Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

Molecular Cell

Volumn 63, Issue 1, 2016, Pages 72-85

  Pak, Chi W ^a   Kosno, Martyna ^a   Holehouse, Alex S ^b,c   Padrick, Shae B ^a   Mittal, Anuradha ^c   Ali, Rustam ^a   Yunus, Ali A ^a   Liu, David R ^d   Pappu, Rohit V ^c   Rosen, Michael K ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTRINSICALLY DISORDERED PROTEIN; NCK PROTEIN; NEPHRIN INTRACELLULAR DOMAIN; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; NEPHRIN;

AMINO ACID COMPOSITION; ARTICLE; BLEACHING; CELL NUCLEUS INCLUSION BODY; CIRCULAR DICHROISM; COACERVATION; COILED BODY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; GEL FILTRATION; GENETIC TRANSFECTION; HELA CELL LINE; HUMAN; HUMAN CELL; HYDROPHOBICITY; INTRACELLULAR PHASE SEPARATION; MICROSCOPY; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHASE SEPARATION; AMINO ACID SEQUENCE; ANIMAL; CELL NUCLEUS; CELL ORGANELLE; CHEMICAL PHENOMENA; CHEMISTRY; COMPUTER SIMULATION; GENETICS; METABOLISM; MOLECULAR MODEL; MOUSE; MUTATION; PROCEDURES; PROTEIN DOMAIN; PROTEOMICS; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY; TIME FACTOR;

AMINO ACID SEQUENCE; ANIMALS; CELL NUCLEUS; COMPUTER SIMULATION; HELA CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INTRINSICALLY DISORDERED PROTEINS; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; MUTATION; ORGANELLES; PROTEIN DOMAINS; PROTEOMICS; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; TIME FACTORS; TRANSFECTION;

EID: 84986234339     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.05.042     Document Type: Article

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