Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes

Arthritis Research and Therapy

Volumn 16, Issue 1, 2014, Pages

  Tsuchida, Anika I ^a   Beekhuizen, Michiel ^a   't Hart, Marieke C ^a   Radstake, Timothy R D J ^a   Dhert, Wouter J A ^a,b   Saris, Daniel B F ^a,c   Van Osch, Gerjo J V M ^d   Creemers, Laura B ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF TWENTE   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FIBROBLAST GROWTH FACTOR 2; GAMMA INTERFERON; GLYCOSAMINOGLYCAN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ALPHA; INTERLEUKIN 7; INTERLEUKIN 8; LEPTIN; LEUKEMIA INHIBITORY FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; ONCOSTATIN M; RANTES; SCATTER FACTOR; TUMOR NECROSIS FACTOR; VASCULOTROPIN; CYTOKINE;

ADULT; AGED; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE INJURY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; OSTEOARTHRITIS; PROTEIN INDUCTION; SYMPTOMATIC CARTILAGE DEFECT; SYNOVIAL FLUID; TISSUE LEVEL; TISSUE REGENERATION; ADOLESCENT; CARTILAGE; CELL CULTURE; CLASSIFICATION; CLUSTER ANALYSIS; JOINT; METABOLISM; MIDDLE AGED; PATHOLOGY; PRINCIPAL COMPONENT ANALYSIS; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARTILAGE; CELLS, CULTURED; CHONDROCYTES; CLUSTER ANALYSIS; CYTOKINES; FEMALE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-13; INTERLEUKIN-1ALPHA; INTERLEUKIN-6; JOINTS; MALE; MIDDLE AGED; ONCOSTATIN M; OSTEOARTHRITIS; PRINCIPAL COMPONENT ANALYSIS; SYNOVIAL FLUID; YOUNG ADULT;

EID: 84988837641     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-014-0441-0     Document Type: Article

References (55)

1. Goldring MB, Marcu KB: Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther 2009, 11:224.
2. McInnes IB, Schett G: The pathogenesis of rheumatoid arthritis. N Engl J Med 2011, 365:2205-2219.
3. de Lange-Brokaar BJ, Ioan-Facsinay A, van Osch GJ, Zuurmond AM, Schoones J, Toes RE, Huizinga TW, Kloppenburg M: Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis Cartilage 2012, 20:1484-1499.
4. Scanzello CR, Goldring SR: The role of synovitis in osteoarthritis pathogenesis. Bone 2012, 51:249-257.
5. Loeuille D, Chary-Valckenaere I, Champigneulle J, Rat AC, Toussaint F, Pinzano-Watrin A, Goebel JC, Mainard D, Blum A, Pourel J, Netter P, Gillet P: Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity. Arthritis Rheum 2005, 52:3492-3501.
6. Yang KG, Saris DB, Verbout AJ, Creemers LB, Dhert WJ: The effect of synovial fluid from injured knee joints on in vitro chondrogenesis. Tissue Eng 2006, 12:2957-2964.
7. Rodrigo JJ, Steadman JR, Syftestad G, Benton H, Silliman J: Effects of human knee synovial fluid on chondrogenesis in vitro. Am J Knee Surg 1995, 8:124-129.
8. Beekhuizen M, Bastiaansen-Jenniskens YM, Koevoet W, Saris DB, Dhert WJ, Creemers LB, van Osch GJ: Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: establishment and characterization of a long-term cartilage-synovium coculture. Arthritis Rheum 2011, 63:1918-1927.
9. Gandhi NS, Mancera RL: The structure of glycosaminoglycans and their interactions with proteins. Chem Biol Drug Des 2008, 72:455-482.
10. Bekkers JE, Saris DB, Tsuchida AI, van Rijen MH, Dhert WJ, Creemers LB: Chondrogenic potential of articular chondrocytes depends on their original location. Tissue Eng Part A 2014, 20:663-671.
11. Dutch Federation of Medical Reseach Societies. [www.federa.org]
12. van Diest PJ: No consent should be needed for using leftover body material for scientific purposes. BMJ 2002, 325:648-651.
13. de Jager W, Prakken BJ, Bijlsma JW, Kuis W, Rijkers GT: Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies. J Immunol Methods 2005, 300:124-135.
14. de Jager W, te Velthuis H, Prakken BJ, Kuis W, Rijkers GT: Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 2003, 10:133-139.
15. Tsuchida AI, Beekhuizen M, Rutgers M, van Osch GJ, Bekkers JE, Bot AG, Geurts B, Dhert WJ, Saris DB, Creemers LB: Interleukin 6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model. Arthritis Res Ther 2012, 14:R262.
16. Farndale RW, Sayers CA, Barrett AJ: A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res 1982, 9:247-248.
17. Nadeshdin WA: Zur Untersuchung der Minderwertigkeit der Organe an Leichen. Deutsche Zeitschrift für die Gesamte Gerichthiche Medizine 1932, 18:426-431.
18. Vanlauwe J, Saris DB, Victor J, Almqvist KF, Bellemans J, Luyten FP: Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: early treatment matters. Am J Sports Med 2011, 39:2566-2574.
19. Filardo G, Vannini F, Marcacci M, Andriolo L, Ferruzzi A, Giannini S, Kon E: Matrix-assisted autologous chondrocyte transplantation for cartilage regeneration in osteoarthritic knees: results and failures at midterm follow-up. Am J Sports Med 2013, 41:95-100.
20. Gallelli L, Galasso O, Falcone D, Southworth S, Greco M, Ventura V, Romualdi P, Corigliano A, Terracciano R, Savino R, Guletta E, Gasparini G, De Sarro G: The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial. Osteoarthritis Cartilage 2013, 21:1400-1408.
21. Beekhuizen M, Osch G, Bot A, Hoekstra M, Saris D, Dhert W, Creemers L: Inhibition of oncostatin M in osteoarthritic synovial fluid enhances GAG production in osteoarthritic cartilage repair. Eur Cell Mater 2013, 26:80-90.
22. Elsaid KA, Fleming BC, Oksendahl HL, Machan JT, Fadale PD, Hulstyn MJ, Shalvoy R, Jay GD: Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum 2008, 58:1707-1715.
23. Heard BJ, Fritzler MJ, Wiley JP, McAllister J, Martin L, El-Gabalawy H, Hart DA, Frank CB, Krawetz R: Intraarticular and systemic inflammatory profiles may identify patients with osteoarthritis. J Rheumatol 2013, 40(8):1379-1387.
24. Ahmad R, Qureshi HY, El Mabrouk M, Sylvester J, Ahmad M, Zafarullah M: Inhibition of interleukin 1-induced matrix metalloproteinase 13 expression in human chondrocytes by interferon gamma. Ann Rheum Dis 2007, 66:782-789.
25. Ahmad R, El Mabrouk M, Sylvester J, Zafarullah M: Human osteoarthritic chondrocytes are impaired in matrix metalloproteinase-13 inhibition by IFN-gamma due to reduced IFN-gamma receptor levels. Osteoarthritis Cartilage 2009, 17:1049-1055.
26. Van Dyken SJ, Locksley RM: Interleukin-4-and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol 2013, 31:317-343.
27. Lafyatis R, Farina A: New insights into the mechanisms of innate immune receptor signalling in fibrosis. Open Rheumatol J 2012, 6:72-79.
28. Cleaver CS, Rowan AD, Cawston TE: Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines. Ann Rheum Dis 2001, 60:150-157.
29. Woods JM, Amin MA, Katschke KJ Jr, Volin MV, Ruth JH, Connors MA, Woodruff DC, Kurata H, Arai K, Haines GK 3rd, Kumar P, Koch AE: Interleukin-13 gene therapy reduces inflammation, vascularization, and bony destruction in rat adjuvant-induced arthritis. Hum Gene Ther 2002, 13:381-393.
30. Nabbe KC, van Lent PL, Holthuysen AE, Sloetjes AW, Koch AE, Radstake TR, van den Berg WB: Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinasemediated cartilage matrix degradation despite enhanced joint inflammation. Arthritis Res Ther 2005, 7:R392-R401.
31. Marshall KW, Zhang H, Yager TD, Nossova N, Dempsey A, Zheng R, Han M, Tang H, Chao S, Liew CC: Blood-based biomarkers for detecting mild osteoarthritis in the human knee. Osteoarthritis Cartilage 2005, 13:861-871.
32. Goldring MB, Otero M, Tsuchimochi K, Ijiri K, Li Y: Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis 2008, 67:iii75-iii82.
33. Pfander D, Kortje D, Zimmermann R, Weseloh G, Kirsch T, Gesslein M, Cramer T, Swoboda B: Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints. Ann Rheum Dis 2001, 60:1070-1073.
34. Ludin A, Sela JJ, Schroeder A, Samuni Y, Nitzan DW, Amir G: Injection of vascular endothelial growth factor into knee joints induces osteoarthritis in mice. Osteoarthritis Cartilage 2012, 21:419-497.
35. Yamairi F, Utsumi H, Ono Y, Komorita N, Tanaka M, Fukunari A: Expression of vascular endothelial growth factor (VEGF) associated with histopathological changes in rodent models of osteoarthritis. J Toxicol Pathol 2011, 24:137-142.
36. Jansen H, Meffert RH, Birkenfeld F, Petersen W, Pufe T: Detection of vascular endothelial growth factor (VEGF) in moderate osteoarthritis in a rabbit model. Ann Anat 2012, 194:452-456.
37. Chen XY, Hao YR, Wang Z, Zhou JL, Jia QX, Qiu B: The effect of vascular endothelial growth factor on aggrecan and type II collagen expression in rat articular chondrocytes. Rheumatol Int 2012, 32:3359-3364.
38. Nagai T, Sato M, Kutsuna T, Kokubo M, Ebihara G, Ohta N, Mochida J: Intravenous administration of anti-vascular endothelial growth factor humanized monoclonal antibody bevacizumab improves articular cartilage repair. Arthritis Res Ther 2010, 12:R178.
39. Ma B, Leijten JC, Wu L, Kip M, van Blitterswijk CA, Post JN, Karperien M: Gene expression profiling of dedifferentiated human articular chondrocytes in monolayer culture. Osteoarthritis Cartilage 2013, 21:599-603.
40. Caron MM, Emans PJ, Surtel DA, Cremers A, Voncken JW, Welting TJ, van Rhijn LW: Activation of NF-kappaB/p65 facilitates early chondrogenic differentiation during endochondral ossification. PLoS One 2012, 7:e33467.
41. Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J: Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell 2008, 133:1006-1018.
42. Kojima H, Kunimoto H, Inoue T, Nakajima K: The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts. Cell Cycle 2012, 11:730-739.
43. Rose J, Soder S, Skhirtladze C, Schmitz N, Gebhard PM, Sesselmann S, Aigner T: DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes. Osteoarthritis Cartilage 2012, 20:1020-1028.
44. Harbo M, Bendix L, Bay-Jensen AC, Graakjaer J, Soe K, Andersen TL, Kjaersgaard-Andersen P, Koelvraa S, Delaisse JM: The distribution pattern of critically short telomeres in human osteoarthritic knees. Arthritis Res Ther 2012, 14:R12.
45. Leong DJ, Sun HB: Events in articular chondrocytes with aging. Curr Osteoporos Rep 2011, 9:196-201.
46. Lambrecht S, Dhaenens M, Almqvist F, Verdonk P, Verbruggen G, Deforce D, Elewaut D: Proteome characterization of human articular chondrocytes leads to novel insights in the function of small heat-shock proteins in chondrocyte homeostasis. Osteoarthritis Cartilage 2010, 18:440-446.
47. Melas IN, Chairakaki AD, Chatzopoulou EI, Messinis DE, Katopodi T, Pliaka V, Samara S, Mitsos A, Dailiana Z, Kollia P, Alexopoulos LG: Modeling of signaling pathways in chondrocytes based on phosphoproteomic and cytokine release data. Osteoarthritis Cartilage 2014, 22:509-518.
48. Hollander AP, Dickinson SC, Sims TJ, Brun P, Cortivo R, Kon E, Marcacci M, Zanasi S, Borrione A, De Luca C, Pavesio A, Soranzo C, Abatangelo G: Maturation of tissue engineered cartilage implanted in injured and osteoarthritic human knees. Tissue Eng 2006, 12:1787-1798.
49. Tallheden T, Bengtsson C, Brantsing C, Sjogren-Jansson E, Carlsson L, Peterson L, Brittberg M, Lindahl A: Proliferation and differentiation potential of chondrocytes from osteoarthritic patients. Arthritis Res Ther 2005, 7:R560-R568.
50. Stoop R, Albrecht D, Gaissmaier C, Fritz J, Felka T, Rudert M, Aicher WK: Comparison of marker gene expression in chondrocytes from patients receiving autologous chondrocyte transplantation versus osteoarthritis patients. Arthritis Res Ther 2007, 9:R60.
51. Cavallo C, Desando G, Facchini A, Grigolo B: Chondrocytes from patients with osteoarthritis express typical extracellular matrix molecules once grown onto a three-dimensional hyaluronan-based scaffold. J Biomed Mater Res A 2010, 93:86-95.
52. Mankin HJ, Dorfman H, Lippiello L, Zarins A: Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 1971, 53:523-537.
53. Bulstra SK, Buurman WA, Walenkamp GH, Van der Linden AJ: Metabolic characteristics of in vitro cultured human chondrocytes in relation to the histopathologic grade of osteoarthritis. Clin Orthop Relat Res 1989, 242:294-302.
54. Heir S, Nerhus TK, Rotterud JH, Loken S, Ekeland A, Engebretsen L, Aroen A: Focal cartilage defects in the knee impair quality of life as much as severe osteoarthritis: a comparison of knee injury and osteoarthritis outcome score in 4 patient categories scheduled for knee surgery. Am J Sports Med 2010, 38:231-237.
55. Lasczkowski GE, Aigner T, Gamerdinger U, Weiler G, Bratzke H: Visualization of postmortem chondrocyte damage by vital staining and confocal laser scanning 3D microscopy. J Forensic Sci 2002, 47:663-666.