메뉴 건너뛰기




Volumn 165, Issue 3, 2006, Pages 326-336

Dynamics of hypoxia, proliferation and apoptosis after irradiation in a murine tumor model

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CASPASE 3; OXYGEN; PIMONIDAZOLE;

EID: 33644516583     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3515.1     Document Type: Article
Times cited : (60)

References (70)
  • 1
    • 0014292997 scopus 로고
    • The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour
    • I. F. Tannock, The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Br. J. Cancer 22, 258-273 (1968).
    • (1968) Br. J. Cancer , vol.22 , pp. 258-273
    • Tannock, I.F.1
  • 2
    • 0018330397 scopus 로고
    • Tumour cell proliferation in relation to the vasculature
    • D. G. Hirst and J. Denekamp, Tumour cell proliferation in relation to the vasculature. Cell Tissue Kinet. 12, 31-42 (1979).
    • (1979) Cell Tissue Kinet. , vol.12 , pp. 31-42
    • Hirst, D.G.1    Denekamp, J.2
  • 5
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • R. H. Thomlinson and L. H. Gray, The histological structure of some human lung cancers and the possible implications for radiotherapy. Br. J. Cancer IX, 539-549 (1955).
    • (1955) Br. J. Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 6
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • P. Vaupel, F. Kallinowski and P. Okunieff, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res. 49, 6449-6465 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 10
    • 0030200651 scopus 로고    scopus 로고
    • Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry
    • K. H. Pigott, S. A. Hill, D. J. Chaplin and M. I. Saunders, Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry. Radiother. Oncol. 40, 45-50 (1996).
    • (1996) Radiother. Oncol. , vol.40 , pp. 45-50
    • Pigott, K.H.1    Hill, S.A.2    Chaplin, D.J.3    Saunders, M.I.4
  • 11
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • M. Höckel and P. Vaupel, Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 93, 266-276 (2001).
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 266-276
    • Höckel, M.1    Vaupel, P.2
  • 12
    • 0034037286 scopus 로고    scopus 로고
    • Microenvironment-induced cancer metastasis
    • E. K. Rofstad, Microenvironment-induced cancer metastasis. Int. J. Radiat. Biol. 76, 589-605 (2000).
    • (2000) Int. J. Radiat. Biol. , vol.76 , pp. 589-605
    • Rofstad, E.K.1
  • 13
    • 0026579513 scopus 로고
    • The effect of treatment time and treatment interruption on tumour control following radical radiotherapy of laryngeal cancer
    • M. B. Barton, T. J. Keane, T. Gadalla and E. Maki, The effect of treatment time and treatment interruption on tumour control following radical radiotherapy of laryngeal cancer. Radiother. Oncol. 23, 137-143 (1992).
    • (1992) Radiother. Oncol. , vol.23 , pp. 137-143
    • Barton, M.B.1    Keane, T.J.2    Gadalla, T.3    Maki, E.4
  • 14
    • 0026676867 scopus 로고
    • The effect of treatment duration in the local control of cervix cancer
    • A. Fyles, T. J. Keane, M. Barton and J. Simm, The effect of treatment duration in the local control of cervix cancer. Radiother. Oncol. 25, 273-279 (1992).
    • (1992) Radiother. Oncol. , vol.25 , pp. 273-279
    • Fyles, A.1    Keane, T.J.2    Barton, M.3    Simm, J.4
  • 16
    • 0023894783 scopus 로고
    • The hazard of accelerated tumor clonogen repopulation during radiotherapy
    • H. R. Withers, J. M. Taylor and B. Maciejewski, The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol. 27, 131-146 (1988).
    • (1988) Acta Oncol. , vol.27 , pp. 131-146
    • Withers, H.R.1    Taylor, J.M.2    Maciejewski, B.3
  • 17
    • 0025067378 scopus 로고
    • Dose-time considerations of head and neck squamous cell carcinomas treated with irradiation
    • J. M. Taylor, H. R. Withers and W. M. Mendenhall, Dose-time considerations of head and neck squamous cell carcinomas treated with irradiation. Radiother. Oncol. 17, 95-102 (1990).
    • (1990) Radiother. Oncol. , vol.17 , pp. 95-102
    • Taylor, J.M.1    Withers, H.R.2    Mendenhall, W.M.3
  • 18
    • 0030737527 scopus 로고    scopus 로고
    • Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: A randomised multicentre trial
    • CHART Steering Committee
    • M. Saunders, S. Dische, A. Barrett, A. Harvey, D. Gibson and M. Parmar, Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: A randomised multicentre trial. CHART Steering Committee. Lancet 350, 161-165 (1997).
    • (1997) Lancet , vol.350 , pp. 161-165
    • Saunders, M.1    Dische, S.2    Barrett, A.3    Harvey, A.4    Gibson, D.5    Parmar, M.6
  • 19
    • 0141540770 scopus 로고    scopus 로고
    • Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial
    • J. Overgaard, H. S. Hansen, L. Specht, M. Overgaard, C. Grau, E. Andersen, J. Bentzen, L. Bastholt, O. Hansen and J. F. Evensen, Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial. Lancet 362, 933-940 (2003).
    • (2003) Lancet , vol.362 , pp. 933-940
    • Overgaard, J.1    Hansen, H.S.2    Specht, L.3    Overgaard, M.4    Grau, C.5    Andersen, E.6    Bentzen, J.7    Bastholt, L.8    Hansen, O.9    Evensen, J.F.10
  • 20
    • 18544409287 scopus 로고    scopus 로고
    • A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003
    • K. K. Fu, T. F. Pajak, A. Trotti, C. U. Jones, S. A. Spencer, T. L. Phillips, A. S. Garden, J. A. Ridge and K. K. Ang, A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003. Int. J. Radiat. Oncol. Biol. Phys. 48, 7-16 (2000).
    • (2000) Int. J. Radiat. Oncol. Biol. Phys. , vol.48 , pp. 7-16
    • Fu, K.K.1    Pajak, T.F.2    Trotti, A.3    Jones, C.U.4    Spencer, S.A.5    Phillips, T.L.6    Garden, A.S.7    Ridge, J.A.8    Ang, K.K.9
  • 21
    • 0029150488 scopus 로고
    • Studies with bromodeoxyuridine in head and neck cancer and accelerated radiotherapy
    • G. D. Wilson, S. Dische and M. I. Saunders, Studies with bromodeoxyuridine in head and neck cancer and accelerated radiotherapy. Radiother. Oncol. 36, 189-197 (1995).
    • (1995) Radiother. Oncol. , vol.36 , pp. 189-197
    • Wilson, G.D.1    Dische, S.2    Saunders, M.I.3
  • 23
    • 0036467638 scopus 로고    scopus 로고
    • Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
    • A. Fyles, M. Milosevic, D. Hedley, M. Pintilie, W. Levin, L. Manchul and R. P. Hill, Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J. Clin. Oncol. 20, 680-687 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 680-687
    • Fyles, A.1    Milosevic, M.2    Hedley, D.3    Pintilie, M.4    Levin, W.5    Manchul, L.6    Hill, R.P.7
  • 24
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • M. Höckel, K. Schlenger, B. Aral, M. Mitze, U. Schaffer and P. Vaupel, Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56, 4509-4515 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 4509-4515
    • Höckel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 26
    • 0015412531 scopus 로고
    • The phenomenon of reoxygenation and its implications for fractionated radiotherapy
    • R. F. Kallman, The phenomenon of reoxygenation and its implications for fractionated radiotherapy. Radiology 105, 135-142 (1972).
    • (1972) Radiology , vol.105 , pp. 135-142
    • Kallman, R.F.1
  • 27
    • 0034114513 scopus 로고    scopus 로고
    • Changes in blood perfusion and hypoxia after irradiation of a human squamous cell carcinoma xenograft tumor line
    • J. Bussink, J. H. A. M. Kaanders, P. F. J. W. Rijken, J. A. Raleigh and A. J. van der Kogel, Changes in blood perfusion and hypoxia after irradiation of a human squamous cell carcinoma xenograft tumor line. Radiat. Res. 153, 398-404 (2000).
    • (2000) Radiat. Res. , vol.153 , pp. 398-404
    • Bussink, J.1    Kaanders, J.H.A.M.2    Rijken, P.F.J.W.3    Raleigh, J.A.4    Van Der Kogel, A.J.5
  • 28
    • 0027935568 scopus 로고
    • Radiation-induced reoxygenation in the SCCVII murine tumour: Evidence for a decrease in oxygen consumption and an increase in tumour perfusion
    • P. L. Olive, Radiation-induced reoxygenation in the SCCVII murine tumour: Evidence for a decrease in oxygen consumption and an increase in tumour perfusion. Radiother. Oncol. 32, 37-46 (1994).
    • (1994) Radiother. Oncol. , vol.32 , pp. 37-46
    • Olive, P.L.1
  • 33
    • 0037024440 scopus 로고    scopus 로고
    • Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis
    • B. M. Fenton, S. F. Paoni, B. K. Beauchamp and I. Ding, Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis. Br. J. Cancer 86, 1831-1836 (2002).
    • (2002) Br. J. Cancer , vol.86 , pp. 1831-1836
    • Fenton, B.M.1    Paoni, S.F.2    Beauchamp, B.K.3    Ding, I.4
  • 38
    • 4444285373 scopus 로고    scopus 로고
    • Effects of nicotinamide and carbogen in different murine colon carcinomas: Immunohistochemical analysis of vascular architecture and microenvironmental parameters
    • H. W. M. van Laarhoven, J. Bussink, J. Lok, C. J. A. Punt, A. Heerschap and A. J. van der Kogel, Effects of nicotinamide and carbogen in different murine colon carcinomas: Immunohistochemical analysis of vascular architecture and microenvironmental parameters. Int. J. Radiat. Oncol. Biol. Phys. 60, 310-321 (2004).
    • (2004) Int. J. Radiat. Oncol. Biol. Phys. , vol.60 , pp. 310-321
    • Van Laarhoven, H.W.M.1    Bussink, J.2    Lok, J.3    Punt, C.J.A.4    Heerschap, A.5    Van Der Kogel, A.J.6
  • 39
    • 0023717342 scopus 로고
    • Measurement of cell kinetics in human tumours in vivo using bromodeoxyuridine incorporation and flow cytometry
    • C. D. Wilson, N. J. McNally, S. Dische, M. I. Saunders, C. Des Rochers, A. A. Lewis and M. H. Bennett, Measurement of cell kinetics in human tumours in vivo using bromodeoxyuridine incorporation and flow cytometry. Br. J. Cancer 58, 423-431 (1988).
    • (1988) Br. J. Cancer , vol.58 , pp. 423-431
    • Wilson, C.D.1    McNally, N.J.2    Dische, S.3    Saunders, M.I.4    Des Rochers, C.5    Lewis, A.A.6    Bennett, M.H.7
  • 41
    • 0023553750 scopus 로고
    • Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer
    • G. J. Peters, J. Van Dijk, J. C. Nadal, C. J. Van Groeningen, J. Lankelma and H. M. Pinedo, Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer. In Vivo 1, 113-117 (1987).
    • (1987) In Vivo , vol.1 , pp. 113-117
    • Peters, G.J.1    Van Dijk, J.2    Nadal, J.C.3    Van Groeningen, C.J.4    Lankelma, J.5    Pinedo, H.M.6
  • 42
    • 0022485265 scopus 로고
    • Covalent binding of a fluorinated 2-nitroimidazole to EMT-6 tumors in Balb/C mice: Detection by F-19 nuclear magnetic resonance at 2.35 T
    • J. A. Raleigh, A. J. Franko, E. O. Treiber, J. A. Lunt and P. S. Allen, Covalent binding of a fluorinated 2-nitroimidazole to EMT-6 tumors in Balb/C mice: Detection by F-19 nuclear magnetic resonance at 2.35 T. Int. J. Radiat. Oncol. Biol. Phys. 12, 1243-1245 (1986).
    • (1986) Int. J. Radiat. Oncol. Biol. Phys. , vol.12 , pp. 1243-1245
    • Raleigh, J.A.1    Franko, A.J.2    Treiber, E.O.3    Lunt, J.A.4    Allen, P.S.5
  • 43
    • 0031008710 scopus 로고    scopus 로고
    • Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime
    • C. Azuma, J. A. Raleigh and D. E. Thrall, Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime. Radiat. Res. 148, 35-42 (1997).
    • (1997) Radiat. Res. , vol.148 , pp. 35-42
    • Azuma, C.1    Raleigh, J.A.2    Thrall, D.E.3
  • 44
    • 0028785458 scopus 로고
    • Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver
    • G. E. Arteel, R. G. Thurman, J. M. Yates and J. A. Raleigh, Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver. Br. J. Cancer 72, 889-895 (1995).
    • (1995) Br. J. Cancer , vol.72 , pp. 889-895
    • Arteel, G.E.1    Thurman, R.G.2    Yates, J.M.3    Raleigh, J.A.4
  • 46
    • 0036270745 scopus 로고    scopus 로고
    • Quantitative analysis of varying hypoxic profiles in relation to functional vessels in different human glioma xenograft lines
    • P. F. J. W. Rijken, J. P. W. Peters and A. J. van der Kogel, Quantitative analysis of varying hypoxic profiles in relation to functional vessels in different human glioma xenograft lines. Radiat. Res. 157, 626-632 (2002).
    • (2002) Radiat. Res. , vol.157 , pp. 626-632
    • Rijken, P.F.J.W.1    Peters, J.P.W.2    Van Der Kogel, A.J.3
  • 48
    • 0032801526 scopus 로고    scopus 로고
    • Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors
    • J. A. Raleigh, S. C. Chou, G. E. Arteel and M. R. Horsman, Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors. Radiat. Res. 151, 580-589 (1999).
    • (1999) Radiat. Res. , vol.151 , pp. 580-589
    • Raleigh, J.A.1    Chou, S.C.2    Arteel, G.E.3    Horsman, M.R.4
  • 49
    • 0028235953 scopus 로고
    • Reoxygenation and rehypoxiation in the SCCVII mouse tumor
    • I. H. Kim and J. M. Brown, Reoxygenation and rehypoxiation in the SCCVII mouse tumor. Int. J. Radiat. Oncol. Biol. Phys. 29, 493-497 (1994).
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.29 , pp. 493-497
    • Kim, I.H.1    Brown, J.M.2
  • 51
    • 0021954509 scopus 로고
    • Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: Evidence that a side-chain label is bound as efficiently as a ring label
    • J. A. Raleigh, A. J. Franko, C. J. Koch and J. L. Born, Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: Evidence that a side-chain label is bound as efficiently as a ring label. Br. J. Cancer 51, 229-235 (1985).
    • (1985) Br. J. Cancer , vol.51 , pp. 229-235
    • Raleigh, J.A.1    Franko, A.J.2    Koch, C.J.3    Born, J.L.4
  • 52
    • 0020581953 scopus 로고
    • Glutathione conjugates of misonidazole
    • A. J. Varghese, Glutathione conjugates of misonidazole. Biochem. Biophys. Res. Commun. 112, 1013-1020 (1983).
    • (1983) Biochem. Biophys. Res. Commun. , vol.112 , pp. 1013-1020
    • Varghese, A.J.1
  • 53
    • 0024286548 scopus 로고
    • Regioselective formation of a misonidazole-glutathione conjugate as a function of pH during chemical reduction
    • E. Chacon, C. J. Morrow, A. A. Leon, J. L. Born and B. R. Smith, Regioselective formation of a misonidazole-glutathione conjugate as a function of pH during chemical reduction. Biochem. Pharmacol. 37, 361-363 (1988).
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 361-363
    • Chacon, E.1    Morrow, C.J.2    Leon, A.A.3    Born, J.L.4    Smith, B.R.5
  • 54
    • 0025650261 scopus 로고
    • Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules
    • J. A. Raleigh and C. J. Koch, Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules. Biochem. Pharmacol. 40, 2457-2464 (1990).
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 2457-2464
    • Raleigh, J.A.1    Koch, C.J.2
  • 55
    • 4344707313 scopus 로고    scopus 로고
    • Quantifying transient hypoxia in human tumor xenografts by flow cytometry
    • K. L. Bennewith and R. E. Durand, Quantifying transient hypoxia in human tumor xenografts by flow cytometry. Cancer Res. 64, 6183-6189 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 6183-6189
    • Bennewith, K.L.1    Durand, R.E.2
  • 56
    • 0019507711 scopus 로고
    • A marker for hypoxic cells in tumours with potential clinical applicability
    • J. D. Chapman, A. J. Franko and J. Sharplin, A marker for hypoxic cells in tumours with potential clinical applicability. Br. J. Cancer 43, 546-550 (1981).
    • (1981) Br. J. Cancer , vol.43 , pp. 546-550
    • Chapman, J.D.1    Franko, A.J.2    Sharplin, J.3
  • 57
    • 0029012868 scopus 로고
    • Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids
    • M. W. Gross, U. Karbach, K. Groebe, A. J. Franko and W. Mueller Klieser, Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids. Int. J. Cancer 61, 567-573 (1995).
    • (1995) Int. J. Cancer , vol.61 , pp. 567-573
    • Gross, M.W.1    Karbach, U.2    Groebe, K.3    Franko, A.J.4    Mueller Klieser, W.5
  • 58
    • 0028196838 scopus 로고
    • ELISA quantification of CCI-103F binding in canine tumors prior to and during irradiation
    • D. E. Thrall, M. C. McEntee, J. M. Cline and J. A. Raleigh, ELISA quantification of CCI-103F binding in canine tumors prior to and during irradiation. Int. J. Radiat. Oncol. Biol. Phys. 28, 649-659 (1994).
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.28 , pp. 649-659
    • Thrall, D.E.1    McEntee, M.C.2    Cline, J.M.3    Raleigh, J.A.4
  • 59
    • 0035146821 scopus 로고    scopus 로고
    • Effects of radiation on tumor intravascular oxygenation, vascular configuration, development of hypoxia, and clonogenic survival
    • B. M. Fenton, E. M. Lord and S. F. Paoni, Effects of radiation on tumor intravascular oxygenation, vascular configuration, development of hypoxia, and clonogenic survival. Radiat. Res. 155, 360-368 (2001).
    • (2001) Radiat. Res. , vol.155 , pp. 360-368
    • Fenton, B.M.1    Lord, E.M.2    Paoni, S.F.3
  • 60
    • 0022997575 scopus 로고
    • Reoxygenation of the RIF-1 tumor after fractionated radiotherapy
    • M. J. Dorie and R. F. Kallman, Reoxygenation of the RIF-1 tumor after fractionated radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 12, 1853-1859 (1986).
    • (1986) Int. J. Radiat. Oncol. Biol. Phys. , vol.12 , pp. 1853-1859
    • Dorie, M.J.1    Kallman, R.F.2
  • 61
    • 0023062644 scopus 로고
    • Oxygen consumption rate of tumour cells as a function of their proliferative status
    • S. Walenta and W. Mueller Klieser, Oxygen consumption rate of tumour cells as a function of their proliferative status. Adv. Exp. Med. Biol. 215, 389-391 (1987).
    • (1987) Adv. Exp. Med. Biol. , vol.215 , pp. 389-391
    • Walenta, S.1    Mueller Klieser, W.2
  • 62
    • 0029666076 scopus 로고    scopus 로고
    • 2-phase cell cycle checkpoint control is associated with increased frequencies of unrejoined chromosome breaks in human tumor cells
    • 2-phase cell cycle checkpoint control is associated with increased frequencies of unrejoined chromosome breaks in human tumor cells. Radiat. Res. 146, 139-143 (1996).
    • (1996) Radiat. Res. , vol.146 , pp. 139-143
    • Schwartz, J.L.1    Cowan, J.2    Grdina, D.J.3    Weichselbaum, R.R.4
  • 63
    • 0028670266 scopus 로고
    • 2 blocks, cyclin B expression and cdc2 expression in human squamous carcinoma cell lines with different radiosensitivities
    • 2 blocks, cyclin B expression and cdc2 expression in human squamous carcinoma cell lines with different radiosensitivities. Radiother. Oncol. 33, 217-227 (1994).
    • (1994) Radiother. Oncol. , vol.33 , pp. 217-227
    • Smeets, M.F.1    Mooren, E.H.2    Begg, A.C.3
  • 64
    • 0029855527 scopus 로고    scopus 로고
    • Anti-BrdUrd labeling of newly synthesized DNA in HL-60 cells triggered to apoptosis
    • L. Zamai, E. Falcieri, P. Gobbi, S. Santi, M. Falconi, G. Marhefka and M. Vitale, Anti-BrdUrd labeling of newly synthesized DNA in HL-60 cells triggered to apoptosis. Cytometry 25, 324-332 (1996).
    • (1996) Cytometry , vol.25 , pp. 324-332
    • Zamai, L.1    Falcieri, E.2    Gobbi, P.3    Santi, S.4    Falconi, M.5    Marhefka, G.6    Vitale, M.7
  • 65
    • 0141731335 scopus 로고    scopus 로고
    • Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent
    • A. H. Kyle, L. A. Huxham, J. H. Baker, H. E. Burston and A. I. Minchinton, Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent. Cancer Res. 63, 5707-5711 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 5707-5711
    • Kyle, A.H.1    Huxham, L.A.2    Baker, J.H.3    Burston, H.E.4    Minchinton, A.I.5
  • 66
    • 0026694681 scopus 로고
    • Tumour proliferation assessed by combined histological and flow cytometric analysis: Implications for therapy in squamous cell carcinoma in the head and neck
    • M. H. Bennett, G. D. Wilson, S. Dische, M. I. Saunders, C. A. Martindale, B. M. Robinson, A. E. O'Halloran, M. D. Leslie and J. H. Laing, Tumour proliferation assessed by combined histological and flow cytometric analysis: Implications for therapy in squamous cell carcinoma in the head and neck. Br. J. Cancer 65, 870-878 (1992).
    • (1992) Br. J. Cancer , vol.65 , pp. 870-878
    • Bennett, M.H.1    Wilson, G.D.2    Dische, S.3    Saunders, M.I.4    Martindale, C.A.5    Robinson, B.M.6    O'Halloran, A.E.7    Leslie, M.D.8    Laing, J.H.9
  • 68
    • 0029035872 scopus 로고
    • Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors
    • T. W. Secomb, R. Hsu, E. T. Ong, J. F. Gross and M. W. Dewhirst, Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol. 34, 313-316 (1995).
    • (1995) Acta Oncol. , vol.34 , pp. 313-316
    • Secomb, T.W.1    Hsu, R.2    Ong, E.T.3    Gross, J.F.4    Dewhirst, M.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.