Ferulic acid ameliorates tnbs-induced ulcerative colitis through modulation of cytokines, oxidative stress, inos, cox-2, and apoptosis in laboratory rats

EXCLI Journal

Volumn 15, Issue , 2016, Pages 482-499

  Sadar, Smeeta S ^a   Vyawahare, Niraj S ^a   Bodhankar, Subhash L ^b  

^a Padmashree Dr D Y Patil College of Pharmacy   (India)

^b BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

Author keywords

Apoptosis; COX 2; Ferulic acid; IL 1 ; IL 6; INOs; TNBS induced colitis; TNF

Indexed keywords

CYCLOOXYGENASE 2; FERULIC ACID; HYDROXYPROLINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MYELOPEROXIDASE; SALAZOSULFAPYRIDINE; TUMOR NECROSIS FACTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOCHEMICAL COMPOSITION; BODY WEIGHT; COLON WEIGHT TO LENGTH RATIO; CONTROLLED STUDY; COX 2 GENE; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME SYNTHESIS; FECES ANALYSIS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; IL 1BETA GENE; IL 6 GENE; IMMUNOMODULATION; INHIBITION KINETICS; INOS GENE; MOLECULAR MODEL; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; RAT; SCORING SYSTEM; STOMACH PARAMETERS; TNF ALPHA GENE; ULCER AREA; ULCERATION INDEX; ULCERATIVE COLITIS; UPREGULATION;

EID: 84984868896     PISSN: None     EISSN: 16112156     Source Type: Journal    
DOI: 10.17179/excli2016-393     Document Type: Article

References (64)

1. Adil M, Visnagri A, Kumar VS, Kandhare AD, Ghosh P, Bodhankar SL.Protective effect of naringin on sodium arsenite induced testicular toxicity via modulation of biochemical perturbations in experimental rats.Pharmacologia.2014;5:222-34.
2. Andres PG, Friedman LS.Epidemiology and the natural course of inflammatory bowel disease.Gastroenterol Clin North Am.1999;28:255-81, vii.
3. Aswar UM, Kandhare AD, Mohan V, Thakurdesai PA.Anti-allergic effect of intranasal administration of type-A procyanidin polyphenols based standardized extract of cinnamon bark in ovalbumin sensitized BALB/c mice.Phytother Res.2015;29:423-33.
4. Balasubashini MS, Rukkumani R, Viswanathan P, Menon VP.Ferulic acid alleviates lipid peroxidation in diabetic rats.Phytother Res.2004;18:310-4.
5. Barros MP, Lemos M, Maistro EL, Leite MF, Sousa JP, Bastos JK, et al.Evaluation of antiulcer activity of the main phenolic acids found in Brazilian Green Propolis.J Ethnopharmacol.2008;120:372-7.
6. Baskaran N, Manoharan S, Balakrishnan S, Pugalendhi P.Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats.Eur J Pharmacol.2010;637:22-9.
7. Ben-Arye E, Goldin E, Wengrower D, Stamper A, Kohn R, Berry E.Wheat grass juice in the treatment of active distal ulcerative colitis: a randomized double-blind placebo-controlled trial.Scand J Gastroenterol.2002;37:444-9.
8. Berg DJ, Davidson N, Kuhn R, Muller W, Menon S, Holland G, et al.Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.J Clin Invest.1996;98:1010-20.
9. Besseau S, Hoffmann L, Geoffroy P, Lapierre C, Pollet B, Legrand M.Flavonoid Accumulation in Arabidopsis Repressed in Lignin Synthesis Affects Auxin Transport and Plant Growth.The Plant Cell.2007;19:148-62.
10. Bischoff SC, Lorentz A, Schwengberg S, Weier G, Raab R, Manns MP.Mast cells are an important cellular source of tumour necrosis factor alpha in human intestinal tissue.Gut.1999;44:643-52.
11. Bossone C, Hosseini JM, Pineiro-Carrero V, Shea- Donohue T.Alterations in spontaneous contractions in vitro after repeated inflammation of rat distal colon.Am J Physiol.2001;280:G949-57.
12. Bourne LC, Rice-Evans C.Bioavailability of ferulic acid.Biochem Biophys Res Commun.1998;253:222-7.
13. Chawla AS, Singh M, Murthy MS, Gupta M, Singh H.Anti-inflammatory action of ferulic acid and its esters in carrageenan induced rat paw oedema model.Indian J Exp Biol.1987;25:187-9.
14. de Faria FM, Luiz-Ferreira A, Socca EA, de Almeida AC, Dunder RJ, Manzo LP, et al.Effects of Rhizophora mangle on experimental colitis induced by TNBS in rats.Evid Based Complement Alternat Med.2012;2012:753971.
15. Dijkstra G, Moshage H, van Dullemen HM, de Jager- Krikken A, Tiebosch AT, Kleibeuker JH, et al.Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease.J Pathol.1998;186:416-21.
16. D'Odorico A, Bortolan S, Cardin R, D'Inca R, Martines D, Ferronato A, et al.Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease.Scand J Gastroenterol.2001;36:1289-94.
17. Fernandez-Banares F, Hinojosa J, Sanchez-Lombrana JL, Navarro E, Martinez-Salmeron JF, Garcia-Puges A, et al.Randomized clinical trial of Plantago ovate seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis.Spanish Group for the Study of Crohn's Disease and Ulcerative Colitis (GETECCU).Am J Gastroenterol.1999;94:427-33.
18. Ghaisas MM, Kshirsagar SB, Sahane RS.Evaluation of wound healing activity of ferulic acid in diabetic rats.Int Wound J.2014;11:523-32.
19. Grisham MB, Pavlick KP, Laroux FS, Hoffman J, Bharwani S, Wolf RE.Nitric oxide and chronic gut inflammation: controversies in inflammatory bowel disease.J Investig Med.2002;50:272-83.
20. Gupta I, Parihar A, Malhotra P, Gupta S, Ludtke R, Safayhi H, et al.Effects of gum resin of Boswellia serrata in patients with chronic colitis.Planta Med.2001;67:391-5.
21. Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, et al.Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, doubleblind, placebo-controlled trial.Clin Gastroenterol Hepatol.2006;4:1502-6.
22. Hilsden RJ, Verhoef MJ, Rasmussen H, Porcino A, DeBruyn JC.Use of complementary and alternative medicine by patients with inflammatory bowel disease.Inflamm Bowel Dis.2011;17:655-62.
23. Hoffmann JC, Pawlowski NN, Kuhl AA, Hohne W, Zeitz M.Animal models of inflammatory bowel disease: an overview.Pathobiology.2002;70:121-30.
24. Honmore V, Kandhare A, Zanwar AA, Rojatkar S, Bodhankar S, Natu A.Artemisia pallens alleviates acetaminophen induced toxicity via modulation of endogenous biomarkers.Pharm Biol.2015;53:571-81.
25. Horvath K, Varga C, Berko A, Posa A, Laszlo F, Whittle BJ.The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis.Eur J Pharmacol.2008;581:315-23.
26. Hyam SR, Jang SE, Jeong JJ, Joh EH, Han MJ, Kim DH.Echinocystic acid, a metabolite of lancemaside A, inhibits TNBS-induced colitis in mice.Int Immunopharmacol.2013;15:433-41.
27. Islam MS, Murata T, Fujisawa M, Nagasaka R, Ushio H, Bari AM, et al.Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice.Br J Pharmacol.2008;154: 812-24.
28. Joshi R, Kumar S, Unnikrishnan M, Mukherjee T.Free radical scavenging reactions of sulfasalazine, 5- aminosalicylic acid and sulfapyridine: mechanistic aspects and antioxidant activity.Free Radic Res.2005;39:1163-72.
29. Kandhare AD, Raygude KS, Ghosh P, Gosavi TP, Bodhankar SL.Patentability of animal models: India and the globe.Int J Pharm Biol Arch.2011;2:1024-32.
30. Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL.Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy.Fitoterapia.2012a;83:650-9.
31. Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL.Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals.Neurosci Lett.2012b;511:18-22.
32. Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Gosavi TP, Badole SL, et al.Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats.Asian Pac J Trop Biomed.2012c;2:337-44.
33. Kandhare AD, Ghosh P, Ghule AE, Zambare GN, Bodhankar SL.Protective effect of Phyllanthus amarus by modulation of endogenous biomarkers and DNA damage in acetic acid induced ulcerative colitis: Role of phyllanthin and hypophyllanthin.Apollo Med.2013;10:87-97.
34. Kandhare AD, Shivakumar V, Rajmane A, Ghosh P, Bodhankar SL.Evaluation of the neuroprotective effect of chrysin via modulation of endogenous biomarkers in a rat model of spinal cord injury.J Nat Med.2014;68:586-603.
35. Kandhare AD, Bodhankar SL, Mohan V, Thakurdesai PA.Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: Decisive role of Bax, Nrf2, NFkappaB, Muc5ac, TNF-alpha and IL-1beta.Chem Biol Interact.2015a;237:151-65.
36. Kandhare AD, Patil MV, Bodhankar SL.L-Arginine attenuates the ethylene glycol induced urolithiasis in ininephrectomized hypertensive rats: role of KIM-1, NGAL, and NOs.Ren Fail.2015b;37:709-21.
37. Kandhare AD, Patil A, Guru A, Mukhrjee A, Sarkar A, Sengupta A, et al.Ameliorative effect of ferulic acid against acetic acid induced ulcerative colitis: Role of HO-1 and Nrf2.Pharmacologia.2016;7:114-24.
38. Kanski J, Aksenova M, Stoyanova A, Butterfield DA.Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structureactivity studies.J Nutr Biochem.2002;13:273-81.
39. Kaplan GG.The global burden of IBD: from.2015 to.2025.Nat Rev Gastroenterol Hepatol.2015;12:720-7.
40. Karamac M, Bucinski A, Pegg R, Amarowicz R.Antioxidant and antiradical activity of ferulates.Czech J Food Sci.2005;23:64-8.
41. Keshavarzian A, Morgan G, Sedghi S, Gordon JH, Doria M.Role of reactive oxygen metabolites in experimental colitis.Gut.1990;31:786-90.
42. Kim JM, Jung HY, Lee JY, Youn J, Lee CH, Kim KH.Mitogen-activated protein kinase and activator protein-1 dependent signals are essential for Bacteroides fragilis enterotoxin-induced enteritis.Eur J Immunol.2005;35:2648-57.
43. Kumar N, Pruthi V.Potential applications of ferulic acid from natural sources.Biotechnol Rep.2014;4:86-93.
44. Kumar N, Pruthi V.Structural elucidation and molecular docking of ferulic acid from Parthenium hysterophorus possessing COX-2 inhibition activity.3 Biotech.2015;5:541-51.
45. Kumar VS, Rajmane AR, Adil M, Kandhare AD, Ghosh P, Bodhankar SL.Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats.J Biomed Res.2014;28:132-45.
46. Langmead L, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, et al.Randomized, doubleblind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis.Aliment Pharmacol Ther.2004;19:739-47.
47. Li X, Yang X, Cai Y, Qin H, Wang L, Wang Y, et al.Proanthocyanidins from grape seeds modulate the NF-kappa B signal transduction pathways in rats with TNBS-induced ulcerative colitis.Molecules.2011;16: 6721-31.
48. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A.Interleukin-10 and the interleukin-10 receptor.Annu Rev Immunol.2001;19:683-765.
49. Motawi TK, Rizk SM, Shehata AH.Effects of curcumin and Ginkgo biloba on matrix metalloproteinases gene expression and other biomarkers of inflammatory bowel disease.J Physiol Biochem.2012;68:529-39.
50. Nenadis N, Zhang HY, Tsimidou MZ.Structureantioxidant activity relationship of ferulic acid derivatives: effect of carbon side chain characteristic groups.J Agric Food Chem.2003;51:1874-9.
51. Ng SC, Lam YT, Tsoi KK, Chan FK, Sung JJ, Wu JC.Systematic review: the efficacy of herbal therapy in inflammatory bowel disease.Aliment Pharmacol Ther.2013;38:854-63.
52. Ogiwara T, Satoh K, Kadoma Y, Murakami Y, Unten S, Atsumi T, et al.Radical scavenging activity and cytotoxicity of ferulic acid.Anticancer Res.2001;22: 2711-7.
53. Ojha S, Javed H, Azimullah S, Abul Khair SB, Haque ME.Neuroprotective potential of ferulic acid in the rotenone model of Parkinson's disease.Drug Des Develop Ther.2015;9:5499-510.
54. Randhawa PK, Singh K, Singh N, Jaggi AS.A review on chemical-induced inflammatory bowel disease models in rodents.Korean J Physiol Pharmacol.2014;18:279-88.
55. Raygude KS, Kandhare AD, Ghosh P, Bodhankar SL.Anticonvulsant effect of fisetin by modulation of endogenous biomarkers.Biomed Prev Nutr.2012a;2: 215-22.
56. Raygude KS, Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL.Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats.Inflammopharmacology.2012b; 20:331-41.
57. Rojas-Cartagena C, Flores I, Appleyard CB.Role of tumor necrosis factor receptors in an animal model of acute colitis.Cytokine.2005;32:85-93.
58. Sandborn WJ, Targan SR, Byers VS, Rutty DA, Mu H, Zhang X, et al.Andrographis paniculata extract (HMPL-004) for active ulcerative colitis.Am J Gastroenterol.2013;108:90-8.
59. Tountas NA, Casini-Raggi V, Yang H, Di Giovine FS, Vecchi M, Kam L, et al.Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis.Gastroenterology.1999;117:806-13.
60. Triantafyllidi A, Xanthos T, Papalois A, Triantafillidis JK.Herbal and plant therapy in patients with inflammatory bowel disease: Ann Gastroenterol.2015;28:210-20.
61. Vauzour D, Rodriguez-Mateos A, Corona G, Oruna- Concha MJ, Spencer JP.Polyphenols and human health: prevention of disease and mechanisms of action.Nutrients.2010;2:1106-31.
62. 2-induced intestinal cell apoptosis in vitro.Int J Mol Med.2015;35:1699-707.
63. Witaicenis A, Luchini AC, Hiruma-Lima CA, Felisbino SL, Garrido-Mesa N, Utrilla P, et al.Suppression of TNBS-induced colitis in rats by 4-methylesculetin, a natural coumarin: comparison with prednisolone and sulphasalazine.Chem Biol Interact.2012;195:76-85.
64. Yamada T, Grisham MB.Role of neutrophil-derived oxidants in the pathogenesis of intestinal inflammation.Klin Wochenschr.1991;69:988-94.