Saffron supplement maintains morphology and function after exposure to damaging light in mammalian retina

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 3, 2008, Pages 1254-1261

  Maccarone, Rita ^a   Di Marco, Stefano ^a   Bisti, Silvia ^a,b,c  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b ARC Centre of Excellence in Visual Science   (Australia)

^c NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; CROCUS SATIVUS EXTRACT; FIBROBLAST GROWTH FACTOR 2; SAFFRON EXTRACT; UNCLASSIFIED DRUG; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL PROTECTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA FRAGMENTATION; DRUG MECHANISM; ELECTRORETINOGRAPHY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIGHT DAMAGE; LIGHT EXPOSURE; MORPHOLOGY; NICK END LABELING; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN LOCALIZATION; RAT; RETINA; RETINA INJURY; RETINA OUTER NUCLEAR LAYER; THICKNESS; TISSUE LEVEL; WESTERN BLOTTING; ANIMAL; CROCUS; DARK ADAPTATION; DRUG EFFECT; FLOWER; FLUORESCENT ANTIBODY TECHNIQUE; LIGHT; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHOTOSTIMULATION; PHYSIOLOGY; RADIATION EXPOSURE; RADIATION INJURY; RETINA DEGENERATION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BETA CAROTENE; BLOTTING, WESTERN; CROCUS; DARK ADAPTATION; ELECTRORETINOGRAPHY; FIBROBLAST GROWTH FACTOR 2; FLOWERS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IN SITU NICK-END LABELING; LIGHT; OXIDATIVE STRESS; PHOTIC STIMULATION; PLANT EXTRACTS; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL DEGENERATION;

EID: 41949111779     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-0438     Document Type: Article

References (26)

1. Wenzel A, Grimm C, Samardzija M, Reme CE. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. Prog Retin Eye Res. 2005;24:275-306.
2. Cao W, Li F, Steinberg RH, Lavail MM. Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP and IGF-I in the rat retina. Exp Eye Res. 2001;72:591-604.
3. Ozaky S, Redeke MJ, Anderson DH. Rapid upregulation of fibroblast growth factor receptor 1 (Flg) by rat photoreceptor cells after injury. Invest Ophthalmol Vis Sci. 2000;41:568-579.
4. Stone J, Maslim J, Valter-Kocsi K, et al. Mechanisms of photoreceptor death and survival in mammalian retina. Prog Retinal Eye Res. 1999;18:691-735.
5. Valter K, van Driel D, Bisti S, Stone J. FGFR1 expression and FGFR1-FGF2 colocalisation in rat retina: sites of FGF2 action on rat photoreceptors. Growth Factors. 2002;20:177-188.
6. Valter K, Bisti S, Stone J. Location of CNTFRα on photoreceptor outer segments: evidence of the site of action of CNTF on photoreceptors. Brain Res. 2003;985:169-175.
7. Valter K, Bisti S, Gargini C, et al. Timecourse of neurotrophic factor upregulation and retinal protection against light damage following optic nerve section. Invest Ophthalmol Vis Sci. 2005; 46:1748-1754.
8. Organisciak DT, Darrow RA, Barsalou L, Darrow RM, Lininger LA. Light-induced damage in the retina: differential effects of dimethylthiourea on photoreceptor survival, apoptosis and DNA oxidation. Photochem Photobiol. 1999;70:261-268.
9. Ranchon I, Gorrand JM, Cluzer J, et al. Functional protection of photoreceptors from light-induced damage by dimethylthiourea and Ginkgo biloba extract. Invest Ophthalmol Vis Sci. 1999;40: 1191-1199.
10. Ranchon I, Chen S, Alvarez K, Anderson RE. Systemic administration of phenyl-N-tert-butylnitrone protects the retina from light damage. Invest Ophthalmol Vis Sci. 2001;42:1375-1379.
11. Ranchon I, LaVail MM, Kotake Y, Anderson RE. Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration. J Neurosci. 2003;23:6050-6057.
12. Sthal W, Sies H. Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta. 2005;1740:101-107.
13. Lohr HR, Kuntchithapautham K, Sharma AK, Rohrer B. Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death. Exp Eye R. 2006;83:380-389.
14. Schmidt-Erfurth U. Nutrition and retina. Dev Ophthalmol. 2005; 38:120-147.
15. Berson EL. Nutrition and retinal degenerations. Int Ophthalmol Clin. 2000;40:93-111.
16. Abdullaev FI. Biological effects of saffron. Biofactors. 1993;4:83-86.
17. Soeda S., Ochiai T., Paopong L, et al. Crocin suppresses tumor necrosis factor-induced cell death of neuronally differentiated PC-12 cells. Life Sci. 2001;69:2887-2898.
18. Giaccio M. Crocetin from saffron: an active component of an ancient spice. Crit Rev Food Sci Nutr. 2004;44:155-172.
19. Gargini C, Bisti S, Demontis GC, Valter K, Stone J, Cervetto L. Electroretinographic changes following section of the optic nerve in pigmented rats. Neuroscience. 2004;126:775-783.
20. Li F, Cao W, Anderson RE. Alleviation of constant-light-induced photoreceptor degeneration by adaptation of adult albino rat to bright cyclic light. Invest Ophthalmol Vis Sci. 2003;44:4968-4975.
21. Gargini C, Belfiore MS, Bisti S, Cervetto L, Valter K, Stone J. The impact of basic fibroblast growth factor on photoreceptor function and morphology. Invest Ophthalmol Vis Sci. 1999;40:2088-2099.
22. Di Loreto S, Spadea L, Cencioni S, et al. Correlation between ERG changes and FGF2 mRNA upregulation in patients with choroidal melanoma. Exp Eye Res. 2002;75:217-225.
23. Ochiai T, Shimeno H, Mishima K, et al. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta. 2007;1770:578-584.
24. Ochiai T, Soeda S, Ohno S, Tanaka H, Shoyama Y, Shimeno H. Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis. Neurochem Int. 2004;44:321-330.
25. Laabich A, Vissvesvaran GP, Lieu KL. Protective effect of crocin against blue light- and white light-mediated photoreceptor cell death in bovine and primate retinal primary cell culture. Invest Ophthalmol Vis Sci. 2006;47:3156-3163.
26. Asai A, Nakano T, Takahashi M, Nagao A. Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice. J Agric Food Chem. 2005; 53:7302-7306.