Brain imaging of pain: State of the art

Journal of Pain Research

Volumn 9, Issue , 2016, Pages 613-624

  Morton, Debbie L ^a   Sandhu, Javin S ^a   Jones, Anthony K P ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Arthritis; EEG; Fibromyalgia; fMRI; PET

Indexed keywords

FLUORODEOXYGLUCOSE;

ANALGESIA; ANTERIOR CINGULATE; ARTERIAL SPIN LABELING; BOLD SIGNAL; BRAIN BLOOD FLOW; CONNECTOME; DIFFUSION TENSOR IMAGING; ELECTROENCEPHALOGRAPHY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; INSULA; INTERMETHOD COMPARISON; MAGNETOENCEPHALOGRAPHY; NERVE CELL PLASTICITY; NEUROCHEMISTRY; NEUROIMAGING; NOCICEPTION; PAIN; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIMARY SOMATOSENSORY CORTEX; REVIEW; SECONDARY SOMATOSENSORY CORTEX; THALAMUS;

EID: 84988957346     PISSN: None     EISSN: 11787090     Source Type: Journal    
DOI: 10.2147/JPR.S60433     Document Type: Review

References (122)

1. Frymoyer JW, Newberg A, Pope M, Wilder D, Clements J, MacPherson B. Spine radiographs in patients with low-back pain. An epidemiological study in men. J Bone Jt Surg. 1984;66(7):1048–1055.
2. Bedson J, Croft PR. The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature. BMC Musculoskelet Disord. 2008;9:116.
3. Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS. Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med. 1994;331(2):69–73.
4. Melzack R. From the gate to the neuromatrix. Pain Suppl. 1999; 6(1):121–126.
5. Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965; 150(699):971–979.
6. Lee MC, Mouraux A, Iannetti GD. Characterizing the cortical activity through which pain emerges from nociception. J Neurosci. 2009;29(24):7909–7916.
7. Treede RD. Transduction and transmission properties of primary nociceptive afferents. Ross Fiziol ZhIm IM Sechenova. 1999;85(1): 205–211.
8. Peyron R, Laurent B, García-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis. Neurophysiol Clin. 2000;30(5):263–288.
9. Moisset X, Bouhassira D. Brain imaging of neuropathic pain. Neuroimage. 2007;37:S80–S88.
10. Obama P. Remarks by the President on the BRAIN Initiative and American Innovation [Internet]. The White House Office of the Press Secretary. 2013 [cited 2015 Dec 14]. Available from: https://www.whitehouse.gov/the-press-office/2013/04/02/remarks-presidentbrain-initiative-and-american-innovation. Accessed July 01 2016.
11. Parens E, Johnston J. Neuroimaging: beginning to appreciate its complexities. Hastings Cent Rep. 2014;44(S2):2–7.
12. Aguirre GK. Functional neuroimaging: technical, logical, and social perspectives. Hastings Cent Rep. 2014;44(S2):S8–S18.
13. Apkarian AV, Bushnell MC, Treede R-D, Zubieta J-K. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain. 2005;9(4):463–484.
14. Fox PT, Raichle ME. Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci U S A. 1986;83(4):1140–1144.
15. Huettel SA, Song AW, McCarthy G. Functional Magnetic Resonance Imaging. 1st ed. Sunderland: Sinauer Associates; 2004.
16. Ogawa S, Lee TM, Kay AR, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A. 1990;87(24):9868–9872.
17. Pauling L, Coryell CD. The magnetic properties and structure of hemoglobin, oxyhemoglobin and carbonmonoxyhemoglobin. Proc Natl Acad Sci U S A. 1936;22(4):210.
18. Thulborn KR, Waterton JC, Matthews PM, Radda GK. Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. Biochim Biophys Acta. 1982;714(2):265–270.
19. Owen D, Bureau Y, Thomas A, Prato F, Lawrence KS. Quantification of pain-induced changes in cerebral blood flow by perfusion MRI. Pain. 2008;136(1–2):85–96.
20. Kato Y, Araki N, Matsuda H, Ito Y, Suzuki C. Arterial spin-labeled MRI study of migraine attacks treated with rizatriptan. J Headache Pain. 2010;11(3):255–258.
21. Wasan AD, Loggia ML, Chen LQ, Napadow V, Kong J, Gollub RL. Neural correlates of chronic low back pain measured by arterial spin labeling. Anesthesiology. 2011;115(2):364–374.
22. Conturo TE, Lori NF, Cull TS, et al. Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci U S A. 1999;96(18): 10422–10427.
23. Smith SM, Jenkinson M, Johansen-Berg H, et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage. 2006;31(4):1487–1505.
24. Davis KD, Moayedi M. Central mechanisms of pain revealed through functional and structural MRI. J Neuroimmune Pharmacol. 2013;8(3): 518–534.
25. Hillman EM. Optical brain imaging in vivo: techniques and applications from animal to man. J Biomed Opt. 2007;12(5):51402.
26. Phelps ME, Hoffman EJ, Mullani NA, Ter-Pogossian MM. Application of annihilation coincidence detection to transaxial reconstruction tomography. J Nucl Med. 1975;16(3):210–224.
27. Phelps ME. Positron computed tomography studies of cerebral glucose metabolism in man: theory and application in nuclear medicine. Semin Nucl Med. 1981;11(1):32–49.
28. Jones AK, Brown WD, Friston KJ, Qi LY, Frackowiak RS. Cortical and subcortical localization of response to pain in man using positron emission tomography. Proc Biol Sci. 1991;244(1309):39–44.
29. Lee CM, Farde L. Using positron emission tomography to facilitate CNS drug development. Trends Pharmacol Sci. 2006;27(6):310–316.
30. Frank R, Hargreaves R. Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov. 2003;2(7):566–580.
31. Jueptner M, Weiller C. Review: does measurement of regional cerebral blood flow reflect synaptic activity? – implications for PET and fMRI. Neuroimage. 1995;2(2PA):148–156.
32. Castillejo-López C, Delgado-Vega AM, Wojcik J, et al. Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. Ann Rheum Dis. 2012;71(1):136–142.
33. Backes H, Walberer M, Endepols H, et al. Whiskers area as extracerebral reference tissue for quantification of rat brain metabolism using (18)F-FDG PET: application to focal cerebral ischemia. J Nucl Med. 2011;52(8):1252–1260.
34. Wehrl HF, Hossain M, Lankes K, et al. Simultaneous PET-MRI reveals brain function in activated and resting state on metabolic, hemodynamic and multiple temporal scales. Nat Med. 2013;19(9):1184–1189.
35. Reivich M, Kuhl D, Wolf A, et al. The [18 F] fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ Res. 1979;44(1):127–137.
36. Jones AK, Huneke NT, Lloyd DM, Brown CA, Watson A. Role of functional brain imaging in understanding rheumatic pain. Curr Rheumatol Rep. 2012;14(6):557–567.
37. Brown CA, El-Deredy W, Jones AK. When the brain expects pain: common neural responses to pain anticipation are related to clinical pain and distress in fibromyalgia and osteoarthritis. Eur J Neurosci. 2014;39(4):663–672.
38. Tran T, Inui K, Hoshiyama M, Lam K, Qiu Y, Kakigi R. Cerebral activation by the signals ascending through unmyelinated C-fibers in humans: a magnetoencephalographic study. Neuroscience. 2002;113:375–386.
39. Ploner M, Gross J, Timmermann L, Schnitzler A. Cortical representation of first and second pain sensation in humans. Proc Natl Acad Sci U S A. 2002;99:12444–12448.
40. Brown CA, Seymour B, Boyle Y, El-Deredy W, Jones AKP. Modulation of pain perception by expectation and uncertainty: behavioral characteristics and anticipatory neural correlates. Pain. 2008;135(3): 240–250.
41. Liu Z, Ding L, He B. Integration of EEG/MEG with MRI and fMRI. IEEE Eng Med Biol Mag. 2006;25(4):46–53.
42. Olier I, Trujillo-Barreto NJ, El-Deredy W. A switching multi-scale dynamical network model of EEG/MEG. Neuroimage. 2013;83:262–287.
43. Darvas F, Pantazis D, Kucukaltun-Yildirim E, Leahy RM. Mapping human brain function with MEG and EEG: methods and validation. Neuroimage. 2004;23(suppl 1):289–299.
44. Hari R, Salmelin R. Magnetoencephalography: from SQUIDs to neuroscience: neuroimage 20th anniversary special edition. Neuroimage. 2012;61(2):386–396.
45. Kulkarni B, Bentley DE, Elliott R, et al. Attention to pain localization and unpleasantness discriminates the functions of the medial and lateral pain systems. Eur J Neurosci. 2005;21(11):3133–3142.
46. Porro CA, Cettolo V, Francescato MP, Baraldi P. Temporal and intensity coding of pain in human cortex. J Neurophysiol. 1998;80(6): 3312–3320.
47. Tolle T, Kaufmann T, Siessmeier T, Lautenbacher S, Berthele A, Munz F. Region-specific encoding of sensory and affective components of pain in the human brain: a positron emission tomography correlation analysis. Ann Neurol. 1999;45:40–47.
48. Brown CA, Huneke NT, Jones AK. Pain Syndromes. Brain Mapping. Elsevier Inc.; 2015:1135–1141.
49. Apkarian AV, Baliki MN, Geha PY. Towards a theory of chronic pain. Prog Neurobiol. 2009;87(2):81–97.
50. Porro CA, Baraldi P, Pagnoni G, et al. Does anticipation of pain affect cortical nociceptive systems? J Neurosci. 2002;22(8):3206–3214.
51. Beydoun A, Morrow TJ, Shen JF, Casey KL. Variability of laser-evoked potentials: attention, arousal and lateralized differences. Electroencephalogr Clin Neurophysiol. 1993;88(3):173–181.
52. Fairhurst M, Wiech K, Dunckley P, Tracey I. Anticipatory brainstem activity predicts neural processing of pain in humans. Pain. 2007;128(1–2):101–110.
53. Hsieh JC, Stone-Elander S, Ingvar M. Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study. Neurosci Lett. 1999;262(1):61–64.
54. Ploghaus A, Tracey I, Gati JS, et al. Dissociating pain from its anticipation in the human brain. Science. 1999;284(18):1979–1981.
55. Sawamoto N, Honda M, Okada T, et al. Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum/posterior insula: an eventrelated functional magnetic resonance imaging study. J Neurosci. 2000;20(19):7438–7445.
56. Price DD, Fields HL. The contribution of desire and expectation to placebo analgesia: implications for new research strategies. In: Harrington A, editor. The Placebo Effect: An Interdisciplinary Exploration. Cambridge, MA: Harvard University Press; 1997:117–137.
57. Benedetti F. No prefrontal control, no placebo response. Pain. 2010;148(3):357–358.
58. Watson A, Power A, Brown C, El-deredy W, Jones A. Placebo analgesia: cognitive influences on therapeutic outcome. Arthritis Res Ther. 2012;14(2):206.
59. Kong J, Gollub RL, Rosman IS, et al. Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J Neurosci. 2006;26(2):381–388.
60. Petrovic P, Ingvar M. Placebo and opioid analgesia imaging a shared neuronal network. Science. 2002;295:1737–1740.
61. Wager TD, Rilling JK, Smith EE, et al. Placebo-induced changes in FMRI in the anticipation and experience of pain. Science. 2004;303(5661):1162–1167.
62. Eippert F, Finsterbusch J, Bingel U, Buchel C. Direct evidence for spinal cord involvement in placebo analgesia. Science. 2009;326(5951):404.
63. Zubieta J-K, Bueller JA, Jackson LR, et al. Placebo effects mediated by endogenous opioid activity on {micro}-opioid receptors. J Neurosci. 2005;25(34):7754–7762.
64. Bingel U, Lorenz J, Schoell E, Weiller C, Buchel C. Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain. 2006;120(12):8–15.
65. Arntz A, de Jong P. Anxiety, attention and pain. J Psychosom Res. 1993;37(4):423–431.
66. Petrovic P, Petersson KM, Ghatan PH, Stone-Elander S, Ingvar M. Pain-related cerebral activation is altered by a distracting cognitive task. Pain. 2000;85(12):19–30.
67. Bantick SJ, Wise RG, Ploghaus A, Clare S, Smith SM, Tracey I. Imaging how attention modulates pain in humans using functional MRI. Brain. 2002;125(pt 2):310–319.
68. Boyle Y, Bentley DE, Watson A, Jones AK. Acoustic noise in functional magnetic resonance imaging reduces pain unpleasantness ratings. Neuroimage. 2006;31(3):1278–1283.
69. Wiech K, Seymour B, Kalisch R, et al. Modulation of pain processing in hyperalgesia by cognitive demand. Neuroimage. 2005;27(1):59–69.
70. Bingel U, Schoell E, Herken W, Buchel C, May A. Habituation to painful stimulation involves the antinociceptive system. Pain. 2007;131(12):21–30.
71. Bingel U, Herken W, Teutsch S, May A. Habituation to painful stimulation involves the antinociceptive system – a 1-year follow-up of 10 participants. Pain. 2008;140(2):393–394.
72. Teutsch S, Herken W, Bingel U, Schoell E, May A. Changes in brain gray matter due to repetitive painful stimulation. Neuroimage. 2008;42(2):845–849.
73. Gracely RH, Petzke F, Wolf JM, Clauw DJ. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum. 2002;46(5):1333–1343.
74. Lawal A, Kern M, Sidhu H, Hofmann C, Shaker R. Novel evidence for hypersensitivity of visceral sensory neural circuitry in irritable bowel syndrome patients. Gastroenterology. 2006;130(1):26–33.
75. Tracey I, Johns E. The pain matrix: reloaded or reborn as we image tonic pain using arterial spin labelling. Pain. 2010;148(3):359–360.
76. Kulkarni B, Bentley DE, Elliott R, et al. Arthritic pain is processed in brain areas concerned with emotions and fear. Arthritis Rheum. 2007;56(4):1345–1354.
77. Parks EL, Geha PY, Baliki MN, Katz J, Schnitzer TJ, Apkarian AV. Brain activity for chronic knee osteoarthritis: dissociating evoked pain from spontaneous pain. Eur J Pain. 2011;15(8):843.e1–843.e14.
78. Gwilym SE, Keltner JR, Warnaby CE, et al. Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Rheum. 2009;61(9):1226–1234.
79. Seymour B, Doherty JPO, Dayan P, et al. Temporal difference models describe higher-order learning in humans. Nature. 2004;429:664–667.
80. Anderson AK, Phelps EA. Lesions of the human amygdala impair enhanced perception of emotionally salient events. Nature. 2001;411(6835):305–309.
81. Bornhovd K, Quante M, Glauche V, Bromm B, Weiller C, Buchel C. Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single-trial fMRI study. Brain. 2002;125(pt 6):1326–1336.
82. Posner MI, Petersen SE. The attention system of the human brain. Annu Rev Neurosci. 1990;13:25–42.
83. Lorenz J, Cross DJ, Minoshima S, Morrow TJ, Paulson PE, Casey KL. A unique representation of heat allodynia in the human brain. Neuron. 2002;35(2):383–393.
84. Hadjipavlou G, Dunckley P, Behrens TE, Tracey I. Determining anatomical connectivities between cortical and brainstem pain processing regions in humans: a diffusion tensor imaging study in healthy controls. Pain. 2006;123(12):169–178.
85. Lorenz J, Minoshima S, Casey KL. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain. 2003;126(pt 5):1079–1091.
86. Koyama T, McHaffie JG, Laurienti PJ, Coghill RC. The subjective experience of pain: where expectations become reality. Proc Natl Acad Sci U S A. 2005;102(36):12950–12955.
87. Ploghaus A, Narain C, Beckmann CF, et al. Exacerbation of pain by anxiety is associated with activity in a hippocampal network. J Neurosci. 2001;21(24):9896–9903.
88. May A. Chronic pain may change the structure of the brain. Pain. 2008;137(1):7–15.
89. Foss JM, Apkarian AV, Chialvo DR. Dynamics of pain: fractal dimension of temporal variability of spontaneous pain differentiates between pain States. J Neurophysiol. 2006;95(2):730–736.
90. Baliki MN, Chialvo DR, Geha PY, et al. Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain. J Neurosci. 2006;26(47):12165–12173.
91. Derbyshire SW, Jones AK, Gyulai F, Clark S, Townsend D, Firestone LL. Pain processing during three levels of noxious stimulation produces differential patterns of central activity. Pain. 1997;73:431–435.
92. Brown CA, Matthews J, Fairclough M, et al. Striatal opioid receptor availability is related to acute and chronic pain perception in arthritis: does opioid adaptation increase resilience to chronic pain? Pain. 2015;156(11):2267–2275.
93. Edwards RR, Cahalan C, Mensing G, Smith M, Haythornthwaite JA. Pain, catastrophizing, and depression in the rheumatic diseases. Nat Rev Rheumatol. 2011;7(4):216–224.
94. Giesecke T, Gracely RH, Williams DA, Geisser ME, Petzke FW, Clauw DJ. The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis Rheum. 2005;52(5):1577–1584.
95. Gracely RH, Geisser ME, Giesecke T, et al. Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain. 2004;127(pt 4):835–843.
96. Apkarian AV, Sosa Y, Sonty S, et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci. 2004;24(46):10410–10415.
97. Schmidt-Wilcke T, Leinisch E, Ganssbauer S, et al. Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients. Pain. 2006;125(12):89–97.
98. Kuchinad A, Schweinhardt P, Seminowicz DA, Wood PB, Chizh BA, Bushnell MC. Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain? J Neurosci. 2007;27(15):4004–4007.
99. Lutz J, Jager L, de Quervain D, et al. White and gray matter abnormalities in the brain of patients with fibromyalgia: a diffusion-tensor and volumetric imaging study. Arthritis Rheum. 2008;58(12):3960–3969.
100. Gwilym SE, Filippini N, Douaud G, Carr AJ, Tracey I. Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum. 2010;62(10):2930–2940.
101. Rodriguez-Raecke R, Niemeier A, Ihle K, Ruether W, May A. Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. J Neurosci. 2009;29(44):13746–13750.
102. Ellingson BM, Mayer E, Harris RJ, et al. Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome. Pain. 2013;154(9):1528–1541.
103. Zubieta JK, Smith YR, Bueller JA, et al. Regional Mu opioid receptor regulation of sensory and affective dimensions of pain. Science. 2001;293(5528):311–315.
104. Jones AK, Watabe H, Cunningham VJ, Jones T. Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [11C]diprenorphine binding and PET. Eur J Pain. 2004;8(5):479–485.
105. Willoch F, Schindler F, Wester HJ, et al. Central poststroke pain and reduced opioid receptor binding within pain processing circuitries: a [11C]diprenorphine PET study. Pain. 2004;108(3):213–220.
106. Harris RE, Clauw DJ, Scott DJ, McLean SA, Gracely RH, Zubieta JK. Decreased central mu-opioid receptor availability in fibromyalgia. J Neurosci. 2007;27(37):10000–10006.
107. Maarrawi J, Peyron R, Mertens P, et al. Differential brain opioid receptor availability in central and peripheral neuropathic pain. Pain. 2007;127(12):183–194.
108. Legangneux E, Mora JJ, Spreux-Varoquaux O, et al. Cerebrospinal fluid biogenic amine metabolites, plasma-rich platelet serotonin and [3H]imipramine reuptake in the primary fibromyalgia syndrome. Rheumatol. 2001;40(3):290–296.
109. Jones AKP, Kitchen ND, Watabe H, et al. Measurement of changes in opioid receptor binding in vivo during trigeminal neuralgic pain using [11C] diprenorphine and positron emission tomography. J Cereb Blood Flow Metab. 1999;19:803–808.
110. Poras H, Bonnard E, Dangé E, Fournié-Zaluski MC, Roques BP. New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment. J Med Chem. 2014;57(13):5748–5763.
111. Wood PB, Patterson Ii JC, Sunderland JJ, Tainter KH, Glabus MF, Lilien DL. Reduced presynaptic dopamine activity in fibromyalgia syndrome demonstrated with positron emission tomography: a pilot study. J Pain. 2007;8(1):51–58.
112. Iannetti GD, Zambreanu L, Wise RG, et al. Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. Proc Natl Acad Sci U S A. 2005;102(50): 18195–18200.
113. Younger JW, Chu LF, D’Arcy NT, Trott KE, Jastrzab LE, Mackey SC. Prescription opioid analgesics rapidly change the human brain. Pain. 2011;152(8):1803–1810.
114. Upadhyay J, Maleki N, Potter J, et al. Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain. 2010;133(pt 7):2098–2114.
115. deCharms RC, Maeda F, Glover GH, et al. Control over brain activation and pain learned by using real-time functional MRI. Proc Natl Acad Sci U S A. 2005;102(51):18626–18631.
116. Emmert K, Breimhorst M, Bauermann T, Birklein F, Van De Ville D, Haller S. Comparison of anterior cingulate vs. insular cortex as targets for real-time fMRI regulation during pain stimulation. Front Behav Neurosci. 2014;8:350.
117. Rance M, Ruttorf M, Nees F, Schad LR, Flor H. Real time fMRI feedback of the anterior cingulate and posterior insular cortex in the processing of pain. Hum Brain Mapp. 2014;35(12):5784–5798.
118. Marquand A, Howard M, Brammer M, Chu C, Coen S, Mourao- Miranda J. Quantitative prediction of subjective pain intensity from whole-brain fMRI data using Gaussian processes. Neuroimage. 2010;49(3):2178–2189.
119. Brown JE, Chatterjee N, Younger J, Mackey S. Towards a physiology- based measure of pain: patterns of human brain activity distinguish painful from non-painful thermal stimulation. PLoS One. 2011;6(9):e24124.
120. Ung H, Brown JE, Johnson KA, Younger J, Hush J, Mackey S. Multivariate classification of structural MRI data detects chronic low back pain. Cereb Cortex. 2014;24(4):1037–1044.
121. Ashburner J, Barnes G, Chen C, et al. SPM8 Manual. Functional Imaging Laboratory Institute of Neurology; London, UK; 2012.
122. Harvey AK, Taylor AM, Wise RG. Imaging pain in arthritis: advances in structural and functional neuroimaging. Curr Pain Headache Rep. 2012;16(6):492–501.