Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations

Cancer Research

Volumn 76, Issue 17, 2016, Pages 5103-5114

  Fehringer, Gordon ^a   Kraft, Peter ^b   Pharoah, Paul D ^c   Eeles, Rosalind A ^d   Chatterjee, Nilanjan ^e   Schumacher, Fredrick R ^f   Schildkraut, Joellen M ^g   Lindström, Sara ^b   Brennan, Paul ^h   Bickeböller, Heike ⁱ   Houlston, Richard S ^d   Landi, Maria Teresa ^e   Caporaso, Neil ^e   Risch, Angela ^j,k,l   Al Olama, Ali Amin ^c   Berndt, Sonja I ^e   Giovannucci, Edward L ^b   Grönberg, Henrik ^m   Kote Jarai, Zsofia ^d   Ma, Jing ^n,o   Muir, Kenneth ^p,q   Stampfer, Meir J ⁿ   Stevens, Victoria L ^r   Wiklund, Fredrik ^m   Willett, Walter C ^b   Goode, Ellen L ^s   Permuth, Jennifer B ^t   Risch, Harvey A ^u   Reid, Brett M ^t   Bezieau, Stephane ^v   Brenner, Hermann ^k   Chan, Andrew T ^w   Chang Claude, Jenny ^k   Hudson, Thomas J ^x   Kocarnik, Jonathan K ^y   Newcomb, Polly A ^y   Schoen, Robert E ^z   Slattery, Martha L ^aa   White, Emily ^y   Adank, Muriel A ^ab   Ahsan, Habibul ^ac   Aittomäki, Kristiina ^ad   Baglietto, Laura ^ae   Blomquist, Carl ^ad   Canzian, Federico ^k   Czene, Kamila ^m   Dos Santos silva, Isabel ^af   Eliassen, A Heather ^b,n   Figueroa, Jonine D ^e   Flesch Janys, Dieter ^ag   Fletcher, Olivia ^d   Garcia Closas, Montserrat ^e   Gaudet, Mia M ^r   Johnson, Nichola ^d   Hall, Per ^m   Hazra, Aditi ⁿ   Hein, Rebecca ^k,ah   Hofman, Albert ^ai   Hopper, John L ^aj   Irwanto, Astrid ^ak   Johansson, Mattias ^h,al   Kaaks, Rudolf ^k   Kibriya, Muhammad G ^ac   Lichtner, Peter ^am   Liu, Jianjun ^ak   Lund, Eiliv ^an   Makalic, Enes ^aj   Meindl, Alfons ^ao   Müller Myhsok, Bertram ^ap   Muranen, Taru A ^ad   Nevanlinna, Heli ^ad   Peeters, Petra H ^aq   Peto, Julian ^af   Prentice, Ross L ^y   Rahman, Nazneen ^d   Sanchez, Maria Jose ^ar,as,at   Schmidt, Daniel F ^aj   Schmutzler, Rita K ^au   Southey, Melissa C ^ae   Tamimi, Rulla ⁿ   Travis, Ruth C ^av   Turnbull, Clare ^d   Uitterlinden, Andre G ^ai   Wang, Zhaoming ^e   Whittemore, Alice S ^aw   Yang, Xiaohong R ^e   Zheng, Wei ^ax   Buchanan, Daniel D ^ae   Casey, Graham ^f   Conti, David V ^f   Edlund, Christopher K ^f   Gallinger, Steven ^a   Haile, Robert W ^aw   Jenkins, Mark ^ae   Marchand, Loïcle ^ay   Li, Li ^az   Lindor, Noralene M ^ba   Schmit, Stephanie L ^f   Thibodeau, Stephen N ^s   Woods, Michael O ^bb   Rafnar, Thorunn ^bc   Gudmundsson, Julius ^bc   Stacey, Simon N ^bc   Stefansson, Kari ^bc   Sulem, Patrick ^bc   Chen, Y Ann ^t   Tyrer, Jonathan P ^c   Christiani, David C ^b   Wei, Yongyue ^b   Shen, Hongbing ^bd   Hu, Zhibin ^bd   Shu, Xiao Ou ^ax   Shiraishi, Kouya ^be   Takahashi, Atsushi ^bf   Bossé, Yohan ^bg   Obeidat, Ma'en ^bh   Nickle, David ^bi   Timens, Wim ^bj   Freedman, Matthew L ^bk   Li, Qiyuan ^bl   Seminara, Daniela ^e   Chanock, Stephen J ^e   Gong, Jian ^y   Peters, Ulrike ^y   Gruber, Stephen B ^f   Amos, Christopher I ^bm   Sellers, Thomas A ^t   Easton, Douglas F ^c   Hunter, David J ^b   Haiman, Christopher A ^f   Henderson, Brian E ^f   Hung, Rayjean J ^a   more..

^a MOUNT SINAI HOSPITAL   (Canada)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^e National Cancer Instititute   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g UNIVERSITY OF VIRGINIA   (United States)

^h INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

ⁱ UNIVERSITY OF GÖTTINGEN   (Germany)

^j UNIVERSITY OF SALZBURG   (Austria)

^k GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^l German Center for Lung Research (DZL)   (Germany)

^m KAROLINSKA INSTITUTE   (Sweden)

ⁿ HARVARD MEDICAL SCHOOL   (United States)

^o BRIGHAM AND WOMEN S HOSPITAL   (United States)

^p UNIVERSITY OF MANCHESTER   (United Kingdom)

^q UNIVERSITY OF WARWICK   (United Kingdom)

^r AMERICAN CANCER SOCIETY   (United States)

^s MAYO CLINIC   (United States)

^t H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^u YALE UNIVERSITY   (United States)

^v CHUNantes   (France)

^w MASSACHUSETTS GENERAL HOSPITAL   (United States)

^x ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^y Fred Hutchinson Cancer Research Center   (United States)

^z UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^aa UNIVERSITY OF UTAH   (United States)

^ab VU UNIVERSITY AMSTERDAM   (Netherlands)

^ac UNIVERSITY OF CHICAGO   (United States)

^ad UNIVERSITY OF HELSINKI   (Finland)

^ae UNIVERSITY OF MELBOURNE   (Australia)

^af LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^ag UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^ah UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^ai ERASMUS MEDICAL CENTER   (Netherlands)

^aj UNIVERSITY OF MELBOURNE   (Australia)

^ak GENOME INSTITUTE OF SINGAPORE   (Singapore)

^al UMEÅ UNIVERSITY   (Sweden)

^am INSTITUTE OF EPIDEMIOLOGY   (Germany)

^an UNIVERSITY OF TROMSØ   (Norway)

^ao TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^ap MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^aq UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^ar ANDALUSIAN SCHOOL OF PUBLIC HEALTH   (Spain)

^as UNIVERSITY OF GRANADA   (Spain)

^at CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^au UNIVERSITY OF COLOGNE   (Germany)

^av UNIVERSITY OF OXFORD   (United Kingdom)

^aw STANFORD UNIVERSITY   (United States)

^ax VANDERBILT UNIVERSITY   (United States)

^ay UNIVERSITY OF HAWAII   (United States)

^az CASE WESTERN RESERVE UNIVERSITY   (United States)

^ba MAYO CLINIC   (United States)

^bb MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^bc DECODE GENETICS   (Iceland)

^bd NANJING MEDICAL UNIVERSITY   (China)

^be NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^bf RIKEN Center for Integrative Medical Sciences   (Japan)

^bg LAVAL UNIVERSITY   (Canada)

^bh UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^bi MERCK RESEARCH LABORATORIES   (United States)

^bj UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^bk DANA FARBER CANCER INSTITUTE   (United States)

^bl XIAMEN UNIVERSITY   (China)

^bm DARTMOUTH MEDICAL SCHOOL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADAM15 GENE; ALS2CR12 GENE; ARTICLE; BRCA2 GENE; BREAST CANCER; CANCER GROWTH; CASP8 GENE; CDKN2BAS1 GENE; CHROMOSOME 1Q; CHROMOSOME 1Q22; COLORECTAL CANCER; CONTROLLED STUDY; GENE LOCUS; GENE REPLICATION; GENETIC IDENTIFICATION; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG CANCER; MAJOR CLINICAL STUDY; MULTIPLE CANCER; OVARY CANCER; PLEIOTROPY; PRIORITY JOURNAL; PROSTATE CANCER; QUANTITATIVE TRAIT LOCUS; SQUAMOUS CELL LUNG CARCINOMA; THBS3 GENE; TUMOR GENE; BREAST TUMOR; COLORECTAL TUMOR; FEMALE; GENETICS; LUNG TUMOR; MALE; OVARY TUMOR; PROSTATE TUMOR;

BREAST NEOPLASMS; COLORECTAL NEOPLASMS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LUNG NEOPLASMS; MALE; OVARIAN NEOPLASMS; PROSTATIC NEOPLASMS;

EID: 84986888945     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-2980     Document Type: Article

References (47)

1. Hindorff LA, MacArthur J, Morales J, Junkins HA, Hall PN, Klemm AK, et al. A Catalog of Published Genome-Wide Association Studies. NIH: Bethesda, MD. Available from: www.genome.gov/gwastudies.
2. Ghoussaini M, Song H, Koessler T, Al Olama AA, Kote-Jarai Z, Driver KE, et al. Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst 2008;100:962-6.
3. Rafnar T, Sulem P, Stacey SN, Geller F, Gudmundsson J, Sigurdsson A, et al. Sequence variants at the TERT-CLPTM1L locus associate withmany cancer types. Nat Genet 2009;41:221-7.
4. Bhattacharjee S, Rajaraman P, Jacobs KB, Wheeler WA, Melin BS, Hartge P, et al. A subset-based approach improves power and interpretation for the combined analysis of genetic association studies of heterogeneous traits. Am J Hum Genet 2012;90:821-35.
5. Peters U, Jiao S, Schumacher FR, Hutter CM, Aragaki AK, Baron JA, et al. Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis. Gastroenterology 2013;144:799-807. e24.
6. Garcia-Closas M, Couch FJ, Lindstrom S, Michailidou K, Schmidt MK, Brook MN, et al. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet 2013;45:392-8.
7. Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet 2013;45:353-61.
8. Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, et al. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet 2013;45:362-70.
9. Siddiq A, Couch FJ, Chen GK, Lindstrom S, Eccles D, Millikan RC, et al. A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet 2012;21:5373-84.
10. Wang Y, McKay JD, Rafnar T, Wang Z, Timofeeva MN, Broderick P, et al. Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet 2014;46:736-41.
11. Wang H, Burnett T, Kono S, Haiman CA, Iwasaki M, Wilkens LR, et al. Transethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun 2014;5:4613.
12. Hung RJ, Ulrich CM, Goode EL, Brhane Y, Muir K, Chan AT, et al. Cross cancer genomic investigation of inflammation pathway for five common cancers: lung, ovary, prostate, breast, and colorectal cancer. J Natl Cancer Inst 2015;107:djv246.
13. Gudbjartsson DF, Helgason H, Gudjonsson SA, Zink F, Oddson A, Gylfason A, et al. Large-scale whole-genome sequencing of the Icelandic population. Nat Genet 2015;47:435-44.
14. Asomaning K, Miller DP, Liu G, Wain JC, Lynch TJ, Su L, et al. Second hand smoke, age of exposure and lung cancer risk. Lung Cancer 2008;61:13-20.
15. Liu G, Wheatley-Price P, Zhou W, Park S, Heist RS, Asomaning K, et al. Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk. Int J Cancer 2008;122:915-8.
16. Al Olama AA, Kote-Jarai Z, Berndt SI, Conti DV, Schumacher F, Han Y, et al. A meta-analysis of 87, 040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat Genet 2014;46:1103-9.
17. Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, et al. A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nat Genet 2012;44:900-3.
18. Hu Z, Wu C, Shi Y, Guo H, Zhao X, Yin Z, et al. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat Genet 2011;43:792-6.
19. Cai Q, Zhang B, Sung H, Low SK, Kweon SS, Lu W, et al. Genomewide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. Nat Genet 2014;46:886-90.
20. Cheng I, Chen GK, Nakagawa H, He J, Wan P, Laurie CC, et al. Evaluating genetic risk for prostate cancer among Japanese and Latinos. Cancer Epidemiol Biomarkers Prev 2012;21:2048-58.
21. Fejerman L, Ahmadiyeh N, Hu D, Huntsman S, Beckman KB, Caswell JL, et al. Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25. Nat Commun 2014;5:5260.
22. Chen F, Chen GK, Stram DO, Millikan RC, Ambrosone CB, John EM, et al. A genome-wide association study of breast cancer in women of African ancestry. Hum Genet 2013;132:39-48.
23. Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, et al. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet 2011;43:570-3.
24. Andreassen OA, Zuber V, Thompson WK, Schork AJ, Bettella F, Djurovic S, et al. Shared common variants in prostate cancer and blood lipids. Int J Epidemiol 2014;43:1205-14.
25. Obeidat M, Miller S, Probert K, Billington CK, Henry AP, Hodge E, et al. GSTCD and INTS12 regulation and expression in the human lung. PLoS One 2013;8:e74630.
26. Li Q, Seo JH, Stranger B, McKenna A, Pe'er I, Laframboise T, et al. Integrative eQTL-based analyses reveal the biology of breast cancer risk loci. Cell 2013;152:633-41.
27. Kuefer R, Day KC, Kleer CG, Sabel MS, Hofer MD, Varambally S, et al. ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease. Neoplasia 2006;8:319-29.
28. Barrett JH, Iles MM, Harland M, Taylor JC, Aitken JF, Andresen PA, et al. Genome-wide association study identifies three new melanoma susceptibility loci. Nat Genet 2011;43:1108-13.
29. Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MW, Pooley KA, et al. A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet 2007;39:352-8.
30. Khan S, Greco D, Michailidou K, Milne RL, Muranen TA, Heikkinen T, et al. MicroRNA related polymorphisms and breast cancer risk. PLoS One 2014;9:e109973.
31. Lin WY, Camp NJ, Ghoussaini M, Beesley J, Michailidou K, Hopper JL, et al. Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet 2014;24:285-98.
32. Turnbull C, Ahmed S, Morrison J, Pernet D, Renwick A, Maranian M, et al. Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet 2010;42:504-7.
33. Saeki N, Saito A, Choi IJ, Matsuo K, Ohnami S, Totsuka H, et al. Afunctional single nucleotide polymorphism in mucin 1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer. Gastroenterology 2011;140:892-902.
34. Nath S, Mukherjee P. MUC1: a multifaceted oncoprotein with a key role in cancer progression. Trends Mol Med 2014;20:332-42.
35. Kharbanda A, Rajabi H, Jin C, Tchaicha J, Kikuchi E, Wong K-K, et al. Targeting the oncogenic MUC1-C protein inhibits mutant EGFR-mediated signaling and survival in non-small cell lung cancer cells. Clin Cancer Res 2014;20:5423-34.
36. Najy AJ, Day KC, Day ML. The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation. J Biol Chem 2008;283:18393-401.
37. Liu X, Wang Z, Zhang X, Chang J, Tang W, Gan L, et al. MUC1 gene polymorphism rs4072037 and susceptibility to gastric cancer: a metaanalysis. SpringerPlus 2014;3:599.
38. Helgason H, Rafnar T, Olafsdottir HS, Jonasson JG, Sigurdsson A, Stacey SN, et al. Loss-of-function variants in ATM confer risk of gastric cancer. Nat Genet 2015;47:906-10.
39. Abnet CC, Wang Z, Song X, Hu N, Zhou FY, Freedman ND, et al. Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. Hum Mol Genet 2012;21:2132-41.
40. Lubahn J, Berndt SI, Jin CH, Klim A, Luly J, Wu WS, et al. Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma. Prostate 2010;70:646-53.
41. Li S, Chai Z, Li Y, Liu D, Bai Z, Situ Z. BZW1, a novel proliferation regulator that promotes growth of salivary muocepodermoid carcinoma. Cancer Lett 2009;284:86-94.
42. Timofeeva MN, Hung RJ, Rafnar T, Christiani DC, Field JK, Bickeboller H, et al. Influence of common genetic variation on lung cancer risk: metaanalysis of 14 900 cases and 29 485 controls. Hum Mol Genet 2012;21:4980-95.
43. Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat Genet 2009;41:899-904.
44. Stacey SN, Sulem P, Masson G, Gudjonsson SA, Thorleifsson G, Jakobsdottir M, et al. New common variants affecting susceptibility to basal cell carcinoma. Nat Genet 2009;41:909-14.
45. Li WQ, Pfeiffer RM, Hyland PL, Shi J, Gu F, Wang Z, et al. Genetic polymorphisms in the 9p21 region associated with risk of multiple cancers. Carcinogenesis 2014;35:2698-705.
46. Kotake Y, Nakagawa T, Kitagawa K, Suzuki S, Liu N, Kitagawa M, et al. Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 (INK4B) tumor suppressor gene. Oncogene 2011;30:1956-62.
47. Xu Z, Taylor JA. SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies. Nucleic Acids Res 2009;37(Web Server issue):W600-5.