Phenolic Composition and Evaluation of Methanol and Aqueous Extracts of Bitter Gourd (Momordica charantia L) Leaves on Angiotensin-I-Converting Enzyme and Some Pro-oxidant-Induced Lipid Peroxidation In Vitro

Journal of Evidence-Based Complementary and Alternative Medicine

Volumn 21, Issue 4, 2016, Pages NP67-NP76

  Shodehinde, Sidiqat A ^a,b   Adefegha, Stephen A ^b   Oboh, Ganiyu ^b   Oyeleye, Sunday I ^b   Olasehinde, Tosin A ^b,c   Nwanna, Emmem E ^b   Adedayo, Bukola C ^b   Boligon, Aline A ^d  

^a ADEKUNLE AJASIN UNIVERSITY   (Nigeria)

^b FEDERAL UNIVERSITY OF TECHNOLOGY   (Nigeria)

^c FEDERAL INSTITUTE OF INDUSTRIAL RESEARCH   (Nigeria)

^d FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

angiotensin 1 converting enzyme; antihypertension; antioxidant; bitter gourd; lipid peroxidation; renoprotection

Indexed keywords

EID: 84989246563     PISSN: 21565872     EISSN: None     Source Type: Journal    
DOI: 10.1177/2156587216636505     Document Type: Article

References (47)

1. Pradeepa R, Mohan V. Hypertension and pre-hypertension in developing countries. Indian J Med Res. 2008;128:688–690.
2. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data, Lancet. 2005;365:217–223.
3. Fowler MJ. Microvascular and macrovascular complications of diabetes. Clin Diabetes. 2008;26:77–82.
4. Beg M, Gupta MA, Khanna VN. Oxidative stress in essential hypertension and role of antioxidants. J Indian Acad Clin Med. 2010;11:287–293.
5. Ceriello A. Possible role of oxidative stress in the pathogenesis of hypertension. Diabetes Care. 2008;31(suppl 2):S181–S184.
6. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44–84.
7. Dessy C, Ferron O. Pathophysiological roles of nitric oxide: in the heart and the coronary vasculature. Curr Med Chem Anti Inflamm Anti Allergy Agents. 2004;3:207–216.
8. Hirata Y, Satonaka H. Hypertension and oxidative stress. JMAJ. 2001;44:540–545.
9. Erdos EG, Skidgel RA. The angiotensin-I-converting enzyme, Lab Investig. 1987;56:345–348.
10. Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension, Asia Pac J Clin Nutr. 2006;15:425–432.
11. Nagarani G, Abirami A, Siddhuraju P. A comparative study on antioxidant potentials, inhibitory activities against key enzymes related to metabolic syndrome, and anti-inflammatory activity of leaf extract from different Momordica species, Food Sci Hum Wellness. 2014;3:36–46.
12. Taylor L. Technical Data Report for Bitter Melon (Momordica charantia). 2nd ed. Austin, TX: Sage Press; 2002.
13. Efird JT, Choi YM, Davies SW, Mehra S, Anderson EJ, Katunga LA. Potential for improved glycemic control with dietary Momordica charantia in patients with insulin resistance and pre-diabetes. Int J Environ Res Public Health. 2014;11:2328–2345.
14. Cartea ME, Francisco M, Soengas P, Velasco P. Phenolic compounds in Brassica vegetables. Molecules. 2011;16:251–280.
15. Wang H, Cao G, Prior RL. Total antioxidant capacity of fruits. J Agric Food Chem. 1996;44:701–705.
16. Molehin OR, Adefegha SA. Comparative study of the aqueous and ethanolic extract of Momordica foetida on the phenolic content and antioxidant properties. Int Food Res J. 2014;21:401–405.
17. Cushman W, Cheung HS. Spectrophotometric assay and properties of the angiotensin-I-converting enzyme of rabbit lung. Biochem Pharmacol. 1971;20:1637–1648.
18. Public Health Service. Public Health Service Policy on Humane Care and Use of Laboratory Animals (PL 99-158). Health Research Extension Act, 1985. Washington, DC: US Department of Health and Human Services; 1996.
19. Bellé NA, Dalmolin GD, Fonini G, Rubim M, Rocha J. Polyamine reduces lipid peroxidation induced by different prooxidant agents. Brain Res. 2004;1008:245–251.
20. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–358.
21. Re R, Pellegrini N, Proteggente Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Rad Biol Med. 1999;26:1231–1237.
22. Mercocci L, Marguire JJ, Droy-Lefaiz MT, Parker L. The nitric oxide-scavenging properties of Ginkgo biloba extract EGB 761. Biochem Biophys Res Commun. 1994;201:748–755.
23. Halliwell B, Gutterdge JM. Formation of a thiobarbituric-acid-reactive substance from deoxyribose in the presence of iron salts: the role of superoxide and hydroxyl radicals. FEBS Lett. 1981;128:347–352.
24. 2+-dependent lipid peroxidation. Free Rad Biol Med. 1987;3:379–387.
25. Puntel RL, Nogueira CW, Rocha JB. Krebs cycle intermediates modulate thiobarbituric reactive species (TBARS) production in rat brain in vitro. Neurochem Res. 2005;30:225–235.
26. Singleton VL, Orthofer R, Lamuela-Raventos RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteau’s reagent. Method Enzymol. 1999;299:152–178.
27. Meda A, Lamien CE, Romito Millogo J, Nacoulma O. Determination of the total phenolic, flavonoid and proline contents in Burkina Faso honey, as well as their radical scavenging activity. Food Chem. 2005;91:571–577.
28. Adedayo BC, Oboh G, Oyeleye SI, Ejakpovi II, Boligon AA, Athayde ML. Blanching alters the phenolic constituents and in vitro antioxidant and anticholinesterases properties of fireweed (Crassocephalum crepidioides). J Taibah Univ Med Sci. 2015;10:419–426.
29. Brunner HR, Laragh JH, Baer L. Essential hypertension: renin and aldosterone, heart attack and stroke. N Engl J Med. 1972;286:441–449.
30. Kwon YI, Apostolidis E, Kim YC, Shetty K. Health benefits of traditional corn, beans and pumpkin: in vitro studies for hyperglycemia and hypertension management. J Med Food. 2007;10:266–275.
31. Kwon YI, Apostolidis E, Shetty K. In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Bioresour Technol. 2008;99:2981–2988.
32. Guerrero L, Castillo J, Quiñones M. Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies. PLoS One. 2012;7(11):e49493.
33. Dabla PK. Renal function in diabetic nephropathy. World J Diabetes. 2010;15:148–156.
34. Oboh G, Agunloye OM, Akinyemi AJ, Ademiluyi AO, Adefegha SA. Comparative study on the inhibitory effect of caffeic and chlorogenic acids on key enzymes linked to Alzheimer’s disease and some pro-oxidant induced oxidative stress in rats’ brain in vitro. Neurochem Res. 2012;38:413–419.
35. Zou MH, Shi CM, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest. 2002;109:817–826.
36. 1 cells. Alternat Anim Test Exp J. 2007;14:453–456.
37. Santos NA, Bezerra CS, Martins NM, Curti C, Bianchi ML, Santos AC. Hydroxyl radical scavenger ameliorates cisplatin-induced nephrotoxicity by preventing oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Cancer Chemother Pharmacol. 2008;61:145–155.
38. Noori S, Mahboob T. Antioxidant effect of carnosine pretreatment on cisplatin- induced renal oxidative stress in rats. Indian J Clin Biochem. 2010;25:86–91.
39. Oboh G, Rocha JBT. Antioxidant in foods: a new challenge for food processors. In: Panglossi HV, ed. Leading Edge Antioxidants Research. New York, NY: Nova Science; 2007:35–64.
40. Rezaeizadeh A, Zuki AB, Abdollahi M. Determination of antioxidant activity in methanol and chloroformic extracts of Momordica charantia. Afr J Biotechnol. 2011;10:4932–4940.
41. Gryszczyńska B, Wielkoszyński MIT, Małecka M, Budzyn-Napierala M, Kasprzak M, Gryszczyńska A. Phenolic acids improve the antioxidant activity of cerulo-plasmin isolated from plasma of healthy volunteers and atherosclerotic patients. J Elementol. 2015;20:83–93.
42. Salih NM, Bayar AH, Hindi MJ. Antioxidant activity of dietary plants: peppermint. Pak J Nutr. 2013;12:571–574.
43. Sadeghi Z, Valizadeh J, Azyzian Shermeh O, Akaberi M. Antioxidant activity and total phenolic content of Boerhavia elegans (choisy) grown in Baluchestan, Iran. Avicenna J Phytomed. 2015;5:1–9.
44. Adefegha SA, Oboh G. Enhancement of total phenolics and antioxidant properties of some tropical green leafy vegetables by steam cooking. J Food Process Preserv. 2011;35:615–622.
45. 2+-induced lipid peroxidation in brain in vitro. Food Chem. 2007;102:178–185.
46. Materska M, Perucka I. Antioxidant activity of the main phenolic compounds isolated from hot pepper fruits (Capsicum annuum L.). J Agric Food Chem. 2005;53:1730–1758.
47. Sathishsekar D, Subramanian S. Antioxidant properties of Momordica charantia (bitter gourd) seeds on Streptozotocin induced diabetic rats. Asia Pac J Clin Nutr. 2005;14:153–158.