Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-inflammatory, and Anti-apoptotic Mechanisms

Journal of Agricultural and Food Chemistry

Volumn 64, Issue 38, 2016, Pages 7291-7297

  Zhao, Liang ^a   Wang, Yong ^a   Liu, Jia ^b   Wang, Kai ^c   Guo, Xiaoxuan ^a   Ji, Baoping ^a   Wu, Wei ^a   Zhou, Feng ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

^c NATIONAL RESEARCH INSTITUTE FOR FAMILY PLANNING   (China)

Author keywords

alcohol; inflammation; isoflavones; liver damage; oxidative stress

Indexed keywords

ALCOHOLS; AMINO ACIDS; ANTIOXIDANTS; BODY FLUIDS; CELL DEATH; DISEASES; MAMMALS; ORGANIC COMPOUNDS; OXIDATIVE STRESS; PATHOLOGY;

ANTIOXIDANT CAPACITY; APOPTOTIC MECHANISMS; HEPATOPROTECTIVE EFFECTS; INFLAMMATION; ISOFLAVONES; LIVER DAMAGE; LOW DENSITY LIPOPROTEINS; TUMOR NECROSIS FACTOR ALPHA;

FLAVONOIDS;

ALANINE AMINOTRANSFERASE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; GENISTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 6; ISOFLAVONE DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; PROTECTIVE AGENT; PUERARIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR;

ANIMAL; APOPTOSIS; BLOOD; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIPID PEROXIDATION; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; METABOLISM; MOUSE;

ALANINE TRANSAMINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; CHOLESTEROL, HDL; CHOLESTEROL, LDL; GENISTEIN; INTERLEUKIN-6; ISOFLAVONES; LIPID PEROXIDATION; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MALONDIALDEHYDE; MICE; MICE, INBRED ICR; PROTECTIVE AGENTS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84989237365     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/acs.jafc.6b02907     Document Type: Article

References (29)

1. Sun, H.; Mu, T.; Liu, X.; Zhang, M.; Chen, J. Purple sweet potato (Ipomoea batatas L.) anthocyanins: preventive effect on acute and subacute alcoholic liver damage and dealcoholic effect J. Agric. Food Chem. 2014, 62, 2364-2373 10.1021/jf405032f
2. Galligan, J. J.; Smathers, R. L.; Shearn, C. T.; Fritz, K. S.; Backos, D. S.; Jiang, H.; Franklin, C. C.; Orlicky, D. J.; MacLean, K. N.; Petersen, D. R. Oxidative stress and the ER stress response in a murine model for early-stage alcoholic liver disease J. Toxicol. 2012, 2012, 207594 10.1155/2012/207594
3. Zhang, J.; Xue, J.; Wang, H.; Zhang, Y.; Xie, M. Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress Phytother. Res. 2011, 25, 638-643 10.1002/ptr.3315
4. O'Shea, R. S.; Dasarathy, S.; McCullough, A. J. Amer Assoc Study Liver, D.; Amer Coll, G., Alcoholic Liver Disease Hepatology 2010, 51, 307-328 10.1002/hep.23258
5. Wang, O.; Cheng, Q.; Liu, J.; Wang, Y.; Zhao, L.; Zhou, F.; Ji, B. P. Hepatoprotective effect of Schisandra chinensis (Turcz.) Baill. lignans and its formula with Rubus idaeus on chronic alcohol-induced liver injury in mice Food Funct. 2014, 5, 3018-3025 10.1039/C4FO00550C
6. Tang, C. C.; Lin, W. L.; Lee, Y. J.; Tang, Y. C.; Wang, C. J. Polyphenol-rich extract of Nelumbo nucifera leaves inhibits alcohol-induced steatohepatitis via reducing hepatic lipid accumulation and anti-inflammation in C57BL/6J mice Food Funct. 2014, 5, 678-687 10.1039/c3fo60478k
7. Orman, E. S.; Odena, G.; Bataller, R. Alcoholic liver disease: pathogenesis, management, and novel targets for therapy J. Gastroenterol. Hepatol. 2013, 28, 77-84 10.1111/jgh.12030
8. Sakamoto, S.; Yusakul, G.; Pongkitwitoon, B.; Tanaka, H.; Morimoto, S. Colloidal gold-based indirect competitive immunochromatographic assay for rapid detection of bioactive isoflavone glycosides daidzin and genistin in soy products Food Chem. 2016, 194, 191-195 10.1016/j.foodchem.2015.08.002
9. Qiu, L. X.; Chen, T. Novel insights into the mechanisms whereby isoflavones protect against fatty liver disease World J. Gastroenterol. 2015, 21, 1099-1107 10.3748/wjg.v21.i4.1099
10. Wong, K. H.; Li, G. Q.; Li, K. M.; Valentina, R. N.; Kelvin, C. Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases J. Ethnopharmacol. 2011, 134, 584-607 10.1016/j.jep.2011.02.001
11. Jin, S. E.; You, K. S.; Min, B. S.; Jung, H. A.; Choi, J. S. Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots Arch. Pharmacal Res. 2012, 35, 823-837 10.1007/s12272-012-0508-x
12. Hirota, K.; Morikawa, K.; Hanada, H.; Nonaka, M.; Nakajima, Y.; Kobayashi, M.; Nakajima, R. Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line J. Agric. Food Chem. 2010, 58, 5821-5827 10.1021/jf903911e
13. Noh, B. K.; Lee, J. K.; Jun, H. J.; Lee, J. H.; Jia, Y.; Hoang, M. H.; Kim, J. W.; Park, K. H.; Lee, S. J. Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase Biochem. Biophys. Res. Commun. 2011, 414, 361-366 10.1016/j.bbrc.2011.09.077
14. Kuzu, N.; Metin, K.; Dagli, A. F.; Akdemir, F.; Orhan, C.; Yalniz, M.; Ozercan, I. H.; Sahin, K.; Bahcecioglu, I. H. Protective role of genistein in acute liver damage induced by carbon tetrachloride Mediators Inflammation 2007, 2007, 36381 10.1155/2007/36381
15. Mohamed Salih, S.; Nallasamy, P.; Muniyandi, P.; Periyasami, V.; Carani Venkatraman, A. Genistein improves liver function and attenuates non-alcoholic fatty liver disease in a rat model of insulin resistance J. Diabetes 2009, 1, 278-287 10.1111/j.1753-0407.2009.00045.x
16. Peng, J. H.; Cui, T.; Huang, F.; Chen, L.; Zhao, Y.; Xu, L.; Xu, L. L.; Feng, Q.; Hu, Y. Y. Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression J. Pharmacol. Exp. Ther. 2013, 344, 646-654 10.1124/jpet.112.201137
17. 1H NMR-based metabonomic approach Phytomedicine 2015, 22, 333-343 10.1016/j.phymed.2015.01.006
18. Zhang, S.; Ji, G.; Liu, J. Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin J. Nutr. Biochem. 2006, 17, 485-491 10.1016/j.jnutbio.2005.09.002
19. Han, Y.; Xu, Q.; Hu, J. N.; Han, X. Y.; Li, W.; Zhao, L. C. Maltol, a food flavoring agent, attenuates acute alcohol-induced oxidative damage in mice Nutrients 2015, 7, 682-696 10.3390/nu7010682
20. Wang, O.; Liu, J.; Cheng, Q.; Guo, X.; Wang, Y.; Zhao, L.; Zhou, F.; Ji, B. P. Effects of ferulic acid and Î-oryzanol on high-fat and high-fructose diet-induced metabolic syndrome in rats PLoS One 2015, 10, e0118135 10.1371/journal.pone.0118135
21. Lim, J. D.; Lee, S. R.; Kim, T.; Jang, S.-A.; Kang, S. C.; Koo, H. J.; Sohn, E.; Bak, J. P.; Namkoong, S.; Kim, H. K. Fucoidan from Fucus vesiculosus protects against alcohol-induced liver damage by modulating inflammatory mediators in mice and HepG2 cells Mar. Drugs 2015, 13, 1051-1067 10.3390/md13021051
22. Koneru, M.; Sahu, B. D.; Kumar, J. M.; Kuncha, M.; Kadari, A.; Kilari, E. K.; Sistla, R. Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (MMPs) and oxidative stress J. Funct. Foods 2016, 22, 588-601 10.1016/j.jff.2016.02.019
23. Chang, Y. Y.; Lin, Y. L.; Yang, D. J.; Liu, C. W.; Hsu, C. L.; Tzang, B. S.; Chen, Y. C. Hepatoprotection of noni juice against chronic alcohol consumption: lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation J. Agric. Food Chem. 2013, 61, 11016-11024 10.1021/jf4038419
24. Cho, J. H.; Kwon, J. E.; Cho, Y.; Kim, I.; Kang, S. C. Anti-inflammatory effect of Angelica gigas via heme oxygenase (HO)-1 expression Nutrients 2015, 7, 4862-4874 10.3390/nu7064862
25. Dong, D.; Xu, L.; Yin, L.; Qi, Y.; Peng, J. Naringin prevents carbon tetrachloride-induced acute liver injury in mice J. Funct. Foods 2015, 12, 179-191 10.1016/j.jff.2014.11.020
26. Lin, Y. L.; Chang, Y. Y.; Yang, D. J.; Tzang, B. S.; Chen, Y. C. Beneficial effects of noni (Morinda citrifolia L.) juice on livers of high-fat dietary hamsters Food Chem. 2013, 140, 31-38 10.1016/j.foodchem.2013.02.035
27. 4-induced hepatotoxicity in ICR mice Nutrients 2016, 8, 107 10.3390/nu8030107
28. Lu, Y.; Wu, D.; Wang, X.; Ward, S. C.; Cederbaum, A. I. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice Free Radical Biol. Med. 2010, 49, 1406-1416 10.1016/j.freeradbiomed.2010.07.026
29. Xiao, J.; Wang, J.; Xing, F.; Han, T.; Jiao, R.; Liong, E. C.; Fung, M. L.; So, K. F.; Tipoe, G. L. Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway PLoS One 2014, 9, e95214 10.1371/journal.pone.0095214