An association between sperm PLCζ levels and varicocele?

Journal of Assisted Reproduction and Genetics

Volumn 33, Issue 12, 2016, Pages 1649-1655

  Janghorban Laricheh, Elham ^a,b   Ghazavi Khorasgani, Nasim ^a,b   Tavalaee, Marziyeh ^a   Zohrabi, Dina ^b   Abbasi, Homayon ^c   Nasr Esfahani, Mohammad H ^a,c  

^a ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

^b Nour Danesh Institute of Higher Education   (Iran)

^c ISFAHAN FERTILITY AND INFERTILITY CENTER   (Iran)

Author keywords

DNA fragmentation; PLC ; Sperm parameters; Varicocele

Indexed keywords

MESSENGER RNA; PHOSPHOLIPASE C DELTA; PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PLCZ1 PROTEIN, HUMAN;

ARTICLE; CHROMATIN STRUCTURE; CLINICAL ARTICLE; DNA FRAGMENTATION; HUMAN; INFERTILITY; MALE; MALE INFERTILITY; OOCYTE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SPERM; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; VARICOCELE; WESTERN BLOTTING; WORLD HEALTH ORGANIZATION; BIOSYNTHESIS; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PATHOLOGY; SPERMATOZOON;

DNA FRAGMENTATION; HUMANS; INFERTILITY, MALE; MALE; OOCYTES; PHOSPHOINOSITIDE PHOSPHOLIPASE C; SEMEN; SPERMATOZOA; VARICOCELE;

EID: 84986296745     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-016-0802-5     Document Type: Article

References (47)

1. Kantartzi PD, Goulis CD, Goulis GD, Papadimas I. Male infertility and varicocele: myths and reality. Hippokratia. 2007;11(3):99–104.
2. Homade A, Esteves S, Agawal A. Varicocele and male infertility: current concepts, controversies and consensus. Springer brief in reproductive biology. Springer; 2016. ISBN: 978-3-319-24934-6.
3. Agarwal A, Deepinder F, Cocuzza M, Agarwal R, Short RA, Sabanegh E, et al. Efficacy of varicocelectomy in improving semen parameters: new meta-analytical approach. Urology. 2007;70(3):532–8.
4. Pastuszak AW, Wang R. Varicocele and testicular function. Asian J Androl. 2015;17(4):659–67.
5. Amdani SN, Yeste M, Jones C, Coward K. Sperm factors and oocyte activation: current controversies and considerations. Biol Reprod. 2015;93(2):50.
6. Anifandis G, Messini CI, Dafopoulos K, Daponte A, Messinis IE. Sperm contributions to oocyte activation: more that meets the eye. J Assist Reprod Genet. 2016;33(3):313–6.
7. Nomikos M, Swann K, Lai FA. Is PAWP the “real” sperm factor? Asian J Androl. 2015;17(3):444–6.
8. Aarabi M, Sutovsky P, Oko R. Re: is PAWP the ‘real’ sperm factor? Asian J Androl. 2015;17(3):446–9.
9. Kashir J, Nomikos M, Swann K, Lai FA. PLCζ or PAWP: revisiting the putative mammalian sperm factor that triggers egg activation and embryogenesis. Mol Hum Reprod. 2015;21(5):383–8.
10. Tosti E, Ménézo Y. Gamete activation: basic knowledge and clinical applications. Hum Reprod Update. 2016;22(4):420–39. Review.
11. Satouh Y, Nozawa K, Ikawa M. Sperm postacrosomal WW domain-binding protein is not required for mouse egg activation. Biol Reprod. 2015;93(4):94.
12. Aghajanpour S, Ghaedi K, Salamian A, Deemeh MR, Tavalaee M, Moshtaghian J. Quantitative expression of phospholipase C zeta, as an index to assess fertilization potential of a semen sample. Hum Reprod. 2011;26(11):2950–6.
13. Yelumalai S, Yeste M, Jones C, Amdani SN, Kashir J, Mounce G, et al. Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection. Fertil Steril. 2015;104(3):561–8.e4.
14. Kashir J, Jones C, Lee HC, Rietdorf K, Nikiforaki D, Durrans C, et al. Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes. Hum Reprod. 2011;26(12):3372–87.
15. Kashir J, Konstantinidis M, Jones C, Lemmon B, Lee HC, Hamer R, et al. A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility. Hum Reprod. 2012;27(1):222–31.
16. Kashir J, Konstantinidis M, Jones C, Heindryckx B, De Sutter P, Parrington J, et al. Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells. Fertil Steril. 2012;98(2):423–31.
17. Kashir J, Jones C, Mounce G, Ramadan WM, Lemmon B, Heindryckx B, et al. Variance in total levels of phospholipase C zeta (PLC-ζ) in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability. Fertil Steril. 2013;99(1):107–17.
18. Heytens E, Parrington J, Coward K, Young C, Lambrecht S, Yoon SY, et al. Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men. Hum Reprod. 2009;24(10):2417–28.
19. Knott JG, Kurokawa M, Fissore RA, Schultz RM, Williams CJ. Transgenic RNA interference reveals role for mouse sperm phospholipase Czeta in triggering Ca2+ oscillations during fertilization. Biol Reprod. 2005;72(4):992–6.
20. Tavalaee M, Nasr-Esfahani MH. Expression profile of PLCf, PAWP, and TR-KIT in association with fertilization potential, embryo development, and pregnancy outcomes in globozoospermic candidates for intra-cytoplasmic sperm injection and artificial oocyte activation. Andrology. 2016; 1–7.
21. Kashir J, Heynen A, Jones C, Durrans C, Craig J, Gadea J, et al. Effects of cryopreservation and density-gradient washing on phospholipase C zeta concentrations in human spermatozoa. Reprod Biomed Online. 2011;23(2):263–7.
22. Sanusi R, Yu Y, Nomikos M, Lai FA, Swann K. Rescue of failed oocyte activation after ICSI in a mouse model of male factor infertility by recombinant phospholipase Cζ. Mol Hum Reprod. 2015;21(10):783–91.
23. World Health Organization. Examination and processing human semen. 5th ed. Cambridge: Cambridge University Press; 2010.
24. Evenson DP. Sperm chromatin structure assay (SCSA). Methods Mol Biol. 2013;927:147–64.
25. Shiraishi K, Takihara H, Matsuyama H. Elevated scrotal temperature, but not varicocele grade, reflects testicular oxidative stress-mediated apoptosis. World J Urol. 2010;28(3):359–64.
26. Shiraishi K, Matsuyama H, Takihara H. Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. Int J Urol. 2012;19(6):538–50.
27. Bahreinian M, Tavalaee M, Abbasi H, Kiani-Esfahani A, Shiravi AH, Nasr-Esfahani MH. DNA hypomethylation predisposes sperm to DNA damage in individuals with varicocele. Syst Biol Reprod Med. 2015;61(4):179–86.
28. Naughton CK, Nangia AK, Agarwal A. Pathophysiology of varicoceles in male infertility. Hum Reprod Update. 2001;7(5):473–81.
29. Setchell BP. The Parkes lecture. Heat and the testis. J Reprod Fertil. 1998;114(2):179–94. Review.
30. Durairajanayagam D, Agarwal A, Ong C. Causes, effects and molecular mechanisms of testicular heat stress. Reprod Biomed Online. 2015;30(1):14–27.
31. Afiyani AA, Deemeh MR, Tavalaee M, Razi M, Bahadorani M, Shokrollahi B, et al. Evaluation of heat-shock protein A2 (HSPA2) in male rats before and after varicocele induction. Mol Reprod Dev. 2014;81(8):766–76.
32. Gadea J, Molla M, Selles E, Marco MA, Garcia-Vazquez FA, Gardon JC. Reduced glutathione content in human sperm is decreased after cryopreservation: effect of to the addition of reduced glutathione the freezing and thawing extenders. Cryobiology. 2011;62(1):40–6.
33. Grasa P, Coward K, Young C, Parrington J. The pattern of localization of the putative oocyte activation factor, phospholipase Czeta, in uncapacitated, capacitated, and ionophore-treated human spermatozoa. Hum Reprod. 2008;23(11):2513–22.
34. Young C, Grasa P, Coward K, Davis LC, Parrington J. Phospholipase C zeta undergoes dynamic changes in its pattern of localization in sperm during capacitation and the acrosome reaction. Fertil Steril. 2009;91(5):2230–42.
35. Oliveira A, Neto A, Almeida C, Silva-Ramos M, Versos R, Barros A, et al. Comparative study of gene expression in patients with varicocele by microarray technology. Andrologia. 2012;44:260–5.
36. Kimmins S, Kotaja N, Davidson I, Sassone-Corsi P. Testis-specific transcription mechanisms promoting male germ-cell differentiation. Reproduction. 2004;128(1):5–12.
37. Cui J, Holmes EH, Greene TG, Liu PK. Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain. FASEB J. 2000;14(7):955–67.
38. Simon L, Proutski I, Stevenson M, Jennings D, McManus J, Lutton D, et al. Sperm DNA damage has a negative association with live-birth rates after IVF. Reprod Biomed Online. 2013;26(1):68–78.
39. Simon L, Liu L, Murphy K, Ge S, Hotaling J, Aston KI, et al. Comparative analysis of three sperm DNA damage assays and sperm nuclear protein content in couples undergoing assisted reproduction treatment. Hum Reprod. 2014;29(5):904–17.
40. Anifandis G, Bounartzi T, Messini CI, Dafopoulos K, Markandona R, Sotiriou S, et al. Sperm DNA fragmentation measured by Halosperm does not impact on embryo quality and ongoing pregnancy rates in IVF/ICSI treatments. Andrologia. 2015;47(3):295–302.
41. Tunc O, Tremellen K. Oxidative DNA damage impairs global sperm DNA methylation in infertile men. J Assist Reprod Genet. 2009;26(9–10):537–44.
42. Nasr-Esfahani MH, Abasi H, Razavi S, Ashrafi S, Tavalaee M. Varicocelectomy: semen parameters and protamine deficiency. Int J Androl. 2009;32(2):115–22.
43. Li F, Yamaguchi K, Okada K, Matsushita K, Ando M, Chiba K, et al. Significant improvement of sperm DNA quality after microsurgical repair of varicocele. Syst Biol Reprod Med. 2012;58(5):274–7.
44. Tavalaee M, Bahreinian M, Barekat F, Abbasi H, Nasr-Esfahani MH. Effect of varicocelectomy on sperm functional characteristics and DNA methylation. Andrologia. 2015;47(8):904–9.
45. Park JH, Kim SK, Kim J, Kim JH, Chang JH, Jee BC. Relationship between phospholipase C zeta immunoreactivity and DNA fragmentation and oxidation in human sperm. Obstet Gynecol Sci. 2015;58(3):232–8.
46. Pasqualotto FF, Braga DP, Figueira RC, Setti AS, Iaconelli Jr A, Borges Jr E. Varicocelectomy does not impact pregnancy outcomes following intracytoplasmic sperm injection procedures. J Androl. 2012;33(2):239–43.
47. Pathak P, Chandrashekar A, Hakky TS, Pastuszak AW. Varicocele management in the era of in vitro fertilization/intracytoplasmic sperm injection. Asian J Androl. 2016;18(3):343–8.