Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 19, 2016, Pages 4743-4747

  Yang, Shu Wei ^a   Pan, Jianping ^a   Yang, Christine ^a   Labroli, Marc ^a   Pan, Weidong ^a   Caldwell, John ^a   Ha, Sookhee ^a   Koseoglu, Sandra ^a   Xiao, Jing C ^a   Mayhood, Todd ^a   Sheth, Payal R ^a   Garlisi, Charles G ^a   Wu, Jin ^a   Lee, Sang Ho ^a   Wang, Hao ^a   Tan, Christopher M ^a   Roemer, Terry ^a   Su, Jing ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antibacterial; MRSA; Wall teichoic acid; WTA

Indexed keywords

ANTIINFECTIVE AGENT; BENZIMIDAZOLE DERIVATIVE; IMIPENEM; TEICHOIC ACID; UNCLASSIFIED DRUG; WALL TEICHOIC ACID BIOSYNTHESIS INHIBITOR;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BACTERICIDAL ACTIVITY; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; DRUG TARGETING; IC50; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN-RESISTANT STAPHYLOCOCCUS EPIDERMIDIS; NONHUMAN; PLASMA PROTEIN BINDING; RAT; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST;

ANIMALS; ANTI-BACTERIAL AGENTS; BENZIMIDAZOLES; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TEICHOIC ACIDS;

EID: 84985906090     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.08.036     Document Type: Article

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