Autophagy, NLRP3 inflammasome and auto-inflammatory/immune diseases

Clinical and Experimental Rheumatology

Volumn 34, Issue , 2016, Pages 12-16

  Zhong, Zhenyu ^a,b   Sanchez Lopez, Elsa ^a,b   Karin, Michael ^a,b  

^a Laboratory of Gene Regulation and Signal Transduction   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Auto inflammatory diseases; Autophagy; Immune diseases; Mitochondria; Mitophagy; mtDNA; mtROS; NLRP3 inflammasome

Indexed keywords

CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; MITOCHONDRIAL DNA; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PROTEIN P62; REACTIVE OXYGEN METABOLITE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; VOLTAGE DEPENDENT ANION CHANNEL; ANTIINFLAMMATORY AGENT; AUTACOID; CYTOKINE; NLRP3 PROTEIN, HUMAN;

ARTICLE; AUTOIMMUNE DISEASE; AUTOINFLAMMATORY DISEASE; AUTOPHAGY; CHRONIC INFLAMMATION; CINCA SYNDROME; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FAMILIAL COLD AUTOINFLAMMATORY SYNDROME; HUMAN; MACROPHAGE; MITOCHONDRIAL MEMBRANE; MITOPHAGY; MUCKLE WELLS SYNDROME; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOIMMUNE DISEASES; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; METABOLISM; MITOCHONDRION; MOLECULARLY TARGETED THERAPY; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AUTOIMMUNE DISEASES; AUTOPHAGY; CYTOKINES; HUMANS; INFLAMMASOMES; INFLAMMATION; INFLAMMATION MEDIATORS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MOLECULAR TARGETED THERAPY; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; SIGNAL TRANSDUCTION;

EID: 84984799135     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. KARIN M, CLEVERS H: Reparative inflammation takes charge of tissue regeneration. Nature 2016; 529: 307-15.
2. MARTINON F, MAYOR A, TSCHOPP J: The inflammasomes: guardians of the body. Annu Rev Immunol 2009; 27: 229-65.
3. BRYDGES SD, BRODERICK L, McGEOUGH MD, PENA CA, MUELLER JL, HOFFMAN HM: Divergence of IL-1, IL-18, cell death in NLRP3 inflammasomopathies. J Clin Invest 2013; 123: 4695-705.
4. GUO H, CALLAWAY JB, TING JP: Inflammasomes: mechanism of action, role in disease, therapeutics. Nat Med 2015; 21: 677-87.
5. LACHMANN HJ, KONE-PAUT I, KUEMMERLE- DESCHNER JB et al.: Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med 2009; 360: 2416-25.
6. BRODERICK L, DE NARDO D, FRANKLIN BS, HOFFMAN HM, LATZ E: The inflammasomesautoinflammatory syndromes. Annu Rev Pathol 2015; 10: 395-424.
7. LEE HM, KIM JJ, KIM HJ, SHONG M, KU BJ, JO EK: Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes 2013; 62: 194-204.
8. YANG CA, HUANG ST, CHIANG BL: Sexdependent differential activation of NLRP3 AIM2 inflammasomes in SLE macrophages. Rheumatology 2015; 54: 324-31.
9. ZHOU R, YAZDI AS, MENU P, TSCHOPP J: A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469: 221-5.
10. ZHONG Z, UMEMURA A, SANCHEZ-LOPEZ E et al.: NF-kappaB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell 2016; 164: 896-910.
11. SAITOH T, FUJITA N, JANG MH et al.: Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008; 456: 264-8.
12. NAKAHIRA K, HASPEL JA, RATHINAM VA et al.: Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011; 12: 222-30.
13. ELLIOTT EI, SUTTERWALA FS: Initiation perpetuation of NLRP3 inflammasome activation assembly. Immunol Rev 2015; 265: 35-52.
14. HOFFMAN HM, MUELLER JL, BROIDE DH, WANDERER AA, KOLODNER RD: Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome Muckle-Wells syndrome. Nat Genet 2001; 29: 301-5.
15. LACHMANN HJ, LOWE P, FELIX SD et al.: In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes. J Exp Med 2009; 206: 1029-36.
16. ROSENGREN S, MUELLER JL, ANDERSON JP et al.: Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia. J Allergy Clin Immunol 2007: 119: 991-6.
17. BAROJA-MAZO A, MARTíN-SáNCHEZ F, GOMEZ AI et al.: The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol 2014; 15: 738-48.
18. HOFFMAN HM, THRONE ML, AMAR NJ et al.: Long-term efficacy safety profile of rilonacept in the treatment of cryopryin-associated periodic syndromes: results of a 72- week open-label extension study. Clin Ther 2012; 34: 2091-103.
19. KUEMMERLE-DESCHNER JB, HACHULLA E, CARTWRIGHT R et al.: Two-year results from an open-label, multicentre, phase III study evaluating the safety efficacy of canakinumab in patients with cryopyrin-associated periodic syndrome across different severity phenotypes. Ann Rheum Dis 2011; 70: 2095- 102.
20. HOFFMAN HM, THRONE ML, AMAR NJ et al.: Efficacy safety of rilonacept (interleukin-Trap) in patients with cryopyrinassociated periodic syndromes: results fromtwo sequential placebo-controlled studies. Arthritis Rheum 2008; 58: 2443-52.
21. KAHLENBERG JM, THACKER SG, BERTHIER CC, COHEN CD, KRETZLER M, KAPLAN MJ: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. J Immunol 2011; 187: 6143-56.
22. MAJAI G, KISS E, TARR T et al.: Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients. Lupus 2014; 23: 133-45.
23. ZHONG Z, ZHAI Y, LIANG S et al.: TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun 2013; 4: 1611.
24. SHIMADA K, CROTHER TR, KARLIN J et al.: Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 2012; 36: 401-14.
25. IYER SS, HE Q, JANCZY JR et al.: Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity 2013; 39: 311- 23.
26. GRETEN FR, ARKAN MC, BOLLRATH J et al.: NF-kappaB is a negative regulator of IL- 1beta secretion as revealed by genetic pharmacological inhibition of IKKbeta. Cell 2007; 130: 918-31.
27. CRIOLLO A, SENOVILLA L, AUTHIER H et al.: The IKK complex contributes to the induction of autophagy. EMBO J 2010; 29: 619-631.