Recent advances in our understanding of HLA-G biology: Lessons from a wide spectrum of human diseases

Journal of Immunology Research

Volumn 2016, Issue , 2016, Pages

  Morandi, Fabio ^a   Rizzo, Roberta ^b   Fainardi, Enrico ^c   Rouas Freiss, Nathalie ^d   Pistoia, Vito ^a  

^a G GASLINI INSTITUTE   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c CAREGGI UNIVERSITY HOSPITAL   (Italy)

^d SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HLA G ANTIGEN;

ANTIGEN FUNCTION; AUTOIMMUNE DISEASE; CANCER IMMUNOLOGY; CLINICAL OUTCOME; HISTOCOMPATIBILITY; HUMAN; INFECTION; INFLAMMATORY DISEASE; NONHUMAN; PREGNANCY; PROGNOSIS; REVIEW; ALLOGRAFT; FEMALE; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOMODULATION; NEOPLASM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALLOGRAFTS; AUTOIMMUNE DISEASES; FEMALE; HLA-G ANTIGENS; HUMANS; IMMUNE TOLERANCE; IMMUNOMODULATION; INFECTION; NEOPLASMS; PREGNANCY;

EID: 84987704296     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2016/4326495     Document Type: Review

References (96)

1. P. Le Bouteiller and F. Lenfant, "Antigen-presenting function(s) of the non-classical HLA-E,-F and-G class I molecules: the beginning of a story," Research in Immunology, vol. 147, no. 5, pp. 301-313, 1996.
2. F. Kievits, P. Ivanyi, P. Krimpenfort, A. Berns, and H. L. Ploegh, "HLA-restricted recognition of viral antigens in HLA transgenic mice," Nature, vol. 329, no. 6138, pp. 447-449, 1987.
3. V. M. Braud, D. S. Allan, and A. J. McMichael, "Functions of nonclassical MHC and non-MHC-encoded class I molecules," Current Opinion in Immunology, vol. 11, no. 1, pp. 100-108, 1999.
4. V. Pistoia, F. Morandi, X. Wang, and S. Ferrone, "Soluble HLA-G: are they clinically relevant?" Seminars in Cancer Biology, vol. 17, no. 6, pp. 469-479, 2007.
5. C. Münz, S. Stevanovíc, and H. Rammensee, "Peptide presentation and NK inhibition by HLA-G," Journal of Reproductive Immunology, vol. 43, no. 2, pp. 139-155, 1999.
6. M. Diehl, C. Münz, W. Keilholz et al., "Nonclassical HLA-G molecules are classical peptide presenters," Current Biology, vol. 6, no. 3, pp. 305-314, 1996.
7. J. Baudhuin, J. Migraine, V. Faivre et al., "Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions," Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 44, pp. 17957-17962, 2013.
8. M. E. Le Page, J. P. Goodridge, E. John, F. T. Christiansen, and C. S. Witt, "Killer Ig-like receptor 2DL4 does not mediate NK cell IFN-γ responses to soluble HLA-G preparations," Journal of Immunology, vol. 192, no. 2, pp. 732-740, 2014.
9. + T cell regulatory mechanism," Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 21, pp. 12150-12155, 2001.
10. F.-A. Le Gal, B. Riteau, C. Sedlik et al., "HLA-G-mediated inhibition of antigen-specifc cytotoxic T lymphocytes," International Immunology, vol. 11, no. 8, pp. 1351-1356, 1999.
11. + cells by interacting with CD8," Journal of Immunology, vol. 164, no. 12, pp. 6100-6104, 2000.
12. S. Le Rond, C. Azéma, I. Krawice-Radanne et al., "Evidence to support the role of HLA-G5 in allograf acceptance through induction of immunosuppressive/regulatory T cells," Journal of Immunology, vol. 176, no. 5, pp. 3266-3276, 2006.
13. T. Tilburgs, Â.C. Crespo, A. Van Der Zwan et al., "HumanHLA-G+ extravillous trophoblasts: immune-activating cells that interact with decidual leukocytes," Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 23, pp. 7219-7224, 2015.
14. A. Naji, C. Menier, F. Morandi et al., "Binding of HLA-G to ITIM-bearing Ig-like transcript 2 receptor suppresses B cell responses," Journal of Immunology, vol. 192, no. 4, pp. 1536-1546, 2014.
15. L. Pazmany, O. Mandelboim, M. Valés-Gómez, D. M. Davis, H. T. Reyburn, and J. L. Strominger, "Protection from natural killer cell-mediated lysis by HLA-G expression on target cells," Science, vol. 274, no. 5288, pp. 792-795, 1996.
16. N. Rouas-Freiss, R. E. Marchal, M. Kirszenbaum, J. Dausset, and E. D. Carosella, "The γ1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: is HLA-G the public ligand for natural killer cell inhibitory receptors?" Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 10, pp. 5249-5254, 1997.
17. C. Li, B. L. Houser, M. L. Nicotra, and J. L. Strominger, "HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells," Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 14, pp. 5767-5772, 2009.
18. A. van der Meer, H. G. M. Lukassen, M. J. C. van Lierop et al., "Membrane-bound HLA-G activates proliferation and interferon-γ production by uterine natural killer cells," Molecular Human Reproduction, vol. 10, no. 3, pp. 189-195, 2004.
19. A. van der Meer, H. G. M. Lukassen, B. van Cranenbroek et al., "Soluble HLA-G promotes T1-type cytokine production by cytokine-activated uterine and peripheral natural killer cells," Molecular Human Reproduction, vol. 13, no. 2, pp. 123-133, 2007.
20. F. Morandi, N. Rouas-Freiss, and V. Pistoia, "The emerging role of soluble HLA-G in the control of chemotaxis," Cytokine and Growth Factor Reviews, vol. 25, no. 3, pp. 327-335, 2014.
21. P. Fons, S. Chabot, J. E. Cartwright et al., "Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells," Blood, vol. 108, no. 8, pp. 2608-2615, 2006.
22. J. E. Boyson, R. Erskine, M. C. Whitman et al., "Disulfde bond-mediated dimerization of HLA-G on the cell surface," Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 25, pp. 16180-16185, 2002.
23. M. Shiroishi, K. Kuroki, L. Rasubala et al., "Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)," Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 44, pp. 16412-16417, 2006.
24. M. Shiroishi, K. Kuroki, T. Ose et al., "Efcient leukocyte Ig-like receptor signaling and crystal structure of disulfde-linked HLA-G dimer," Journal of Biological Chemistry, vol. 281, no. 15, pp. 10439-10447, 2006.
25. K. Kuroki and K. Maenaka, "Immune modulation of HLA-G dimer in maternal-fetal interface," European Journal of Immunology, vol. 37, no. 7, pp. 1727-1729, 2007.
26. M. Zhong, X. Weng, Z. Liang et al., "Dimerization of soluble HLA-G by IgG-Fc fragment augments ILT2-mediated inhibition of T-cell alloresponse," Transplantation, vol. 87, no. 1, pp. 8-15, 2009.
27. L. Loumagne, J. Baudhuin, B. Favier, F. Montespan, E. D. Carosella, and N. Rouas-Freiss, "In vivo evidence that secretion of HLA-G by immunogenic tumor cells allows their evasion from immunosurveillance," International Journal of Cancer, vol. 135, no. 9, pp. 2107-2117, 2014.
28. J. Zheng, C. Xu, D. Chu et al., "Human leukocyte antigen G is associated with esophageal squamous cell carcinoma progression and poor prognosis," Immunology Letters, vol. 161, no. 1, pp. 13-19, 2014.
29. M. S. Reimers, C. C. Engels, H. Putter et al., "Prognostic value of HLA class I, HLA-E, HLA-G and Tregs in rectal cancer: a retrospective cohort study," BMC Cancer, vol. 14, article 486, 2014.
30. Z.-Y. Guo, Y.-G. Lv, L. Wang et al., "Predictive value of HLA-G and HLA-E in the prognosis of colorectal cancer patients," Cellular Immunology, vol. 293, no. 1, pp. 10-16, 2015.
31. W.-H. Yan, D. Liu, H.-Y. Lu, Y.-Y. Li, X. Zhang, and A. Lin, "Signifcance of tumour cell HLA-G5/-G6 isoform expression in discrimination for adenocarcinoma from squamous cell carcinoma in lung cancer patients," Journal of Cellular and Molecular Medicine, vol. 19, no. 4, pp. 778-785, 2015.
32. Y.-F. Xu, Y. Lu, H. Cheng et al., "High expression of human leukocyte antigen-G is associated with a poor prognosis in patients with PDAC," Current Molecular Medicine, vol. 15, no. 4, pp. 360-367, 2015.
33. Y. Wang, X. Fan, H. Li et al., "Tumor border sharpness correlates with HLA-G expression in low-grade gliomas," Journal of Neuroimmunology, vol. 282, pp. 1-6, 2015.
34. S. Jasinski-Bergner, A. Reches, C. Stoehr et al., "Identifcation of novel microRNAs regulating HLA-G expression and investigating their clinical relevance in renal cell carcinoma," Oncotarget, vol. 7, no. 18, pp. 26866-26878, 2016.
35. Z. Guan, B. Song, F. Liu, D. Sun, K. Wang, and H. Qu, "TGF-γ induces HLA-G expression through inhibiting miR-152 in gastric cancer cells," Journal of Biomedical Science, vol. 22, p. 107, 2015.
36. D.-P. Xu, W.-W. Shi, T.-T. Zhang et al., "Elevation of HLA-G-expressing DC-10 cells in patients with gastric cancer," Human Immunology, vol. 77, no. 9, pp. 800-804, 2016.
37. D. Wu, I. Kuiaste, P. Moreau, E. Carosella, and P. Yotnda, "Rescuing lymphocytes from HLA-G immunosuppressive efects mediated by the tumor microenvironment," Oncotarget, vol. 6, no. 35, pp. 37385-37397, 2015.
38. L. Zhou, Z.-Y. Niu, Z.-Y. Liang et al., "HLA-G impairs host immune response and predicts poor prognosis in pancreatic cancer," American Journal of Translational Research, vol. 7, no. 10, pp. 2036-2044, 2015.
39. L. König, S. Kasimir-Bauer, O. Hofmann et al., "The prognostic impact of soluble and vesicular HLA-G and its relationship to circulating tumor cells in neoadjuvant treated breast cancer patients," Human Immunology, vol. 77, no. 9, pp. 791-799, 2016.
40. I. Zidi, N. Kharrat, R. Sebai et al., "Pregnancy and breastfeeding: a new theory for sHLA-G in breast cancer patients?" Immuno-logic Research, vol. 64, no. 2, pp. 636-639, 2015.
41. M. Bielska, M. Bojo, G. Klimkiewicz-Wojciechowska et al., "Human leukocyte antigen-G polymorphisms infuence the clinical outcome in difuse large B-cell lymphoma," Genes Chromosomes and Cancer, vol. 54, no. 3, pp. 185-193, 2015.
42. A. Wísniewski, A. Kowal, E. Wyrodek et al., "Genetic polymorphisms and expression of HLA-G and its receptors, KIR2DL4 and LILRB1, in non-small cell lung cancer," Tissue Antigens, vol. 85, no. 6, pp. 466-475, 2015.
43. F. M. Zambra, V. Biolchi, C. C. de Cerqueira, I. S. Brum, E. C. Castelli, and J. A. Chies, "Immunogenetics of prostate cancer and benign hyperplasia-the potential use of an HLA-G variant as a tag SNP for prostate cancer risk," HLA, vol. 87, no. 2, pp. 79-88, 2016.
44. S. Khorrami, H. Mohammadpour, K. Shahzamani et al., "The relationship between HLA-G and viral loads in non-responder HCV-infected patients afer combined therapy with IFN-γ2γ and ribavirin," Human Immunology, vol. 76, no. 2-3, pp. 181-186, 2015.
45. R. Rizzo, V. Audrito, P. Vacca et al., "HLA-G is a component of the chronic lymphocytic leukemia escape repertoire to generate immune suppression: impact of the HLA-G 14 base pair (rs66554220) polymorphism," Haematologica, vol. 99, no. 5, pp. 888-896, 2014.
46. T. Tilburgs, J. H. Evans, Â. C. Crespo, and J. L. Strominger, "The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface," Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 43, pp. 13312-13317, 2015.
47. S. Djurisic, L. Skibsted, and T. V. F. Hviid, "A phenotypic analysis of regulatory t cells and uterine NK cells from frst trimester pregnancies and associations with HLA-G," American Journal of Reproductive Immunology, vol. 74, no. 5, pp. 427-444, 2015.
48. L. M. Ferreira, T. B. Meissner, T. S. Mikkelsen et al., "A distant trophoblast-specifc enhancer controls HLA-G expression at the maternal-fetal interface," Proceedings of the National Academy of Sciences, vol. 113, no. 19, pp. 5364-5369, 2016.
49. L. Klitkou, M. Dahl, T. V. F. Hviid et al., "Human leukocyte antigen (HLA)-G during pregnancy part I: correlations between maternal soluble HLA-G at midterm, at term, and umbilical cord blood soluble HLA-G at term," Human Immunology, vol. 76, no. 4, pp. 254-259, 2015.
50. M. Dahl, L. Klitkou, O. B. Christiansen et al., "Human leukocyte antigen (HLA)-G during pregnancy part II: associations between maternal and fetal HLA-G genotypes and soluble HLA-G," Human Immunology, vol. 76, no. 4, pp. 260-271, 2015.
51. M. Dahl, T. L. Perin, S. Djurisic et al., "Soluble human leukocyte antigen-G in seminal plasma is associated with HLA-G genotype: possible implications for fertility success," American Journal of Reproductive Immunology, vol. 72, no. 1, pp. 89-105, 2014.
52. L. E. E. L. O. Lashley, L. A. J. van der Westerlaken, G. W. Haasnoot et al., "Maternal HLA-C2 and 14 bp insertion in HLA-G is associated with recurrent implantation failure afer in vitro fertilization treatment," Tissue Antigens, vol. 84, no. 6, pp. 536-544, 2014.
53. R. Rizzo, G. Lo Monte, D. Bortolotti et al., "Impact of soluble HLA-G levels and endometrial NK cells in uterine fushing samples from primary and secondary unexplained infertile women," International Journal of Molecular Sciences, vol. 16, no. 3, pp. 5510-5516, 2015.
54. K. Quach, S. A. Grover, S. Kenigsberg, and C. L. Librach, "A combination of single nucleotide polymorphisms in the 3′ untranslated region of HLA-G is associated with preeclamp-sia," Human Immunology, vol. 75, no. 12, pp. 1163-1170, 2014.
55. D. Agrawal, S. Prakash, M. K. Misra, S. R. Phadke, and S. Agrawal, "Implication of HLA-G 5′ upstream regulatory region polymorphisms in idiopathic recurrent spontaneous abortions," Reproductive BioMedicine Online, vol. 30, no. 1, pp. 82-91, 2015.
56. F. Beneventi, M. Simonetta, E. Locatelli et al., "Temporal variation in soluble human leukocyte antigen-G (sHLA-G) and pregnancy-associated plasma protein A (PAPP-A) in pregnancies complicated by gestational diabetes mellitus and in controls," American Journal of Reproductive Immunology, vol. 72, no. 4, pp. 413-421, 2014.
57. F. Beneventi, C. Badulli, E. Locatelli et al., "Soluble HLA-G in pregnancies complicated by autoimmune rheumatic diseases," Journal of Reproductive Immunology, vol. 110, pp. 67-73, 2015.
58. E. Catamo, L. Zupin, L. Segat, F. Celsi, and S. Crovella, "HLA-G and susceptibility to develop celiac disease," Human Immunology, vol. 76, no. 1, pp. 36-41, 2015.
59. E. Catamo, C. Addobbati, L. Segat et al., "HLA-G gene polymorphisms associated with susceptibility to rheumatoid arthritis disease and its severity in Brazilian patients," Tissue Antigens, vol. 84, no. 3, pp. 308-315, 2014.
60. C. M. Mariaselvam, A. B. Chaaben, S. Salah et al., "Human leukocyte antigen-G polymorphism infuences the age of onset and autoantibody status in rheumatoid arthritis," Tissue Antigens, vol. 85, no. 3, pp. 182-189, 2015.
61. T. D. Veit, C. P. S. de Lima, L. C. Cavalheiro et al., "HLA-G +3142 polymorphism as a susceptibility marker in two rheumatoid arthritis populations in Brazil," Tissue Antigens, vol. 83, no. 4, pp. 260-266, 2014.
62. T. D. Veit, J. A. B. Chies, M. Switala et al., "The paradox of high availability and low recognition of soluble HLA-G by LILRB1 receptor in rheumatoid arthritis patients," PLoS ONE, vol. 10, no. 4, article e123838, 2015.
63. X. Zhang, S. Li, Y. Zhang et al., "Meta-analysis of the relationship between 14bp insertion/deletion polymorphism of HLA-G gene and susceptibility to systemic lupus erythematosus," Human Immunology, vol. 75, no. 12, pp. 1171-1176, 2014.
64. E. Favoino, I. E. Favia, S. Vettori et al., "Clinical correlates of human leucocyte antigen (HLA)-G in systemic sclerosis," Clinical and Experimental Immunology, vol. 181, no. 1, pp. 100-109, 2015.
65. I. Zidi, H. Ben Yahia, D. Bortolotti et al., "Association between sHLA-G and HLA-G 14-bpdeletion/insertion polymorphism in Crohn's disease," International Immunology, vol. 27, no. 6, pp. 289-296, 2015.
66. E. Fainardi, D. Bortolotti, S. Bolzani et al., "Cerebrospinal fuid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis," Multiple Sclerosis Journal, vol. 22, no. 2, pp. 245-249, 2016.
67. N. Mohammadi, M. Adib, F. Alsahebfosoul, M. Kazemi, and M. Etemadifar, "An investigation into the association between HLA-G 14 bp insertion/deletion polymorphism and multiple sclerosis susceptibility," Journal of Neuroimmunology, vol. 290, pp. 115-118, 2016.
68. R. S. de Albuquerque, C. T. Mendes-Junior, N. Lucena-Silva et al., "Association of HLA-G 3′ untranslated region variants with type 1 diabetes mellitus," Human Immunology, vol. 77, no. 4, pp. 358-364, 2016.
69. A. Borghi, R. Rizzo, M. Corazza et al., "HLA-G 14-bp polymorphism: a possible marker of systemic treatment response in psoriasis vulgaris? Preliminary results of a retrospective study," Dermatologic Terapy, vol. 27, no. 5, pp. 284-289, 2014.
70. D. Naidoo, A. C. Wu, M. H. Brilliant et al., "A polymorphism in HLA-G modifes statin beneft in asthma," Pharmacogenomics Journal, vol. 15, no. 3, pp. 272-277, 2015.
71. M. Han, Y. Jiang, K. Lao et al., "sHLA-G involved in the apoptosis of decidual natural killer cells following toxoplasma gondii infection," Infammation, vol. 37, no. 5, pp. 1718-1727, 2014.
72. I. Sadissou, T. d'Almeida, G. Cottrell et al., "High plasma levels of HLA-G are associated with low birth weight and with an increased risk of malaria in infancy," Malaria Journal, vol. 13, no. 1, article 312, 2014.
73. D. Bortolotti, J. LeMaoult, C. Trapella, D. D. Luca, E. D. Carosella, and R. Rizzo, "Pseudomonas aeruginosa quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine-lactone induces HLA-G expression in human immune cells," Infection and Immunity, vol. 83, no. 10, pp. 3918-3925, 2015.
74. R. Rizzo, G. Bergamini, D. Bortolotti et al., "HLA-G expression and regulation during Pseudomonas aeruginosa infection in cystic fbrosis patients," Future Microbiology, vol. 11, no. 3, pp. 363-373, 2016.
75. D. M. B. Oliveira Souza, J. Genre, T. G. Alves Silva et al., "Upregulation of soluble HLA-G5 and HLA-G6 isoforms in the milder histopathological stages of Helicobacter pylori infection: a role for subverting immune responses?" Scandinavian Journal of Immunology, vol. 83, no. 1, pp. 38-43, 2016.
76. A. B. Laaribi, I. Zidi, N. Hannachi et al., "Association of an HLA-G 14-bp Insertion/Deletion polymorphism with high HBV replication in chronic hepatitis," Journal of Viral Hepatitis, vol. 22, no. 10, pp. 835-841, 2015.
77. M. K. Misra, S. K. Pandey, R. Kapoor et al., "HLA-G gene expression infuenced at allelic level in association with end stage renal disease and acute allograf rejection," Human Immunology, vol. 75, no. 8, pp. 833-839, 2014.
78. S. R. White, T. Floreth, C. Liao, and S. M. Bhorade, "Association of soluble HLA-G with acute rejection episodes and early development of bronchiolitis obliterans in lung transplantation," PLoS ONE, vol. 9, no. 7, Article ID e103643, 2014.
79. O. Brugière, G. Tabut, I. Krawice-Radanne et al., "Role of HLA-G as a predictive marker of low risk of chronic rejection in lung transplant recipients: a clinical prospective study," American Journal of Transplantation, vol. 15, no. 2, pp. 461-471, 2015.
80. ∗01:04∼UTR3 recipient correlates with lower survival and higher frequency of chronic rejection afer lung transplantation," American Journal of Transplantation, vol. 15, no. 9, pp. 2413-2420, 2015.
81. + regulatory T cells are potent suppressors of grafversus-host disease in vivo," The FASEB Journal, vol. 28, no. 8, pp. 3435-3445, 2014.
82. S. Jasinski-Bergner, C. Stoehr, J. Bukur et al., "Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infltration in renal cell carcinoma," OncoImmunology, vol. 4, no. 6, Article ID e1008805, 2015.
83. S. Khorrami, R. Rahimi, H. Mohammadpour et al., "Association of HLA-G∗01:01:02:01/G∗01:04:01 polymorphism with gastric adenocarcinoma," Human Immunology, vol. 77, no. 2, pp. 153-157, 2016.
84. P. Le Bouteiller, "HLA-G in human early pregnancy: control of uterine immune cell activation and likely vascular remodeling," Biomedical Journal, vol. 38, no. 1, pp. 32-38, 2015.
85. M. H. Larsen, M. Bzorek, M. B. Pass et al., "Human leukocyte antigen-G in the male reproductive system and in seminal plasma," Molecular Human Reproduction, vol. 17, no. 12, pp. 727-738, 2011.
86. R. Rizzo, D. Bortolotti, S. Bolzani, and E. Fainardi, "HLA-G molecules in autoimmune diseases and infections," Frontiers in Immunology, vol. 5, article 592, 2014.
87. R. Rizzo, L. Melchiorri, L. Simone et al., "Diferent production of soluble HLA-G antigens by peripheral blood mononuclear cells in ulcerative colitis and Crohn's disease: a noninvasive diagnostic tool?" Infammatory Bowel Diseases, vol. 14, no. 1, pp. 100-105, 2008.
88. S. Aractingi, N. Briand, C. Le Danf et al., "HLA-G and NK receptor are expressed in psoriatic skin: a possible pathway for regulating infltrating T cells?" American Journal of Pathology, vol. 159, no. 1, pp. 71-77, 2001.
89. E. Gazit, Y. Slomov, I. Goldberg, S. Brenner, and R. Loewen-thal, "HLA-G is associated with pemphigus vulgaris in Jewish patients," Human Immunology, vol. 65, no. 1, pp. 39-46, 2004.
90. M. I. Torres, M. A. López-Casado, J. Luque, J. Peña, and A. Ríos, "New advances in coeliac disease: serum and intestinal expression of HLA-G," International Immunology, vol. 18, no. 5, pp. 713-718, 2006.
91. R. Rizzo, T. V. F. Hviid, M. Govoni et al., "HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus," Tissue Antigens, vol. 71, no. 6, pp. 520-529, 2008.
92. R. Rizzo, C. E. Mapp, L. Melchiorri et al., "Defective production of soluble HLA-G molecules by peripheral blood monocytes in patients with asthma," The Journal of Allergy and Clinical Immunology, vol. 115, no. 3, pp. 508-513, 2005.
93. I. Prigione, F. Penco, A. Martini, M. Gattorno, V. Pistoia, and F. Morandi, "HLA-G and HLA-E in patients with juvenile idiopathic arthritis," Rheumatology, vol. 50, no. 5, pp. 966-972, 2011.
94. R. Rizzo, I. Farina, D. Bortolotti et al., "HLA-G may predict the disease course in patients with early rheumatoid arthritis," Human Immunology, vol. 74, no. 4, pp. 425-432, 2013.
95. L. Amiot, N. Vu, and M. Samson, "Immunomodulatory properties of HLA-G in infectious diseases," Journal of Immunology Research, vol. 2014, Article ID 298569, 14 pages, 2014.
96. V. Rebmann, F. Da Silva Nardi, B. Wagner, and P. A. Horn, "HLA-G as a tolerogenic molecule in transplantation and pregnancy," Journal of Immunology Research, vol. 2014, Article ID 297073, 16 pages, 2014.