Sildenafil mediates blood-flow redistribution and neuroprotection after neonatal hypoxia-ischemia

Stroke

Volumn 45, Issue 3, 2014, Pages 850-856

  Charriaut Marlangue, Christiane ^a,b   Nguyen, Thao ^a   Bonnin, Philippe ^c   Duy, An Phan ^a   Leger, Pierre Louis ^a,b   Csaba, Zsolt ^a   Pansiot, Julien ^a,b   Bourgeois, Thomas ^a,b   Renolleau, Sylvain ^d   Baud, Olivier ^a,e  

^a INSERM   (France)

^b Fondation PremUP   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Neonatal stroke; Nitric oxide; Sildenafil

Indexed keywords

SILDENAFIL; CYCLIC GMP; NEUROPROTECTIVE AGENT; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; ASTROCYTOSIS; BLOOD BRAIN BARRIER; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; CAROTID ARTERY OBSTRUCTION; CELL ACTIVATION; CELL DEATH; CELL DENSITY; CELL DISRUPTION; CONTROLLED STUDY; CORPUS CALLOSUM; DOPPLER ECHOGRAPHY; DRUG DOSE COMPARISON; ENDOTHELIUM CELL; EXPERIMENTAL NEUROLOGIC DISEASE; GLIA CELL; HIPPOCAMPUS; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOHISTOCHEMISTRY; INTERNAL CAROTID ARTERY; LOCOMOTION; MACROPHAGE; MICROGLIA; MOTOR COORDINATION; NEUROPROTECTION; NEWBORN; NEWBORN HYPOXIA; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; WHITE MATTER; ANIMAL; BLOOD GAS ANALYSIS; BLOOD PRESSURE; BRAIN CIRCULATION; DRUG EFFECT; GLIA; HEMISPHERIC DOMINANCE; INFLAMMATION; MACROPHAGE ACTIVATION; MICROCIRCULATION; MOTOR ACTIVITY; NEONATAL STROKE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; PSYCHOMOTOR PERFORMANCE;

NEONATAL STROKE; NITRIC OXIDE; SILDENAFIL;

ANIMALS; ANIMALS, NEWBORN; BLOOD GAS ANALYSIS; BLOOD PRESSURE; CELL DEATH; CEREBROVASCULAR CIRCULATION; CYCLIC GMP; FUNCTIONAL LATERALITY; HYPOXIA-ISCHEMIA, BRAIN; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFLAMMATION; MACROPHAGE ACTIVATION; MICROCIRCULATION; MOTOR ACTIVITY; NEUROGLIA; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PSYCHOMOTOR PERFORMANCE; PURINES; RATS; SULFONES;

EID: 84899474537     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.003606     Document Type: Article

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