-
2
-
-
84892805731
-
-
Siegal, R., Ma, J., Zou, Z., Jemal, A. Cancer statistics, 2014. CA 64, 9-29 (2014).
-
(2014)
Cancer Statistics, 2014 CA
, vol.64
, pp. 9-29
-
-
Siegal, R.1
Ma, J.2
Zou, Z.3
Jemal, A.4
-
3
-
-
62249176551
-
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
-
Iacobuzio-Donahue, C. A. et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J. Clin. Oncol. 27, 1806-1813 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 1806-1813
-
-
Iacobuzio-Donahue, C.A.1
-
4
-
-
84915813644
-
Pancreatic adenocarcinoma
-
Ryan, D. P., Hong, T. S., Bardeesy, N. Pancreatic adenocarcinoma. N. Engl. J. Med. 371, 1039-1049 (2014).
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 1039-1049
-
-
Ryan, D.P.1
Hong, T.S.2
Bardeesy, N.3
-
5
-
-
80054686286
-
Tumor metastasis: Molecular insights and evolving paradigms
-
Valastyan, S., Weinberg, R. A. Tumor metastasis: molecular insights and evolving paradigms. Cell 147, 275-292 (2011).
-
(2011)
Cell
, vol.147
, pp. 275-292
-
-
Valastyan, S.1
Weinberg, R.A.2
-
6
-
-
84865839326
-
Epithelial-mesenchymal transitions: Insights from development
-
Lim, J., Thiery, J. P. Epithelial-mesenchymal transitions: insights from development. Development 139, 3471-3486 (2012).
-
(2012)
Development
, vol.139
, pp. 3471-3486
-
-
Lim, J.1
Thiery, J.P.2
-
7
-
-
0032080416
-
Pancreatic carcinoma-correlation between E-cadherin and alpha-catenin expression status and liver metastasis
-
Gunji, N. et al. Pancreatic carcinoma-correlation between E-cadherin and alpha-catenin expression status and liver metastasis. Cancer 82, 1649-1656 (1998).
-
(1998)
Cancer
, vol.82
, pp. 1649-1656
-
-
Gunji, N.1
-
8
-
-
10944268101
-
Elevated expression of E-cadherin and alpha-, and gammacatenins in metastatic lesions compared with primary epithelial ovarian carcinomas
-
Imai, T. et al. Elevated expression of E-cadherin and alpha-, and gammacatenins in metastatic lesions compared with primary epithelial ovarian carcinomas. Hum. Pathol. 35, 1469-1476 (2004).
-
(2004)
Hum. Pathol.
, vol.35
, pp. 1469-1476
-
-
Imai, T.1
-
9
-
-
0642336851
-
E-cadherin expression in primary carcinomas of the breast and its distant metastases
-
Kowalski, P. J., Rubin, M. A., Kleer, C. G. E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res. 5, R217-R222 (2003).
-
(2003)
Breast Cancer Res.
, vol.5
, pp. R217-R222
-
-
Kowalski, P.J.1
Rubin, M.A.2
Kleer, C.G.3
-
10
-
-
84861527239
-
To differentiate or not-routes towards metastasis
-
Brabletz, T. To differentiate or not-routes towards metastasis. Nat. Rev. Cancer 12, 425-436 (2012).
-
(2012)
Nat. Rev. Cancer
, vol.12
, pp. 425-436
-
-
Brabletz, T.1
-
11
-
-
33845809125
-
Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2
-
Chaffer, C. L. et al. Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Res. 66, 11271-11278 (2006).
-
(2006)
Cancer Res.
, vol.66
, pp. 11271-11278
-
-
Chaffer, C.L.1
-
12
-
-
84870845421
-
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
-
Tsai, J. H., Donaher, J. L., Murphy, D. A., Chau, S., Yang, J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22, 725-736 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 725-736
-
-
Tsai, J.H.1
Donaher, J.L.2
Murphy, D.A.3
Chau, S.4
Yang, J.5
-
13
-
-
84870816403
-
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
-
Ocana, O. H. et al. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 22, 709-724 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 709-724
-
-
Ocana, O.H.1
-
14
-
-
84902537071
-
-
(eds Grippo P. J. Munshi H. G. ) (Transworld Research Network Trivandrum India
-
Rasheed, Z., Matsui, W., Maitra, A. in Pancreatic Cancer and Tumor Microenvironment (eds Grippo, P. J., Munshi, H. G. ) (Transworld Research Network, Trivandrum, India, 2012).
-
(2012)
Pancreatic Cancer and Tumor Microenvironment
-
-
Rasheed, Z.1
Matsui, W.2
Maitra, A.3
-
15
-
-
84856088337
-
EMT and dissemination precede pancreatic tumor formation
-
Rhim, A. D. et al. EMT and dissemination precede pancreatic tumor formation. Cell 148, 349-361 (2012).
-
(2012)
Cell
, vol.148
, pp. 349-361
-
-
Rhim, A.D.1
-
16
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani, S. R. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437-450 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
-
17
-
-
19344362405
-
Trp53(R172H) and KraS(G12D) cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani, S. R. et al. Trp53(R172H) and KraS(G12D) cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7, 469-483 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
-
18
-
-
24644480749
-
Molecular requirements for epithelialmesenchymal transition during tumor progression
-
Huber, M. A., Kraut, N., Beug, H. Molecular requirements for epithelialmesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17, 548-558 (2005).
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 548-558
-
-
Huber, M.A.1
Kraut, N.2
Beug, H.3
-
19
-
-
0038106228
-
Regulation of tight junctions during the epithelium-mesenchyme transition: Direct repression of the gene expression of claudins/occludin by Snail
-
Ikenouchi, J., Matsuda, M., Furuse, M., Tsukita, S. Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J. Cell Sci. 116, 1959-1967 (2003).
-
(2003)
J. Cell Sci.
, vol.116
, pp. 1959-1967
-
-
Ikenouchi, J.1
Matsuda, M.2
Furuse, M.3
Tsukita, S.4
-
20
-
-
22244432840
-
The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program
-
De Craene, B. et al. The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program. Cancer Res. 65, 6237-6244 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 6237-6244
-
-
De Craene, B.1
-
21
-
-
0030670132
-
Early role of Fsp1 in epithelial-mesenchymal transformation
-
Okada, H., Danoff, T. M., Kalluri, R., Neilson, E. G. Early role of Fsp1 in epithelial-mesenchymal transformation. Am. J. Physiol.-Renal Physiol. 273, F563-F574 (1997).
-
(1997)
Am. J. Physiol.-Renal Physiol.
, vol.273
, pp. F563-F574
-
-
Okada, H.1
Danoff, T.M.2
Kalluri, R.3
Neilson, E.G.4
-
22
-
-
35548974844
-
The transcription factor ZEB1 (delta EF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
-
Aigner, K. et al. The transcription factor ZEB1 (delta EF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene 26, 6979-6988 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 6979-6988
-
-
Aigner, K.1
-
23
-
-
84883456329
-
Deciphering the role of stroma in pancreatic cancer
-
Waghray, M., Yalamanchili, M., di Magliano, M. P., Simeone, D. M. Deciphering the role of stroma in pancreatic cancer. Curr. Opin. Gastroenterol. 29, 537-543 (2013).
-
(2013)
Curr. Opin. Gastroenterol.
, vol.29
, pp. 537-543
-
-
Waghray, M.1
Yalamanchili, M.2
Di Magliano, M.P.3
Simeone, D.M.4
-
24
-
-
84948407218
-
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
-
Zheng, X. et al. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nat. Med. 527, 525-530 (2015).
-
(2015)
Nat. Med.
, vol.527
, pp. 525-530
-
-
Zheng, X.1
-
25
-
-
71849112654
-
Desmoplasia of pancreatic ductal adenocarcinoma
-
Pandol, S., Edderkaoui, M., Gukovsky, I., Lugea, A., Gukovskaya, A. Desmoplasia of pancreatic ductal adenocarcinoma. Clin. Gastroenterol. Hepatol. 7, S44-S47 (2009).
-
(2009)
Clin. Gastroenterol. Hepatol.
, vol.7
, pp. S44-S47
-
-
Pandol, S.1
Edderkaoui, M.2
Gukovsky, I.3
Lugea, A.4
Gukovskaya, A.5
-
26
-
-
78649737455
-
The extracellular matrix at a glance
-
Frantz, C., Stewart, K. M., Weaver, V. M. The extracellular matrix at a glance. J. Cell Sci. 123, 4195-4200 (2010).
-
(2010)
J. Cell Sci.
, vol.123
, pp. 4195-4200
-
-
Frantz, C.1
Stewart, K.M.2
Weaver, V.M.3
-
27
-
-
84862150896
-
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
-
Bayne, L. J. et al. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer cell 21, 822-835 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 822-835
-
-
Bayne, L.J.1
-
28
-
-
35148814410
-
Dynamics of the immune reaction to pancreatic cancer from inception to invasion
-
Clark, C. E. et al. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res. 67, 9518-9527 (2007).
-
(2007)
Cancer Res.
, vol.67
, pp. 9518-9527
-
-
Clark, C.E.1
-
29
-
-
67149143399
-
Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive, K. P. et al. Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461 (2009).
-
(2009)
Science
, vol.324
, pp. 1457-1461
-
-
Olive, K.P.1
-
30
-
-
84858602107
-
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
-
Provenzano, P. P. et al. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21, 418-429 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 418-429
-
-
Provenzano, P.P.1
-
31
-
-
84948407218
-
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
-
Zheng, X. F. et al. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature 527, 525 (2015).
-
(2015)
Nature
, vol.527
, pp. 525
-
-
Zheng, X.F.1
-
32
-
-
34447331032
-
Expression of snail in pancreatic cancer promotes metastasis and chemoresistance
-
Yin, T. et al. Expression of snail in pancreatic cancer promotes metastasis and chemoresistance. J. Surg. Res. 141, 196-203 (2007).
-
(2007)
J. Surg. Res.
, vol.141
, pp. 196-203
-
-
Yin, T.1
-
33
-
-
36349006961
-
Development and characterization of gemcitabine-resistant pancreatic tumor cells
-
Shah, A. N. et al. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann. Surg. Oncol. 14, 3629-3637 (2007).
-
(2007)
Ann. Surg. Oncol.
, vol.14
, pp. 3629-3637
-
-
Shah, A.N.1
-
34
-
-
84987815361
-
Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer
-
Whatcott, C. J., Watanabe, A., LoBello, J., Von Hoff, D., Han, H. Y. Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer. Cancer Res. 74 (2014).
-
(2014)
Cancer Res.
, vol.74
-
-
Whatcott, C.J.1
Watanabe, A.2
LoBello, J.3
Von Hoff, D.4
Han, H.Y.5
-
35
-
-
84902435628
-
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
-
Rhim, A. D. et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell 25, 735-747 (2014).
-
(2014)
Cancer Cell
, vol.25
, pp. 735-747
-
-
Rhim, A.D.1
-
36
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
-
Von Hoff, D. D. et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N. Engl. J. Med. 369, 1691-1703 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 1691-1703
-
-
Von Hoff, D.D.1
-
37
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
Conroy, T. et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N. Engl. J. Med. 364, 1817-1825 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 1817-1825
-
-
Conroy, T.1
-
38
-
-
84871157346
-
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
-
Jacobetz, M. A. et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 62, 112-120 (2013).
-
(2013)
Gut
, vol.62
, pp. 112-120
-
-
Jacobetz, M.A.1
-
39
-
-
79953756460
-
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
-
Collisson, E. A. et al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat. Med. 17, 500-503 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 500-503
-
-
Collisson, E.A.1
-
40
-
-
85029134673
-
The Ets-transcription factor Etv1 regulates stromal expansion and metastasis in pancreatic cancer
-
Heeg, S. et al. The Ets-transcription factor Etv1 regulates stromal expansion and metastasis in pancreatic cancer. Gastroenterology 148, S47-S47 (2015).
-
(2015)
Gastroenterology
, vol.148
, pp. S47-S47
-
-
Heeg, S.1
-
41
-
-
68649119049
-
SPARC correlation with response to gemcitabine (G) plus nab-paclitaxel (nab-P) in patients with advanced metastatic pancreatic cancer: A phase I/II study
-
Von Hoff, D. D. et al. SPARC correlation with response to gemcitabine (G) plus nab-paclitaxel (nab-P) in patients with advanced metastatic pancreatic cancer: A phase I/II study. J. Clin. Oncol. 27, 4525 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 4525
-
-
Von Hoff, D.D.1
-
42
-
-
84947210334
-
SPARC expression did not predict efficacy of nab-paclitaxel plus gemcitabine or gemcitabine alone for metastatic pancreatic cancer in an exploratory analysis of the phase III MPACT trial
-
Hidalgo, M. et al. SPARC expression did not predict efficacy of nab-paclitaxel plus gemcitabine or gemcitabine alone for metastatic pancreatic cancer in an exploratory analysis of the phase III MPACT trial. Clin. Cancer Res. 41, 4811-4818 (2015).
-
(2015)
Clin. Cancer Res.
, vol.41
, pp. 4811-4818
-
-
Hidalgo, M.1
-
43
-
-
84899954489
-
SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice
-
Neesse, A. et al. SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice. Gut 63, 974-983 (2014).
-
(2014)
Gut
, vol.63
, pp. 974-983
-
-
Neesse, A.1
-
44
-
-
83355169753
-
Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial
-
Von Hoff, D. D. et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J. Clin. Oncol. 29, 4548-4554 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 4548-4554
-
-
Von Hoff, D.D.1
-
45
-
-
70350227356
-
Color deconvolution for the analysis of tissue microarrays
-
Cornish, T. C., Halushka, M. K. Color deconvolution for the analysis of tissue microarrays. Anal. Quant. Cytol. Histol. 31, 304-312 (2009).
-
(2009)
Anal. Quant. Cytol. Histol.
, vol.31
, pp. 304-312
-
-
Cornish, T.C.1
Halushka, M.K.2
|