Hypoglycemic, antiperoxidative and antihyperlipidemic effects of saponins from Solanum anguivi Lam. fruits in alloxan-induced diabetic rats

South African Journal of Botany

Volumn 88, Issue , 2013, Pages 56-61

  Elekofehinti, O O ^a,c,d   Kamdem, J P ^b   Kade, I J ^c   Rocha, J B T ^b   Adanlawo, I G ^d  

^a ADEKUNLE AJASIN UNIVERSITY   (Nigeria)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^c FEDERAL UNIVERSITY OF TECHNOLOGY   (Nigeria)

^d UNIVERSITY OF ADO EKITI   (Nigeria)

Author keywords

Alloxan; Antidiabetic; Hypoglycemic; Hypolipidemic; Saponin; Solanum anguivi

Indexed keywords

ANTIOXIDANT; DIABETES; ENZYME ACTIVITY; FRUIT; HERB; INHIBITION; LIPID; PROTEIN; RODENT; SECONDARY METABOLITE;

RATTUS; SOLANUM;

EID: 84983719882     PISSN: 02546299     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sajb.2013.04.010     Document Type: Article

References (56)

1. Adanlawo I.G., Akanji M.A. Effect of chronic administration of saponin extract from the fruits of Solanum anguivi Lam. on alkaline phosphatase activities of some rat tissues. Nigerian Journal of Biochemistry and Molecular Biology 2003, 18:59-62.
2. Aebi H. Catalase in vitro. Methods in Enzymology 1984, 105:121-126.
3. Akanji M.A., Nlumanze S.E. Alkaline phosphatase activities repeated suramin administration in some rat tissues cellular systems. Pharmacology and Toxicology 1987, 61:182-183.
4. Bagri P., Ali M., Aeri V., Bhowmik M., Sultana S. Antidiabetic effect of Punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food and Chemical Toxicology 2009, 47:50-54.
5. Bhavsar S.K., Singh S., Giri S., Jain M.R., Santani D.D. Effect of saponins from Helicteres isora on lipid and glucose metabolism regulating genes expression. Journal of Ethnopharmacology 2009, 124:426-433.
6. Bierman E.L. Atherogenesis in diabetes. Arteriosclerosis and Thrombosis 1992, 12:647-656.
7. Bukenya-Ziraba R. Solanum anguivi Lam. Plant Resources of Tropical Africa 2. Vegetables 2004, PROTA Foundations/Backhuys Publishers/CTA, Wageningen. G.J.H. Gruben, O.A. Denton (Eds.).
8. Cho S.Y., Park J.Y., Park E.M., Choi M.S., Lee M.Y., Jeon S.M., Jang M.K., Kim M.J., Gupta R.K., Kesari A.N., Watal G., Murthy P.S., Chandra R., Maithal K., Tandon V. Hypoglycemic and antidiabetic effect of aqueous extract of leaves of Annona squamosa. Current Science 2005, 88:1244-1254.
9. Chopra R.N., Chopra I.C., Handi K.L., Kapor L.D. Indigenous Drugs of India 1994, Academic Publishers, Calcutta, India.
10. Dave G.S., Kalia K. Hyperglycemia induced oxidative stress in type-1 and type-2 diabetic patients with and without nephropathy. Cell Molecular Biology 2007, 53:68-78.
11. Dinesh k.B., Analava M., Manjunatha M. Azadirachtolide: an anti-diabetic and hypolipidemic effects from Azadirachta indica leaves. Pharmacognosy Communication 2011, 1:78-84.
12. Dujovne C.A., Harris W.S. The pharmacological treatment of dyslipidemia. Annual Review of Pharmacology and Toxicology 1989, 29:265-288.
13. Edziri H., Ammar S., Souad L., Mahjoub M.A., Mastori M., Aouni M., Mighri Z., Verschaeve L. In vitro evaluation of antimicrobial and antioxidant activities of some Tunisian vegetables. South African Journal of Botany 2012, 78:252-256.
14. Elekofehinti O.O., Adanlawo I.G., Fakoya A., Saliu J.A., Sodehinde S.A. Effect of saponin from Solanum anguivi Lam. fruit on heart and kidney superoxide dismutase, catalase and malondialdehyde in rat. Current Research Journal of Biological Sciences 2012, 4:530-533.
15. Elekofehinti O.O., Adanlawo I.G., Saliu J.A., Sodehinde S.A. Saponins from Solanum anguivi fruits exhibit hypolipidemic potential in Rattus novergicus. Der Pharmacia Lettre 2012, 4:811-814.
16. Esterbauer H. Estimation of peroxidative damage: a critical review. Pathology Biology Paris 1996, 44:25-28. ( (PMID: 8734296)).
17. Eu C.H., Lim W.Y., Ton S.H., Kadir K.A. Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet induced obese rats. Lipids in Health and Disease 2010, 9:1-9.
18. Goldstein B.J. Insulin resistance as the core defect in type 2 diabetes mellitus. The American Journal of Cardiology 2002, 90:3-10.
19. Grover J.K., Yadav S., Vats V. Medicinal plants of India with antidiabetic potential. Journal of Ethnopharmacology 2002, 81:81-100.
20. Guide for the Care and Use of Laboratory Animals ILAR, National Research Council 1986, National Academies Press, 1986 (p. 65, ISBN 0309053773).
21. Honbu T., Ikeda T., Zhu X.H., Yoshihara O., Okawa M., Nafady A.M., Nohara T. New steroidal glycosides from the fruits of Solanum anguivi. Journal of Natural Products 2000, 65:1918-1920.
22. Inzucchi S.E. Oral antihyperglycemic therapy for type 2 diabetes: scientific review. Journal of the American Medical Association 2002, 287:360-372.
23. Janero D.R. Malondialdehyde and thiobarbituric acid reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radical Biology & Medicine 1990, 9:515-540.
24. Jansen P.C.M. Cleome viscosa L. Internet Record from Protabase. PROTA (Plant Resources of Tropical Africa/Ressources végétales de l'Afrique tropicale), Wageningen, Netherlands 2004, ( (28 April 2008)). G.J.H. Grubben, O.A. Denton (Eds.).
25. Joshep L., Ira D., Maddux B., Grodsky G. Oxidative stress and stress - activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocrine Reviews 2002, 23:599-622.
26. Kalaivanam K.N., Mala D., Sara R.M. Lipid peroxidation in type 2 diabetes mellitus. International Journal of Diabetes in Developing Countries 2010, 26:30-32.
27. Keaney F.J., Localzo J. Diabetes, oxidative stress and platelet activation. Circulation 1999, 99:189-191.
28. Kennedy A.L., Lyons T.J. Glycation, oxidation and lipoxidation in the development of diabetic complications. Metabolism 1997, 46:14-21.
29. Kim Y.Y., Kang H.J., Ko S.K., Chung S.H. Sopungsungi-won (SP) prevents the onset of hyperglycemia and hyperlipidemia in Zucker diabetic fatty rats. Archives of Pharmaceutical Research 2002, 25:923-931.
30. Lee K.T., Jung T.W., Lee H.J., Kim S.G., Shin Y.S., Whang W.K. The antidiabetic effect of genosenoside Rb2 via activation of AMPK. Archives of Pharmaceutical Research 2011, 34:1201-1208.
31. Li W.L., Zhen H.C., Bukuru J., De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of Ethnopharmacology 2004, 92:1-21.
32. Marica J.B., Valjko B., Jadranka B., Zeljko M., Ivan J., Zeljko R. Impact of glycemic control on antioxidant enzyme activity in patients with Type 2 diabetes mellitus. Diabetologic Croatica 2005, 33:131-135.
33. Nishikawa T., Edelstein D., Du X.L. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000, 404:787-790.
34. Ogbonnia S., Adekunle A.A., Bosa M.K., Enwuru V.N. Evaluation of acute and subacute toxicity of Alstonia congensis Engler (Apocynaceae) bark and Xylopia aethiopica (Dunal) A. Rich (Annonaceae) fruits mixtures used in the treatment of diabetes. African Journal of Biotechnology 2008, 7:701-705.
35. Okhawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal of Biochemistry 1979, 95:351-358.
36. Pearl K., Laasko M., Uusitupa M. Diabetes and atherosclerosis: an epidemiologic view. Diabetes Metabolic Review 1987, 3:463-524.
37. Peipei Y., Shan Z., Siyu C., Jieyuan L., Lingling S., Xinjie W., Yujun L., Chao M. Hypoglycemic and hypolipidemic effects of polyphenols from burs of Castanea mollissima blume. Molecules 2011, 16:9764-9774.
38. Rajesh K.G., Achyut N.K., Sandhya D., Ameetabh T., Vibha T., Ramesh C., Geeta W. In vivo evaluation of antioxidant and anti-lipidimic potential of Annona squamosal aqueous extract in Type 2 diabetic models. Journal of Ethnopharmacology 2008, 118:21-25.
39. Ripperger H., Himmelreich U. Anguivine and isoanguivine, steroid alkaloid glycosides from Solanum anguivi. Phytochemistry 1994, 37:1725-1727.
40. Sakatani T., Shirayama T.S., Uzaki Y., Yamamoto T.M., Ani H., Kawasaki T., Sugihara H., Matsubara H. The association between cholesterol and mortality in heart failure. Comparison between patients with and without coronary artery disease. International Heart Journal 2005, 46:619-629.
41. Shah J.G., Patel M.S., Patel K.V., Gandhi T.R. Evaluation of anti-diabetic and antioxidant activity of Centratherum anthelmintica in STZ-induced diabetes in rats. The International Internet Journal of Pharmacology 2008, 6:1-10.
42. Sharma N., Garg V. Antidiabetic and antioxidant potential of ethanolic extract of Butea monosperma leaves in alloxan-induced diabetic mice. Indian Journal of Biochemistry & Biophysics 2009, 46:99-105.
43. Sharma V.K., Kumar S., Patel H.J., Hugar S. Hypoglycemic activity of Ficus glomerata in alloxan induced diabetic rat. International Journal of Pharmaceutical Sciences Review and Research 2010, 1:18-22.
44. Sun M., Zigman S. An improved spectrophotomeric assay for superoxide dismutase based on epinephrine autoxidation. Annals of Biochemistry 1978, 90:81-89.
45. Szkudelski T. The mechanism of alloxan and streptozotocin action in β cells of the rat pancreas. Physiology Research 2001, 50:536-546.
46. Tahrani A.A., Piya M.K., Kennedy A., Barnett A.H. Glycemic control in type 2 diabetes: targets and new therapies. Pharmacology Therapy 2010, 125:328-361.
47. Uebanso T., Arai H., Taketani Y., Fukaya M., Yamamoto H., Mizuno A., Uryu K., Hada T., Takeda E. Extracts of Momordica charantia suppress postprandial hyperglycemia in rats. Journal of Nutritional Science and Vitaminology 2007, 53:482-488.
48. Vanhorebeek I., De Vos R., Mesotten D., Wouters P.J., De Wolf-Peeters C., Van den Berghe G. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 2005, 365:53-59.
49. Vanhorebeek I., Ellger B., De Vos R., Boussemaere M., Debaveye Y., Perre S.V., Rabbani N., Thornalley P.J., Van den Berghe G. Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness. Critical Care Medicine 2009, 37:1355-1364.
50. Vasan S., Foiles P., Founds H. Therapeutic potential of breakers in advanced glycation end product-protein cross links. Archives of Biochemistry and Biophysics 2003, 419:89-96.
51. Villeneuve L.M., Natarajan R. The role of epigenetics in the pathology of diabetic complications. American Journal of Physiology. Renal Physiology 2010, 299:14-25.
52. Warrier P.K., Nambiar V.P.K., Raman K. Solanum anguivi Lam. Indian Medicinal Plants 1996, vol. V. Orient Longman Limited, Madras India.
53. Wohaieb S.A., Goldin D.V. Alterations in free radical tissue defense mechanism in streptozotocin-induced diabetes in rat. Effects of insulin treatment. Diabetes 1987, 36:1014-1018.
54. Wolff S.P., Bascal Z.A., Hunt J.V. Autoxidative glycosylation: free radicals and glycation theory. Progress in Clinical and Biological Research 1989, 304:259-275.
55. Yoganarasimhan S.N. Medicinal Plant of India 1996, vol. I. Interline Publishing Pvt. Ltd., Bangalore, India.
56. Zhu X.H., Ikeda T., Nohara T. Studies on the constituents of solanaceous plants. Steroidal glycosides from the fruits of Solanum anguivi. Chemical Pharmacology Bulletin 2000, 48(4):568-570.