Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Moretti, Raffaella ^a,b   Leger, Pierre Louis ^a,c   Besson, Valérie C ^a   Csaba, Zsolt ^a   Pansiot, Julien ^a   Di Criscio, Lorena ^a   Gentili, Andrea ^a   Titomanlio, Luigi ^a   Bonnin, Philippe ^a   Baud, Olivier ^a   Charriaut Marlangue, Christiane ^a,d  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIVERSITY OF UDINE   (Italy)

^c ARMAND TROUSSEAU HOSPITAL   (France)

^d HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Focal ischemia; M2 microglia; Microcirculation; Microglia; Neonatal mice

Indexed keywords

CD32 ANTIGEN; CD86 ANTIGEN; SILDENAFIL; PHOSPHODIESTERASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BLOOD FLOW VELOCITY; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN TISSUE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC IMAGING; GENE EXPRESSION PROFILING; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MICROCIRCULATION; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROMODULATION; NEWBORN; NONHUMAN; PERINATAL PERIOD; PHENOTYPE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBECTOMY DEVICE; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; PATHOLOGY; POLYMERASE CHAIN REACTION;

ANIMALS; ANIMALS, NEWBORN; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICROGLIA; PHOSPHODIESTERASE INHIBITORS; POLYMERASE CHAIN REACTION; SILDENAFIL CITRATE;

EID: 84989231070     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0560-4     Document Type: Article

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