powell SM, et al. Cdx2 protein expression in normal and malignant human tissues: An immunohistochemical survey using tissue microarrays. Mod Pathol. 2003;16:913-919
44. Groisman GM, Bernheim J, Halpern M, et al. Expression of the intestinal marker Cdx2 in secondary adenocarcinomas of the colorectum. Arch Pathol Lab Med. 2005;129:920-923
45. De Lott LB, Morrison C, Suster S, et al. CDX2 is a useful marker of intestinal-type differentiation: A tissue microarraybased study of 629 tumors from various sites. Arch Pathol Lab Med. 2005;129:1100-1105
46. Inamura K, Satoh Y, Okumura S, et al. Pulmonary adenocarcinomas with enteric differentiation: histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas. Am J Surg Pathol. 2005;29:660-665
47. Logani S, Oliva E, Arnell PM, et al. Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma. Mod Pathol. 2005;18:19-25
48. Suh N, Yang XJ, Tretiakova MS, et al. Value of CDX2, villin, and a-methylacyl coenzyme A racemase immunostains in the distinction between primary adenocarcinoma of the bladder and secondary colorectal adenocarcinoma. Mod Pathol. 2005; 18:1217-1222
49. Saad RS, Silverman JF, Khalifa MA, et al. CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma. Appl Immunohistochem Mol Morphol. 2009;17:196-201
50. Bacchi CE, Gown AM. Distribution and pattern of expression of villin, a gastrointestinal-associated cytoskeletal protein, in human carcinomas: A study employing paraffin-embedded tissue. Lab Invest. 1991;64:418-424
51. Tan J, Sidhu G, Greco MA, et al. Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets. Hum Pathol. 1998;29:390-396
52. Goldstein NS, Thomas M. Mucinous and nonmucinous bronchioloalveolar adenocarcinomas have distinct staining patterns with thyroid transcription factor and cytokeratin 20 antibodies. Am J Clin Pathol. 2001;116:319-325
53. Tamboli P, Mohsin SK, Hailemariam S, et al. Colonic adenocarcinoma metastatic to the urinary tract versus primary tumors of the urinary tract with glandular differentiation: A report of 7 cases and investigation using a limited immunohistochemical panel. Arch Pathol Lab Med. 2002; 126:1057-1063
54. Bismar TA, Humphrey PA, Grignon DJ, et al. Expression of betacatenin in prostatic adenocarcinomas: A comparison with colorectal adenocarcinomas. Am J Clin Pathol. 2004;121:557-563
55. Albores-Saavedra J, Simpson K, Dancer YJ, et al. Intestinal type adenocarcinoma: A previously unrecognized histologic variant of ductal carcinoma of the pancreas. Ann Diagn Pathol. 2007;11:3-9
56. Lau SK, Prakash S, Geller SA, et al. Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma. Hum Pathol. 2002;33:1175-1181
57. Chu PG, Schwarz RE, Lau SK, et al. Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: Application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol. 2005;29:359-367
58. Zen Y, Quaglia A, Heaton N, et al. Two distinct pathways of carcinogenesis in primary sclerosing cholangitis. Histopathology. 2011;59:1100-1110
59. Wong BW, Luk JM, Ng IO, et al. Identification of liverintestine cadherin in hepatocellular carcinoma - a potential disease marker. Biochem Biophys Res Commun. 2003;311: 618-624
60. Raspollini MR, Baroni G, Taddei A, et al. Primary cervical adenocarcinoma with intestinal differentiation and colonic carcinoma metastatic to cervix: An investigation using Cdx-2 and a limited immunohistochemical panel. Arch Pathol Lab Med. 2003;127:1586-1590
61. Lanza G, Gafà R, Matteuzzi M, et al. Medullary-type poorly differentiated adenocarcinoma of the large bowel: A distinct clinicopathologic entity characterized by microsatellite instability and improved survival. J Clin Oncol. 1999;17:2429-2438
62. Alexander J, Watanabe T, Wu TT, et al. Histopathological identification of colon cancer with microsatellite instability. Am J Pathol. 2001;158:527-535
63. Hinoi T, Tani M, Lucas PC, et al. Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. Am J Pathol. 2001;159:2239-2248
64. Winn B, Tavares R, Fanion J, et al. Differentiating the undifferentiated: Immunohistochemical profile of medullary carcinoma of the colon with an emphasis on intestinal differentiation. Hum Pathol. 2009;40:398-404
65. Ko S, Chu KM, Luk JM, et al. CDX2 co-localizes with liverintestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach. J Pathol. 2005;205:615-622