Use of preoperative gabapentin significantly reduces postoperative opioid consumption: A meta-analysis

Journal of Pain Research

Volumn 9, Issue , 2016, Pages 631-640

  Arumugam, Sudha ^a   Lau, Christine S M ^a,b   Chamberlain, Ronald S ^a,b,c  

^a SAINT BARNABAS MEDICAL CENTER   (United States)

^b University School of Medicine St George's   (Grenada)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Gabapentin; Opioid; Postoperative pain; Preemptive analgesia

Indexed keywords

FENTANYL; GABAPENTIN; MORPHINE; OPIATE; TRAMADOL;

ANALGESIA; ARTICLE; DISEASE ASSOCIATION; DRUG USE; HUMAN; INCIDENCE; NAUSEA; OUTCOME ASSESSMENT; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PREOPERATIVE TREATMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); SOMNOLENCE; VOMITING;

EID: 84988961053     PISSN: None     EISSN: 11787090     Source Type: Journal    
DOI: 10.2147/JPR.S112626     Document Type: Article

References (45)

1. Centers for Disease Control and Prevention. National Center for Health Statistics. 2016. Available from: http://www.cdc.gov/nchs/fastats/. Accessed August 3, 2016.
2. Schug SA, Large RG. Economic considerations in pain management. Pharmacoeconomics. 1993;3(4):260-267.
3. Owen H, McMillan V, Rogowski D. Postoperative pain therapy: a survey of patients’ expectations and their experiences. Pain. 1990;41(3):303-307.
4. Carr DB, Goudas LC. Acute pain. Lancet. 1999;353(9169):2051-2058.
5. Macrae WA. Chronic post-surgical pain: 10 years on. Br J Anaesth. 2008;101(1):77-86.
6. Searle RD, Simpson MP, Simpson KH, Milton R, Bennett MI. Can chronic neuropathic pain following thoracic surgery be predicted during the postoperative period? Interact Cardiovasc Thorac Surg. 2009;9(6):999-1002.
7. Clarke H, Poon M, Weinrib A, Katznelson R, Wentlandt K, Katz J. Preventive analgesia and novel strategies for the prevention of chronic post-surgical pain. Drugs. 2015;75(4):339-351.
8. Perkins FM, Kehlet H. Chronic pain as an outcome of surgery. A review of predictive factors. Anesthesiology. 2000;93(4):1123-1133.
9. Benyamin R, Trescot AM, Datta S, et al. Opioid complications and side effects. Pain Physician. 2008;11(2 Suppl):S105-S120.
10. Anwari JS, Iqbal S. Antihistamines and potentiation of opioid induced sedation and respiratory depression. Anaesthesia. 2003;58(5):494-495.
11. Ashburn MA, Love G, Pace NL. Respiratory-related critical events with intravenous patient-controlled analgesia. Clin J Pain. 1994;10(1):52-56.
12. Etches RC. Respiratory depression associated with patient-controlled analgesia: a review of eight cases. Can J Anaesth. 1994;41(2):125-132.
13. Oderda GM, Said Q, Evans RS, et al. Opioid-related adverse drug events in surgical hospitalizations: impact on costs and length of stay. Ann Pharmacother. 2007;41(3):400-406.
14. Joshi SS, Jagadeesh AM. Efficacy of perioperative pregabalin in acute and chronic post-operative pain after off-pump coronary artery bypass surgery: a randomized, double-blind placebo controlled trial. Ann Card Anaesth. 2013;16(3):180-185.
15. White PF. Multimodal analgesia: its role in preventing postoperative pain. Curr Opin Investig Drugs. 2008;9(1):76-82.
16. Costantini R, Affaitati G, Fabrizio A, Giamberardino MA. Controlling pain in the post-operative setting. Int J Clin Pharmacol Ther. 2011;49(2):116-127.
17. Chang CY, Challa CK, Shah J, Eloy JD. Gabapentin in acute postoperative pain management. Biomed Res Int. 2014;2014:631756.
18. Bockbrader HN, Wesche D, Miller R, Chapel S, Janiczek N, Burger P. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet. 2010;49(10):661-669.
19. Alayed N, Alghanaim N, Tan X, Tulandi T. Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstet Gynecol. 2014;123(6):1221-1229.
20. Bharti N, Bala I, Narayan V, Singh G. Effect of gabapentin pretreatment on propofol consumption, hemodynamic variables, and postoperative pain relief in breast cancer surgery. Acta Anaesthesiol Taiwan. 2013;51(1):10-13.
21. Kinney MA, Mantilla CB, Carns PE, et al. Preoperative gabapentin for acute post-thoracotomy analgesia: a randomized, double-blinded, active placebo-controlled study. Pain Pract. 2012;12(3):175-183.
22. Moore A, Costello J, Wieczorek P, Shah V, Taddio A, Carvalho JC. Gabapentin improves postcesarean delivery pain management: a randomized, placebo-controlled trial. Anesth Analg. 2011;112(1):167-173.
23. Pandey CK, Sahay S, Gupta D, et al. Preemptive gabapentin decreases postoperative pain after lumbar discoidectomy. Can J Anaesth. 2004;51(10):986-989.
24. Breivik H. Postoperative pain management: why is it difficult to show that it improves outcome? Eur J Anaesthesiol. 1998;15(6):748-751.
25. Joshi GP, Ogunnaike BO. Consequences of inadequate postoperative pain relief and chronic persistent postoperative pain. Anesthesiol Clin North America. 2005;23(1):21-36.
26. Elvir-Lazo OL, White PF. The role of multimodal analgesia in pain management after ambulatory surgery. Curr Opin Anaesthesiol. 2010;23(6):697-703.
27. McLean MJ, Gidal BE. Gabapentin dosing in the treatment of epilepsy. Clin Ther. 2003;25(5):1382-1406.
28. Mao J, Chen LL. Gabapentin in pain management. Anesth Analg. 2000;91(3):680-687.
29. Guttuso T Jr, Roscoe J, Griggs J. Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. Lancet. 2003;361(9370):1703-1705.
30. Felix R, Gurnett CA, De WM, Campbell KP. Dissection of functional domains of the voltage-dependent Ca2+ channel alpha2delta subunit. J Neurosci. 1997;17(18):6884-6891.
31. Grant MC, Lee H, Page AJ, Hobson D, Wick E, Wu CL. The effect of preoperative gabapentin on postoperative nausea and vomiting: a meta-analysis. Anesth Analg. 2016;122(4):976-985.
32. Rivkin A, Rivkin MA. Perioperative nonopioid agents for pain control in spinal surgery. Am J Health Syst Pharm. 2014;71(21):1845-1857.
33. Goa KL, Sorkin EM. Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. Drugs. 1993;46(3):409-427.
34. Pandey CK, Priye S, Singh S, Singh U, Singh RB, Singh PK. Preemptive use of gabapentin significantly decreases postoperative pain and rescue analgesic requirements in laparoscopic cholecystectomy. Can J Anaesth. 2004;51(4):358-363.
35. Turan A, Karamanlioglu B, Memis D, Usar P, Pamukcu Z, Ture M. The analgesic effects of gabapentin after total abdominal hysterectomy. Anesth Analg. 2004;98(5):1370-1373.
36. Turan A, Karamanlioglu B, Memis D, et al. Analgesic effects of gabapentin after spinal surgery. Anesthesiology. 2004;100(4):935-938.
37. Radhakrishnan M, Bithal PK, Chaturvedi A. Effect of preemptive gabapentin on postoperative pain relief and morphine consumption following lumbar laminectomy and discectomy: a randomized, double-blinded, placebo-controlled study. J Neurosurg Anesthesiol. 2005;17(3):125-128.
38. Adam F, Menigaux C, Sessler DI, Chauvin M. A single preoperative dose of gabapentin (800 milligrams) does not augment postoperative analgesia in patients given interscalene brachial plexus blocks for arthroscopic shoulder surgery. Anesth Analg. 2006;103(5):1278-1282.
39. Al-Mujadi H, Refai AR, Katzarov MG, Dehrab NA, Batra YK, Al-Qattan AR. Preemptive gabapentin reduces postoperative pain and opioid demand following thyroid surgery. Can J Anaesth. 2006;53(3):268-273.
40. Pandey CK, Priye S, Ambesh SP, Singh S, Singh U, Singh PK. Prophylactic gabapentin for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled study. J Postgrad Med. 2006;52(2):97-100.
41. Montazeri K, Kashefi P, Honarmand A. Pre-emptive gabapentin significantly reduces postoperative pain and morphine demand following lower extremity orthopaedic surgery. Singapore Med J. 2007;48(8):748-751.
42. Grover VK, Mathew PJ, Yaddanapudi S, Sehgal S. A single dose of preoperative gabapentin for pain reduction and requirement of morphine after total mastectomy and axillary dissection: randomized placebocontrolled double-blind trial. J Postgrad Med. 2009;55(4):257-260.
43. Srivastava U, Kumar A, Saxena S, Mishra AR, Saraswat N, Mishra S. Effect of preoperative gabapentin on postoperative pain and tramadol consumption after minilap open cholecystectomy: a randomized doubleblind, placebo-controlled trial. Eur J Anaesthesiol. 2010;27(4):331-335.
44. Deniz MN, Sertoz N, Erhan E, Ugur G. Effects of preoperative gabapentin on postoperative pain after radical retropubic prostatectomy. J Int Med Res. 2012;40(6):2362-2369.
45. Short J, Downey K, Bernstein P, Shah V, Carvalho JC. A single preoperative dose of gabapentin does not improve postcesarean delivery pain management: a randomized, double-blind, placebo-controlled dose-finding trial. Anesth Analg. 2012;115(6):1336-1342.