Improved oral bioavailability and anticancer efficacy on breast cancer of paclitaxel via Novel Soluplus®—Solutol® HS15 binary mixed micelles system

International Journal of Pharmaceutics

Volumn 512, Issue 1, 2016, Pages 186-193

  Hou, Jian ^a,b   Sun, E ^a   Sun, Congyong ^b   Wang, Jing ^a   Yang, Lei ^a,b   Jia, Xiao bin ^a,b   Zhang, Zhen hai ^a  

^a KEY LABORATORY OF NEW DRUG DELIVERY SYSTEM OF CHINESE MATERIA MEDICA   (China)

^b JIANGSU UNIVERSITY   (China)

Author keywords

Anti tumor; Caco 2 monolayer; HE staining; Micelles; Oral bioavailability; Paclitaxel; Soluplus ; Solutol HS15

Indexed keywords

PACLITAXEL; SOLUTOL HS 15; DRUG CARRIER; MACROGOL DERIVATIVE; MICELLE; POLYMER; POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMER; POLYVINYL DERIVATIVE; STEARIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APPARENT PERMEABILITY; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG DELIVERY DEVICE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SOLUBILITY; GASTROINTESTINAL ABSORPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MALE; MICELLE; MOUSE; MTT ASSAY; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE; TANDEM MASS SPECTROMETRY; TRANSCYTOSIS; TUMOR VOLUME; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ZETA POTENTIAL; ANIMAL; BIOAVAILABILITY; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG RELEASE; DRUG SCREENING; ORAL DRUG ADMINISTRATION; TUMOR CELL LINE;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; CELL SURVIVAL; DRUG CARRIERS; DRUG LIBERATION; MALE; MICE; MICELLES; PACLITAXEL; POLYETHYLENE GLYCOLS; POLYMERS; POLYVINYLS; RATS; STEARIC ACIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84983613448     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.08.045     Document Type: Article

References (34)

1. Akiyama, K., Maishi, N., Ohga, N., Hida, Y., Ohba, Y., Alam, M.T., Kawamoto, T., Ohmura, H., Yamada, K., Torii, C., Shindoh, M., Hida, K., Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel. Am. J. Pathol. 185 (2015), 572–580.
2. Alani, A.W., Rao, D.A., Seidel, R., Wang, J., Jiao, J., Kwon, G.S., The effect of novel surfactants and Solutol HS 15 on paclitaxel aqueous solubility and permeability across a Caco-2 monolayer. J. Pharm. Sci. 99 (2010), 3473–3485.
3. Batrakova, E.V., Li, S., Vinogradov, S.V., Alakhov, V.Y., Miller, D.W., Kabanov, A.V., Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization. J. Pharmacol. Exp. Ther. 299 (2001), 483–493.
4. ®)-TPGS mixed micelles for encapsulation of paclitaxel with enhanced in vitro cytotoxicity on breast and ovarian cancer cell lines. Colloids Surf. B Biointerfaces 140 (2016), 403–411.
5. Cabral, H., Kataoka, K., Progress of drug-loaded polymeric micelles into clinical studies. J. Controled Release 190 (2014), 465–476.
6. Chen, Y., Zhang, W., Huang, Y., Gao, F., Sha, X., Fang, X., Pluronic-based functional polymeric mixed micelles for co-delivery of doxorubicin and paclitaxel to multidrug resisitant tumor. Int. J. Pharm. 488 (2015), 44–58.
7. Chen, G., Jaskula SztulR. Harrison, A., Dammalapati, A., Xu, W., Cheng, Y., Chen, H., Gong, S., KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy. Biomaterials 97 (2016), 22–23.
8. Dahmani, F.Z., Yang, H., Zhou, J., Yao, J., Zhang, T., Zhang, Q., Enhanced oral bioavailability of paclitaxel in pluronic/LHR mixed polymeric micelles: preparation, in vitro and in vivo evaluation. Eur. J. Pharm. Sci. 47 (2012), 179–189.
9. Dehghan, K.P., Saadat, E., Ravar, F., Akbari, H., Dorkoosh, F., Pluronic F127 polymeric micelles for co-delivery of paclitaxel and lapatinib against metastatic breast cancer: preparation, optimization and in vitro evaluation. Pharm. Dev. Technol., 29, 2014.
10. Feng, Y., Sun, C., Yuan, Y., Zhu, Y., Wan, J., Firempong, C.K., Omari-Siaw, E., Xu, Y., Pu, Z., Yu, J., Xu, X., Enhanced oral bioavailability and in vivo antioxidant activity of chlorogenic acid via liposomal formulation. Int. J. Pharm. 501 (2016), 342–359.
11. Gelderblom, H., Verweij, J., Nooter, K., Sparreboom, A., Cremophor EL: thedrawbacks and advantages of vehicle selection for drug formulation. Eur. J. Cancer. 37 (2001), 1590–1598.
12. Hou, J., Wang, J., Sun, E., Yang, L., Yan, H.M., Jia, X.B., Zhang, Z.H., Preparation and evaluation of icariside II-loaded binary mixed micelles using Solutol HS15 and Pluronic F127 as carriers. Drug Deliv. 11 (2016), 1–9.
13. Howat, S., Park, B., Oh, I.S., Jin, Y.W., Lee, E.K., Loake, G.J., Paclitaxel: biosynthesis, production and future prospects. N. Biotechnol. 31 (2014), 242–245.
14. Illum, L., Jordan, F., Lewis, A.L., CriticalSorb: a novel efficient nasal delivery system for human growth hormone based on Solutol HS15. J. Controled Release 162 (2012), 194–200.
15. Ji, X., Gao, Y., Chen, L., Zhang, Z., Deng, Y., Li, Y., Nanohybrid systems of non-ionic surfactant inserting liposomes loading paclitaxel for reversal of multidrug resistance. Int. J. Pharm. 422 (2012), 390–397.
16. Jin, X., Zhou, B., Xue, L., San, W., Soluplus micelles as a potential drug delivery system for reversal of resistant tumor. Biomed. Pharmacother. 69 (2015), 388–395.
17. Kim, S.A., Kim, S.W., Choi, H.K., Han, H.K., Enhanced systemic exposure of saquinavir via the concomitant use of curcumin-loaded solid dispersion in rats. Eur. J. Pharm. Sci. 49 (2013), 800–804.
18. Lee, K., Chae, S.W., Xia, Y., Kim, N.J., Kim, H.J., Rhie, S., Lee, H.J., Effect of coumarin derivative-mediated inhibition of P-glycoprotein on oral bioavailability and therapeutic efficacy of paclitaxel. Eur. J. Pharmacol. 15 (2014), 381–388.
19. Lee, J.Y., Kang, W.S., Piao, J., Yoon, I.S., Kim, D.D., Cho, H.J., Soluplus/TPGS-based solid disperions prepared by hot-melt extrusion equipped with twin-screw systems for enhancing oral bioavailability of valsartan. Drug Des. Devel. Ther. 9 (2015), 2745–2756.
20. Mehta, S.K., Jindal, N., Mixed micelles of lecithin-tyloxapol as pharmaceutical nanocarriers for anti-tubercular drug delivery. Colloids Surf. B Biointerfaces 110 (2013), 419–425.
21. ® HS15/water phase diagram and the impact of the (9-tetrahydrocannabinol solubilization. J. Colloid. Interface. Sci. 390 (2013), 129–136.
22. ®-based solid dosage forms of improved dissolution. J. Pharm. Sci. 101 (2012), 322–332.
23. Prashant, K., Keerti, Jain, Narendra, K.J., Dendrimer as nanocarrier for drug delivery. Prog. Polym. Sci. 39 (2014), 268–307.
24. Réti-Nagy, K., Malanga, M., Fenyvesi, É., Szente, L., Vámosi, G., Váradi, J., Bácskay, I., Fehér, P., Ujhelyi, Z., Róka, E., Vecsernyés, M., Balogh, G., Vasvári, G., Fenyvesi, F., Endocytosis of fluorescent cyclodextrins by intestinal Caco-2 cells and its role in paclitaxel drug delivery. Int. J. Pharm. 496 (2015), 509–517.
25. Ravar, F., Saadat, E., Gholami, M., Dehghankelishadi, P., Mahdavi, M., Azami, S., Dorkoosh, F.A., Hyaluronic acid-coated liposomes for targeted delivery of paclitaxel, in-vitro characterization and in-vivo evaluation. J. Controled Release 229 (2016), 10–22.
26. Rowinsky, E.K., Onetto, N., Canetta, R.M., Arbuck, S.G., Taxol: the first of the taxanes, an important new class of antitumor agents. Semin. Oncol. 19 (1992), 646–662.
27. ® HS15) investigated In vitro in cell cultures. Pharm. Res. 32 (2015), 516–527.
28. Song, J., Huang, H., Xia, Z., Wei, Y., Yao, N., Zhang, L., Yan, H., Jia, X., Zhang, Z., TPGS/Phospholipids mixed micelles for delivery of icariside II to multidrug-resistant breast cancer. Integr. Cancer Ther., 20, 2015 (Epub ahead of print).
29. Teow, H.M., Zhou, Z., Najlah, M., Yusof, S.R., Abbott, N.J., D'Emanuele, A., Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier. Int. J. Pharm. 441 (2013), 701–711.
30. Tripathi, A., Misra, K., Inhibition of P-glycoprotein mediated efflux of paclitaxel by coumarin derivatives in cancer stem cells: an insilico approach. Comb. Chem. High. Throughput. Screen, 2016 (Epub ahead of print).
31. Xia, D., Yu H1, Tao, J., Zeng, J., Zhu, Q., Zhu, C., Gan, Y., Supersaturated polymeric micelles for oral cyclosporine A delivery:The role of Soluplus–sodium dodecyl sulfate complex. Colloids Surf. B. Biointerfaces 141 (2016), 301–310.
32. Yuan, H., Sun, B., Gao, F., Lan, M., Synergistic anticancer effects of andrographolide and paclitaxel against A549 NSCLC cells. Pharm. Biol. 9 (2016), 1–7.
33. Zhang, N., Xu, X., Zhang, X., Qu, D., Xue, L., Mo, R., Zhang, C., Nanocomposite hydrogel incorporating gold nanorods and paclitaxel-loaded chitosan micelles for combination photothermal-chemotherapy. Int. J. Pharm. 497 (2016), 210–221.
34. Zhou, Z., D'Emanuele, A., Attwood, D., Solubility enhancement of paclitaxel using a linear-dendriticblock copolymer. Int. J. Pharm. 452 (2013), 173–179.