DJ-1 expression in cervical carcinoma and its effects on cell viability and apoptosis

Medical Science Monitor

Volumn 22, Issue , 2016, Pages 2943-2949

  Wang, Han ^a   Gao, Weiwei ^a  

^a Department of Respiratory Medicine   (China)

Author keywords

Apoptosis; Cell survival; Pten phosphohydrolase; Rna interference; Uterine cervical neoplasms

Indexed keywords

DJ 1 PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PARK7 PROTEIN, HUMAN; PROTEIN DEGLYCASE DJ-1; PTEN PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL VIABILITY ASSAY; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MTT ASSAY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEQUENCE ANALYSIS; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING; CELL SURVIVAL; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; UTERINE CERVIX TUMOR;

APOPTOSIS; CELL SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; PHOSPHORYLATION; PROTEIN DEGLYCASE DJ-1; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; UTERINE CERVICAL NEOPLASMS;

EID: 84983470706     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.896861     Document Type: Article

References (35)

1. Ma D, Cheng Y, Zhang Y et al: Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics. Chin J Cancer Res, 2013; 25: 656–61
2. Sankaranarayanan R, Ferlay J: Worldwide burden of gynaecological cancer: The size of the problem. Best Prac Res Clin Obstet Gynaecol, 2006; 20: 207–25
3. Lim GCC, Rampal S, Yahaya H: Cancer incidence in peninsular Malaysia, 2003–2005: The third report of the National Cancer Registry, Malaysia. National Cancer Registry; 2008
4. Hong WK, Hait WN: Holland Frei cancer medicine eight. PMPH-USA; 2010
5. Tsang CM, Lau EPW, Di K et al: Berberine inhibits Rho GTPases and cell migration at low doses but induces G2 arrest and apoptosis at high doses in human cancer cells. Int J Mol Med, 2009; 24: 131–38
6. Sinha S, Yang W: Cellular signaling for activation of Rho GTPase Cdc42. C Signal, 2008; 20: 1927–34
7. Ismail IA, Kang HS, Lee H-J et al: DJ-1 upregulates breast cancer cell invasion by repressing KLF17 expression. Br J Cancer, 2014; 110: 1298–306
8. Hang L, Min W, Min L et al: Expression and role of DJ-1 in leukemia. Biochem Biophys Research Commun, 2008; 375: 477–83
9. Mei T, Cui YZ, Song GH et al: Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer, 2008; 8: 1–11
10. Arnouk H, Merkley MA, Podolsky RH et al: Characterization of Molecular Markers Indicative of Cervical Cancer Progression. Proteomics Clin Appl, 2009; 3: 516–27
11. Yuen HF, Chan YP, Law S et al: DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev, 2008; 17: 3593–602
12. Zhu XL, Wang ZF, Lei WB et al: DJ-1: A novel independent prognostic marker for survival in glottic squamous cell carcinoma. Cancer Sci, 2010; 101: 1320–25
13. Zhou L, Snow B, Binari RC, Manoukian AS: DJ-1, a novel regulator of the tumor suppressor PTEN: Cancer Cell. Cancer Cell, 2005; 7: 263–73
14. Yilmaz OH, Valdez R, Theisen BK et al: PTEN-dependence distinguishes haematopoietic stem cells from leukemia-initating cells. Nature, 2006; 441: 475–82
15. Du J, Wang LN, Li CX et al: MicroRNA-221 targets PTEN to reduce the sensitivity of cervical cancer cells to gefitinib through the PI3K/Akt signaling pathway. Tumor Biology, 2015 [Epub ahead of print]
16. Elbashir SM, Harborth J, Weber K, Tuschl T: Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods, 2002; 26: 199–213
17. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real- time quantitative PCR and the 2–DDCT method. Methods, 2001; 25: 402–8
18. Zhen S, Hua L, Takahashi Y et al: In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by CRISPR/Cas9. Biochem Biophys Res Commun, 2014; 450: 1422–26
19. Bronsert P, Enderle-Ammour K, Bader M et al: Cancer cell invasion and EMT marker expression: A three-dimensional study of the human cancer-host interface. J Pathol, 2014; 234: 410–22
20. Xiangyi H, Zhong Z, Jianfang L et al: DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA. Carcinogenesis 2012; 33: 555–62
21. Laderach DJ, Gentilini LD, Laura G et al: A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease. Cancer Res, 2013; 73: 86–96
22. Douglas H, Weinberg RA. Hallmarks of cancer: The next generation. Cell, 2011; 144: 646–74
23. Davidson B, Hadar R, Schlossberg A et al: Expression and clinical role of DJ- 1, a negative regulator of PTEN, in ovarian carcinoma. Hum Pathol, 2008; 39: 87–95
24. Lee H, Choi SK, Ro JY: Overexpression of DJ-1 and HSP90a, and loss of PTEN associated with invasive urothelial carcinoma of urinary bladder: Possible prognostic markers. Oncol Lett, 2012; 3: 507–12
25. Li Y, Cui J, Zhang C-h et al: High-expression of DJ-1 and loss of PTEN associated with tumor metastasis and correlated with poor prognosis of gastric carcinoma. Int J Med Sci, 2013; 10: 1689–97
26. Kawate T, Iwaya K, Koshikawa K et al: High levels of DJ-1 protein and isoelectric point 6.3 isoform in sera of breast cancer patients. Cancer Sci, 2015; 106(7): 938–43
27. Mirantes C, Eritja N, Dosil MA et al: An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias. Dis Model Mech, 2013; 6: 710–20
28. Fong P, Meng L-R: Effect of mTOR inhibitors in nude mice with endometrial carcinoma and variable PTEN expression status. Med Sci Monit Basic Res, 2014; 20: 146–52
29. Petros K, Papi RM, Xeni P et al: Tumor suppressor PTEN in breast cancer: heterozygosity, mutations and protein expression. Anticancer Res, 2014; 34: 1387–400
30. Maraiz H: Effects of stromal cell derived factor on PTEN. 2014, https://wwwlap-publishingcom
31. Song MS, Salmena L, Pandolfi PP: The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol, 2012; 13: 283–96
32. Amit S, Swain WA, Donna R et al: Phospho-Akt expression is associated with a favorable outcome in non-small cell lung cancer. Clin Cancer Res, 2005; 11: 2930–36
33. Kulik G, Klippel A, Weber MJ: Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol, 1997; 17: 1595–606
34. Brunet A, Bonni A, Zigmond MJ et al: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 1999; 96: 857–68
35. Hossein A, Rousseaux MWC, Marcogliese PC et al: DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proc Natl Acad Sci USA, 2010; 107: 3186–91