Null allele mutants of trt-1, the catalytic subunit of telomerase in Caenorhabditis elegans, are less sensitive to Mn-induced toxicity and DAergic degeneration

NeuroToxicology

Volumn 57, Issue , 2016, Pages 54-60

  Ijomone, Omamuyovwi M ^a,b,c   Miah, Mahfuzur R ^b   Peres, Tanara V ^b   Nwoha, Polycarp U ^c   Aschner, Michael ^b  

^a CROSS RIVER UNIVERSITY OF TECHNOLOGY   (Nigeria)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

Author keywords

C. elegans; DAergic degeneration; Manganese; Telomerase; trt 1

Indexed keywords

GREEN FLUORESCENT PROTEIN; MANGANESE; MANGANESE CHLORIDE; SODIUM CHLORIDE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE REVERSE TRANSCRIPTASE 1; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; CHLORIDE; DAT-1 PROTEIN, C ELEGANS; DOPAMINE; DOPAMINE TRANSPORTER; MANGANESE DERIVATIVE; TYROSINE 3 MONOOXYGENASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASAL SLOWING RESPONSE; BEHAVIOR; CAENORHABDITIS ELEGANS; CHEMOTAXIS; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; ENZYME ACTIVE SITE; GENE; HYPERSENSITIVITY; INTOXICATION; LARVAL STAGE; LETHALITY; MUTANT; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; NULL ALLELE; PARASITE SURVIVAL; PRIORITY JOURNAL; PROTEIN FUNCTION; TRT 1 GENE; WILD TYPE; ANIMAL; CHEMICALLY INDUCED; DEGENERATIVE DISEASE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INSTRUMENTAL CONDITIONING; LOCOMOTION; METABOLISM; MORTALITY; MUTATION; PHYSIOLOGY; SURVIVAL ANALYSIS; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHLORIDES; CONDITIONING, OPERANT; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; LOCOMOTION; MANGANESE COMPOUNDS; MUTATION; NEURODEGENERATIVE DISEASES; SURVIVAL ANALYSIS; TELOMERASE; TYROSINE 3-MONOOXYGENASE;

EID: 84985028744     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2016.08.016     Document Type: Article

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