Pharbilignan C induces apoptosis through a mitochondria-mediated intrinsic pathway in human breast cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 19, 2016, Pages 4645-4649

  Park, Yong Joo ^a   Choi, Chang Ik ^b   Chung, Kyu Hyuck ^a   Kim, Ki Hyun ^a  

^a Sungkyunkwan University   (South Korea)

^b Dongguk University   (South Korea)

Author keywords

Antiproliferative; Apoptosis; Intrinsic pathway; Pharbilignan C; Pharbitis nil

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 7; CASPASE 9; DOXORUBICIN; PHARBILIGNAN C; PLANT EXTRACT; PROCASPASE 3; PROCASPASE 9; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SENSITIVITY; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC50; IPOMOEA NIL; MCF 7 CELL LINE; MDA MB 231 CELL LINE; MITOCHONDRION; PLANT SEED; PROTEIN CLEAVAGE; UPREGULATION; WESTERN BLOTTING; BREAST TUMOR; DRUG EFFECTS; DRUG SCREENING; FEMALE; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BENZOFURANS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL;

EID: 84985952473     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.08.054     Document Type: Article

References (29)

1. 1 Agarwal, G., Pradeep, P.V., Aggarwal, V., Yip, C.H., Cheung, P.S., World J. Surg., 31, 2007, 1031.
2. 2 Abdullah, A.S., Mohammed, A.S., Abdullah, R., Mirghani, M.E., Al-Qubaisi, M., BMC Complement. Altern. Med., 14, 2014, 199.
3. 3 Looi, C.Y., Arya, A., Cheah, F.K., Muharram, B., Leong, K.H., Mohamad, K., Wong, W.F., Rai, N., Mustafa, M.R., PLoS One, 8, 2013, e56643.
4. 4 Zhang, Z., Teruya, K., Yoshida, T., Eto, H., Shirahata, S., Mar. Drugs, 11, 2013, 81.
5. 5 Kim, K.H., Kim, J.Y., Kwak, J.H., Pyo, S., Phytomedicine, 22, 2015, 820.
6. 6 Shao, Z.M., Shen, Z.Z., Fontana, J.A., Barsky, S.H., Anticancer Res., 20, 2000, 2409.
7. 7 Badve, S., Dabbs, D.J., Schnitt, S.J., Baehner, F.L., Decker, T., Eusebi, V., Fox, S.B., Ichihara, S., Jacquemier, J., Lakhani, S.R., Palacios, J., Rakha, E.A., Richardson, A.L., Schmitt, F.C., Tan, P.H., Tse, G.M., Weigelt, B., Ellis, I.O., Reis-Filho, J.S., Mod. Pathol., 24, 2011, 157.
8. 8 Banerjee, S., Reis-Filho, J.S., Ashley, S., Steele, D., Ashworth, A., Lakhani, S.R., Smith, I.E., J. Clin. Pathol., 59, 2006, 729.
9. 9 Xu, J., Loo, G.J., Cell. Biochem., 82, 2001, 78.
10. 10 Kim, K.H., Woo, K.W., Moon, E., Choi, S.U., Kim, S.Y., Choi, S.Z., Son, M.W., Lee, K.R., J. Agric. Food Chem., 62, 2014, 7746.
11. 11 Kim, K.H., Choi, S.U., Son, M.W., Choi, S.Z., Clardy, J., Lee, K.R., J. Nat. Prod., 76, 2013, 1376.
12. 12 Kim, K.H., Ha, S.K., Choi, S.U., Kim, S.Y., Lee, K.R., Chem. Pharm. Bull., 59, 2011, 1425.
13. 13 Kim, K.H., Choi, S.U., Son, M.W., Lee, K.R., Chem. Pharm. Bull., 58, 2010, 1532.
14. 14 Kim, K.H., Choi, S.U., Lee, K.R., J. Nat. Prod., 72, 2009, 1121.
15. 15 Bensky, D., Gamble, A., Chinese Herbal Medicine. revised ed., 1993, Materia Medica, Eastland Press, Seattle, 121.
16. 16 Lee, T.H., Choi, J.J., Kim, D.H., Choi, S., Lee, K.R., Son, M., Jin, M., Phytomedicine, 15, 2008, 836.
17. 17 Sun, Y.N., Wei, L., Song, S.B., Yan, X.T., Yang, S.Y., Kim, Y.H., Nat. Prod. Sci., 20, 2014, 232.
18. 18 Pieters, L., Van Dyck, S., Gao, M., Bai, R., Hamel, E., Vlietinck, A., Lemiere, G., J. Med. Chem., 42, 1999, 5475.
19. 19 Xu, H., Lv, M., Tian, X., Curr. Med. Chem., 16, 2009, 327.
20. 20 Mierta, S.V., Dyckb, S.V., Schmidtc, T.J., Brund, R., Vlietincka, A., Lemiereb, G., Pieters, L., Med. Chem., 13, 2005, 661.
21. 21 Bose, J.S., Gangan, V., Prakash, R., Jain, S.K., Manna, S.K., J. Med. Chem., 52, 2009, 3184.
22. 22 Yin, S.Y., Jian, F.Y., Chien, S.C., Hsieh, M.C., Hsiao, P.W., Lee, W.H., Lee, W.H., Kuo, Y.H., Yang, N.S., Nat. Commun., 7, 2016, 11909.
23. 23 Kim, S.J., Kim, A.K., J. Ginseng Res., 39, 2015, 125.
24. 24 Lin, Y., Jiang, D., Li, Y., Han, X., Yu, D., Park, J.H., Jin, Y.H., J. Ginseng Res., 39, 2015, 22.
25. 25 Oltvai, Z.N., Milliman, C.L., Korsmeyer, S.J., Cell, 74, 1993, 609.
26. 26 Gottlieb, E., Armour, S.M., Harris, M.H., Thompson, C.B., Cell Death Differ., 10, 2003, 709.
27. 27 Halestrap, A.P., Clarke, S.J., Javadov, S.A., Cardiovasc. Res., 61, 2004, 372.
28. 28 Martinou, J.C., Desagher, S., Antonsson, B., Nat. Cell Biol., 2, 2000, E41.
29. 29 Porter, A.G., Janicke, R.U., Cell Death Differ., 6, 1999, 99.