-
1
-
-
84929023302
-
Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges
-
SMOLEN JS, ALETAHA D: Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges. Nat Rev Rheumatol 2015; 11: 276-89.
-
(2015)
Nat Rev Rheumatol
, vol.11
, pp. 276-289
-
-
Smolen, J.S.1
Aletaha, D.2
-
2
-
-
84984805273
-
A Promising Target in Rheumatoid Arthritis Treatment: Granulocyte-Macrophage Colony-Stimulating Factor
-
AVCI AB, FEIST E, BURMESTER GR: A Promising Target in Rheumatoid Arthritis Treatment: Granulocyte-Macrophage Colony-Stimulating Factor. Curr Treat Options in Rheum 2015; 1: 320-33.
-
(2015)
Curr Treat Options in Rheum
, vol.1
, pp. 320-333
-
-
Avci, A.B.1
Feist, E.2
Burmester, G.R.3
-
3
-
-
0025241216
-
Cytokine regulation of colony-stimulating factor production in cultured human synovial fibroblasts: I. Induction of GM-CSF and G-CSF production by interleukin-1 and tumor necrosis factor
-
LEIZER T, CEBON J, LAYTON JE, HAMILTON JA: Cytokine regulation of colony-stimulating factor production in cultured human synovial fibroblasts: I. Induction of GM-CSF and G-CSF production by interleukin-1 and tumor necrosis factor. Blood 1990; 76: 1989-96.
-
(1990)
Blood
, vol.76
, pp. 1989-1996
-
-
Leizer, T.1
Cebon, J.2
Layton, J.E.3
Hamilton, J.A.4
-
4
-
-
0025837768
-
Human articular cartilage and chondrocytes produce hemopoietic colony-stimulating factors in culture in response to IL-1
-
CAMPBELL IK, NOVAK U, CEBON J, LAYTON JE, HAMILTON JA: Human articular cartilage and chondrocytes produce hemopoietic colony-stimulating factors in culture in response to IL-1. J Immunol 1991; 147: 1238-46.
-
(1991)
J Immunol
, vol.147
, pp. 1238-1246
-
-
Campbell, I.K.1
Novak, U.2
Cebon, J.3
Layton, J.E.4
Hamilton, J.A.5
-
5
-
-
46249090513
-
Colony-stimulating factors in inflammation and autoimmunity
-
HAMILTON JA: Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 2008; 8: 533-44.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 533-544
-
-
Hamilton, J.A.1
-
6
-
-
30344449182
-
Functions of granulocyte-macrophage colony-stimulating factor
-
FLEETWOOD AJ, COOK AD, HAMILTON JA: Functions of granulocyte-macrophage colony-stimulating factor. Crit Rev Immunol 2005; 25: 405-28.
-
(2005)
Crit Rev Immunol
, vol.25
, pp. 405-428
-
-
Fleetwood, A.J.1
Cook, A.D.2
Hamilton, J.A.3
-
7
-
-
48449102092
-
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation
-
HANSEN G, HERCUS TR, McCLURE BJ et al.: The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell 2008; 134: 496-507.
-
(2008)
Cell
, vol.134
, pp. 496-507
-
-
Hansen, G.1
Hercus, T.R.2
Mcclure, B.J.3
-
8
-
-
0032531031
-
Saturation mutagenesis of the beta subunit of the human granulocyte-macrophage colonystimulating factor receptor shows clustering of constitutive mutations, activation of ERK MAP kinase and STAT pathways, and differential beta subunit tyrosine phosphorylation
-
JENKINS BJ, BLAKE TJ, GONDA TJ: Saturation mutagenesis of the beta subunit of the human granulocyte-macrophage colonystimulating factor receptor shows clustering of constitutive mutations, activation of ERK MAP kinase and STAT pathways, and differential beta subunit tyrosine phosphorylation. Blood 1998; 92: 1989-2002.
-
(1998)
Blood
, vol.92
, pp. 1989-2002
-
-
Jenkins, B.J.1
Blake, T.J.2
Gonda, T.J.3
-
9
-
-
0027494821
-
Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling
-
SATO N, SAKAMAKI K, TERADA N, ARAI K, MIYAJIMA A: Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO J 1993; 12: 4181-9.
-
(1993)
EMBO J
, vol.12
, pp. 4181-4189
-
-
Sato, N.1
Sakamaki, K.2
Terada, N.3
Arai, K.4
Miyajima, A.5
-
10
-
-
84949626705
-
The betac receptor family -Structural insights and their functional implications
-
BROUGHTON SE, NERO TL, DHAGAT U et al.: The betac receptor family -Structural insights and their functional implications. Cytokine 2015; 74: 247-58.
-
(2015)
Cytokine
, vol.74
, pp. 247-258
-
-
Broughton, S.E.1
Nero, T.L.2
Dhagat, U.3
-
12
-
-
84883140800
-
High yield production of a soluble human interleukin-3 variant from E. coli with wildtype bioactivity and improved radiolabeling properties
-
HERCUS TR, BARRY EF, DOTTORE M, et al.: High yield production of a soluble human interleukin-3 variant from E. coli with wildtype bioactivity and improved radiolabeling properties. PLoS One 2013; 8: e74376.
-
(2013)
PLoS One
, vol.8
-
-
Hercus, T.R.1
Barry, E.F.2
Dottore, M.3
-
13
-
-
4644226608
-
Stimulus-dependent requirement for granulocytemacrophage colony-stimulating factor in inflammation
-
COOK AD, BRAINE EL, HAMILTON JA: Stimulus-dependent requirement for granulocytemacrophage colony-stimulating factor in inflammation. J Immunol 2004; 173: 4643-51.
-
(2004)
J Immunol
, vol.173
, pp. 4643-4651
-
-
Cook, A.D.1
Braine, E.L.2
Hamilton, J.A.3
-
14
-
-
84954198071
-
Targeting GM-CSF in inflammatory diseases
-
WICKS IP, ROBERTS AW: Targeting GM-CSF in inflammatory diseases. Nat Rev Rheumatol 2016; 12: 37-48.
-
(2016)
Nat Rev Rheumatol
, vol.12
, pp. 37-48
-
-
Wicks, I.P.1
Roberts, A.W.2
-
15
-
-
34247124840
-
Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation
-
FLEETWOOD AJ, LAWRENCE T, HAMILTON JA, COOK AD: Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation. J Immunol 2007; 178: 5245-52.
-
(2007)
J Immunol
, vol.178
, pp. 5245-5252
-
-
Fleetwood, A.J.1
Lawrence, T.2
Hamilton, J.A.3
Cook, A.D.4
-
16
-
-
0036839143
-
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
-
MANTOVANI A, SOZZANI S, LOCATI M, ALLAVENA P, SICA A: Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002; 23: 549-55.
-
(2002)
Trends Immunol
, vol.23
, pp. 549-555
-
-
Mantovani, A.1
Sozzani, S.2
Locati, M.3
Allavena, P.4
Sica, A.5
-
17
-
-
84938512496
-
Interleukin 10 hampers endothelial cell differentiation and enhances the effects of interferon alpha on lupus endothelial cell progenitors
-
CATES AM, HOLDEN VI, MYERS EM, SMITH CK, KAPLAN MJ, KAHLENBERG JM: Interleukin 10 hampers endothelial cell differentiation and enhances the effects of interferon alpha on lupus endothelial cell progenitors. Rheumatology 2015; 54: 1114-23.
-
(2015)
Rheumatology
, vol.54
, pp. 1114-1123
-
-
Cates, A.M.1
Holden, V.I.2
Myers, E.M.3
Smith, C.K.4
Kaplan, M.J.5
Kahlenberg, J.M.6
-
18
-
-
84866130874
-
Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33
-
WILLART MA, DESWARTE K, POULIOT P et al.: Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med 2012; 209: 1505-17.
-
(2012)
J Exp Med
, vol.209
, pp. 1505-1517
-
-
Willart, M.A.1
Deswarte, K.2
Pouliot, P.3
-
19
-
-
79951671510
-
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
-
KRAUSGRUBER T, BLAZEK K, SMALLIE T et al.: IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol 2011; 12: 231-8.
-
(2011)
Nat Immunol
, vol.12
, pp. 231-238
-
-
Krausgruber, T.1
Blazek, K.2
Smallie, T.3
-
20
-
-
79955958973
-
Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers
-
SIERRA-FILARDI E, PUIG-KROGER A, BLANCO FJ et al.: Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood 2011; 117: 5092-101.
-
(2011)
Blood
, vol.117
, pp. 5092-5101
-
-
Sierra-Filardi, E.1
Puig-Kroger, A.2
Blanco, F.J.3
-
21
-
-
0028236526
-
Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology
-
STANLEY E, LIESCHKE GJ, GRAIL D et al.: Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci USA 1994; 91: 5592-6.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 5592-5596
-
-
Stanley, E.1
Lieschke, G.J.2
Grail, D.3
-
22
-
-
0027732734
-
Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis
-
FARAHAT MN, YANNI G, POSTON R, PANAYI GS: Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis 1993; 52: 870-5.
-
(1993)
Ann Rheum Dis
, vol.52
, pp. 870-875
-
-
Farahat, M.N.1
Yanni, G.2
Poston, R.3
Panayi, G.S.4
-
23
-
-
0028580620
-
Measurement of colony-stimulating factors in synovial fluid: potential clinical value
-
BELL AL, MAGILL MK, McKANE WR, KIRK F, IRVINE AE: Measurement of colony-stimulating factors in synovial fluid: potential clinical value. Rheumatol Int 1995; 14: 177-82.
-
(1995)
Rheumatol Int
, vol.14
, pp. 177-182
-
-
Bell, A.L.1
Magill, M.K.2
Mckane, W.R.3
Kirk, F.4
Irvine, A.E.5
-
24
-
-
0027494777
-
Expression of GMCSF receptor in rheumatoid arthritis
-
FIELD M, CLINTON L: Expression of GMCSF receptor in rheumatoid arthritis. Lancet 1993; 342: 1244.
-
(1993)
Lancet
, vol.342
, pp. 1244
-
-
Field, M.1
Clinton, L.2
-
25
-
-
0028328236
-
Evidence for GM-CSF receptor expression in synovial tissue. An analysis by semi-quantitative polymerase chain reaction on rheumatoid arthritis and osteoarthritis synovial biopsies
-
BERENBAUM F, RAJZBAUM G, AMOR B, TOUBERT A: Evidence for GM-CSF receptor expression in synovial tissue. An analysis by semi-quantitative polymerase chain reaction on rheumatoid arthritis and osteoarthritis synovial biopsies. Eur cytokine Netw 1994; 5: 43-6.
-
(1994)
Eur cytokine Netw
, vol.5
, pp. 43-46
-
-
Berenbaum, F.1
Rajzbaum, G.2
Amor, B.3
Toubert, A.4
-
26
-
-
0030066502
-
Synovial tissue macrophage populations and articular damage in rheumatoid arthritis
-
MULHERIN D, FITZGERALD O, BRESNIHAN B: Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum 1996; 39: 115-24.
-
(1996)
Arthritis Rheum
, vol.39
, pp. 115-124
-
-
Mulherin, D.1
Fitzgerald, O.2
Bresnihan, B.3
-
27
-
-
19544374324
-
Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis
-
HARINGMAN JJ, GERLAG DM, ZWINDERMAN AH et al.: Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis. Ann Rheum Dis 2005; 64: 834-8.
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 834-838
-
-
Haringman, J.J.1
Gerlag, D.M.2
Zwinderman, A.H.3
-
28
-
-
36048940661
-
Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker
-
WIJBRANDTS CA, VERGUNST CE, HARINGMAN JJ, GERLAG DM, SMEETS TJ, TAK PP: Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarker. Arthritis Rheum 2007; 56: 3869-71.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 3869-3871
-
-
Wijbrandts, C.A.1
Vergunst, C.E.2
Haringman, J.J.3
Gerlag, D.M.4
Smeets, T.J.5
Tak, P.P.6
-
29
-
-
79956116032
-
RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
-
CODARRI L, GYULVESZI G, TOSEVSKI V et al.: RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 2011; 12: 560-7.
-
(2011)
Nat Immunol
, vol.12
, pp. 560-567
-
-
Codarri, L.1
Gyulveszi, G.2
Tosevski, V.3
-
30
-
-
79956152607
-
The encephalitogenicity of T(H)17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF
-
El-BEHI M, CIRIC B, DAI H et al.: The encephalitogenicity of T(H)17 cells is dependent on IL-1-and IL-23-induced production of the cytokine GM-CSF. Nat Immunol 2011; 12: 568-75.
-
(2011)
Nat Immunol
, vol.12
, pp. 568-575
-
-
El-Behi, M.1
Ciric, B.2
Dai, H.3
-
31
-
-
0034851864
-
Blockade of collageninduced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease
-
COOK AD, BRAINE EL, CAMPBELL IK, RICH MJ, HAMILTON JA: Blockade of collageninduced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease. Arthritis Res 2001; 3: 293-8.
-
(2001)
Arthritis Res
, vol.3
, pp. 293-298
-
-
Cook, A.D.1
Braine, E.L.2
Campbell, I.K.3
Rich, M.J.4
Hamilton, J.A.5
-
32
-
-
34147198271
-
GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice
-
PLATER-ZYBERK C, JOOSTEN LA, HELSEN MM, HEPP J, BAEUERLE PA, van den BERG WB: GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice. Ann Rheum Dis 2007; 66: 452-7.
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 452-457
-
-
Plater-Zyberk, C.1
Joosten, L.A.2
Helsen, M.M.3
Hepp, J.4
Baeuerle, P.A.5
Van Den Berg, W.B.6
-
33
-
-
0030744451
-
Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice
-
CAMPBELL IK, BENDELE A, SMITH DA, HAMILTON JA: Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice. Ann Rheum Dis 1997;56: 364-8.
-
(1997)
Ann Rheum Dis
, vol.56
, pp. 364-368
-
-
Campbell, I.K.1
Bendele, A.2
Smith, D.A.3
Hamilton, J.A.4
-
34
-
-
0023482090
-
Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage
-
LANG RA, METCALF D, CUTHBERTSON RA et al.: Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage. Cell 1987; 51: 675-86.
-
(1987)
Cell
, vol.51
, pp. 675-686
-
-
Lang, R.A.1
Metcalf, D.2
Cuthbertson, R.A.3
-
35
-
-
0032193230
-
Protection from collagen-induced arthritis in granulocytemacrophage colony-stimulating factor-deficient mice
-
CAMPBELL IK, RICH MJ, BISCHOF RJ, DUNN AR, GRAIL D, HAMILTON JA: Protection from collagen-induced arthritis in granulocytemacrophage colony-stimulating factor-deficient mice. J Immunol 1998; 161: 3639-44.
-
(1998)
J Immunol
, vol.161
, pp. 3639-3644
-
-
Campbell, I.K.1
Rich, M.J.2
Bischof, R.J.3
Dunn, A.R.4
Grail, D.5
Hamilton, J.A.6
-
36
-
-
77953025999
-
ERK activation by GM-CSF reduces effectiveness of p38 inhibitor on inhibiting TNFalpha release
-
HUA F, HENSTOCK PV, TANG B: ERK activation by GM-CSF reduces effectiveness of p38 inhibitor on inhibiting TNFalpha release. Int Immunopharmacol 2010; 10: 730-7.
-
(2010)
Int Immunopharmacol
, vol.10
, pp. 730-737
-
-
Hua, F.1
Henstock, P.V.2
Tang, B.3
-
37
-
-
77955333700
-
Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line
-
ESPELIN CW, GOLDSIPE A, SORGER PK, LAUFFENBURGER DA, de GRAAF D, HENDRIKS BS: Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line. Mol Biosyst 2010; 6: 1956-72.
-
(2010)
Mol Biosyst
, vol.6
, pp. 1956-1972
-
-
Espelin, C.W.1
Goldsipe, A.2
Sorger, P.K.3
Lauffenburger, D.A.4
de Graaf, D.5
Hendriks, B.S.6
-
38
-
-
84936743560
-
Complementary action of granulocyte-macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-kappaB ligand and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis
-
van NIEUWENHUIJZE AE, van de LOO FA, WALGREEN B et al.: Complementary action of granulocyte-macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-kappaB ligand and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis. Arthritis Res Ther 2015; 17: 163.
-
(2015)
Arthritis Res Ther
, vol.17
, pp. 163
-
-
Van Nieuwenhuijze, A.E.1
Van de Loo, F.A.2
Walgreen, B.3
-
39
-
-
66149105578
-
Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor alpha-independent mouse model
-
PLATER-ZYBERK C, JOOSTEN LA, HELSEN MM, KOENDERS MI, BAEUERLE PA, van den BERG WB: Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor alpha-independent mouse model. Ann Rheum Dis 2009; 68: 721-8.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 721-728
-
-
Plater-Zyberk, C.1
Joosten, L.A.2
Helsen, M.M.3
Koenders, M.I.4
Baeuerle, P.A.5
Van Den berg, W.B.6
-
40
-
-
0028657036
-
Long-term remission of neutropenia in Felty's syndrome after a short GM-CSF treatment
-
PEREIRA J, VELLOSO ED, LOTERIO HA, LAURINDO IM, CHAMONE DA: Long-term remission of neutropenia in Felty's syndrome after a short GM-CSF treatment. Acta Haematol 1994; 92: 154-6.
-
(1994)
Acta Haematol
, vol.92
, pp. 154-156
-
-
Pereira, J.1
Velloso, E.D.2
Loterio, H.A.3
Laurindo, I.M.4
Chamone, D.A.5
-
41
-
-
0024408624
-
Correction of granulocytopenia in Felty's syndrome by granulocyte-macrophage colonystimulating factor. Simultaneous induction of interleukin-6 release and flare-up of the arthritis
-
HAZENBERG BP, Van LEEUWEN MA, Van RIJSWIJK MH, STERN AC, VELLENGA E: Correction of granulocytopenia in Felty's syndrome by granulocyte-macrophage colonystimulating factor. Simultaneous induction of interleukin-6 release and flare-up of the arthritis. Blood 1989; 74: 2769-70.
-
(1989)
Blood
, vol.74
, pp. 2769-2770
-
-
Hazenberg, B.P.1
Van L.Eeuwen, M.A.2
Van R.Ijswijk, M.H.3
Stern, A.C.4
Vellenga, E.5
-
42
-
-
0025886355
-
Flare-up of rheumatoid arthritis during GMCSF treatment after chemotherapy
-
de VRIES EG, WILLEMSE PH, BIESMA B, STERN AC, LIMBURG PC, VELLENGA E: Flare-up of rheumatoid arthritis during GMCSF treatment after chemotherapy. Lancet 1991; 338: 517-8.
-
(1991)
Lancet
, vol.338
, pp. 517-518
-
-
De V.Ries, E.G.1
Willemse, P.H.2
Biesma, B.3
Stern, A.C.4
Limburg, P.C.5
Vellenga, E.6
-
43
-
-
80955177524
-
Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-alpha, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study
-
BURMESTER GR, FEIST E, SLEEMAN MA, WANG B, WHITE B, MAGRINI F: Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-alpha, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study. Ann Rheum Dis 2011; 70: 1542-9.
-
(2011)
Ann Rheum Dis
, vol.70
, pp. 1542-1549
-
-
Burmester, G.R.1
Feist, E.2
Sleeman, M.A.3
Wang, B.4
White, B.5
Magrini, F.6
-
44
-
-
84881479459
-
Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis
-
BURMESTER GR, WEINBLATT ME, McINNES IB et al.: Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis. Ann Rheum Dis 2013; 72: 1445-52.
-
(2013)
Ann Rheum Dis
, vol.72
, pp. 1445-1452
-
-
Burmester, G.R.1
Weinblatt, M.E.2
Mcinnes, I.B.3
-
45
-
-
84983421796
-
Efficacy and safety of mavrilimumab in Japanese subjects with rheumatoid arthritis: findings from a Phase IIa study
-
TAKEUCHI T, TANAKA Y, CLOSE D, GODWOOD A, WU CY, SAURIGNY D: Efficacy and safety of mavrilimumab in Japanese subjects with rheumatoid arthritis: findings from a Phase IIa study. Mod Rheumatol 2015; 25: 21-30.
-
(2015)
Mod Rheumatol
, vol.25
, pp. 21-30
-
-
Takeuchi, T.1
Tanaka, Y.2
Close, D.3
Godwood, A.4
Wu, C.Y.5
Saurigny, D.6
-
46
-
-
84983425440
-
Efficacy and safety of mavrilimumab, a fully human GM-CSFR-alpha monoclonal antibody in patients with rheumatoid arthritis: primary results from the EARTH EXPLORER 1 study [abstract
-
BURMESTER GR, McINNES IB, KREMER JM et al.: Efficacy and safety of mavrilimumab, a fully human GM-CSFR-alpha monoclonal antibody in patients with rheumatoid arthritis: primary results from the EARTH EXPLORER 1 study [abstract]. EULAR 2015: Ann Rheum Dis 2015; 74 (Suppl. 2): 78.
-
(2015)
EULAR 2015: Ann Rheum Dis
, vol.74
, pp. 78
-
-
Burmester, G.R.1
Mcinnes, I.B.2
Kremer, J.M.3
-
47
-
-
85007430685
-
Patient-reported outcomes (PROS) during treatment with mavrilimumab, a fully human monoclonal antibody targeting GM-CSFR-alpha, in the phase IIb EARTH EXPLORER 1 study [abstract]. EULAR 2015
-
KREMER JM, BURMESTER GR, WEINBLATT M et al.: Patient-reported outcomes (PROS) during treatment with mavrilimumab, a fully human monoclonal antibody targeting GM-CSFR-alpha, in the phase IIb EARTH EXPLORER 1 study [abstract]. EULAR 2015. Ann Rheum Dis 2015; 74 (Suppl. 2): 483.
-
(2015)
Ann Rheum Dis
, vol.74
, pp. 483
-
-
Kremer, J.M.1
Burmester, G.R.2
Weinblatt, M.3
-
48
-
-
84984782416
-
Rapid Onset of Clinical Benefit Is Associated with a Reduction in Validated Biomarkers of Disease in Patients with Rheumatoid Arthritis Treated with Mavrilimumab, a Human Monoclonal Antibody Targeting GM-CSFR [abstract]
-
McINNES IB, BURMESTER GR, KREMER JM et al.: Rapid Onset of Clinical Benefit Is Associated with a Reduction in Validated Biomarkers of Disease in Patients with Rheumatoid Arthritis Treated with Mavrilimumab, a Human Monoclonal Antibody Targeting GM-CSFR [abstract]. ACR 2014.
-
(2014)
ACR
-
-
Mcinnes, I.B.1
Burmester, G.R.2
Kremer, J.M.3
-
49
-
-
84984787546
-
Sustained response to mavrilimumab in rheumatoid arthritis patients via suppression of macrophage and T cells [abstract]. EULAR 2015
-
GUO X, SINIBALDI D, KUZIORA M et al.: Sustained response to mavrilimumab in rheumatoid arthritis patients via suppression of macrophage and T cells [abstract]. EULAR 2015. Ann Rheum Dis 2015; 74 (Suppl. 2):734.
-
(2015)
Ann Rheum Dis
, vol.74
, pp. 734
-
-
Guo, X.1
Sinibaldi, D.2
Kuziora, M.3
-
50
-
-
84984831550
-
Exposure-efficacy analysis of mavrilimumab in rheumatoid arthritis: modeling and simulation of phase II clinical data [abstract]. EULAR 2015
-
JIN DC, WU CY, ROSKOS LK, GODWOOD A, CLOSE D, WANG B: Exposure-efficacy analysis of mavrilimumab in rheumatoid arthritis: modeling and simulation of phase II clinical data [abstract]. EULAR 2015. Ann Rheum Dis 2015; 74 (Suppl. 2): 1043.
-
(2015)
Ann Rheum Dis
, vol.74
, pp. 1043
-
-
Jin, D.C.1
Wu, C.Y.2
Roskos, L.K.3
Godwood, A.4
Close, D.5
Wang, B.6
-
51
-
-
85051910438
-
Analysis of Patient-Reported Outcomes during Treatment with Mavrilimumab, a Human Monoclonal Antibody Targeting GM-CSFRá, in the Randomized Phase 2b Earth Explorer 1 Study [abstract]
-
KREMER JM, BURMESTER GR, WEINBLATT M et al.: Analysis of Patient-Reported Outcomes during Treatment with Mavrilimumab, a Human Monoclonal Antibody Targeting GM-CSFRá, in the Randomized Phase 2b Earth Explorer 1 Study [abstract]. ACR 2014.
-
(2014)
ACR
-
-
Kremer, J.M.1
Burmester, G.R.2
Weinblatt, M.3
-
52
-
-
84984843505
-
Rapid onset of clinical benefit in patients with RA treated with mavrilimumab, a fully human monoclonal antibody targeting GM-CSFR-alpha: subanalysis of the phase IIb EARTH EXPLORER 1 study [abstract]. EULAR 2015
-
McINNES IB, BURMESTER GR, KREMER JM et al.: Rapid onset of clinical benefit in patients with RA treated with mavrilimumab, a fully human monoclonal antibody targeting GM-CSFR-alpha: subanalysis of the phase IIb EARTH EXPLORER 1 study [abstract]. EULAR 2015. Ann Rheum Dis 2015; 74 (Suppl. 2): 723.
-
(2015)
Ann Rheum Dis
, vol.74
, pp. 723
-
-
Mcinnes, I.B.1
Burmester, G.R.2
Kremer, J.M.3
-
54
-
-
84959118502
-
Long-term Safety and Efficacy of Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor-a (GM-CSFR-a) Monoclonal Antibody, in Patients with Rheumatoid Arthritis (RA) [abstract] ACR 2015
-
BURMESTER GR, McINNES I, KREMER J et al.: Long-term Safety and Efficacy of Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor-a (GM-CSFR-a) Monoclonal Antibody, in Patients with Rheumatoid Arthritis (RA) [abstract]. ACR 2015. Arthritis Rheumatol 2015; 67 (Suppl. 10).
-
(2015)
Arthritis Rheumatol
, vol.67
-
-
Burmester, G.R.1
Mcinnes, I.2
Kremer, J.3
-
55
-
-
84934969613
-
MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebocontrolled, dose-escalation trial
-
BEHRENS F, TAK PP, OSTERGAARD M et al.: MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebocontrolled, dose-escalation trial. Ann Rheum Dis 2015; 74: 1058-64.
-
(2015)
Ann Rheum Dis
, vol.74
, pp. 1058-1064
-
-
Behrens, F.1
Tak, P.P.2
Ostergaard, M.3
-
56
-
-
85007456378
-
First-In-Patient Study Of Namilumab, An Anti-Gm-Csf Monoclonal Antibody, In Active Rheumatoid arthritis: Results Of The Priora Phase Ib Study [Abstract]. Eular 2015
-
HUIZINGA TWJ, BATALOV A, YABLANSKI K et al.: First-in-patient study of namilumab, an anti-GM-CSF monoclonal antibody, in active rheumatoid arthritis: results of the PRIORA phase Ib study [abstract]. EULAR 2015. Ann Rheum Dis 2015; 74 (Suppl. 2): 733.
-
(2015)
Ann Rheum Dis
, vol.74
, pp. 733
-
-
Huizinga, T.W.J.1
Batalov, A.2
Yablanski, K.3
-
61
-
-
84984826420
-
-
ClinicalTrials.gov [Access date: May 15].
-
Study of KB003 In Biologics-Inadequate Rheumatoid Arthritis. ClinicalTrials. gov [Access date: May 15, 2016]; Available from: https://clinicaltrials.gov/ct2/ results?term=NCT00995449.
-
(2016)
Study of KB003 In Biologics-Inadequate Rheumatoid Arthritis
-
-
|