Prevention and Cure of Systemic Escherichia coli K1 Infection by Modification of the Bacterial Phenotype

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 5, 2004, Pages 1503-1508

  Mushtaq, Naseem ^a   Redpath, Maria B ^a   Luzio, J Paul ^b   Taylor, Peter W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIUM K1 ANTIGEN; ENDOSIALIDASE E; POLYSIALIC ACID; RECOMBINANT ENZYME; SIALIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CELL; BACTERIAL MEMBRANE; BACTERIAL STRAIN; BACTERIOPHAGE; CONTROLLED STUDY; DEPOLYMERIZATION; ENTEROBACTER INFECTION; ESCHERICHIA COLI; MENINGITIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SEPSIS;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, BACTERIAL; BACTERIOPHAGES; COMPLEMENT SYSTEM PROTEINS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; MENINGITIS, ESCHERICHIA COLI; NEURAMINIDASE; PLASMIDS; POLYSACCHARIDES, BACTERIAL; RATS; RECOMBINANT PROTEINS;

EID: 2142758676     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.5.1503-1508.2004     Document Type: Article

References (31)

1. Achtman, M., A. Mercer, B. Kusecek, A. Pohl, M. Heuzenroeder, W. Aaronson, A. Sutton, and R. P. Silver. 1983. Six widespread bacterial clones among Escherichia coli K1 isolates. Infect. Immun. 39:315-335.
2. Avery, O. T., and R. Dubos. 1931. The protective action of a specific enzyme against type III pneumococcus infection in mice. J. Exp. Med. 54:73-89.
3. Cross, A. S. 1990. The biologic significance of bacterial encapsulation. Curr. Top. Microbiol. Immunol. 150:87-95.
4. Dubos, R., and O. T. Avery. 1931. Decomposition of the capsular polysaccharide of pneumococcal type III by a bacterial enzyme. J. Exp. Med. 54: 51-71.
5. Glode, M. P., A. Sutton, E. R. Moxon, and J. B. Robbins. 1977. Pathogenesis of neonatal Escherichia coli meningitis: induction of bacteremia and meningitis in infant rats fed E. coli K1. Infect. Immun. 16:75-80.
6. Goodner, K., R. Dubos, and O. T. Avery. 1932. The action of a specific enzyme upon the dermal infection of rabbits with type III pneumococcus. J. Exp. Med. 55:393-404.
7. Greenwood, D. 1997. Modes of action, p. 10-22. In F. O'Grady, H. P. Lambert, R. G. Finch, and D. Greenwood (ed.), Antibiotics and chemotherapy, 7th ed. Churchill Livingstone, New York, N.Y.
8. Gross, R. J., T. Cheasty, and B. Rowe. 1977. Isolation of bacteriophages specific for the K1 polysaccharide antigen of Escherichia coli. J. Clin. Microbiol. 6:548-550.
9. Kim, K. S. 2003. Pathogenesis of bacterial meningitis: from bacteraemia to neuronal injury. Nat. Rev. Neurosci. 4:376-385.
10. Kim, K. J., S. J. Elliott, F. Di Cello, M. F. Stins, and K. S. Kim. 2003. The K1 capsule modulates trafficking of E. coli-containing vacuoles and enhances intracellular bacterial survival in human brain microvascular endothelial cells. Cell. Microbiol. 5:245-252.
11. Kolb-Mäurer, A., A. Umkmeir, U. Kämmerer, C. Hübner, T. Leimbach, A. Stade, E. Kämpgen, M. Frosch, and G. Dietrich. 2001. Interaction of Neisseria meningitidis with human dendritic cells. Infect. Immun. 69:6912-6922.
12. Korhonen, T. K., M. V. Valtonen, J. Parkkinen, V. Vaisanen-Rhen, J. Finne, F. Orskov, I. Orskov, S. B. Svenson, and P. H. Makela. 1985. Serotypes, hemolysin production, and receptor recognition of Escherichia coli strains associated with neonatal sepsis and meningitis. Infect. Immun. 48:486-491.
13. Kornelisse, R. F., R. de Groot, and H. J. Neijens. 1995. Bacterial meningitis: mechanisms of disease and therapy. Eur. J. Pediatr. 154:85-96.
14. Kwiatkowski, B., B. Boschek, H. Thiele, and S. Stirm. 1982. Endo-N-acetyl-neuraminidase associated with bacteriophage particles. J. Virol. 43:697-704.
15. Leggate, D. R., J. M. Bryant, M. B. Redpath, D. Head, P. W. Taylor, and J. P. Luzio. 2002. Expression, mutagenesis and kinetic analysis of recombinant K1E endosialidase to define the site of proteolytic processing and requirements for catalysis. Mol. Microbiol. 44:749-760.
16. Loeffler, J. M., D. Nelson, and V. A. Fischetti. 2001. Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase. Science 294: 2170-2172.
17. Long, G. S., J. M. Bryant, P. W. Taylor, and J. P. Luzio. 1995. Complete nucleotide sequence of the gene encoding bacteriophage E endosialidase: implications for K1E endosialidase structure and function. Biochem. J. 309: 543-550.
18. McGowen, M. M., J. Vionnet, and W. F. Vann. 2001. Elongation of alternating α2,8/2,9 polysialic acid by the Escherichia coli K92 polysialiyltransferase. Glycobiology 11:613-620.
19. Moxon, E. R., and J. S. Kroll. 1990. The role of bacterial polysaccharide capsules as virulence factors. Curr. Top. Microbiol. Immunol. 150:65-85.
20. Pluschke, G., A. Mercer, B. Kusecek, A. Pohl, and M. Achtman. 1983. Induction of bacteremia in newborn rats by Escherichia coli K1 is correlated with only certain O (lipopolysaccharide) antigen types. Infect. Immun. 39: 599-608.
21. Polin, R. A., and M. C. Harris. 2001. Neonatal bacterial meningitis. Semin. Neonatol. 6:157-172.
22. Schuch, R., D. Nelson, and V. A. Fischetti. 2002. A bacteriolytic agent that detects and kills Bacillus anthracis. Nature 418:884-889.
23. Seki, T., and Y. Arai. 1993. Distribution and possible roles of the highly polysialated neural cell adhesion molecule (NCAM-H) in the developing and adult nervous system. Neurosci. Res. 17:265-290.
24. Tan, Y.-T., D. J. Tillett, and I. A. McKay. 2000. Molecular strategies for overcoming antibiotic resistance in bacteria. Mol. Med. Today 6:309-314.
25. Taylor, P. W. 1976. Immunochemical investigations on lipopolysaccharides and acidic polysaccharides from serum-sensitive and serum-resistant strains of Escherichia coli isolated from urinary-tract infections. J. Med. Microbiol. 9:405-421.
26. Taylor, P. W. 1993. Non-immunoglobulin activators of the complement system, p. 37-68. In R. B. Sim (ed.), Activators and inhibitors of complement. Kluwer, Dordrecht, The Netherlands.
27. Taylor, P. W. 1995. Resistance of bacteria to complement, p. 49-64. In J. A. Roth, C. A. Bolin, K. A. Brogden, F. C. Minion, and M. J. Wannemuehler (ed.), Virulence mechanisms of bacterial pathogens. American Society for Microbiology, Washington, D.C.
28. Taylor, P. W., P. D. Stapleton, and J. P. Luzio. 2002. New ways to treat bacterial infections. Drug Disc. Today 7:1086-1091.
29. Tomlinson, S., and P. W. Taylor. 1985. Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide. J. Virol. 55:374-378.
30. Troy, F. A. 1992. Polysialylation: from bacteria to brains. Glycobiology 2:5-23.
31. Williams, A. J., and Nadel, S. 2001. Bacterial meningitis: current controversies in approaches to treatment. CNS Drugs 15:909-919.