E3 ubiquitin ligases for MHC molecules

Current Opinion in Immunology

Volumn 21, Issue 1, 2009, Pages 78-83

  Ishido, Satoshi ^a   Goto, Eiji ^a   Matsuki, Yohei ^a   Ohmura Hoshino, Mari ^a  

^a RIKEN Center for Integrative Medical Sciences   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN; PROTEIN MARCH 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; LYSOSOME; REVIEW; VIRUS INFECTION;

ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS; HUMANS; IMMUNITY, CELLULAR; PROTEIN TRANSPORT; RING FINGER DOMAINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; VIRAL PROTEINS; VIRULENCE; VIRUS DISEASES; VIRUSES;

EID: 64049087818     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2009.01.002     Document Type: Review

References (42)

1. Hershko A., and Ciechanover A. The ubiquitin system. Annu Rev Biochem 67 (1998) 425-479
2. Laney J.D., and Hochstrasser M. Substrate targeting in the ubiquitin system. Cell 97 (1999) 427-430
3. Joazeiro C.A., and Weissman A.M. RING finger proteins: mediators of ubiquitin ligase activity. Cell 102 (2000) 549-552
4. Coscoy L., and Ganem D. PHD domains and E3 ubiquitin ligases: viruses make the connection. Trends Cell Biol 13 (2003) 7-12
5. Ohmura-Hoshino M., Goto E., Matsuki Y., Aoki M., Mito M., Uematsu M., Hotta H., and Ishido S. A novel family of membrane-bound e3 ubiquitin ligases. J Biochem (Tokyo) 140 (2006) 147-154
6. Ishido S., Wang C., Lee B.S., Cohen G.B., and Jung J.U. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins. J Virol 74 (2000) 5300-5309
7. Coscoy L., and Ganem D. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis. Proc Natl Acad Sci U S A 97 (2000) 8051-8056
8. Stevenson P.G., Efstathiou S., Doherty P.C., and Lehner P.J. Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses. Proc Natl Acad Sci U S A 97 (2000) 8455-8460
9. Haque M., Ueda K., Nakano K., Hirata Y., Parravicini C., Corbellino M., and Yamanishi K. Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8. J Gen Virol 82 (2001) 1175-1180
10. Mansouri M., Bartee E., Gouveia K., Hovey Nerenberg B.T., Barrett J., Thomas L., Thomas G., McFadden G., and Fruh K. The PHD/LAP-domain protein M153R of myxomavirus is a ubiquitin ligase that induces the rapid internalization and lysosomal destruction of CD4. J Virol 77 (2003) 1427-1440
11. Fruh K., Bartee E., Gouveia K., and Mansouri M. Immune evasion by a novel family of viral PHD/LAP-finger proteins of gamma-2 herpesviruses and poxviruses. Virus Res 88 (2002) 55-69
12. •], these are the first reports of MARCH family members. Also, these reports led to the discovery of a physiological E3 for MHC class II.
13. •].
14. Holzerlandt R., Orengo C., Kellam P., and Alba M.M. Identification of new herpesvirus gene homologs in the human genome. Genome Res 12 (2002) 1739-1748
15. Alcami A., and Koszinowski U.H. Viral mechanisms of immune evasion. Immunol Today 21 (2000) 447-455
16. Choi J., Means R.E., Damania B., and Jung J.U. Molecular piracy of Kaposi's sarcoma associated herpesvirus. Cytokine Growth Factor Rev 12 (2001) 245-257
17. Matsuki Y., Ohmura-Hoshino M., Goto E., Aoki M., Mito-Yoshida M., Uematsu M., Hasegawa T., Koseki H., Ohara O., Nakayama M., et al. Novel regulation of MHC class II function in B cells. EMBO J 26 (2007) 846-854. This is the first paper demonstrating that MHC class II is regulated by MARCH-I-mediated ubiquitination in the steady state in mice.
18. De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., and Gatti E. MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc Natl Acad Sci U S A 105 (2008) 3491-3496. This is the first paper demonstrating that in human dendritic cells, MHC class II is regulated by MARCH-I, and that activating stimuli decrease MHC II ubiquitination by inhibiting MARCH-I expression.
19. Thibodeau J., Bourgeois-Daigneault M.C., Huppe G., Tremblay J., Aumont A., Houde M., Bartee E., Brunet A., Gauvreau M.E., de Gassart A., et al. Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. Eur J Immunol 38 (2008) 1225-1230. This is the first paper demonstrating that MARCH-I expression is regulated by cytokines that inhibit antigen presentation.
20. Coscoy L. Immune evasion by Kaposi's sarcoma-associated herpesvirus. Nat Rev Immunol 7 (2007) 391-401. This is an excellent review of recent progress on KSHV-mediated immune modulation.
21. Stevenson P.G., May J.S., Smith X.G., Marques S., Adler H., Koszinowski U.H., Simas J.P., and Efstathiou S. K3-mediated evasion of CD8(+) T cells aids amplification of a latent gamma-herpesvirus. Nat Immunol 3 (2002) 733-740. This is an important study showing the pathological relevance of viral MIRs in the context of infection.
22. Smith C.M., Gill M.B., May J.S., and Stevenson P.G. Murine gammaherpesvirus-68 inhibits antigen presentation by dendritic cells. PLoS ONE 2 (2007) e1048
23. Thomas M., Boname J.M., Field S., Nejentsev S., Salio M., Cerundolo V., Wills M., and Lehner P.J. Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity. Proc Natl Acad Sci U S A 105 (2008) 1656-1661
24. Russo J.J., Bohenzky R.A., Chien M.C., Chen J., Yan M., Maddalena D., Parry J.P., Peruzzi D., Edelman I.S., Chang Y., et al. Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A 93 (1996) 14862-14867
25. Haque M., Chen J., Ueda K., Mori Y., Nakano K., Hirata Y., Kanamori S., Uchiyama Y., Inagi R., Okuno T., et al. Identification and analysis of the K5 gene of Kaposi's sarcoma-associated herpesvirus. J Virol 74 (2000) 2867-2875
26. Rimessi P., Bonaccorsi A., Sturzl M., Fabris M., Brocca-Cofano E., Caputo A., Melucci-Vigo G., Falchi M., Cafaro A., Cassai E., et al. Transcription pattern of human herpesvirus 8 open reading frame K3 in primary effusion lymphoma and Kaposi's sarcoma. J Virol 75 (2001) 7161-7174
27. Krishnan H.H., Naranatt P.P., Smith M.S., Zeng L., Bloomer C., and Chandran B. Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent decline of lytic gene expression. J Virol 78 (2004) 3601-3620
28. Adang L.A., Tomescu C., Law W.K., and Kedes D.H. Intracellular Kaposi's sarcoma-associated herpesvirus load determines early loss of immune synapse components. J Virol 81 (2007) 5079-5090
29. Shin J.S., Ebersold M., Pypaert M., Delamarre L., Hartley A., and Mellman I. Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature 444 (2006) 115-118
30. van Niel G., Wubbolts R., Ten Broeke T., Buschow S.I., Ossendorp F.A., Melief C.J., Raposo G., van Balkom B.W., and Stoorvogel W. Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination. Immunity 25 (2006) 885-894
31. van Niel G., Wubbolts R., and Stoorvogel W. Endosomal sorting of MHC class II determines antigen presentation by dendritic cells. Curr Opin Cell Biol 20 (2008) 437-444. This is an excellent review of recent advances on the regulation of MHC II trafficking.
32. Shortman K., and Naik S.H. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 7 (2007) 19-30
33. Young L.J., Wilson N.S., Schnorrer P., Proietto A., ten Broeke T., Matsuki Y., Mount A.M., Belz G.T., O'Keeffe M., Ohmura-Hoshino M., et al. Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells. Nat Immunol 9 (2008) 1244-1252
34. Yonashiro R., Ishido S., Kyo S., Fukuda T., Goto E., Matsuki Y., Ohmura-Hoshino M., Sada K., Hotta H., Yamamura H., et al. A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. EMBO J 25 (2006) 3618-3626
35. Nakamura N., Kimura Y., Tokuda M., Honda S., and Hirose S. MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology. EMBO Rep 7 (2006) 1019-1022
36. Hoer S., Smith L., and Lehner P.J. MARCH-IX mediates ubiquitination and downregulation of ICAM-1. FEBS Lett 581 (2007) 45-51
37. Bartee E., McCormack A., and Fruh K. Quantitative membrane proteomics reveals new cellular targets of viral immune modulators. PLoS Pathog 2 (2006) e107
38. Goto E., Mito-Yoshida M., Uematsu M., Aoki M., Matsuki Y., Ohmura-Hoshino M., Hotta H., Miyagishi M., and Ishido S. An excellent monitoring system for surface ubiquitination-induced internalization in mammals. PLoS ONE 3 (2008) e1490
39. Lybarger L., Wang X., Harris M., and Hansen T.H. Viral immune evasion molecules attack the ER peptide-loading complex and exploit ER-associated degradation pathways. Curr Opin Immunol 17 (2005) 71-78
40. Duncan L.M., Piper S., Dodd R.B., Saville M.K., Sanderson C.M., Luzio J.P., and Lehner P.J. Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules. EMBO J 25 (2006) 1635-1645
41. Lehner P.J., Hoer S., Dodd R., and Duncan L.M. Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases. Immunol Rev 207 (2005) 112-125
42. Kirkpatrick D.S., Hathaway N.A., Hanna J., Elsasser S., Rush J., Finley D., King R.W., and Gygi S.P. Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol 8 (2006) 700-710. This is an important paper describing new technique for analysis of the composition of ubiquitin chain. At present, this method is utilized by specialists in ubiquitin biology.