-
1
-
-
80054872790
-
Alcoholic liver disease: Pathogenesis and new therapeutic targets
-
Gao, B. & Bataller, R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 141, 1572-1585, doi: 10.1053/j.gastro.2011.09.002 (2011).
-
(2011)
Gastroenterology
, vol.141
, pp. 1572-1585
-
-
Gao, B.1
Bataller, R.2
-
2
-
-
84963516671
-
Alcoholic hepatitis: Translational approaches to develop targeted therapies
-
In press, doi: 10.1002/hep.28530
-
Mandrekar, P., Bataller, R., Tsukamoto, H. & Gao, B. Alcoholic hepatitis: Translational approaches to develop targeted therapies. Hepatology. In press, doi: 10.1002/hep.28530 (2016).
-
(2016)
Hepatology
-
-
Mandrekar, P.1
Bataller, R.2
Tsukamoto, H.3
Gao, B.4
-
3
-
-
77957967787
-
Lipin-The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism
-
Bou Khalil, M., Blais, A., Figeys, D. & Yao, Z. Lipin-The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism. Biochim Biophys Acta. 1801, 1249-1259, doi: 10.1016/j.bbalip.2010.07.008 (2010).
-
(2010)
Biochim Biophys Acta.
, vol.1801
, pp. 1249-1259
-
-
Bou Khalil, M.1
Blais, A.2
Figeys, D.3
Yao, Z.4
-
4
-
-
79961165137
-
MTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
Peterson, T. R., et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 146, 408-420, doi: 10.1016/j. cell.2011.06.034 (2011).
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
-
5
-
-
33747853190
-
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway
-
Finck, B. N., et al. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 4, 199-210, doi: 10.1016/j.cmet.2006.08.005 (2006).
-
(2006)
Cell Metab.
, vol.4
, pp. 199-210
-
-
Finck, B.N.1
-
6
-
-
77953400436
-
Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors
-
Kim, H. B., et al. Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol Cell Biol. 30, 3126-3139, doi: 10.1128/MCB.01671-09 (2010).
-
(2010)
Mol Cell Biol.
, vol.30
, pp. 3126-3139
-
-
Kim, H.B.1
-
7
-
-
80755188929
-
Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes
-
Takahashi, N., et al. Suppression of lipin-1 expression increases monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 415, 200-205, doi: 10.1016/j.bbrc.2011.10.060 (2011).
-
(2011)
Biochem Biophys Res Commun.
, vol.415
, pp. 200-205
-
-
Takahashi, N.1
-
8
-
-
57349175059
-
LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes
-
Lu, B., et al. LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 295, E1502-E1509, doi: 10.1152/ajpendo.90323.2008 (2008).
-
(2008)
Am J Physiol Endocrinol Metab.
, vol.295
, pp. E1502-E1509
-
-
Lu, B.1
-
9
-
-
84888306160
-
Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice
-
Hu, M., et al. Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice. Hepatology 58, 1953-1963, doi: 10.1002/hep.26589 (2013).
-
(2013)
Hepatology
, vol.58
, pp. 1953-1963
-
-
Hu, M.1
-
10
-
-
84928041008
-
MiR-217 regulates ethanol-induced hepatic inflammation by disrupting sirtuin 1-lipin-1signaling
-
Yin, H., Liang, X., Jogasuria, A., Davidson, N. O. & You, M. miR-217 regulates ethanol-induced hepatic inflammation by disrupting sirtuin 1-lipin-1signaling. Am J Pathol. 185, 1286-1296, doi: 10.1016/j.ajpath.2015.01.030 (2015).
-
(2015)
Am J Pathol.
, vol.185
, pp. 1286-1296
-
-
Yin, H.1
Liang, X.2
Jogasuria, A.3
Davidson, N.O.4
You, M.5
-
11
-
-
84939606543
-
Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses
-
Navratil, A. R., et al. Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses. Atherosclerosis 242, 424-432, doi: 10.1016/j.atherosclerosis.2015.08.012 (2015).
-
(2015)
Atherosclerosis
, vol.242
, pp. 424-432
-
-
Navratil, A.R.1
-
12
-
-
84908146266
-
Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages
-
Meana, C., et al. Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages. J Immunol. 193, 4614-4622, doi: 10.4049/jimmunol.1400238 (2014).
-
(2014)
J Immunol.
, vol.193
, pp. 4614-4622
-
-
Meana, C.1
-
13
-
-
79956194049
-
Subcellular localization and role of lipin-1 in human macrophages
-
Valdearcos, M., et al. Subcellular localization and role of lipin-1 in human macrophages. J Immunol. 186, 6004-6013, doi: 10.4049/jimmunol.1003279 (2011).
-
(2011)
J Immunol.
, vol.186
, pp. 6004-6013
-
-
Valdearcos, M.1
-
14
-
-
84894348922
-
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver
-
Yin, H., et al. Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. Gastroenterology 146, 801-811, doi: 10.1053/j.gastro.2013.11.008 (2014).
-
(2014)
Gastroenterology
, vol.146
, pp. 801-811
-
-
Yin, H.1
-
15
-
-
84871870225
-
Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice
-
Everitt, H., et al. Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice. Am J Physiol Gastrointest Liver Physiol. 304, G38-G47, doi: 10.1152/ajpgi.00309.2012 (2013).
-
(2013)
Am J Physiol Gastrointest Liver Physiol.
, vol.304
, pp. G38-G47
-
-
Everitt, H.1
-
16
-
-
84856379516
-
Regulation of hepatic lipin-1 by ethanol: Role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice
-
Hu, M., et al. Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice. Hepatology 55, 437-446, doi: 10.1002/hep.24708 (2012).
-
(2012)
Hepatology
, vol.55
, pp. 437-446
-
-
Hu, M.1
-
17
-
-
77249094005
-
Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
-
Shen, Z., Liang, X., Rogers, C. Q., Rideout D. & You M. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol. 298, G364-G374, doi: 10.1152/ajpgi.00456.2009 (2010).
-
(2010)
Am J Physiol Gastrointest Liver Physiol.
, vol.298
, pp. G364-G374
-
-
Shen, Z.1
Liang, X.2
Rogers, C.Q.3
Rideout, D.4
You, M.5
-
18
-
-
0028858883
-
Activity and subcellular distribution of phosphatidate phosphohydrolase (EC 3. 134) in alcoholic liver disease
-
Simpson, K. J., Venkatesan, S., Martin, A., Brindley, D. N. & Peters, T. J. Activity and subcellular distribution of phosphatidate phosphohydrolase (EC 3. 134) in alcoholic liver disease. Alcohol Alcohol 30, 31-36 (1995).
-
(1995)
Alcohol Alcohol
, vol.30
, pp. 31-36
-
-
Simpson, K.J.1
Venkatesan, S.2
Martin, A.3
Brindley, D.N.4
Peters, T.J.5
-
19
-
-
45349108600
-
Phosphatidic acid mediates demyelination in Lpin1 mutant mice
-
Nadra, K., et al. Phosphatidic acid mediates demyelination in Lpin1 mutant mice. Genes Dev. 22, 1647-1661, doi: 10.1101/gad.1638008 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 1647-1661
-
-
Nadra, K.1
-
20
-
-
84875160269
-
Mouse model of chronic and binge ethanol feeding (the NIAAA model)
-
Bertola, A., Mathews, S., Ki, S. H., Wang, H. & Gao B. Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc. 8, 627-637, doi: 10.1038/nprot.2013.032 (2013).
-
(2013)
Nat Protoc.
, vol.8
, pp. 627-637
-
-
Bertola, A.1
Mathews, S.2
Ki, S.H.3
Wang, H.4
Gao, B.5
-
21
-
-
84956625214
-
Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease
-
Wieser, V., et al. Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease. J Hepatol. 64, 872-880, doi: 10.1016/j. jhep.2015.11.037 (2016).
-
(2016)
J Hepatol.
, vol.64
, pp. 872-880
-
-
Wieser, V.1
-
22
-
-
77955474503
-
Complement and alcoholic liver disease: Role of C1q in the pathogenesis of ethanol-induced liver injury in mice
-
Cohen, J. I., Roychowdhury, S., McMullen, M. R., Stavitsky, A. B. & Nagy, L. E. Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice. Gastroenterology 139, 664-674, doi: 10.1053/j.gastro.2010.04.041 (2010).
-
(2010)
Gastroenterology
, vol.139
, pp. 664-674
-
-
Cohen, J.I.1
Roychowdhury, S.2
McMullen, M.R.3
Stavitsky, A.B.4
Nagy, L.E.5
-
23
-
-
24144496133
-
Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
-
You, M., Considine, R. V., Leone, T. C., Kelly, D. P. & Crabb, D. W. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology. 42, 568-577, doi: 10.1002/hep.20821 (2005).
-
(2005)
Hepatology.
, vol.42
, pp. 568-577
-
-
You, M.1
Considine, R.V.2
Leone, T.C.3
Kelly, D.P.4
Crabb, D.W.5
-
24
-
-
84870302181
-
MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity
-
Kusminski, C. M., et al. MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity. Nat Med. 18, 1539-1549, doi: 10.1038/nm.2899 (2012).
-
(2012)
Nat Med.
, vol.18
, pp. 1539-1549
-
-
Kusminski, C.M.1
-
25
-
-
27844546989
-
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
-
Inagaki, T., et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab. 2, 217-225, doi: 10.1016/j.cmet.2005.09.001 (2005).
-
(2005)
Cell Metab.
, vol.2
, pp. 217-225
-
-
Inagaki, T.1
-
26
-
-
84910077652
-
Fibroblast growth factor receptor 4 (FGFR4) deficiency improves insulin resistance and glucose metabolism under dietinduced obesity conditions
-
Ge, H., et al. Fibroblast growth factor receptor 4 (FGFR4) deficiency improves insulin resistance and glucose metabolism under dietinduced obesity conditions. J Biol Chem. 289, 30470-30480, doi: 10.1074/jbc.M114.592022 (2014).
-
(2014)
J Biol Chem.
, vol.289
, pp. 30470-30480
-
-
Ge, H.1
-
27
-
-
84878789770
-
Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels
-
Vergnes, L., Lee, J. M., Chin, R. G., Auwerx, J. & Reue, K. Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Cell Metab. 17, 916-928, doi: 10.1016/j.cmet.2013.04.007 (2013).
-
(2013)
Cell Metab.
, vol.17
, pp. 916-928
-
-
Vergnes, L.1
Lee, J.M.2
Chin, R.G.3
Auwerx, J.4
Reue, K.5
-
28
-
-
84876146580
-
Free fatty acids repress small heterodimer partner (SHP) activation and adiponectincounteracts bile acidinduced liver injury in superobese patients with nonalcoholic steatohepatitis
-
Bechmann, L. P., et al. Free fatty acids repress small heterodimer partner (SHP) activation and adiponectincounteracts bile acidinduced liver injury in superobese patients with nonalcoholic steatohepatitis. Hepatology. 57, 1394-1406, doi: 10.1002/hep.26225 (2013).
-
(2013)
Hepatology
, vol.57
, pp. 1394-1406
-
-
Bechmann, L.P.1
-
29
-
-
84879097423
-
Adiponectin bile acids, and burnt-out nonalcoholic steatohepatitis: New light on an old paradox
-
Claudel, T. & Trauner, M. Adiponectin, bile acids, and burnt-out nonalcoholic steatohepatitis: new light on an old paradox. Hepatology 57, 2106-2109, doi: 10.1002/hep.26340 (2013).
-
(2013)
Hepatology
, vol.57
, pp. 2106-2109
-
-
Claudel, T.1
Trauner, M.2
-
30
-
-
84982185515
-
Adiponectin as an anti-fibrotic and anti-inflammatory adipokine in the liver
-
Park, P. H., Sanz-Garcia, C. & Nagy L. E. Adiponectin as an anti-fibrotic and anti-inflammatory adipokine in the liver. Curr Pathobiol Rep. 3, 243-252, doi: 10.1007/s40139-015-0094-y (2015).
-
(2015)
Curr Pathobiol Rep.
, vol.3
, pp. 243-252
-
-
Park, P.H.1
Sanz-Garcia, C.2
Nagy, L.E.3
-
31
-
-
84949884025
-
Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2-deficient mice
-
Zhou, M., et al. Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2-deficient mice. Hepatology 63, 914-929, doi: 10.1002/hep.28257 (2016).
-
(2016)
Hepatology
, vol.63
, pp. 914-929
-
-
Zhou, M.1
-
32
-
-
84948958649
-
Lipopolysaccharide induces a downregulation of adiponectin receptors in-vitro and in-vivo
-
Hall, A., et al. Lipopolysaccharide induces a downregulation of adiponectin receptors in-vitro and in-vivo. PeerJ. 3, e1428, doi: 10.7717/peerj.1428 (2015).
-
(2015)
PeerJ.
, vol.3
, pp. e1428
-
-
Hall, A.1
-
33
-
-
79959522403
-
Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice
-
Liang, X., et al. Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice. Antioxid Redox Signal 15, 425-435, doi: 10.1089/ars.2010.3780 (2011).
-
(2011)
Antioxid Redox Signal
, vol.15
, pp. 425-435
-
-
Liang, X.1
-
34
-
-
84995695511
-
The Detrimental Role Played by Lipocalin-2 in Alcoholic Fatty Liver in Mice
-
Yan, C., et al. The Detrimental Role Played by Lipocalin-2 in Alcoholic Fatty Liver in Mice. Am J Pathol. 186, 2417-2428, doi: 10.1016/j.ajpath.2016.05.006 (2016).
-
(2016)
Am J Pathol.
, vol.186
, pp. 2417-2428
-
-
Yan, C.1
-
35
-
-
0028858883
-
Activity and subcellular distribution of phosphatidate phosphohydrolase (EC 3. 134) in alcoholic liver disease
-
Simpson, K. J., et al. Activity and subcellular distribution of phosphatidate phosphohydrolase (EC 3. 134) in alcoholic liver disease. Alcohol Alcohol 30, 31-36 (1995).
-
(1995)
Alcohol Alcohol
, vol.30
, pp. 31-36
-
-
Simpson, K.J.1
|