Surface-functionalized, pH-responsive poly(lactic-co-glycolic acid)-based microparticles for intranasal vaccine delivery: Effect of surface modification with chitosan and mannan

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 109, Issue , 2016, Pages 24-34

  Li, Ze ^a   Xiong, Fangfang ^a   He, Jintian ^a   Dai, Xiaojing ^a   Wang, Gaizhen ^b  

^a HEBEI NORMAL UNIVERSITY   (China)

^b HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antigen intracellular release; Chitosan; Intranasal vaccination; Mannan; pH responsive; PLGA microparticles

Indexed keywords

CHITOSAN; GAMMA INTERFERON; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; INTERLEUKIN 2; MANNAN; POLYGLACTIN; ANTIGEN; DRUG CARRIER; EMULSION; GLYCOL; LACTIC ACID; MICROSPHERE; NANOPARTICLE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR IMMUNITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOPLASM; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; EMULSION; ENDOSOME; FEMALE; HYDRODYNAMICS; IMMUNOGENICITY; IN VIVO STUDY; LYSOSOME; MACROPHAGE; NONHUMAN; PARTICLE SIZE; PH; PROTEIN SECRETION; RAT; SURFACE CHARGE; SURFACE PROPERTY; ZETA POTENTIAL; ANIMAL; CHEMISTRY; CYTOLOGY; INTRANASAL DRUG ADMINISTRATION; METABOLISM; MOUSE; PERITONEUM MACROPHAGE; SPRAGUE DAWLEY RAT;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIGENS; CHITOSAN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EMULSIONS; ENDOSOMES; FEMALE; GLYCOLS; HEPATITIS B SURFACE ANTIGENS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; LYSOSOMES; MACROPHAGES; MACROPHAGES, PERITONEAL; MANNANS; MICE; MICROSPHERES; NANOPARTICLES; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES; VACCINES;

EID: 84988624536     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2016.08.012     Document Type: Article

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