Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 47, 2015, Pages E6426-E6435

  Banjade, Sudeep ^a,b   Wu, Qiong ^a   Mittal, Anuradha ^c   Peeples, William B ^a,b   Pappu, Rohit V ^c   Rosen, Michael K ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Adaptor proteins; Interdomain linker; Intrinsically disordered; Multivalency; Phase separation

Indexed keywords

ACTIN; ACTIN RELATED PROTEIN 2-3 COMPLEX; ELEMENT; NCK PROTEIN; NEPHRIN; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PROTEIN SH3; ONCOPROTEIN; PROLINE; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL ADHESION; COMPUTER SIMULATION; CYTOSOL; GELATION; HUMAN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHASE SEPARATION; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN MOTIF; SEPARATION TECHNIQUE; SEQUENCE ANALYSIS; STATIC ELECTRICITY; CHEMISTRY; CONSERVED SEQUENCE; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CONSERVED SEQUENCE; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS; PROLINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL;

EID: 84947985485     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1508778112     Document Type: Article

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