Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells

NeuroToxicology

Volumn 57, Issue , 2016, Pages 45-53

  Begum, Aynun N ^a   Aguilar, Jose S ^a   Elias, Lourdes ^a   Hong, Yiling ^a  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Glutamatergic neurons; Human embryonic stem cells; Neurodegeneration; Neurodifferentiation; Neurotoxicity; Silver nanoparticle

Indexed keywords

3 NITROTYROSINE; CALCIUM ION; CALMODULIN; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; MICROTUBULE ASSOCIATED PROTEIN 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEURONAL NITRIC OXIDE SYNTHASE; POSTSYNAPTIC DENSITY PROTEIN 95; POVIDONE; REACTIVE OXYGEN METABOLITE; SILVER NANOPARTICLE; TAU PROTEIN; VESICULAR GLUTAMATE TRANSPORTER 1; 3-NITROTYROSINE; CALCIUM; GLUTAMATE RECEPTOR; GLUTAMIC ACID DERIVATIVE; METAL NANOPARTICLE; NERVE PROTEIN; SILVER; TYROSINE;

ARTICLE; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXCITOTOXICITY; GLUTAMATERGIC NEURON; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN EMBRYONIC STEM CELL; IMMUNOCYTOCHEMISTRY; NERVE CELL; NERVE FIBER GROWTH; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL SIZE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; NEURITE; SIGNAL TRANSDUCTION; TIME FACTOR; TRANSFORMED CELL LINE;

CALCIUM; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; CELL SIZE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMATES; HUMAN EMBRYONIC STEM CELLS; HUMANS; L-LACTATE DEHYDROGENASE; METAL NANOPARTICLES; NERVE TISSUE PROTEINS; NEURITES; NEURONS; NITRIC OXIDE SYNTHASE TYPE I; REACTIVE OXYGEN SPECIES; RECEPTORS, GLUTAMATE; SIGNAL TRANSDUCTION; SILVER; TIME FACTORS; TYROSINE; VESICULAR GLUTAMATE TRANSPORT PROTEIN 1;

EID: 84985004238     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2016.08.015     Document Type: Article

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