Identification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis

Nature Communications

Volumn 6, Issue , 2015, Pages

  Wang, Bin ^a,b   Guo, Fang ^a,b   Ren, Jinwei ^a   Ai, Guomin ^a   Aigle, Bertrand ^c,d   Fan, Keqiang ^a   Yang, Keqian ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c UNIVERSITÉ DE LORRAINE   (France)

^d UNIVERSITÉ DE LORRAINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALP1U PROTEIN; ANTIBIOTIC AGENT; BACTERIAL PROTEIN; HYDROLASE; KINAMYCIN; LOM6 PROTEIN; LOMAIVITICIN; UNCLASSIFIED DRUG; ALP1U PROTEIN, STREPTOMYCES AMBOFACIENS; ANTINEOPLASTIC ANTIBIOTIC; EPOXIDE; EPOXIDE HYDROLASE; FLUORENE DERIVATIVE; KINAMYCIN F; LOM6 PROTEIN, STREPTOMYCES AMBOFACIENS; LOMAIVITICIN A; LOMAIVITICIN B; QUINONE DERIVATIVE;

ANTIBIOTICS; CATALYSIS; DEHYDRATION; ENZYME ACTIVITY; GENE EXPRESSION; HYDROLYSIS; SECONDARY METABOLITE;

ALP1U GENE; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CONTROLLED STUDY; DEACETYLATION; DIMERIZATION; DRUG HYDROLYSIS; DRUG TRANSFORMATION; GENE CLUSTER; GENE IDENTIFICATION; LOM6 GENE; NONHUMAN; PHARMACOPHORE; STREPTOMYCES AMBOFACIENS; BIOSYNTHESIS; CATALYSIS; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; STREPTOMYCES;

ANTIBIOTICS, ANTINEOPLASTIC; BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; EPOXIDE HYDROLASES; EPOXY COMPOUNDS; FLUORENES; MASS SPECTROMETRY; QUINONES; STREPTOMYCES;

EID: 84986587227     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8674     Document Type: Article

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