Nanoemulsions for dermal controlled release of oleanolic and ursolic acids: In vitro, ex vivo and in vivo characterization

Colloids and Surfaces B: Biointerfaces

Volumn 130, Issue , 2015, Pages 40-47

  Alvarado, H L ^a   Abrego, G ^a   Souto, E B ^b,c   Garduno Ramirez M L ^d   Clares, B ^e   Garcia M L ^a   Calpena, A C ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d CENTRO DE INVESTIGACIONES QUÍMICAS   (Mexico)

^e UNIVERSITY OF GRANADA   (Spain)

Author keywords

Anti inflammatory activity; Nanoemulsion; Oleanolic acid; Topical administration; Ursolic acid

Indexed keywords

CARBOXYLIC ACIDS; OIL SHALE; PROPYLENE; SURFACE ACTIVE AGENTS;

ANTI-INFLAMMATORY ACTIVITY; FRANZ DIFFUSION CELLS; NANOEMULSION; OLEANOLIC ACIDS; PENTACYCLIC TRITERPENES; PSEUDOTERNARY PHASE DIAGRAMS; SYNTHETIC MIXTURES; URSOLIC ACID;

MIXTURES;

CASTOR OIL; COSURFACTANT; INDOMETACIN; LABRASOL; NATURAL PRODUCT; OLEANOLIC ACID; PENTACYCLIC TRITERPENE; PROPYLENE GLYCOL; TRANSCUTOL P; UNCLASSIFIED DRUG; URSOLIC ACID; DELAYED RELEASE FORMULATION; EMULSION; NANOPARTICLE; TRITERPENE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CHEMICAL COMPOSITION; CHEMICAL PARAMETERS; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DERMAL CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG ISOLATION; DRUG MECHANISM; DRUG PENETRATION; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; NANOEMULSION; NONHUMAN; OTITIS; PRIORITY JOURNAL; SKIN PENETRATION; SKIN TOXICITY; VISCOSITY; ADMINISTRATION AND DOSAGE; CHEMISTRY; CUTANEOUS DRUG ADMINISTRATION; DELAYED RELEASE FORMULATION; DRUG STABILITY; EMULSION; KINETICS; METABOLISM; PHARMACOKINETICS; PROCEDURES; SKIN; SKIN ABSORPTION; SOLUBILITY; TEMPERATURE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ADMINISTRATION, CUTANEOUS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; HUMANS; KINETICS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; OLEANOLIC ACID; SKIN; SKIN ABSORPTION; SOLUBILITY; TEMPERATURE; TRITERPENES; VISCOSITY;

EID: 84927943818     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2015.03.062     Document Type: Article

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