Back to the drawing board: Understanding the complexity of hepatic innate lymphoid cells

European Journal of Immunology

Volumn 46, Issue 9, 2016, Pages 2095-2098

  Marotel, Marie ^a   Hasan, Uzma ^a   Viel, Sébastien ^a   Marçais, Antoine ^a   Walzer, Thierry ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

CXCR6; Innate immunity; Innate lymphoid cells (ILCs); Liver; NK cells

Indexed keywords

CELL MIGRATION; DNA BINDING MOTIF; HUMAN; IMMUNE RESPONSE; LIVER CELL; LYMPH VESSEL; LYMPHOID CELL; MEMORY T LYMPHOCYTE; NATURAL KILLER CELL; NONHUMAN; NOTE; PHENOTYPE; PRIORITY JOURNAL;

EID: 84985898480     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201646584     Document Type: Note

References (29)

1. Harmon, C., Robinson, M., Fahey, R., Whelan, S.-A., Houlihan, D., Geoghegan, J. and O'Farelly, C., The human adult liver is enriched with tissue-resident Eomes(hi) T-bet(lo) CD56(bright) natural killer cells with reduced pro-inflammatory potential. Eur. J. Immunol. 2016. 46: 2111–2120.
2. Franciszkiewicz, K., Salou, M., Legoux, F., Zhou, Q., Cui, Y., Bessoles, S. and Lantz, O., MHC class I-related molecule, MR1, and mucosal-associated invariant T cells. Immunol. Rev. 2016. 272: 120–138.
3. Godfrey, D. I., Uldrich, A. P., McCluskey, J., Rossjohn, J. and Moody, D. B., The burgeoning family of unconventional T cells. Nat. Immunol. 2015. 16: 1114–1123.
4. Lugthart, G., Melsen, J. E., Vervat, C., van Ostaijen-Ten Dam, M. M., Corver, W. E., Roelen, D. L., van Bergen, J. et al., Human lymphoid tissues harbor a distinct CD69+CXCR6+ NK cell population. J. Immunol. Baltim. Md. 1950 2016. 197: 78–84.
5. Melsen, J. E., Lugthart, G., Lankester, A. C. and Schilham, M. W., Human circulating and tissue-resident CD56 bright natural killer cell populations. NK Cell Biol. 2016. 262. DOI: 10.3389/fimmu.2016.00262.
6. Papaioannou, V. E., The T-box gene family: emerging roles in development, stem cells and cancer. Dev. Camb. Engl. 2014. 141: 3819–3833.
7. Gordon, S. M., Chaix, J., Rupp, L. J., Wu, J., Madera, S., Sun, J. C., Lindsten, T. et al., The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity 2012. 36: 55–67.
8. Pikovskaya, O., Chaix, J., Rothman, N. J., Collins, A., Chen, Y.-H., Scipioni, A. M., Vivier, E. et al., Cutting edge: eomesodermin is sufficient to direct type 1 innate lymphocyte development into the conventional NK lineage. J. Immunol. Baltim. Md. 1950 2016. 196: 1449–1454.
9. van Helden, M. J., Goossens, S., Daussy, C., Mathieu, A.-L., Faure, F., Marçais, A., Vandamme, N. et al., Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection. J. Exp. Med. 2015. 212: 2015–2025.
10. Koues, O. I., Collins, P. L., Cella, M., Robinette, M. L., Porter, S. I., Pyfrom, S. C., Payton, J. E. et al., Distinct gene regulatory pathways for human innate versus adaptive lymphoid cells. Cell 2016. 165: 1134–1146.
11. Stegmann, K. A., Robertson, F., Hansi, N., Gill, U., Pallant, C., Christophides, T., Pallett, L. J. et al., CXCR6 marks a novel subset of T-bet(lo)Eomes(hi) natural killer cells residing in human liver. Sci. Rep. 2016. 6: 26157.
12. Hudspeth, K., Donadon, M., Cimino, M., Pontarini, E., Tentorio, P., Preti, M., Hong, M. et al., Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways. J. Autoimmun. 2016. 66: 40–50.
13. Shiow, L. R., Rosen, D. B., N, B., Xu, Y., An, J., Lanier, L. L., Cyster, J. G. et al., CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs. Nature 2006. 440: 4.
14. Beura, L. K., Hamilton, S. E., Bi, K., Schenkel, J. M., Odumade, O. A., Casey, K. A., Thompson, E. A. et al., Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature 2016. 532: 512–516.
15. Moroso, V., Famili, F., Papazian, N., Cupedo, T., van der Laan, L. J. W., Kazemier, G., Metselaar, H. J. et al., NK cells can generate from precursors in the adult human liver. Eur. J. Immunol. 2011. 41: 3340–3350.
16. Daussy, C., Faure, F., Mayol, K., Viel, S., Gasteiger, G., Charrier, E., Bienvenu, J. et al., T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow. J. Exp. Med. 2014. 211: 563–577.
17. Thomas, S. Y., Scanlon, S. T., Griewank, K. G., Constantinides, M. G., Savage, A. K., Barr, K. A., Meng, F. et al., PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J. Exp. Med. 2011. 208: 88.
18. Pinhas, N., Sternberg-Simon, M., Chiossone, L., Shahaf, G., Walzer, T., Vivier, E. and Mehr, R., Murine peripheral NK-cell populations originate from site-specific immature NK cells more than from BM-derived NK cells. Eur. J. Immunol. 2016. 46: 1258–1270.
19. Björkström, N. K., Ljunggren, H.-G. and Michaëlsson, J., Emerging insights into natural killer cells in human peripheral tissues. Nat. Rev. Immunol. 2016. 16: 310–320.
20. Burt, B. M., Plitas, G., Zhao, Z., Bamboat, Z. M., Nguyen, H. M., Dupont, B. and DeMatteo, R. P., The lytic potential of human liver NK cells is restricted by their limited expression of inhibitory killer Ig-like receptors. J. Immunol. Baltim. Md. 1950 2009. 183: 1789–1796.
21. Takeda, K., Cretney, E., Hayakawa, Y., Ota, T., Akiba, H., Ogasawara, K., Yagita, H. et al., TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver. Blood 2005. 105: 9.
22. Rehermann, B., Natural killer cells in viral hepatitis. Cell. Mol. Gastroenterol. Hepatol. 2015. 1: 578–588.
23. Peppa, D., Gill, U. S., Reynolds, G., Easom, N. J. W., Pallett, L. J., Schurich, A., Micco, L. et al., Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion. J. Exp. Med. 2013. 210: 99–114.
24. Schuster, I. S., Wikstrom, M. E., Brizard, G., Coudert, J. D., Estcourt, M. J., Manzur, M., O'Reilly, L. A. et al., TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity. Immunity 2014. 41: 646–656.
25. Harmon, C., Sanchez-Fueyo, A., O'Farrelly, C. and Houlihan, D. D., Natural killer cells and liver transplantation: orchestrators of rejection or tolerance? Am. J. Transplant. Off. J. Am. Soc. Transplant. Am. Soc. Transpl. Surg. 2016. 16: 751–757.
26. Fasbender, F., Widera, A., Hengstler, J. G. and Watzl, C., Natural Killer Cells and Liver Fibrosis. Front. Immunol. 2016. 7: 19.
27. Klose, C. S. N. and Artis, D., Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis. Nat. Immunol. 2016. 17: 765–774.
28. O'Sullivan, T. E., Sun, J. C. and Lanier, L. L., Natural Killer Cell Memory. Immunity 2015. 43: 634–645.
29. Marquardt, N., Béziat, V., Nyström, S., Hengst, J., Ivarsson, M. A., Kekäläinen, E., Johansson, H. et al., Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J. Immunol. Baltim. Md. 1950 2015. 194: 2467–2471.