Influence of freeze-drying and γ-irradiation in preclinical studies of flurbiprofen polymeric nanoparticles for ocular delivery using d-(+)-trehalose and polyethylene glycol

International Journal of Nanomedicine

Volumn 11, Issue , 2016, Pages 4093-4106

  Ramos Yacasi, Gladys Rosario ^a   García López, María Luisa ^a   Espina García, Marta ^a   Parra Coca, Alexander ^a   Calpena Campmany, Ana Cristina ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

D (+) trehalose; Flurbiprofen; Freeze drying; Nanoparticles; Polyethylene glycol 3350; irradiation

Indexed keywords

DEXTRO TREHALOSE; FLURBIPROFEN; MACROGOL; TREHALOSE; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; MACROGOL 3350; MACROGOL DERIVATIVE; NANOPARTICLE; POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG PENETRATION; DRUG STABILITY; DRUG STERILITY; DRUG TOLERABILITY; EX VIVO STUDY; EYE INFLAMMATION; FLOW KINETICS; FREEZE DRYING; GAMMA RADIATION; IN VIVO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; PRECLINICAL STUDY; ANIMAL; CHEMISTRY; CHICKEN; CORNEA; DRUG EFFECTS; EYE; INFLAMMATION; INTRAOCULAR DRUG ADMINISTRATION; MALE; PIG; PROCEDURES;

ADMINISTRATION, OPHTHALMIC; ANIMALS; ANTI-INFLAMMATORY AGENTS; CHICKENS; CORNEA; EYE; FLURBIPROFEN; FREEZE DRYING; GAMMA RAYS; INFLAMMATION; MALE; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYMERS; RHEOLOGY; SWINE; TREHALOSE;

EID: 84985940551     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S105606     Document Type: Article

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