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Volumn 213, Issue 9, 2016, Pages 1881-1900

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(36)  Chopra, Martin a,b,h   Biehl, Marlene a,b   Steinfatt, Tim a,b   Brandl, Andreas a,b   Kums, Juliane a   Amich, Jorge a,b   Vaeth, Martin b,i   Kuen, Janina b   Holtappels, Rafaela d   Podlech, Jürgen d   Mottok, Anja b,j   Kraus, Sabrina a,b   Jordán Garrote, Ana Laura a,b   Bäuerlein, Carina A a,b   Brede, Christian a,b   Ribechini, Eliana b   Fick, Andrea a   Seher, Axel a   Polz, Johannes e   Ottmüller, Katja J a,b   more..


Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR AGONIST; STAR2 AGONIST; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG; INTERLEUKIN 2;

EID: 84984829560     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20151563     Document Type: Article
Times cited : (131)

References (62)
  • 2
    • 84979678661 scopus 로고    scopus 로고
    • Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling.
    • Ban, L., W. Kuhtreiber, J. Butterworth, Y. Okubo, É.S. Vanamee, and D.L. Faustman. 2015. Strategic internal covalent cross-linking of TNF produces a stable TNF trimer with improved TNFR2 signaling. Mol. Cell. Ther. 3:7. http://dx.doi.org/10.1186/s40591-015-0044-4
    • (2015) Mol. Cell. Ther. , vol.3 , pp. 7
    • Ban, L.1    Kuhtreiber, W.2    Butterworth, J.3    Okubo, Y.4    Vanamee, E.S.5    Faustman, D.L.6
  • 3
    • 23044472871 scopus 로고    scopus 로고
    • In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets.
    • Beilhack, A., S. Schulz, J. Baker, G.F. Beilhack, C.B. Wieland, E.I. Herman, E.M. Baker, Y.A. Cao, C.H. Contag, and R.S. Negrin. 2005. In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. Blood. 106:1113-1122. http://dx.doi.org/10.1182/blood -2005-02-0509
    • (2005) Blood. , vol.106 , pp. 1113-1122
    • Beilhack, A.1    Schulz, S.2    Baker, J.3    Beilhack, G.F.4    Wieland, C.B.5    Herman, E.I.6    Baker, E.M.7    Cao, Y.A.8    Contag, C.H.9    Negrin, R.S.10
  • 5
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics.
    • Brunstein, C.G., J.S. Miller, Q. Cao, D.H. McKenna, K.L. Hippen, J. Curtsinger, T. Defor, B.L. Levine, C.H. June, P. Rubinstein, et al. 2011. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood. 117:1061-1070. http://dx.doi.org/10.1182/blood -2010-07-293795
    • (2011) Blood. , vol.117 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3    McKenna, D.H.4    Hippen, K.L.5    Curtsinger, J.6    Defor, T.7    Levine, B.L.8    June, C.H.9    Rubinstein, P.10
  • 12
    • 84892532073 scopus 로고    scopus 로고
    • Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation.
    • Chopra, M., S. Kraus, S. Schwinn, M. Ritz, K. Mattenheimer, A. Mottok, A. Rosenwald, H. Einsele, and A. Beilhack. 2013b. Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation. PLoS One. 8:e81320. http://dx.doi.org/10.1371/journal.pone.0081320
    • (2013) PLoS One. , vol.8 , pp. e81320
    • Chopra, M.1    Kraus, S.2    Schwinn, S.3    Ritz, M.4    Mattenheimer, K.5    Mottok, A.6    Rosenwald, A.7    Einsele, H.8    Beilhack, A.9
  • 14
    • 84937773001 scopus 로고    scopus 로고
    • Blocking TWE AK-Fn14 interaction inhibits hematopoietic stem cell transplantationinduced intestinal cell death and reduces GVHD.
    • Chopra, M., A. Brandl, D. Siegmund, A. Mottok, V. Schäfer, M. Biehl, S. Kraus, C.A. Bäuerlein, M. Ritz, K. Mattenheimer, et al. 2015. Blocking TWE AK-Fn14 interaction inhibits hematopoietic stem cell transplantationinduced intestinal cell death and reduces GVHD. Blood. 126:437-444. http://dx.doi.org/10.1182/blood -2015-01-620583
    • (2015) Blood. , vol.126 , pp. 437-444
    • Chopra, M.1    Brandl, A.2    Siegmund, D.3    Mottok, A.4    Schäfer, V.5    Biehl, M.6    Kraus, S.7    Bäuerlein, C.A.8    Ritz, M.9    Mattenheimer, K.10
  • 15
    • 77954734137 scopus 로고    scopus 로고
    • Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells.
    • Coghill, J.M., M.J. Carlson, A. Panoskaltsis-Mortari, M.L. West, J.E. Burgents, B.R. Blazar, and J.S. Serody. 2010. Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells. Blood. 115:4914-4922. http://dx.doi.org/10.1182/blood -2009-08-239848
    • (2010) Blood. , vol.115 , pp. 4914-4922
    • Coghill, J.M.1    Carlson, M.J.2    Panoskaltsis-Mortari, A.3    West, M.L.4    Burgents, J.E.5    Blazar, B.R.6    Serody, J.S.7
  • 16
    • 0029909099 scopus 로고    scopus 로고
    • An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin.
    • Cooke, K.R., L. Kobzik, T.R. Martin, J. Brewer, J. Delmonte Jr., J.M. Crawford, and J.L. Ferrara. 1996. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood. 88:3230-3239.
    • (1996) Blood. , vol.88 , pp. 3230-3239
    • Cooke, K.R.1    Kobzik, L.2    Martin, T.R.3    Brewer, J.4    Delmonte, J.5    Crawford, J.M.6    Ferrara, J.L.7
  • 18
    • 80053597291 scopus 로고    scopus 로고
    • Regulatory T cells in stem cell transplantation: strategies and first clinical experiences.
    • Edinger, M., and P. Hoffmann. 2011. Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. Curr. Opin. Immunol. 23:679-684. http://dx.doi.org/10.1016/j.coi.2011.06.006
    • (2011) Curr. Opin. Immunol. , vol.23 , pp. 679-684
    • Edinger, M.1    Hoffmann, P.2
  • 19
    • 0141461418 scopus 로고    scopus 로고
    • + regulatory T cells preserve graftversus- tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation.
    • + regulatory T cells preserve graftversus- tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat. Med. 9:1144-1150. http://dx.doi.org/10.1038/nm915
    • (2003) Nat. Med. , vol.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3    Drago, K.4    Fathman, C.G.5    Strober, S.6    Negrin, R.S.7
  • 20
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy.
    • Ehrenstein, M.R., J.G. Evans, A. Singh, S. Moore, G. Warnes, D.A. Isenberg, and C. Mauri. 2004. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J. Exp. Med. 200:277-285. http://dx.doi.org/10.1084/jem.20040165
    • (2004) J. Exp. Med. , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6    Mauri, C.7
  • 21
    • 0142041982 scopus 로고    scopus 로고
    • TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases.
    • Feldmann, M., and R.N. Maini. 2003. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat. Med. 9:1245-1250. http://dx.doi.org/10.1038/nm939
    • (2003) Nat. Med. , vol.9 , pp. 1245-1250
    • Feldmann, M.1    Maini, R.N.2
  • 24
    • 2542476855 scopus 로고    scopus 로고
    • Clinical aspects of CMV infection after stem cell transplantation.
    • Hebart, H., and H. Einsele. 2004. Clinical aspects of CMV infection after stem cell transplantation. Hum. Immunol. 65:432-436. http://dx.doi.org/10.1016/j.humimm.2004.02.022
    • (2004) Hum. Immunol. , vol.65 , pp. 432-436
    • Hebart, H.1    Einsele, H.2
  • 25
    • 0037025943 scopus 로고    scopus 로고
    • + regulatory T cells suppress lethal acute graftversus- host disease after allogeneic bone marrow transplantation.
    • + regulatory T cells suppress lethal acute graftversus- host disease after allogeneic bone marrow transplantation. J. Exp. Med. 196:389-399. http://dx.doi.org/10.1084/jem.20020399
    • (2002) J. Exp. Med. , vol.196 , pp. 389-399
    • Hoffmann, P.1    Ermann, J.2    Edinger, M.3    Fathman, C.G.4    Strober, S.5
  • 27
    • 0242557055 scopus 로고    scopus 로고
    • Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response.
    • Jones, S.C., G.F. Murphy, and R. Korngold. 2003. Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response. Biol. Blood Marrow Transplant. 9:243-256. http://dx.doi.org/10.1053/bbmt.2003.50027
    • (2003) Biol. Blood Marrow Transplant. , vol.9 , pp. 243-256
    • Jones, S.C.1    Murphy, G.F.2    Korngold, R.3
  • 28
    • 0037373487 scopus 로고    scopus 로고
    • Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720.
    • Kim, Y.M., T. Sachs, W. Asavaroengchai, R. Bronson, and M. Sykes. 2003. Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720. J. Clin. Invest. 111:659-669. http://dx.doi.org/10.1172/JCI200316950
    • (2003) J. Clin. Invest. , vol.111 , pp. 659-669
    • Kim, Y.M.1    Sachs, T.2    Asavaroengchai, W.3    Bronson, R.4    Sykes, M.5
  • 29
    • 78049276260 scopus 로고    scopus 로고
    • Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
    • Klages, K., C.T. Mayer, K. Lahl, C. Loddenkemper, M.W. Teng, S.F. Ngiow, M.J. Smyth, A. Hamann, J. Huehn, and T. Sparwasser. 2010. Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res. 70:7788-7799. http://dx.doi.org/10.1158/0008-5472.CAN -10-1736
    • (2010) Cancer Res. , vol.70 , pp. 7788-7799
    • Klages, K.1    Mayer, C.T.2    Lahl, K.3    Loddenkemper, C.4    Teng, M.W.5    Ngiow, S.F.6    Smyth, M.J.7    Hamann, A.8    Huehn, J.9    Sparwasser, T.10
  • 30
    • 67650216399 scopus 로고    scopus 로고
    • Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases.
    • Ko, J.M., A.B. Gottlieb, and J.F. Kerbleski. 2009. Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases. J. Dermatolog. Treat. 20:100-108. http://dx.doi.org/10.1080/09546630802441234
    • (2009) J. Dermatolog. Treat. , vol.20 , pp. 100-108
    • Ko, J.M.1    Gottlieb, A.B.2    Kerbleski, J.F.3
  • 31
    • 34547423966 scopus 로고    scopus 로고
    • Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras.
    • Komatsu, N., and S. Hori. 2007. Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras. Proc. Natl. Acad. Sci. USA. 104:8959-8964. http://dx.doi.org/10.1073/pnas.0702004104
    • (2007) Proc. Natl. Acad. Sci. USA. , vol.104 , pp. 8959-8964
    • Komatsu, N.1    Hori, S.2
  • 32
    • 80052893511 scopus 로고    scopus 로고
    • Implications of TNF-α in the pathogenesis and management of GVHD.
    • Levine, J.E. 2011. Implications of TNF-α in the pathogenesis and management of GVHD. Int. J. Hematol. 93:571-577. http://dx.doi.org/10.1007/s12185-011-0803-1
    • (2011) Int. J. Hematol. , vol.93 , pp. 571-577
    • Levine, J.E.1
  • 33
    • 0025756330 scopus 로고
    • Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.
    • Lewis, M., L.A. Tartaglia, A. Lee, G.L. Bennett, G.C. Rice, G.H. Wong, E.Y. Chen, and D.V. Goeddel. 1991. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc. Natl. Acad. Sci. USA. 88:2830-2834. http://dx.doi.org/10.1073/pnas.88.7.2830
    • (1991) Proc. Natl. Acad. Sci. USA. , vol.88 , pp. 2830-2834
    • Lewis, M.1    Tartaglia, L.A.2    Lee, A.3    Bennett, G.L.4    Rice, G.C.5    Wong, G.H.6    Chen, E.Y.7    Goeddel, D.V.8
  • 34
    • 84861548052 scopus 로고    scopus 로고
    • Emerging concepts in haematopoietic cell transplantation.
    • Li, H.W., and M. Sykes. 2012. Emerging concepts in haematopoietic cell transplantation. Nat. Rev. Immunol. 12:403-416. http://dx.doi.org/10.1038/nri3226
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 403-416
    • Li, H.W.1    Sykes, M.2
  • 35
    • 36649003890 scopus 로고    scopus 로고
    • high T-regulatory cells in allergic asthma is subjected to TNF-α modulation.
    • high T-regulatory cells in allergic asthma is subjected to TNF-α modulation. Allergy. 63:67-74. http://dx.doi.org/10.1111/j.1398-9995.2007.01526.x
    • (2008) Allergy. , vol.63 , pp. 67-74
    • Lin, Y.L.1    Shieh, C.C.2    Wang, J.Y.3
  • 36
    • 0027382150 scopus 로고
    • Human tumor necrosis factor α (TNF α) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.
    • Loetscher, H., D. Stueber, D. Banner, F. Mackay, and W. Lesslauer. 1993. Human tumor necrosis factor α (TNF α) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors. J. Biol. Chem. 268:26350-26357.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26350-26357
    • Loetscher, H.1    Stueber, D.2    Banner, D.3    Mackay, F.4    Lesslauer, W.5
  • 37
    • 0037114705 scopus 로고    scopus 로고
    • Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors.
    • Marr, K.A., R.A. Carter, M. Boeckh, P. Martin, and L. Corey. 2002. Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood. 100:4358-4366. http://dx.doi.org/10.1182/blood -2002-05-1496
    • (2002) Blood. , vol.100 , pp. 4358-4366
    • Marr, K.A.1    Carter, R.A.2    Boeckh, M.3    Martin, P.4    Corey, L.5
  • 38
    • 84904899365 scopus 로고    scopus 로고
    • HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse.
    • Martelli, M.F., M. Di Ianni, L. Ruggeri, F. Falzetti, A. Carotti, A. Terenzi, A. Pierini, M.S. Massei, L. Amico, E. Urbani, et al. 2014. HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse. Blood. 124:638-644. http://dx.doi.org/10.1182/blood -2014-03-564401
    • (2014) Blood. , vol.124 , pp. 638-644
    • Martelli, M.F.1    Di Ianni, M.2    Ruggeri, L.3    Falzetti, F.4    Carotti, A.5    Terenzi, A.6    Pierini, A.7    Massei, M.S.8    Amico, L.9    Urbani, E.10
  • 39
    • 84941778190 scopus 로고    scopus 로고
    • Transmembrane TNFTNFR2 impairs Th17 differentiation by promoting IL2 expression.
    • Miller, P.G., M.B. Bonn, and S.C. McKarns. 2015. Transmembrane TNFTNFR2 impairs Th17 differentiation by promoting IL2 expression. J. Immunol. 195:2633-2647. http://dx.doi.org/10.4049/jimmunol.1500286
    • (2015) J. Immunol. , vol.195 , pp. 2633-2647
    • Miller, P.G.1    Bonn, M.B.2    McKarns, S.C.3
  • 40
    • 33846446041 scopus 로고    scopus 로고
    • Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β.
    • Nadkarni, S., C. Mauri, and M.R. Ehrenstein. 2007. Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β. J. Exp. Med. 204:33-39. http://dx.doi.org/10.1084/jem.20061531
    • (2007) J. Exp. Med. , vol.204 , pp. 33-39
    • Nadkarni, S.1    Mauri, C.2    Ehrenstein, M.R.3
  • 42
    • 33947203388 scopus 로고    scopus 로고
    • In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation.
    • Nguyen, V.H., R. Zeiser, D.L. Dasilva, D.S. Chang, A. Beilhack, C.H. Contag, and R.S. Negrin. 2007. In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. Blood. 109:2649-2656. http://dx.doi.org/10.1182/blood -2006-08-044529
    • (2007) Blood. , vol.109 , pp. 2649-2656
    • Nguyen, V.H.1    Zeiser, R.2    Dasilva, D.L.3    Chang, D.S.4    Beilhack, A.5    Contag, C.H.6    Negrin, R.S.7
  • 43
    • 84875153425 scopus 로고    scopus 로고
    • Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis.
    • Nie, H., Y. Zheng, R. Li, T.B. Guo, D. He, L. Fang, X. Liu, L. Xiao, X. Chen, B. Wan, et al. 2013. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat. Med. 19:322-328. http://dx.doi.org/10.1038/nm.3085
    • (2013) Nat. Med. , vol.19 , pp. 322-328
    • Nie, H.1    Zheng, Y.2    Li, R.3    Guo, T.B.4    He, D.5    Fang, L.6    Liu, X.7    Xiao, L.8    Chen, X.9    Wan, B.10
  • 44
    • 84889562494 scopus 로고    scopus 로고
    • Homogeneous expansion of human T-regulatory cells via tumor necrosis factor receptor 2.
    • Okubo, Y., T. Mera, L. Wang, and D.L. Faustman. 2013. Homogeneous expansion of human T-regulatory cells via tumor necrosis factor receptor 2. Sci. Rep. 3:3153. http://dx.doi.org/10.1038/srep03153
    • (2013) Sci. Rep. , vol.3 , pp. 3153
    • Okubo, Y.1    Mera, T.2    Wang, L.3    Faustman, D.L.4
  • 46
    • 0033860425 scopus 로고    scopus 로고
    • Murine model of interstitial cytomegalovirus pneumonia in syngeneic bone marrow transplantation: persistence of protective pulmonary CD8-T-cell infiltrates after clearance of acute infection.
    • Podlech, J., R. Holtappels, M.F. Pahl-Seibert, H.P. Steffens, and M.J. Reddehase. 2000. Murine model of interstitial cytomegalovirus pneumonia in syngeneic bone marrow transplantation: persistence of protective pulmonary CD8-T-cell infiltrates after clearance of acute infection. J. Virol. 74:7496-7507. http://dx.doi.org/10.1128/JVI.74.16.7496-7507.2000
    • (2000) J. Virol. , vol.74 , pp. 7496-7507
    • Podlech, J.1    Holtappels, R.2    Pahl-Seibert, M.F.3    Steffens, H.P.4    Reddehase, M.J.5
  • 47
    • 0347786829 scopus 로고    scopus 로고
    • Animal models: murine cytomegalovirus
    • S.H.E. Kaufmann and D. Kabelitz, editors. Academic Press, San Diego
    • Podlech, J., R. Holtappels, N.K.A. Grzimek, and M.J. Reddehase. 2002. Animal models: murine cytomegalovirus. In Immunology of Infection. S.H.E. Kaufmann and D. Kabelitz, editors. Academic Press, San Diego. 493-525. http://dx.doi.org/10.1016/S0580-9517(02)32103-2
    • (2002) Immunology of Infection , pp. 493-525
    • Podlech, J.1    Holtappels, R.2    Grzimek, N.K.A.3    Reddehase, M.J.4
  • 49
    • 77951234694 scopus 로고    scopus 로고
    • Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2).
    • Rauert, H., A. Wicovsky, N. Müller, D. Siegmund, V. Spindler, J. Waschke, C. Kneitz, and H. Wajant. 2010. Membrane tumor necrosis factor (TNF) induces p100 processing via TNF receptor-2 (TNFR2). J. Biol. Chem. 285:7394-7404. http://dx.doi.org/10.1074/jbc. M109.037341
    • (2010) J. Biol. Chem. , vol.285 , pp. 7394-7404
    • Rauert, H.1    Wicovsky, A.2    Müller, N.3    Siegmund, D.4    Spindler, V.5    Waschke, J.6    Kneitz, C.7    Wajant, H.8
  • 50
    • 0035464263 scopus 로고    scopus 로고
    • Demyelinating and neurologic events reported in association with tumor necrosis factor α antagonism: by what mechanisms could tumor necrosis factor α antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis?
    • Robinson, W.H., M.C. Genovese, and L.W. Moreland. 2001. Demyelinating and neurologic events reported in association with tumor necrosis factor α antagonism: by what mechanisms could tumor necrosis factor α antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis? Arthritis Rheum. 44:1977-1983. http://dx.doi.org/10.1002/1529-0131(200109)44 :9<1977::AID-ART345>3.0.CO;2-6
    • (2001) Arthritis Rheum. , vol.44 , pp. 1977-1983
    • Robinson, W.H.1    Genovese, M.C.2    Moreland, L.W.3
  • 51
    • 84255160968 scopus 로고    scopus 로고
    • Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412.
    • Römer, P.S., S. Berr, E. Avota, S.Y. Na, M. Battaglia, I. ten Berge, H. Einsele, and T. Hünig. 2011. Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412. Blood. 118:6772-6782. http://dx.doi.org/10.1182/blood -2010-12-319780
    • (2011) Blood. , vol.118 , pp. 6772-6782
    • Römer, P.S.1    Berr, S.2    Avota, E.3    Na, S.Y.4    Battaglia, M.5    ten Berge, I.6    Einsele, H.7    Hünig, T.8
  • 52
    • 0005636077 scopus 로고
    • Molecular studies of murine mutant BALB/c-H-2dm2 define a deletion of several class I genes including the entire H-2Ld gene.
    • Rubocki, R.J., T.H. Hansen, and D.R. Lee. 1986. Molecular studies of murine mutant BALB/c-H-2dm2 define a deletion of several class I genes including the entire H-2Ld gene. Proc. Natl. Acad. Sci. USA. 83:9606-9610. http://dx.doi.org/10.1073/pnas.83.24.9606
    • (1986) Proc. Natl. Acad. Sci. USA. , vol.83 , pp. 9606-9610
    • Rubocki, R.J.1    Hansen, T.H.2    Lee, D.R.3
  • 53
    • 84891590554 scopus 로고    scopus 로고
    • Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation.
    • Schneidawind, D., A. Pierini, and R.S. Negrin. 2013. Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation. Blood. 122:3116-3121. http://dx.doi.org/10.1182/blood -2013-08-453126
    • (2013) Blood. , vol.122 , pp. 3116-3121
    • Schneidawind, D.1    Pierini, A.2    Negrin, R.S.3
  • 54
    • 84911861882 scopus 로고    scopus 로고
    • CD4+ invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T cells.
    • Schneidawind, D., A. Pierini, M. Alvarez, Y. Pan, J. Baker, C. Buechele, R.H. Luong, E.H. Meyer, and R.S. Negrin. 2014. CD4+ invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T cells. Blood. 124:3320-3328. http://dx.doi.org/10.1182/blood -2014-05-576017
    • (2014) Blood. , vol.124 , pp. 3320-3328
    • Schneidawind, D.1    Pierini, A.2    Alvarez, M.3    Pan, Y.4    Baker, J.5    Buechele, C.6    Luong, R.H.7    Meyer, E.H.8    Negrin, R.S.9
  • 55
    • 0032550366 scopus 로고    scopus 로고
    • Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity.
    • Schneider, P., N. Holler, J.L. Bodmer, M. Hahne, K. Frei, A. Fontana, and J. Tschopp. 1998. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J. Exp. Med. 187:1205-1213. http://dx.doi.org/10.1084/jem.187.8.1205
    • (1998) J. Exp. Med. , vol.187 , pp. 1205-1213
    • Schneider, P.1    Holler, N.2    Bodmer, J.L.3    Hahne, M.4    Frei, K.5    Fontana, A.6    Tschopp, J.7
  • 60
    • 84887347546 scopus 로고    scopus 로고
    • Human regulatory T cells against minor histocompatibility antigens: ex vivo expansion for prevention of graft-versus-host disease.
    • Veerapathran, A., J. Pidala, F. Beato, B. Betts, J. Kim, J.G. Turner, M.K. Hellerstein, X.Z. Yu, W. Janssen, and C. Anasetti. 2013. Human regulatory T cells against minor histocompatibility antigens: ex vivo expansion for prevention of graft-versus-host disease. Blood. 122:2251-2261. http://dx.doi.org/10.1182/blood -2013-03-492397
    • (2013) Blood. , vol.122 , pp. 2251-2261
    • Veerapathran, A.1    Pidala, J.2    Beato, F.3    Betts, B.4    Kim, J.5    Turner, J.G.6    Hellerstein, M.K.7    Yu, X.Z.8    Janssen, W.9    Anasetti, C.10
  • 61
    • 34247867901 scopus 로고    scopus 로고
    • Immunobiology of allogeneic hematopoietic stem cell transplantation.
    • Welniak, L.A., B.R. Blazar, and W.J. Murphy. 2007. Immunobiology of allogeneic hematopoietic stem cell transplantation. Annu. Rev. Immunol. 25:139-170. http://dx.doi.org/10.1146/annurev.immunol.25.022106.141606
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 139-170
    • Welniak, L.A.1    Blazar, B.R.2    Murphy, W.J.3
  • 62
    • 84875708261 scopus 로고    scopus 로고
    • TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway.
    • Zhang, Q., F. Cui, L. Fang, J. Hong, B. Zheng, and J.Z. Zhang. 2013. TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway. J. Mol. Cell Biol. 5:85-98. http://dx.doi.org/10.1093/jmcb/mjs063
    • (2013) J. Mol. Cell Biol. , vol.5 , pp. 85-98
    • Zhang, Q.1    Cui, F.2    Fang, L.3    Hong, J.4    Zheng, B.5    Zhang, J.Z.6


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