The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli

Journal of Infectious Diseases

Volumn 214, Issue 6, 2016, Pages 916-924

  Garcie, Christophe ^a,b   Tronnet, Sophie ^b   Garénaux, Amélie ^d   McCarthy, Alex J ^e   Brachmann, Alexander O ^f   Pénary, Marie ^b   Houle, Sébastien ^d   Nougayrède, Jean Philippe ^b   Piel, Jörn ^f   Taylor, Peter W ^e   Dozois, Charles M ^d   Genevaux, Pierre ^c   Oswald, Eric ^a,b   Martin, Patricia ^a,b  

^a TOULOUSE UNIVERSITY HOSPITAL   (France)

^b UMR 1220 TCEM (INRA ENITAB)   (France)

^c CNRS   (France)

^d INRS INSTITUT ARMAND FRAPPIER   (Canada)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f ETH ZURICH   (Switzerland)

Author keywords

colibactin; Escherichia coli; heat shock proteins; Hsp90; HtpG; meningitis; siderophores; stress response; virulence; yersiniabactin

Indexed keywords

COLIBACTIN; HEAT SHOCK PROTEIN 90; HISTONE H2AX; POLYKETIDE; SIDEROPHORE; UNCLASSIFIED DRUG; YERSINIABACTIN; ENDOPEPTIDASE CLP; ESCHERICHIA COLI PROTEIN; HTPG PROTEIN, E COLI; MUTAGENIC AGENT; PEPTIDE; PHENOL DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; ESCHERICHIA COLI; FEMALE; GENOTOXICITY; HEAT SHOCK; HEAT STRESS; HOST PATHOGEN INTERACTION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; ANIMAL; C57BL MOUSE; DISEASE MODEL; ESCHERICHIA COLI INFECTION; GENE DELETION; GENETICS; METABOLISM; MICROBIOLOGY; PATHOLOGY; PROTEIN ANALYSIS; VIRULENCE; WISTAR RAT;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOPEPTIDASE CLP; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; FEMALE; GENE DELETION; HSP90 HEAT-SHOCK PROTEINS; MICE, INBRED C57BL; MUTAGENS; PEPTIDES; PHENOLS; POLYKETIDES; PROTEIN INTERACTION MAPPING; RATS, WISTAR; SIDEROPHORES; THIAZOLES; VIRULENCE;

EID: 84985030772     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiw294     Document Type: Article

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