Mechanism of mucosal permeability enhancement of CriticalSorb® (Solutol® HS15) investigated in vitro in cell cultures

Pharmaceutical Research

Volumn 32, Issue 2, 2015, Pages 516-527

  Shubber, Saif ^a   Vllasaliu, Driton ^a,b   Rauch, Cyril ^c   Jordan, Faron ^d   Illum, Lisbeth ^d   Stolnik, Snjezana ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LINCOLN   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d Critical Pharmaceuticals Limited   (United Kingdom)

Author keywords

Absorption enhancers; Calu 3 cells; Mucosal protein delivery; Solutol HS15; Surfactants

Indexed keywords

CHITOSAN; F ACTIN; LACTATE DEHYDROGENASE; PROTEIN ZO1; SOLUTOL HS 15; SURFACTANT; MACROGOL DERIVATIVE; MICELLE; STEARIC ACID DERIVATIVE;

ACTIN FILAMENT; ARTICLE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE RESISTANCE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; DRUG ABSORPTION; DRUG DELIVERY DEVICE; ELECTRIC RESISTANCE; ENDOCYTOSIS; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VITRO STUDY; MICELLE; PARTICLE SIZE; PRIORITY JOURNAL; TIGHT JUNCTION; CACO 2 CELL LINE; CELL SURVIVAL; DRUG DELIVERY SYSTEM; K562 CELL LINE; METABOLISM; MUCOSA; PERMEABILITY; PHYSIOLOGY; PROCEDURES; SOLUBILITY;

CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; HUMANS; K562 CELLS; MICELLES; MUCOUS MEMBRANE; PERMEABILITY; POLYETHYLENE GLYCOLS; SOLUBILITY; STEARIC ACIDS;

EID: 84921448854     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1481-5     Document Type: Article

References (40)

1. Aungst BJ, Rogers NJ, Shefter E. Comparison of nasal, rectal, buccal, sublingual and intramuscular insulin efficacy and the effects of a bile salt absorption enhancer. J Pharmacol Exp Ther. 1988;244(1):23-7.
2. Vllasaliu D, Casettari L, Fowler R, Exposito-Harris R, Garnett M, Illum L, et al. Absorption-promoting effects of chitosan in airway and intestinal cell lines: a comparative study. Int J Pharm. 2012;430(1-2):151-60.
3. Stolnik S, Shakesheff K. Formulations for delivery of therapeutic proteins. Biotechnol Lett. 2009;31(1):1-11.
4. Vllasaliu D, Shubber S, Fowler R, Garnett M, Alexander C, Stolnik S. Epithelial toxicity of alkylglycoside surfactants. J Pharm Sci. 2013;102(1):114-25.
5. Xiang J, Fang X, Li X. Transbuccal delivery of 2′,3′-dideoxycytidine: in vitro permeation study and histological investigation. Int J Pharm. 2002;231(1):57-66.
6. Vllasaliu D, Exposito-Harris R, Heras A, Casettari L, Garnett M, Illum L, et al. Tight junction modulation by chitosan nanoparticles: comparison with chitosan solution. Int J Pharm. 2010;400(1-2):183-93.
7. Rosenthal R, Günzel D, Finger C, Krug SM, Richter JF, Schulzke JD, et al. The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier. Biomaterials. 2012;33(9):2791-800.
8. Illum L, Jordan F, Lewis AL. CriticalSorb (TM): a novel efficient nasal delivery system for human growth hormone based on solutol HS15. J Control Release. 2012;162(1):194-200.
9. Alani AWG, Rao DA, Seidel R, Wang J, Jiao J, Kwon GS. The effect of novel surfactants and solutol (R) HS 15 on paclitaxel aqueous solubility and permeability across a caco-2 monolayer. J Pharm Sci. 2010;99(8):3473-85.
10. Brayden DJ, Bzik VA, Lewis AL, Illum L. CriticalSorb (TM) promotes permeation of flux markers across isolated Rat intestinal mucosae and caco-2 monolayers. Pharm Res. 2012;29(9):2543-54.
11. Grainger CI, Greenwell LL, Lockley DJ, Martin GP, Forbes B. Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier. PharmRes. 2006;23:1482-90.
12. Ong HX, Traini D, Young PM. Pharmaceutical applications of the Calu-3 lung epithelia cell line. Expert Opin Drug Deliv. 2013;10:1287-302.
13. Schipper NG, Olsson S, Hoogstraate JA, de Boer AG, Varum KM, Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement. Pharm Res. 1997;14(7):923-9.
14. Artursson P, Lindmark T, Davis S, Illum L. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm Res. 1994;11(9):1358-61.
15. Rauch C, Farge E. Endocytosis switch controlled by transmembrane osmotic pressure and phospholipid number asymmetry. Biophys J. 2000;78(6):3036-47.
16. Aguiar J, Carpena P, Molina-Bolivar JA, Ruiz CC. On the determination of the critical micelle concentration by the pyrene 1: 3 ratio method. J Colloid Interface Sci. 2003;258(1):116-22.
17. Dominguez A, Fernandez A, Gonzalez N, Iglesias E, Montenegro L. Determination of critical micelle concentration of some surfactants by three techniques. J Chem Educ. 1997;74(10):1227-31.
18. Angelo R, Rousseau K, Grant M, Leone-Bay A, Richardson P. Technosphere insulin: defining the role of technosphere particles at the cellular level. J Diabetes Sci Technol. 2009;3(3):545-54.
19. Rizzoli SO, Richards DA, Betz WJ. Monitoring synaptic vesicle recycling in frog motor nerve terminals with FM dyes. J Neurocytol. 2003;32(5-8):539-49.
20. Rauch C, Pluen A, Foster N, Loughna P, Mobasheri A, Lagadic-Gossmann D, et al . On some aspects of the thermodynamic of membrane recycling mediated by fluid phase endocytosis: evaluation of published data and perspectives. Cell Biochem Biophys. 2010;56(2-3):73-90.
21. BASF. Solutol® HS 15: Technical Information. Health and Nutrition,. 2003.
22. Briganti G, D'Arrigo G, Falconi L, Maccarini M. Interfacial properties of nonionic micellar aggregates as a function of temperature and concentration. Colloids Surf A. 2000;164(1):19-25.
23. Lin H, Gebhardt M, Bian S, Kwon KA, Shim C-K, Chung S-J, et al. Enhancing effect of surfactants on fexofenadine center dot HCl transport across the human nasal epithelial cell monolayer. Int J Pharm. 2007;330(1-2):23-31.
24. Inacio AS, Mesquita KA, Baptista M, Ramalho-Santos J, Vaz WLC, Vieira OV. In vitro surfactant structure-toxicity relationships: implications for surfactant use in sexually transmitted infection prophylaxis and contraception. Plos One. 2011;6(5):e19850.
25. Webborn PJH, Parker AJ, Denton RL, Riley RJ. In vitro-in vivo extrapolation of hepatic clearance involving active uptake: theoretical and experimental aspects. Xenobiotica. 2007;37(10-11):1090-109.
26. Prete PSC, Domingues CC, Meirelles NC, Malheiros SVP, Goni FM, de Paula E, et al. Multiple stages of detergent-erythrocyte membrane interaction-A spin label study. Biochim Biophys Acta. 2011;1808(1):164-70.
27. Lichtenberg D, Ahyayauch H, Goni FM. The mechanism of detergent solubilization of lipid bilayers. Biophys J. 2013;105(2): 289-99.
28. Caroni P. Actin cytoskeleton regulation through modulation of PI(4, 5)P-2 rafts. Embo J. 2001;20(16):4332-6.
29. Suwalsky M, Mennickent S, Norris B, Villena F, Sotomayor CP. Effects of the antiepileptic drug carbamazepine on human erythrocytes. Toxicol in Vitro. 2006;20(8):1363-9.
30. Busch S, Unruh T. The influence of additives on the nanoscopic dynamics of the phospholipid dimyristoylphosphatidylcholine. Biochim Biophys Acta. 2011;1808(1):199-208.
31. Arouri A, Mouritsen OG. Membrane-perturbing effect of fatty acids and lysolipids. Prog Lipid Res. 2013;52(1):130-40.
32. Brown DA, London E. Structure and origin of ordered lipid domains in biological membranes. J Membr Biol. 1998;164(2):103-14.
33. Schuck S, Honsho M, Ekroos K, Shevchenko A, Simons K. Resistance of cell membranes to different detergents. Proc Natl Acad Sci U S A. 2003;100(10):5795-800.
34. Ibarguren M, López DJ, Encinar JA, González-Ros JM, Busquets X, Escribá PV. Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives. Biochim Biophys Acta. 2013;1828(11):2553-63.
35. Park M-J, Chung Y-C, Chun BC. PEG-based surfactants that show high selectivity in disrupting vesicular membrane with or without cholesterol. Colloids Surf B. 2003;32(1):11-8.
36. Vllasaliu D, Shubber S, Garnett M, Alexander C, Eaton M, Stolnik S. Evaluation of calcium depletion as a strategy for enhancement of mucosal absorption of macromolecules. Biochem Biophys Res Commun. 2012;418(1):128-33.
37. Deng Z, Zink T, Chen H-y, Walters D, Liu F-t, Liu G-y. Impact of actin rearrangement and degranulation on the membrane structure of primary mast cells: a combined atomic force and laser scanning confocal microscopy investigation. Biophys J. 2009;96(4):1629-39.
38. Laux T, Fukami K, Thelen M, Golub T, Frey D, Caroni P. GAP43, MARCKS, and CAP23 modulate PI(4,5)P-2 at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J Cell Biol. 2000;149(7):1455-71.
39. Fanning AS, Jameson BJ, Jesaitis LA, Anderson JM. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J Biol Chem. 1998;273(45):29745-53.
40. Gale JE, Marcotti W, Kennedy HJ, Kros CJ, Richardson GP. FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel. J Neurosci. 2001;21(18):7013-25.