Gefitinib, an EGFR tyrosine kinase inhibitor, prevents smoke-mediated ciliated airway epithelial cell loss and promotes their recovery

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  Valencia Gattas, Monica ^a   Conner, Gregory E ^a   Fregien, Nevis L ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; FORKHEAD TRANSCRIPTION FACTOR; FOXJ1 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; SMOKE;

ACIDIFICATION; AIRWAY EPITHELIAL CELL; ANTIBODY SPECIFICITY; ARTICLE; BASAL CELL; CELL DIFFERENTIATION; CELL VIABILITY; CILIATED EPITHELIUM CELL; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; SMOKING; WESTERN BLOTTING; ADVERSE EFFECTS; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL SURVIVAL; CILIUM; DRUG EFFECTS; EPITHELIUM CELL; METABOLISM; PATHOLOGY; RESPIRATORY MUCOSA; SMOKE;

CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; CILIA; EPITHELIAL CELLS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MAP KINASE SIGNALING SYSTEM; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; SMOKE; SMOKING;

EID: 84984783715     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0160216     Document Type: Article

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