IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 37, 2016, Pages E5444-E5453

  Beltra, Jean Christophe ^a,b   Bourbonnais, Sara ^b   Bédard, Nathalie ^c   Charpentier, Tania ^d   Boulangé, Moana ^a,b   Michaud, Eva ^a,b   Boufaied, Ines ^a   Bruneau, Julie ^b,c   Shoukry, Naglaa H ^b,c   Lamarre, Alain ^d   Decaluwe, Hélène ^a,b  

^a UNIVERSITY OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^d INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

CD8 T cell; Exhaustion; IL 15; IL 2; Memory T cell

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CASPASE 3; CD160 PROTEIN; GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 2 RECEPTOR BETA GAMMA; INTERLEUKIN 7; LAG 3 PROTEIN; PROTEIN; PROTEIN BCL 2; STAT5 PROTEIN; TIM 3 PROTEIN; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CD244 PROTEIN, MOUSE; HAVCR2 PROTEIN, MOUSE; HEPATITIS A VIRUS CELLULAR RECEPTOR 2; IL2RB PROTEIN, MOUSE; SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CD8+ T LYMPHOCYTE; CELL COUNT; CELL DIFFERENTIATION; CHRONIC VIRAL INFECTION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; MEMORY; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STABLE EXPRESSION; T LYMPHOCYTE; VIRAL CLEARANCE; VIRUS INFECTION; ANIMAL; GENETICS; HEPACIVIRUS; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; METABOLISM; PATHOGENICITY; PATHOLOGY; VIROLOGY;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; HEPACIVIRUS; HEPATITIS A VIRUS CELLULAR RECEPTOR 2; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-15; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; INTERLEUKIN-7; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE FAMILY;

EID: 84987606105     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1604256113     Document Type: Article

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