Imaging tumor hypoxia: Blood-borne delivery of imaging agents is fundamentally di®erent in hypoxia subtypes

Journal of Innovative Optical Health Sciences

Volumn 7, Issue 2, 2014, Pages

  Vaupel, Peter ^a   Mayer, Arnulf ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

acute hypoxia; chronic hypoxia; Delivery of imaging agents; hypoxia subtypes; tumor hypoxia

Indexed keywords

BLOOD;

ACUTE HYPOXIA; CHRONIC HYPOXIAS; HYPOXIA SUBTYPES; IMAGING AGENT; TUMOR HYPOXIA;

TUMORS;

EID: 84898549709     PISSN: 17935458     EISSN: 17937205     Source Type: Journal    
DOI: 10.1142/S179354581330005X     Document Type: Article

References (19)

1. P. Vaupel, A. Mayer, M. Höckel, \Tumor hypoxia and malignant progression," Methods Enzymol. 381, 335-354 (2004). (Pubitemid 38401518)
2. P. Vaupel, M. Höckel, A. Mayer, \Detection and characterization of tumor hypoxia using pO2 histography," Antioxid. Redox. Signal. 9, 1221-1235 (2007). (Pubitemid 47080831)
3. P. Vaupel, A. Mayer, \Hypoxia in cancer: Signi-cance and impact on clinical outcome," Cancer Metastasis Rev. 26, 225-239 (2007). (Pubitemid 47101660)
4. M. Höckel, C. Knoop, K. Schlenger, B. Vorndran, E. Baussmann,M. Mitze, P. G. Knapstein, P. Vaupel, \Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix," Radiother. Oncol. 26, 45-50 (1993). (Pubitemid 23063609)
5. M. Höckel, K. Schlenger, B. Aral, M. Mitze, U. Schäer, P. Vaupel, \Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix," Cancer Res. 56, 4509-4515 (1996). (Pubitemid 26330463)
6. A. Mayer, P. Vaupel, \Hypoxia, lactate accumulation, and acidosis: Siblings or accomplices driving tumor progression and resistance to therapy?" Adv. Exp. Med. Biol. 789, 203-209 (2013).
7. M. R. Horsman, L. S. Mortensen, J. B. Petersen, M. Busk, J. Overgaard, \Imaging hypoxia to improve radiotherapy outcome," Nat. Rev. Clin. Oncol. 9, 674-687 (2012).
8. A. R. Padhani, K. A. Krohn, J. S. Lewis, M. Alber, \Imaging oxygenation of human tumours," Eur. Radiol. 17, 861-872 (2007). (Pubitemid 46772763)
9. S. T. Astner, K. Shi, P. Vaupel, M. Molls, \Imaging of tumor physiology: Impacts on clinical radiation oncology," Exp. Oncol. 32, 149-152 (2010).
10. F. C. Gaertner, M. Souvatzoglou, G. Brix, A. J. Beer, \Imaging of hypoxia using PET and MRI," Curr. Pharm. Biotechnol. 13, 552-570 (2012).
11. J. L. Tatum, G. J. Kello, R. J. Gillies, J. M. Arbeit, J. M. Brown, K. S. Chao, J. D. Chapman, W. C. Eckelman, A. W. Fyles, A. J. Giaccia, R. P. Hill, C. J. Koch, M. C. Krishna, K. A. Krohn, J. S. Lewis, R. P. Mason, G. Melillo, A. R. Padhani, G. Powis, J. G. Rajendran, R. Reba, S. P. Robinson, G. L. Semenza, H. M. Swartz, P. Vaupel, D. Yang, B. Croft, J. Homan, G. Liu, H. Stone, D. Sullivan, \Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy," Int. J. Radiat. Biol. 82, 699-757 (2006). (Pubitemid 44832019)
12. R. H. Thomlinson, L. H. Gray, \The histological structure of some human lung cancers and the possible implications for radiotherapy," Br. J. Cancer 9, 539-549 (1955).
13. J. M. Brown, \Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation," Br. J. Radiol. 52, 650-656 (1979). (Pubitemid 9239867)
14. D. J. Chaplin, R. E. Durand, P. L. Olive, \Acute hypoxia in tumors: Implications for modiers of radiation e®ects," Int. J. Radiat. Oncol. Biol. Phys. 12, 1279-1282 (1986). (Pubitemid 16030598)
15. C. Bayer, K. Shi, S. T. Astner, C. A. Maftei, P. Vaupel, \Acute versus chronic hypoxia: Why a simplied classication is simply not enough," Int. J. Radiat. Oncol. Biol. Phys. 80, 965-968 (2011).
16. C. Bayer, P. Vaupel, \Acute versus chronic hypoxia in tumors: Controversial data concerning time frames and biological consequences," Strahlenther. Onkol. 188, 616-627 (2012).
17. C. A. Maftei, C. Bayer, K. Shi, S. T. Astner, P. Vaupel, \Quantitative assessment of hypoxia subtypes in microcirculatory supply units of malignant tumors using (immuno-)uorescence techniques," Strahlenther. Onkol. 187, 260-266 (2011).
18. P. Vaupel, A. Mayer, \Hypoxia in tumors: Pathogenesis- related classication, characterization of hypoxia- subtypes, and associated biological and clinical implications," Adv. Exp. Med. Biol., in press (2014).
19. S. Matsumoto, H. Yasui, J. B. Mitchell, M. C. Krishna, \Imaging cycling tumor hypoxia," Cancer Res. 70, 10019-10023 (2010).