New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment

Journal of Medicinal Chemistry

Volumn 57, Issue 13, 2014, Pages 5748-5763

  Poras, Hervé ^a   Bonnard, Elisabeth ^a   Dangé, Emilie ^a   Fournié Zaluski, Marie Claude ^a   Roques, Bernard P ^a,b  

^a Pharmaleads   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (1 ETHOXYCARBONYLMETHYLOXYCARBONYLETHYL) CARBAMOYL] 3 THIOPHEN 3 YLPROPYLDISULFANYLMETHYL] 3 METHYLSULFANYLPROPYL AMMONIUM TRIFLUOROACETATE; 1 [2 [1 (2 ETHOXYCARBONYLOXYETHOXYCARBONYL) ETHYLCARBAMOYL] 3 THIOPHEN 3 YLPROPYLDISULFONYLMETHYL] 3 METHYLSULFANYLPROPYL AMMONIUM TRIFLUOROACETATE; 1 [2 [1 (2 HYDROXY 1 HYDROXYMETHYLETHOXYCARBONYL) ETHYLCARBAMOYL] 3 THIOPHEN 3 YLPROPYLDISULFANYLMETHYL] 3 METHYLSULFANYL PROPYL AMMONIUM TRIFLUOROACETATE; 1 [2 [1 (2 METHANESULFONYLETHOXYCARBONYL) ETHYLCARBAMOYL] 3 THIOPHEN 3 YLPROPYLDISULFONYLMETHYL] 3 METHYLSULFANYLPROPYL AMMONIUM TRIFLUOROACETATE; 1 [2 [1 (2,3 DIACETOPROPOXYCARBONYL)ETHYLCARBAMOYL] 3 THIOPHEN 3 YKPROPYLDISULFANULMETHYL] 3 METHYLSULFANYLPROPYL AMONIUM TRIFLUOROACETATE; 3 METHYLSULFANYL 1 [2 [1 (3,4,5,6 TETRAHYDROXYTETRAHYDROPYRAN 2 YLMETHOXYCARBONYL] ETHYLCARBAMOYL] 3 THIOPHEN 3 YL PROPYLDISULFANYLMETHYL] PROPYO AMMONIUM TRIFLUOROACETATE; ANALGESIC AGENT; ENKEPHALIN; ENKEPHALINASE INHIBITOR; MEMBRANE METALLOENDOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG SAFETY; DRUG SYNTHESIS; ENZYMATIC DEGRADATION; HOT PLATE TEST; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; RAT; TAIL FLICK TEST;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; ANTIGENS, CD13; DISULFIDES; ENKEPHALINS; HUMANS; MALE; MICE; NEPRILYSIN; NEURALGIA; PHENYLPROPIONATES; PRODRUGS; PROTEASE INHIBITORS; RATS;

EID: 84904283325     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500602h     Document Type: Article

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