The ocular hypotensive effect of saffron extract in primary open angle glaucoma: A pilot study

BMC Complementary and Alternative Medicine

Volumn 14, Issue 1, 2014, Pages

  Bonyadi, Mohammad Hossein Jabbarpoor ^a,b   Yazdani, Shahin ^c   Saadat, Saeed ^d  

^a GONABAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TABRIZ   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d SHAHROUD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antioxidative effect; Hypotensive effect; Open angle glaucoma; Saffron extract

Indexed keywords

CROCUS SATIVUS EXTRACT; DORZOLAMIDE; EYE DROPS; PLACEBO; TIMOLOL;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROCUS SATIVUS; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; FEMALE; HUMAN; INTRAOCULAR PRESSURE; MALE; OPEN ANGLE GLAUCOMA; PILOT STUDY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 84988847872     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-399     Document Type: Article

References (35)

1. Quigley HA: Number of people with glaucoma worldwide. Br J Ophthalmol 1996, 80(5):389-393.
2. Sommer A: Intraocular pressure and glaucoma. Am J Ophthalmol 1989, 107(2):186-188.
3. Quigley HA: Open-angle glaucoma. N Engl J Med 1993, 328(15):1097-1106.
4. Izzotti A, Saccà SC, Longobardi M, Cartiglia C: Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of glaucoma. Invest Ophthalmol Vis Sci 2009, 50(11):5251-5258.
5. Majsterek I, Malinowska K, Stanczyk M, Kowalski M, Blaszczyk J, Kurowska AK, Kaminska A, Szaflik J, Szaflik JP: Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma. Exp Mol Pathol 2011, 90(2):231-237.
6. Erdurmus M, Yagci R, Atis Ö, Karadag R, Akbas A, Hepsen IF: Antioxidant status and oxidative stress in primary open angle glaucoma and pseudoexfoliative glaucoma. Curr Eye Res 2011, 36(8):713-718.
7. Izzotti A, Bagnis A, Saccà SC: The role of oxidative stress in glaucoma. Mutat Res 2006, 612(2):105-114.
8. Ferreira SM, Lerner SF, Brunzini R, Evelson PA, Llesuy SF: Oxidative stress markers in aqueous humor of glaucoma patients. Am J Ophthalmol 2004, 137(1):62-69.
9. Jia LY, Sun L, Fan DS, Lam DS, Pang CP, Yam GH: Effect of topical Ginkgo biloba extract on steroid-induced changes in the trabecular meshwork and intraocular pressure. Arch Ophthalmol 2008, 126(12):1700-1706.
10. Assimopoulou AN, Sinakos Z, Papageorgiou VP: Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother Res 2005, 19(11):997-1000.
11. Ochiai T, Shimeno H, Mishima K, Iwasaki K, Fujiwara M, Tanaka H, Shoyama Y, Toda A, Eyanagi R, Soeda S: Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta 2007, 1770(4):578-584.
12. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A: Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci 2005, 8(3):387-393.
13. Bolhassani A, Khavari A, Bathaie SZ: Saffron and natural carotenoids: Biochemical activities and anti-tumor effects. Biochim Biophys Acta 2014, 1845(1):20-30.
14. Shahmansouri N, Farokhnia M, Abbasi SH, Kassaian SE, Noorbala Tafti AA, Gougol A, Yekehtaz H, Forghani S, Mahmoodian M, Saroukhani S, Arjmandi-Beglar A, Akhondzadeh S: A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients. J Affect Disord 2014, 155:216-222.
15. Makri OE, Ferlemi AV, Lamari FN, Georgakopoulos CD: Saffron administration prevents selenite-induced cataractogenesis. Mol Vis 2013, 19:1188-1197.
16. Age-Related Eye Disease Study Group: A randomized, placebo-controlled, clinical trial of high-dose supplements with vitamins C and E, betacarotene, and zinc for age related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001, 119(10):1417-1436.
17. Ravindran RD, Vashist P, Gupta SK, Young IS, Maraini G, Camparini M, Jayanthi R, John N, Fitzpatrick KE, Chakravarthy U, Ravilla TD, Fletcher AE: Inverse association of vitamin C with cataract in older people in India. Ophthalmology 2011, 118(10):1958-1965.
18. Izzotti A, Saccà SC, Longobardi M, Cartiglia C: Mitochondrial damage in the trabecular meshwork of patients with glaucoma. Arch Ophthalmol 2010, 128(6):724-730.
19. Saccà SC, Izzotti A, Rossi P, Traverso C: Glaucomatous outflow pathway and oxidative stress. Exp Eye Res 2007, 84(3):389-399.
20. Tezel G, Wax MB: Glial modulation of retinal ganglion cell death in glaucoma. J Glaucoma 2003, 12(1):63-68.
21. Wood JP, Lascaratos G, Bron AJ, Osborne NN: The influence of visible light exposure on cultured RGC-5 cells. Mol Vis 2007, 14:334-344.
22. Zhou L, Li Y, Yue BY: Oxidative stress affects cytoskeletal structure and cell-matrix interactions in cells from an ocular tissue: the trabecular meshwork. J Cell Physiol 1999, 180(2):182-189.
23. Li AF, Tane N, Roy S: Fibronectin over expression inhibits trabecular meshwork cell monolayer permeability. Mol Vis 2004, 10:750-757.
24. Maccarone R, Di Marco S, Bisti S: Saffron supplement maintains morphology and function after exposure to damaging light in mammalian retina. Invest Ophthalmol Vis Sci 2008, 49:1254-1261.
25. Eckert A, Keil U, Kressmann S, Schindowski K, Leutner S, Leutz S, Müller WE: Effects of EGb761 Gingko biloba extract on mitochondrial functions and oxidative stress. Pharmacopsychiatry 2003, 36(1):S15-S23.
26. Takuma K, Hoshina Y, Arai S, Himeno Y, Matsuo A, Funatsu Y, Kitahara Y, Ibi D, Hayase M, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M, Yamada K: Ginkgo biloba extract EGb 761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats. Neuroscience 2007, 149(2):256-262.
27. He Y, Leung KW, Zhang YH, Duan S, Zhong XF, Jiang RZ, Peng Z, Tombran-Tink J, Ge J: Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants. Invest Ophthalmol Vis Sci 2008, 49(4):1447-1458.
28. Chen M, Liu B, Gao Q, Zhuo Y, Ge J: Mitochondria-targeted peptide MTP-131alleviates mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 2011, 1; 52(10):7027-7037.
29. Giaconi JA, Yu F, Stone KL, Pedula KL, Ensrud KE, Cauley JA, Hochberg MC, Coleman AL, Study of Osteoporotic Fractures Research Group: The association of consumption of fruits/vegetables with decreased risk of glaucoma among older African-American women in the study of osteoporotic fractures. Study of Osteoporotic Fractures Research Group. Am J Ophthalmol 2012, 154(4):635-644.
30. Kang JH, Pasquale LR, Willett W, Rosner B, Egan KM, Faberowski N, Hankinson SE: Antioxidant intake and primary open-angle glaucoma: a prospective study. Am J Epidemiol 2003, 158(4):337-346.
31. Schmidt M, Betti G, Hensel A: Saffron in phytotherapy: pharmacology and clinical uses. Wien Med Wochenschr 2007, 157(13-14):315-319.
32. Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F: Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med 2004, 4:12.
33. Falsini B, Piccardi M, Minnella A, Savastano C, Capoluongo E, Fadda A, Balestrazzi E, Maccarone R, Bisti S: Influence of saffron supplementation on retinal flicker sensitivity in early age-related macular degeneration. Invest Ophthalmol Vis Sci 2010, 51(12):6118-6124.
34. Alpha-Tocopherol T, Group BCCPS: The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994, 330(15):1029-1035.
35. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Williams JH Jr, Barnhart S, Cherniack MG, Brodkin CA, Hammar S: Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst 1996, 88(21):1550-1559.