Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R

Microvascular Research

Volumn 106, Issue , 2016, Pages 117-127

  Li, Wei ^a   Suwanwela, Nijasri C ^a   Patumraj, Suthiluk ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Curcumin; Ischemia reperfusion; Middle cerebral artery occlusion; Nuclear factor erythroid related factor 2; Nuclear factor kappa B

Indexed keywords

CORN OIL; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; TRANSCRIPTION FACTOR NRF2; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; NEUROPROTECTIVE AGENT; NFE2L2 PROTEIN, RAT; RELA PROTEIN, RAT; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTI APOPTOTIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VOLUME; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN WATER; CAPILLARY PERMEABILITY; CELL DEATH; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; INFARCTION VOLUME; LIPID PEROXIDATION; MALE; MEMBRANE DAMAGE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC DISEASE; NEUROLOGICAL DEFICIT SCORE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SCORING SYSTEM; UPREGULATION; WATER CONTENT; WISTAR RAT; ANIMAL; APOPTOSIS; DISEASE MODEL; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; BLOOD-BRAIN BARRIER; BRAIN EDEMA; CAPILLARY PERMEABILITY; CURCUMIN; DISEASE MODELS, ANIMAL; DOWN-REGULATION; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RATS, WISTAR; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTOR RELA; UP-REGULATION;

EID: 84983551823     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2015.12.008     Document Type: Article

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