Role of hydroxypropyl-β-cyclodextrin on freeze-dried and gamma-irradiated PLGA and PLGA-PEG diblock copolymer nanospheres for ophthalmic flurbiprofen delivery

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 1357-1371

  Vega, Estefanía ^a   Antonia Egea M ^a   Calpena, Ana Cristina ^a   Espina, Marta ^a   Luisa Garcia M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

irradiation; Freeze drying; Hydroxypropyl cyclodextrin; Nanospheres; Poly(D,L lactide co glycolide); Poly(ethylene glycol)

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; FLURBIPROFEN; NANOSPHERE; POLY(LACTIDE CO GLYCOLIDE) POLY(ETHYLENE GLYCOL) NANOSPHERE; POLYGLACTIN; UNCLASSIFIED DRUG; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; CRYOPROTECTIVE AGENT; LACTIC ACID; MACROGOL DERIVATIVE; POLY(LACTIC GLYCOLIC ACID) POLY(ETHYLENEGLYCOL) COPOLYMER; POLY(LACTIC-GLYCOLIC ACID)-POLY(ETHYLENEGLYCOL) COPOLYMER; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA; CRYOPROTECTION; DRUG DIFFUSION; DRUG PENETRATION; DRUG TOLERANCE; DRUG UPTAKE; ENTRAPMENT EFFICIENCY; EX VIVO STUDY; FREEZE DRYING; GAMMA IRRADIATION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PARTICLE SIZE; PHARMACEUTICS; PHYSICAL CHEMISTRY; RABBIT; SUSTAINED DRUG RELEASE; THERMOSTABILITY; ZETA POTENTIAL; ANALYSIS OF VARIANCE; ANIMAL; CHEMISTRY; CORNEA EPITHELIUM; DRUG EFFECT; DRUG STABILITY; GAMMA RADIATION; INTRAOCULAR DRUG ADMINISTRATION; MALE; METABOLISM; RADIATION EXPOSURE;

ADMINISTRATION, OPHTHALMIC; ANALYSIS OF VARIANCE; ANIMALS; BETA-CYCLODEXTRINS; CORNEA; CRYOPROTECTIVE AGENTS; DRUG STABILITY; EPITHELIUM, CORNEAL; FLURBIPROFEN; FREEZE DRYING; GAMMA RAYS; LACTIC ACID; MALE; NANOSPHERES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYGLACTIN 910; POLYGLYCOLIC ACID; RABBITS;

EID: 84862327323     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S28481     Document Type: Article

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