Truncation of Ube3a-ATS Unsilences Paternal Ube3a and Ameliorates Behavioral Defects in the Angelman Syndrome Mouse Model

PLoS Genetics

Volumn 9, Issue 12, 2013, Pages

  Meng, Linyan ^a   Person, Richard Erwin ^a   Huang, Wei ^a   Zhu, Ping Jun ^a   Costa Mattioli, Mauro ^a   Beaudet, Arthur L ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; UBE3A ATS; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; GENE CASSETTE; GENE DOSAGE; GENE LOCATION; GENE SILENCING; GENE TARGETING; HAPPY PUPPET SYNDROME; IN VIVO STUDY; LONG TERM POTENTIATION; MALE; NONHUMAN; PATERNITY; PHENOTYPE; TRANSCRIPTION ELONGATION; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; UBE3A GENE;

ANGELMAN SYNDROME; ANIMALS; DISEASE MODELS, ANIMAL; GENE SILENCING; GENOMIC IMPRINTING; HUMANS; INTELLECTUAL DISABILITY; MICE; MOLECULAR TARGETED THERAPY; NEURONS; RNA, ANTISENSE; SPEECH DISORDERS; TRANSCRIPTION, GENETIC; UBIQUITIN-PROTEIN LIGASES;

EID: 84892744170     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004039     Document Type: Article

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