메뉴 건너뛰기




Volumn 923, Issue , 2016, Pages 77-86

Tumor hypoxia: Causative mechanisms, microregional heterogeneities, and the role of tissue-based hypoxia markers

Author keywords

Detection; Heterogeneities; Hypoxia markers; Malignant progression; Multiparametric immunohistochemistry; Subtypes; Tumor hypoxia

Indexed keywords

2 NITROIMIDAZOLE; BIOLOGICAL MARKER; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PIMONIDAZOLE; OXYGEN; TUMOR MARKER;

EID: 84984782771     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-38810-6_11     Document Type: Conference Paper
Times cited : (37)

References (31)
  • 1
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel P (2004) Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 14(3):198–206
    • (2004) Semin Radiat Oncol , vol.14 , Issue.3 , pp. 198-206
    • Vaupel, P.1
  • 2
    • 54049134838 scopus 로고    scopus 로고
    • Hypoxia and aggressive tumor phenotype: Implications for therapy and prognosis
    • Vaupel P (2008) Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis. Oncologist 13(Suppl 3):21–26
    • (2008) Oncologist , vol.13 , pp. 21-26
    • Vaupel, P.1
  • 3
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Signifi cance and impact on clinical outcome
    • Vaupel P, Mayer A (2007) Hypoxia in cancer: signifi cance and impact on clinical outcome. Cancer Metastasis Rev 26(2):225–239
    • (2007) Cancer Metastasis Rev , vol.26 , Issue.2 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 4
    • 84898542253 scopus 로고    scopus 로고
    • Hypoxia in tumors: Pathogenesis-related classifi cation, characterization of hypoxia subtypes, and associated biological and clinical implications
    • Vaupel P, Mayer A (2014) Hypoxia in tumors: pathogenesis-related classifi cation, characterization of hypoxia subtypes, and associated biological and clinical implications. Adv Exp Med Biol 812:19–24
    • (2014) Adv Exp Med Biol , vol.812 , pp. 19-24
    • Vaupel, P.1    Mayer, A.2
  • 5
    • 79955739452 scopus 로고    scopus 로고
    • Acute versus chronic hypoxia: Why a simplifi ed classifi cation is simply not enough
    • Bayer C, Shi K, Astner ST et al (2011) Acute versus chronic hypoxia: why a simplifi ed classifi cation is simply not enough. Int J Radiat Oncol Biol Phys 80(4):965–968
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , Issue.4 , pp. 965-968
    • Bayer, C.1    Shi, K.2    Astner, S.T.3
  • 6
    • 84898549709 scopus 로고    scopus 로고
    • Imaging tumor hypoxia: Blood-borne delivery of imaging agents is fundamentally different in hypoxia subtypes
    • Vaupel P, Mayer A (2014) Imaging tumor hypoxia: blood-borne delivery of imaging agents is fundamentally different in hypoxia subtypes. J Innov Opt Health Sci 07(02):1330005
    • (2014) J Innov Opt Health Sci , vol.7 , Issue.2
    • Vaupel, P.1    Mayer, A.2
  • 8
    • 84905900196 scopus 로고    scopus 로고
    • How in vivo EPR measures and images oxygen
    • Epel B, Redler G, Halpern H (2014) How in vivo EPR measures and images oxygen. Adv Exp Med Biol 812:113–119
    • (2014) Adv Exp Med Biol , vol.812 , pp. 113-119
    • Epel, B.1    Redler, G.2    Halpern, H.3
  • 9
    • 84892448556 scopus 로고    scopus 로고
    • Clinical EPR: Unique opportunities and some challenges
    • Swartz HM, Williams BB, Zaki BI et al (2014) Clinical EPR: unique opportunities and some challenges. Acad Radiol 21(2):197–206
    • (2014) Acad Radiol , vol.21 , Issue.2 , pp. 197-206
    • Swartz, H.M.1    Williams, B.B.2    Zaki, B.I.3
  • 11
    • 33846850493 scopus 로고    scopus 로고
    • Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers
    • Ljungkvist AS, Bussink J, Kaanders JH et al (2007) Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers. Radiat Res 167(2):127–145
    • (2007) Radiat Res , vol.167 , Issue.2 , pp. 127-145
    • Ljungkvist, A.S.1    Bussink, J.2    Kaanders, J.H.3
  • 12
    • 30544449463 scopus 로고    scopus 로고
    • A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker
    • Kleiter MM, Thrall DE, Malarkey DE et al (2006) A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker. Int J Radiat Oncol Biol Phys 64(2):592–602
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , Issue.2 , pp. 592-602
    • Kleiter, M.M.1    Thrall, D.E.2    Malarkey, D.E.3
  • 13
    • 33644516583 scopus 로고    scopus 로고
    • Dynamics of hypoxia, proliferation and apoptosis after irradiation in a murine tumor model
    • Ljungkvist AS, Bussink J, Kaanders JH et al (2006) Dynamics of hypoxia, proliferation and apoptosis after irradiation in a murine tumor model. Radiat Res 165(3):326–336
    • (2006) Radiat Res , vol.165 , Issue.3 , pp. 326-336
    • Ljungkvist, A.S.1    Bussink, J.2    Kaanders, J.H.3
  • 14
    • 79955729281 scopus 로고    scopus 로고
    • Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts
    • Yaromina A, Kroeber T, Meinzer A et al (2011) Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts. Int J Radiat Oncol Biol Phys 80(4):1205–1213
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , Issue.4 , pp. 1205-1213
    • Yaromina, A.1    Kroeber, T.2    Meinzer, A.3
  • 15
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza GL, Wang GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12(12):5447–5454
    • (1992) Mol Cell Biol , vol.12 , Issue.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 17
    • 0035347260 scopus 로고    scopus 로고
    • Induction of HIF-1α in response to hypoxia is instantaneous
    • Jewell UR, Kvietikova I, Scheid A et al (2001) Induction of HIF-1α in response to hypoxia is instantaneous. FASEB J 15(7):1312–1314
    • (2001) FASEB J , vol.15 , Issue.7 , pp. 1312-1314
    • Jewell, U.R.1    Kvietikova, I.2    Scheid, A.3
  • 18
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E et al (1999) Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res 59(22):5830–5835
    • (1999) Cancer Res , vol.59 , Issue.22 , pp. 5830-5835
    • Zhong, H.1    de Marzo, A.M.2    Laughner, E.3
  • 19
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxiainducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC et al (2000) The expression and distribution of the hypoxiainducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157(2):411–421
    • (2000) Am J Pathol , vol.157 , Issue.2 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3
  • 20
    • 0037100063 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1α in cervical carcinomas: Correlation with tumor oxygenation
    • Haugland HK, Vukovic V, Pintilie M et al (2002) Expression of hypoxia-inducible factor-1α in cervical carcinomas: correlation with tumor oxygenation. Int J Radiat Oncol Biol Phys 53(4):854–861
    • (2002) Int J Radiat Oncol Biol Phys , vol.53 , Issue.4 , pp. 854-861
    • Haugland, H.K.1    Vukovic, V.2    Pintilie, M.3
  • 21
    • 0037178551 scopus 로고    scopus 로고
    • Nuclear expression of hypoxia-inducible factor 1alpha protein is heterogeneous in human malignant cells under normoxic conditions
    • Zhong H, Mabjeesh N, Willard M et al (2002) Nuclear expression of hypoxia-inducible factor 1alpha protein is heterogeneous in human malignant cells under normoxic conditions. Cancer Lett 181(2):233–238
    • (2002) Cancer Lett , vol.181 , Issue.2 , pp. 233-238
    • Zhong, H.1    Mabjeesh, N.2    Willard, M.3
  • 23
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon PC, Hirota K, Semenza GL (2001) FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15(20):2675–2686
    • (2001) Genes Dev , vol.15 , Issue.20 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 24
    • 0034900493 scopus 로고    scopus 로고
    • Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix
    • Airley R, Loncaster J, Davidson S et al (2001) Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clin Cancer Res 7(4):928–934
    • (2001) Clin Cancer Res , vol.7 , Issue.4 , pp. 928-934
    • Airley, R.1    Loncaster, J.2    Davidson, S.3
  • 25
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster JA, Harris AL, Davidson SE et al (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 61(17):6394–6399
    • (2001) Cancer Res , vol.61 , Issue.17 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3
  • 26
    • 4143118037 scopus 로고    scopus 로고
    • Lack of correlation between expression of HIF-1α protein and oxygenation status in identical tissue areas of squamous cell carcinomas of the uterine cervix
    • Mayer A, Wree A, Höckel M et al (2004) Lack of correlation between expression of HIF-1α protein and oxygenation status in identical tissue areas of squamous cell carcinomas of the uterine cervix. Cancer Res 64(16):5876–5881
    • (2004) Cancer Res , vol.64 , Issue.16 , pp. 5876-5881
    • Mayer, A.1    Wree, A.2    Höckel, M.3
  • 27
    • 27144451824 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix
    • Mayer A, Höckel M, Vaupel P (2005) Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix. Clin Cancer Res 11(20):7220–7225
    • (2005) Clin Cancer Res , vol.11 , Issue.20 , pp. 7220-7225
    • Mayer, A.1    Höckel, M.2    Vaupel, P.3
  • 28
    • 17644425583 scopus 로고    scopus 로고
    • Microregional expression of glucose transporter-1 and oxygenation status: Lack of correlation in locally advanced cervical cancers
    • Mayer A, Höckel M, Wree A et al (2005) Microregional expression of glucose transporter-1 and oxygenation status: lack of correlation in locally advanced cervical cancers. Clin Cancer Res 11(7):2768–2773
    • (2005) Clin Cancer Res , vol.11 , Issue.7 , pp. 2768-2773
    • Mayer, A.1    Höckel, M.2    Wree, A.3
  • 29
    • 40549100361 scopus 로고    scopus 로고
    • Prognostic impact of HIF-1α expression in patients with defi nitive radiotherapy for cervical cancer
    • Dellas K, Bache M, Pigorsch SU et al (2008) Prognostic impact of HIF-1α expression in patients with defi nitive radiotherapy for cervical cancer. Strahlenther Onkol 184(3):169–174
    • (2008) Strahlenther Onkol , vol.184 , Issue.3 , pp. 169-174
    • Dellas, K.1    Bache, M.2    Pigorsch, S.U.3
  • 30
    • 49649084777 scopus 로고    scopus 로고
    • Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia
    • Mayer A, Höckel M, Wree A et al (2008) Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia. Cancer Res 68(12):4719–4726
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4719-4726
    • Mayer, A.1    Höckel, M.2    Wree, A.3
  • 31
    • 84984790823 scopus 로고    scopus 로고
    • Hypoxia markers and their clinical relevance
    • Osinsky S, Friess H, Vaupel P (eds), Akademperiodyka, Kiev, Ukraine
    • Mayer A, Vaupel P (2011) Hypoxia markers and their clinical relevance. In: Osinsky S, Friess H, Vaupel P (eds) Tumor hypoxia in the clinical setting. Akademperiodyka, Kiev, Ukraine, pp 187–202
    • (2011) Tumor Hypoxia in the Clinical Setting , pp. 187-202
    • Mayer, A.1    Vaupel, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.