메뉴 건너뛰기




Volumn 64, Issue 9, 2004, Pages 3030-3036

Clustering of Minimal Deleted Regions Reveals Distinct Genetic Pathways of Human Hepatocellular Carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

EID: 84984532070     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-2320     Document Type: Article
Times cited : (39)

References (52)
  • 1
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000: The global picture
    • Parkin DM, Bray FI, Devesa SS. Cancer burden in the year 2000: the global picture. Eur J Cancer 2001;37(Suppl 8):S4-66.
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 8
    • Parkin, D.M.1    Bray, F.I.2    Devesa, S.S.3
  • 2
    • 0002330978 scopus 로고    scopus 로고
    • Epidemiology, risk factors, etiology, premalignant lesions and carcinogenesis
    • Leong AS-Y, Liew CT, Lau JWY, Johnson PJ, editors. New York: Oxford University Press
    • Leong AS-Y. Epidemiology, risk factors, etiology, premalignant lesions and carcinogenesis. In: Leong AS-Y, Liew CT, Lau JWY, Johnson PJ, editors, Hepatocellular carcinoma: diagnosis, investigation and management. New York: Oxford University Press, 1999. p. 1-17
    • (1999) Hepatocellular Carcinoma: Diagnosis, Investigation and Management , pp. 1-17
    • Leong, A.S.-Y.1
  • 3
    • 0019451351 scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus: A prospective study of 22 707 men in Taiwan
    • Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22 707 men in Taiwan. Lancet 1981;2:1129-33.
    • (1981) Lancet , vol.2 , pp. 1129-1133
    • Beasley, R.P.1    Hwang, L.Y.2    Lin, C.C.3    Chien, C.S.4
  • 4
    • 84984538753 scopus 로고    scopus 로고
    • Hepatitis B virus infection and hepatocellular carcinoma: Molecular genetics and clinical perspectives
    • Chen PJ, Chen DS. Hepatitis B virus infection and hepatocellular carcinoma: molecular genetics and clinical perspectives. Semin liver Dis 1999;19:253-62.
    • (1999) Semin Liver Dis , vol.19 , pp. 253-262
    • Chen, P.J.1    Chen, D.S.2
  • 5
    • 84984555343 scopus 로고    scopus 로고
    • Hepatitis B e antigen and the risk of hepatocellular carcinoma
    • Yang HI, Lu SN, Liaw YF, et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 2002;347:168-74.
    • (2002) N Engl J Med , vol.347 , pp. 168-174
    • Yang, H.I.1    Lu, S.N.2    Liaw, Y.F.3
  • 6
    • 0036841697 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: An epidemiologic view
    • El-Serag HB. Hepatocellular carcinoma: an epidemiologic view. J Clin Gastroenterol 2002;35:S72-8.
    • (2002) J Clin Gastroenterol , vol.35
    • El-Serag, H.B.1
  • 7
    • 0033545541 scopus 로고    scopus 로고
    • Rising incidence of hepatocellular carcinoma in the United States
    • El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med 1999;340:745-50.
    • (1999) N Engl J Med , vol.340 , pp. 745-750
    • El-Serag, H.B.1    Mason, A.C.2
  • 10
    • 0025828517 scopus 로고
    • Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
    • Bressac B, Kew M, Wands J, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991;350:429-31.
    • (1991) Nature , vol.350 , pp. 429-431
    • Bressac, B.1    Kew, M.2    Wands, J.3    Ozturk, M.4
  • 11
    • 0345006147 scopus 로고    scopus 로고
    • Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas
    • de La Coste A, Romagnolo B, Billuart P, et al. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 1998;95:8847-51.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8847-8851
    • De La Coste, A.1    Romagnolo, B.2    Billuart, P.3
  • 12
    • 0027935784 scopus 로고
    • RB tumor suppressor gene expression in hepatocellular carcinomas from patients infected with the hepatitis B virus
    • Hsia CC, Di Bisceglie AM, Kleiner DE Jr, Farshid M, Tabor E. RB tumor suppressor gene expression in hepatocellular carcinomas from patients infected with the hepatitis B virus. J Med Virol 1994;44:67-73.
    • (1994) J Med Virol , vol.44 , pp. 67-73
    • Hsia, C.C.1    Di Bisceglie, A.M.2    Kleiner Jr., D.E.3    Farshid, M.4    Tabor, E.5
  • 13
    • 0033590404 scopus 로고    scopus 로고
    • High frequency of p16TNK4A gene alterations in hepatocellular carcinoma
    • Liew CT, Li HM, Lo KW, et al. High frequency of p16TNK4A gene alterations in hepatocellular carcinoma. Oncogene 1999;18:789-95.
    • (1999) Oncogene , vol.18 , pp. 789-795
    • Liew, C.T.1    Li, H.M.2    Lo, K.W.3
  • 14
    • 0032924622 scopus 로고    scopus 로고
    • p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
    • Matsuda Y, Ichida T, Matsuzawa J, Sugimura K, Asakura H. p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma. Gastroenterology 1999;116:394-400.
    • (1999) Gastroenterology , vol.116 , pp. 394-400
    • Matsuda, Y.1    Ichida, T.2    Matsuzawa, J.3    Sugimura, K.4    Asakura, H.5
  • 15
    • 0028804071 scopus 로고
    • M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
    • De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nat Genet 1995;11:447-9.
    • (1995) Nat Genet , vol.11 , pp. 447-449
    • De Souza, A.T.1    Hankins, G.R.2    Washington, M.K.3    Orton, T.C.4    Jirtle, R.L.5
  • 16
    • 0029792883 scopus 로고    scopus 로고
    • Mutations in the BRCA2 gene in hepatocellular carcinomas
    • Katagiri T, Nakamura Y, Miki Y. Mutations in the BRCA2 gene in hepatocellular carcinomas. Cancer Res 1996;56:4575-7.
    • (1996) Cancer Res , vol.56 , pp. 4575-4577
    • Katagiri, T.1    Nakamura, Y.2    Miki, Y.3
  • 17
    • 0033606964 scopus 로고    scopus 로고
    • Smad2 and Smad4 gene mutations in hepatocellular carcinoma
    • Yakicier MC, Irmak MB, Romano A, Kew M, Ozturk M. Smad2 and Smad4 gene mutations in hepatocellular carcinoma. Oncogene 1999;18:4879-83.
    • (1999) Oncogene , vol.18 , pp. 4879-4883
    • Yakicier, M.C.1    Irmak, M.B.2    Romano, A.3    Kew, M.4    Ozturk, M.5
  • 18
    • 0033803788 scopus 로고    scopus 로고
    • Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma
    • Liao C, Zhao M, Song H, Uchida K, Yokoyama KK, Li T. Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma. Hepatology 2000;32:721-7.
    • (2000) Hepatology , vol.32 , pp. 721-727
    • Liao, C.1    Zhao, M.2    Song, H.3    Uchida, K.4    Yokoyama, K.K.5    Li, T.6
  • 19
    • 0035887204 scopus 로고    scopus 로고
    • A novel growth suppressor gene on chromosome 17p13.3 with a high frequency of mutation in human hepatocellular carcinoma
    • Zhao X, Li J, He Y, et al. A novel growth suppressor gene on chromosome 17p13.3 with a high frequency of mutation in human hepatocellular carcinoma. Cancer Res 2001;61:7383-7.
    • (2001) Cancer Res , vol.61 , pp. 7383-7387
    • Zhao, X.1    Li, J.2    He, Y.3
  • 20
    • 0032524031 scopus 로고    scopus 로고
    • Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP
    • Yuan BZ, Miller MI, Keck CL, Zimonjic DB, Thorgeirsson SS, Popescu NC. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. Cancer Res 1998;58:2196-9.
    • (1998) Cancer Res , vol.58 , pp. 2196-2199
    • Yuan, B.Z.1    Miller, M.I.2    Keck, C.L.3    Zimonjic, D.B.4    Thorgeirsson, S.S.5    Popescu, N.C.6
  • 21
    • 0033587014 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutations in hepatocellular carcinomas
    • Yao YJ, Ping XL, Zhang H, et al. PTEN/MMAC1 mutations in hepatocellular carcinomas. Oncogene 1999;18:3181-5.
    • (1999) Oncogene , vol.18 , pp. 3181-3185
    • Yao, Y.J.1    Ping, X.L.2    Zhang, H.3
  • 22
    • 0034088858 scopus 로고    scopus 로고
    • AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
    • Satoh S, Daigo Y, Furukawa Y, et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000;24:245-50.
    • (2000) Nat Genet , vol.24 , pp. 245-250
    • Satoh, S.1    Daigo, Y.2    Furukawa, Y.3
  • 23
    • 18644363653 scopus 로고    scopus 로고
    • Bi-allelic inactivation of TCF1 in hepatic adenomas
    • Bluteau O, Jeannot E, Bioulac-Sage P, et al. Bi-allelic inactivation of TCF1 in hepatic adenomas. Nat Genet 2002;32:312-5.
    • (2002) Nat Genet , vol.32 , pp. 312-315
    • Bluteau, O.1    Jeannot, E.2    Bioulac-Sage, P.3
  • 24
    • 0027682801 scopus 로고
    • Amplification of the c-myc gene in human hepatocellular carcinoma: Biologic significance
    • Peng SY, Lai PL, Hsu HC. Amplification of the c-myc gene in human hepatocellular carcinoma: biologic significance. J Formos Med Assoc 1993;92:866-70.
    • (1993) J Formos Med Assoc , vol.92 , pp. 866-870
    • Peng, S.Y.1    Lai, P.L.2    Hsu, H.C.3
  • 25
    • 0033978257 scopus 로고    scopus 로고
    • Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas
    • Higashitsuji H, Itoh K, Nagao T, et al. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. Nat Med 2000;6:96-9.
    • (2000) Nat Med , vol.6 , pp. 96-99
    • Higashitsuji, H.1    Itoh, K.2    Nagao, T.3
  • 26
    • 0027430295 scopus 로고
    • Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma
    • Zhang YJ, Jiang W, Chen CJ, et al. Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma. Biochem Biophys Res Commun 1993;196:1010-6.
    • (1993) Biochem Biophys Res Commun , vol.196 , pp. 1010-1016
    • Zhang, Y.J.1    Jiang, W.2    Chen, C.J.3
  • 27
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • Yoshikawa H, Matsubara K, Qian GS, et al. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 2001;28:29-35.
    • (2001) Nat Genet , vol.28 , pp. 29-35
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.S.3
  • 28
    • 18844482200 scopus 로고    scopus 로고
    • GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas
    • Tchou JC, Lin X, Freije D, et al. GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas. Int J Oncol 2000;16:663-76.
    • (2000) Int J Oncol , vol.16 , pp. 663-676
    • Tchou, J.C.1    Lin, X.2    Freije, D.3
  • 29
    • 0034597517 scopus 로고    scopus 로고
    • Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 σ gene in human hepatocellular carcinoma
    • Iwata N, Yamamoto H, Sasaki S, et al. Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 σ gene in human hepatocellular carcinoma. Oncogene 2000;19:5298-302.
    • (2000) Oncogene , vol.19 , pp. 5298-5302
    • Iwata, N.1    Yamamoto, H.2    Sasaki, S.3
  • 30
    • 0036896602 scopus 로고    scopus 로고
    • A phylogenetic analysis identifies heterogeneity among hepatocellular carcinomas
    • McGlynn KA, Edmonson MN, Michielli RA, et al. A phylogenetic analysis identifies heterogeneity among hepatocellular carcinomas. Hepatology 2002;36:1341-8.
    • (2002) Hepatology , vol.36 , pp. 1341-1348
    • McGlynn, K.A.1    Edmonson, M.N.2    Michielli, R.A.3
  • 31
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet 2002;31:339-46.
    • (2002) Nat Genet , vol.31 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 32
    • 0033867475 scopus 로고    scopus 로고
    • Genetics of hepatocellular carcinoma
    • Buendia MA. Genetics of hepatocellular carcinoma. Semin Cancer Biol 2000;10:185-200.
    • (2000) Semin Cancer Biol , vol.10 , pp. 185-200
    • Buendia, M.A.1
  • 33
    • 0034995765 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
    • Laurent-Puig P, Legoix P, Bluteau O, et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 2001;120:1763-73.
    • (2001) Gastroenterology , vol.120 , pp. 1763-1773
    • Laurent-Puig, P.1    Legoix, P.2    Bluteau, O.3
  • 34
    • 84983724119 scopus 로고    scopus 로고
    • Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT.p16(INK4A), and p19(ARF) genes in nasopharyngeal carcinoma
    • Ko JY, Lee TC, Hsiao CF, et al. Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT.p16(INK4A), and p19(ARF) genes in nasopharyngeal carcinoma. Cancer 2002;94:1987-96.
    • (2002) Cancer , vol.94 , pp. 1987-1996
    • Ko, J.Y.1    Lee, T.C.2    Hsiao, C.F.3
  • 35
    • 0034282535 scopus 로고    scopus 로고
    • Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering
    • Girard L, Zochbauer-Muller S, Virmani AK, Gazdar AF, Minna JD. Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering. Cancer Res 2000;60:4894-906.
    • (2000) Cancer Res , vol.60 , pp. 4894-4906
    • Girard, L.1    Zochbauer-Muller, S.2    Virmani, A.K.3    Gazdar, A.F.4    Minna, J.D.5
  • 36
    • 0036147076 scopus 로고    scopus 로고
    • Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: Molecular basis of its occurrence
    • Thiagalingam S, Foy RL, Cheng KH, Lee HJ, Thiagalingam A, Ponte JF. Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence. Curr Opin Oncol 2002;14:65-72.
    • (2002) Curr Opin Oncol , vol.14 , pp. 65-72
    • Thiagalingam, S.1    Foy, R.L.2    Cheng, K.H.3    Lee, H.J.4    Thiagalingam, A.5    Ponte, J.F.6
  • 38
    • 0000553457 scopus 로고
    • P-value adjustments for multiple tests in multivariate binomial models
    • Westfall PH, Young SS. P-value adjustments for multiple tests in multivariate binomial models. J Am Stat Assoc 1989;84:780-6.
    • (1989) J Am Stat Assoc , vol.84 , pp. 780-786
    • Westfall, P.H.1    Young, S.S.2
  • 40
    • 0033031437 scopus 로고    scopus 로고
    • DNA arrays for analysis of gene expression
    • Eisen MB, Brown PO. DNA arrays for analysis of gene expression. Methods Enzymol 1999;303:179-205.
    • (1999) Methods Enzymol , vol.303 , pp. 179-205
    • Eisen, M.B.1    Brown, P.O.2
  • 41
    • 0032231877 scopus 로고    scopus 로고
    • Comprehensive human genetic maps: Individual and sex-specific variation in recombination
    • Broman KW, Murray JC, Sheffield VC, White RL, Weber JL. Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet 1998;63:861-9.
    • (1998) Am J Hum Genet , vol.63 , pp. 861-869
    • Broman, K.W.1    Murray, J.C.2    Sheffield, V.C.3    White, R.L.4    Weber, J.L.5
  • 43
    • 0002874089 scopus 로고    scopus 로고
    • A distinct tumor suppressor gene locus on chromosome 15q21.1 in sporadic form of colorectal cancer
    • Park WS, Park JY, Oh RR, et al. A distinct tumor suppressor gene locus on chromosome 15q21.1 in sporadic form of colorectal cancer. Cancer Res 2000;60:70-3.
    • (2000) Cancer Res , vol.60 , pp. 70-73
    • Park, W.S.1    Park, J.Y.2    Oh, R.R.3
  • 44
    • 0037531519 scopus 로고    scopus 로고
    • Chromosomal region 15q21.1 is a frequent target of allelic imbalance in advanced breast carcinomas
    • Rhiem K, Klein A, Munch M, et al. Chromosomal region 15q21.1 is a frequent target of allelic imbalance in advanced breast carcinomas. Int J Cancer 2003;106:74-7.
    • (2003) Int J Cancer , vol.106 , pp. 74-77
    • Rhiem, K.1    Klein, A.2    Munch, M.3
  • 46
    • 0345707580 scopus 로고    scopus 로고
    • High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder
    • Natrajan R, Louhelainen J, Williams S, Laye J, Knowles MA. High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder. Cancer Res 2003;63:7657-62.
    • (2003) Cancer Res , vol.63 , pp. 7657-7662
    • Natrajan, R.1    Louhelainen, J.2    Williams, S.3    Laye, J.4    Knowles, M.A.5
  • 47
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 48
    • 0036216526 scopus 로고    scopus 로고
    • Genes involved in hepatocellular carcinoma: Deregulation in cell cycling and apoptosis
    • Tannapfel A, Wittekind C. Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis. Virchows Arch 2002;440:345-52.
    • (2002) Virchows Arch , vol.440 , pp. 345-352
    • Tannapfel, A.1    Wittekind, C.2
  • 49
    • 0034495080 scopus 로고    scopus 로고
    • β-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis
    • Hsu HC, Jeng YM, Mao TL, Chu JS, Lai PL, Peng SY. β-Catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 2000;157:763-70.
    • (2000) Am J Pathol , vol.157 , pp. 763-770
    • Hsu, H.C.1    Jeng, Y.M.2    Mao, T.L.3    Chu, J.S.4    Lai, P.L.5    Peng, S.Y.6
  • 50
    • 0037174667 scopus 로고    scopus 로고
    • Cancer biology: A matter of dosage
    • Fodde R, Smits R. Cancer biology: a matter of dosage. Science 2002;298:761-3.
    • (2002) Science , vol.298 , pp. 761-763
    • Fodde, R.1    Smits, R.2
  • 51
    • 0034425049 scopus 로고    scopus 로고
    • Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays
    • Lindblad-Toh K, Tanenbaum DM, Daly MJ, et al. Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nat Biotechnol 2000;18:1001-5.
    • (2000) Nat Biotechnol , vol.18 , pp. 1001-1005
    • Lindblad-Toh, K.1    Tanenbaum, D.M.2    Daly, M.J.3
  • 52
    • 0032823523 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA copy-number changes using cDNA microarrays
    • Pollack JR, Perou CM, Alizadeh AA, et al. Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet 1999;23:41-6.
    • (1999) Nat Genet , vol.23 , pp. 41-46
    • Pollack, J.R.1    Perou, C.M.2    Alizadeh, A.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.